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Journal Article 
The ototoxic effects of ethyl benzene in rats 
Cappaert, NLM; Klis, SFL; Muijser, H; de Groot, JCMJ; Kulig, BM; Smoorenburg, GF 
Hearing Research
ISSN: 0378-5955 
BIOSIS COPYRIGHT: BIOL ABS. Exposure to organic solvents has been shown to be ototoxic in animals and there is evidence that these solvents can induce hearing loss in humans. In this study, the effects of inhalation of the possibly ototoxic solvent ethyl benzene on the cochlear function and morphology were evaluated using three complementary techniques: (1) reflex modification audiometry (RMA), (2) electrocochleography and (3) histological examination of the cochleas. Rats were exposed to either ethyl benzene (800 ppm, 8 h (1-24 kHz). Histological examination of the cochlea showed outer hair cell (OHC) loss, especially inthe upper basal and lower middle turns (corresponding to the mid-frequency region) to an extent of 65%. We conclude that exposure to 800 ppm ethyl benzene for 8 h/day during 5 days induces hearing loss in rats due to OHC loss. 
rat; ethyl benzene; ototoxicity; reflex modification audiometry; electrocochleography; histology 
Administration, Inhalation 
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