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Mouse Lung Tumor

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  • 1.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers

    Authors: Abujiang, P; Mori, TJ; Takahashi, T; Tanaka, F; Kasyu, I; Hitomi, S; Hiai, H
    (1998)
    Minus Sign. Click to see only selected choices. Our recent linkage study of urethane-induced pulmonary adenomas in SMXA RI strains of mouse revealed . . . Plus Sign. Click to expand choices. Our recent linkage study of urethane-induced pulmonary adenomas in SMXA RI strains of mouse revealed two host resistance genes, Par1 (chromosome 11) and Par3 (chromosome 12). The map positions of Par1 and Par3 correspond to human 17q11-23 and 14q11-24, based on synteny between mouse and human. In this study, we examined the loss of heterozygosity (LOH) in these two homologous human chromosomal regions in 30 primary lung adenocarcinoma samples with matched normal DNA. Using 15 highly polymorphic markers, two commonly deleted regions were identified on human chromosomes 14 and 17, respectively. At 17q21, nine (53%) of 17 informative tumors showed LOH between D17S588 and D17S518. On the other hand, at 14q11-12, seven (32%) of 22 informative tumors showed LOH at loci between D14S261 and D14S80. Subsequently, we examined 25 squamous cell carcinomas (SQ) and 24 small cell carcinomas (SCC). At 14q11-12, six (38%) of 16 informative SQ and five (42%) of 12 informative SCC showed LOH. In contrast, at 17q11-23, one (7%) of 15 informative SQ and two (14%) of 14 SCC showed LOH. Therefore, the gene on 17q seemed to affect selectively adenocarcinomas, whereas the other gene on 14q, all three types of lung carcinomas. These observations indicate that a comparative genetic analysis provides a promising approach to survey genes involved in multifactorial process of human lung carcinogenesis.
    Tags: Human Relevance, Mouse Models, Session 2 – Comparative Pathology, Standard Strain MM
  • 2.
    Technical Report
    Technical
    Report
    Toxicological profile for styrene

    Author: ATSDR
    (2010) Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. [ATSDR Tox Profile]
    Minus Sign. Click to see only selected choices. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects . . . Plus Sign. Click to expand choices. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies.
  • 3.
    Technical Report
    Technical
    Report
    Toxicological profile for naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene

    Author: ATSDR
    (2005) (NTIS/02937293). Atlanta, GA: Agency for Toxic Substances and Disease Regristry.
    Minus Sign. Click to see only selected choices. Toxicological Profiles are a unique compilation of toxicological information on a given hazardous substance. . . . Plus Sign. Click to expand choices. Toxicological Profiles are a unique compilation of toxicological information on a given hazardous substance. Each profile reflects a comprehensive and extensive evaluation, summary, and interpretation of available toxicologic and epidemiologic information on a substance. Health care providers treating patients potentially exposed to hazardous substances will find the following information helpful for fast answers to often-asked questions.
    Tags:
  • 4.
    Technical Report
    Technical
    Report
    Cancer facts & figures 2014

    Author: American Cancer Society
    (2014) Atlanta, GA: American Cancer Society.
    Tags: Human Lung Cancer, Session 1 – Epidemiology and Human Pathophysiology
  • 5.
    Technical Report
    Technical
    Report
    Cancer facts & figures 2012

    Author: American Cancer Society
    (2012) Atlanta, GA: American Cancer Society.
    Tags: Human Lung Cancer, Human Pathophysiology, Key Reference, Session 1 – Epidemiology and Human Pathophysiology
  • 6.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Chromosomal aberrations and sister-chromatid exchanges in lymphocytes of men occupationally exposed to styrene in a plastic boat factory

    Authors: Andersson, HC; Tranberg, EA; Uggla, AH; Zetterberg, G
    (1980) DNA Repair 73:387-401.
    Minus Sign. Click to see only selected choices. Summary Workers in a Swedish factory making boats from plastics reinforced with glass fibre are exposed . . . Plus Sign. Click to expand choices. Summary Workers in a Swedish factory making boats from plastics reinforced with glass fibre are exposed to a variety of chemicals, including styrene which is mutagenic after metabolic activation. The concentration of styrene in the air was measured in the breathing zones of workers occupied with various processes in boat making. Samples of air were taken 6 times during the years 1973-1978. The total exposure to styrene for the workers during this period was calculated and expressed as the average concentration in mg per m3 air during an 8-h workshift multiplied by the number of years of employment. A low-dose group (x = 137 mg X m-3) and a high-dose group (x = 1204 mg X m-3) were identified. Blood samples were taken' in 1978 from workers belonging to the exposed groups and from a matched control group of employees in the same factory not exposed to styrene. Lymphocytes were cultured and examined for chromosomal aberrations and sister-chromatid exchanges. Exposed workers had a significantly (p < 0.001) higher number of chromosomal aberrations (36 persons, x = 7.9 aberrations/100 cells) compared with employees in the control group (37 persons, x = 3.2 aberrations/100 cells). There was no significant difference between the mean values of the number of chromosomal aberrations between the highly exposed and the less exposed groups. But in the less exposed group there was an increase in the frequency of chromosomal aberrations with increasing exposure to styrene (r = 0.576). In the highly exposed group this dose response was not observed r = -0.231). For the frequency of sister-chromatid exchanges (SCE) a slight (p < 0.05) increase was found in the styrene-exposed group (20 persons, x = 8.4 SCE/cell). The control group (21 persons) had a mean value of 7.5 SCE/cell. Again there was no difference between the highly exposed and the less exposed groups. Other environmental factors that may have clastogenic effects were studied, but multiple regression analysis failed to show a candidate responsible for the increase in chromosomal abnormalities in the exposed group.
    Tags: Epidemiology, Genotoxicity, Session 1 – Epidemiology and Human Pathophysiology, Session 4 – Cellular & Subcellular Events, Styrene Epi

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  • 7.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
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    Article
    Cancer incidence among Finnish workers exposed to aromatic hydrocarbons

    Authors: Anttila, A; Pukkala, E; Riala, R; Sallmen, M; Hemminki, K
    (1998) International Archives of Occupational and Environmental Health 71:187-193.
    Minus Sign. Click to see only selected choices. To assess whether occupational exposure to aromatic hydrocarbons increases carcinogenic risk.

    Plus Sign. Click to expand choices. To assess whether occupational exposure to aromatic hydrocarbons increases carcinogenic risk.

    We followed cancer incidence among 3,922 male and 1,379 female workers monitored for exposure to styrene, toluene, or xylene. The follow-up after the first personal measurement comprised 66,500 person-years at risk over the period 1973-1992. We computed the indirectly standardized incidence ratios (SIR) with 95% confidence interval (CI) with regard to age-, gender-, and period-specific incidence rates of cancer in the Finnish general population.

    The overall rate of cancer incidence for the total cohort was fairly similar to that of the general population. The risk for nervous system tumors was increased at 10 years after the first personal measurement (SIR 2.80, CI 1.03-6.08). For styrene there was an excess risk for rectal cancer (SIR 3.11, CI 1.14-6.77), and risks for pancreatic and nervous system tumors were increased nonsignificantly. For toluene and xylene, no clear increase in cancer risk was found.

    The data are not supportive of an overall increase in the cancer risk for these solvents, even though we cannot rule out site-specific associations with the rectum, pancreas, and nervous system. There is supporting evidence in the epidemiology literature for pancreatic cancer risk and heavy exposure to styrene. More studies are warranted on solvents, with detailed information on lifetime exposures and habits being collected whenever possible.
    Tags: Cancer, Epidemiology, Human Pathophysiology, Session 1 – Epidemiology and Human Pathophysiology
  • 8.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Chromosomal aberrations and micronuclei in reinforced plastics workers exposed to styrene

    Authors: Anwar, WA; Shamy, MY
    (1995) Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis 327:41-47.
    Minus Sign. Click to see only selected choices. The aim of this study was to investigate the cytogenetic changes induced in humans exposed to styrene . . . Plus Sign. Click to expand choices. The aim of this study was to investigate the cytogenetic changes induced in humans exposed to styrene in a reinforced plastics plant. Blood and urine samples were collected from 18 styrene exposed workers and 18 age and sex matched control subjects from the administrative department of the same factory. Chromosome aberrations (CAs) and micronuclei (MN) (cytokinesis block method) were analyzed in blood lymphocytes. All of the subjects included in the study were male non-smokers. The duration of employment ranged from 10 to 22 years (14.3 ▒ 4.4). In order to monitor exposure to styrene, urinary mandelic acid (MA) levels were measured using a standard colorimetric method. The level of thioethers in the urine was also determined colorimetrically. The mean level of mandelic acid was significantly higher in the exposed workers (328.44 ▒ 266.21 mg/g creatinine) compared with that of the controls (50.09 ▒ 16.84 mg/g creatinine) (p < 0.05). The level of urinary thioethers was found to be higher among the exposed workers. The number of cells with chromosomal aberrations was significantly higher in the workers (6.06 ▒ 4.41) compared with the controls (3.44 ▒ 2.28) (p < 0.05). There was no significant increase in the frequency of micronuclei in the exposed workers compared to controls. Our results support earlier findings on increased rates of chromosomal aberrations in reinforced plastics workers.
    Tags: Genotoxicity, Key Reference, Session 4 – Cellular & Subcellular Events
  • 9.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Cytogenetic biomonitoring of styrene-exposed plastic boat builders

    Authors: Artuso, M; Angotzi, G; Bonassi, S; Bonatti, S; De Ferrari, M; Gargano, D; Lastrucci, L; Miligi, L; Sbrana, C; Abbandandolo, A
    (1995) Archives of Environmental Contamination and Toxicology 29:270-274.
    Minus Sign. Click to see only selected choices. Earlier studies have produced evidence for an association between work-related styrene exposure and . . . Plus Sign. Click to expand choices. Earlier studies have produced evidence for an association between work-related styrene exposure and cytogenetic damage, while more recent studies have failed to show such an association. In the present study, chromosome aberrations (CA) and sister chromatid exchanges (SCE) were measured in peripheral blood lymphocytes of 46 male workers employed in a fiber-reinforced plastic boat building factory and exposed to styrene. Two groups of 23 workers each, characterized by different exposure levels (ranges: 2-120 mg/rn3 and 86-1389 mg/m3 ambient air) were studied, fifty-one controls matched by sex, age and smoking habits were included. Randomized blood samples were analyzed for cytogenetic damage separately in two laboratories. Interlaboratory differences in the scoring of CA and SCE were noted. However, increases of the considered cytogenetic endpoints in exposed vs control groups were consistently observed in both laboratories. Multivariate statistical analysis of pooled data revealed increases of CA ranging between 19% (RR = 1.19; 95% C.I., 0.80-I .78; chromatid-type aberrations, low exposure group) and 144% (RR = 2.44; 95% C.I., 1.26-4.70; chromosome-type aberrations, high exposure group). Parallel excess of SCE in styrene exposed workers was also observed, although at a lesser extent (RR = 1.22; 95% C.I., 1.05-1.43, low exposure group; RR = 1.26; 95% C.I.,1.07-1.47, high exposure group). These findings suggest the presence of a causal association between occupational exposure to styrene and cytogenetic damage in the plastic boat building factory that was the object of the study.
    Tags: Epidemiology, Genotoxicity, Session 1 – Epidemiology and Human Pathophysiology, Session 4 – Cellular & Subcellular Events, Styrene Epi

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  • 10.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
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    Article
    Radiologic implications of the 2011 classification of adenocarcinoma of the lung

    Authors: Austin, JH; Garg, K; Aberle, D; Yankelevitz, D; Kuriyama, K; Lee, HJ; Brambilla, E; Travis, WD
    (2013)
    Minus Sign. Click to see only selected choices. Now the leading subtype of lung cancer, adenocarcinoma received a new classification in 2011. For tumors . . . Plus Sign. Click to expand choices. Now the leading subtype of lung cancer, adenocarcinoma received a new classification in 2011. For tumors categorized previously as bronchioloalveolar carcinoma (BAC), criteria and terminology had not been uniform, so the 2011 classification provided four new terms: (a) adenocarcinoma in situ (AIS), representing histopathologically a small (≤3-cm), noninvasive lepidic growth, which at computed tomography (CT) is usually nonsolid; (b) minimally invasive adenocarcinoma, representing histopathologically a small (≤3-cm) and predominantly lepidic growth that has 5-mm or smaller invasion, which at CT is mainly nonsolid but may have a central solid component of up to approximately 5 mm; (c) lepidic predominant nonmucinous adenocarcinoma, representing histopathologically invasive adenocarcinoma that shows predominantly lepidic nonmucinous growth, which at CT is usually part solid but may be nonsolid or occasionally have cystic components; and (d) invasive mucinous adenocarcinoma, histopathologically showing lepidic growth as its predominant component, which at CT varies widely from solid to mostly solid to part solid to nonsolid and may be single or multiple (when multifocal, it was formerly called multicentric BAC). In addition, new histopathologic subcategories of acinar, papillary, micropapillary, and solid predominant adenocarcinoma are now described, all as nonmucinous, predominantly invasive, may include a small lepidic component, and at CT are usually solid but may include a small nonsolid component. The micropapillary subtype has a poorer prognosis than the other subtypes. In addition, molecular genetic correlations for the subcategories of adenocarcinoma of the lung are now a topic of increasing interest. As the new classification enters common use, further descriptions of related correlations can be anticipated.
    Tags: Classification, Human Lung Cancer, Session 1 – Epidemiology and Human Pathophysiology
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Key Reference (49)
Session 1 – Epidemiology and Human Pathophysiology (175)
Human Lung Cancer (34)
Classification (11)
Mechanisms (8)
Upstream Markers (5)
Epidemiology (128)
Styrene Epi (45)
Ethylbenzene Epi (1)
Human Pathophysiology (107)
Session 2 – Comparative Pathology (109)
Mouse Models (76)
Initiation/Promotion (8)
Standard Strain MM (20)
Human Relevance (5)
Genetically Engineered MM (3)
Comparative Pathology (16)
Tissue/Species Concordance (9)
Session 3 – Biological Mechanisms (122)
Absorption & Distribution (1)
Metabolism & Excretion (89)
CYP 2F/Cytotoxicity (0)
Session 4 – Cellular & Subcellular Events (165)
Cellular Toxicity (19)
Genotoxicity (74)
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Molecular toxicology (49)
PBPK (42)
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