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Journal Article 
Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen quality 
Mocarelli, P; Gerthoux, PM; Patterson, DG, Jr; Milani, S; Limonata, G; Bertona, M; Signorini, S; Tramacere, P; Colombo, L; Crespi, C; Brambilla, P; Sarto, C; Carreri, V; Sampson, EJ; Turner, WE; Needham, LL 
Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924 
BACKGROUND: Environmental toxicants are allegedly involved in decreasing semen quality in recent decades; however, definitive proof is not yet available. In 1976 an accident exposed residents in
Seveso, Italy, to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
OBJECTIVE: The purpose of this study was to investigate reproductive hormones and sperm quality in exposed males.
METHODS: We studied 135 males exposed to TCDD at three age groups, infancy/prepuberty (1?9 years), puberty (10?17 years), and adulthood (18?26 years), and 184 healthy male comparisons using 1976 serum TCDD levels and semen quality and reproductive hormones from samples
collected 22 years later.
RESULTS: Relative to comparisons, 71 men (mean age at exposure, 6.2 years; median serum TCDD, 210 ppt) at 22?31 years of age showed reductions in sperm concentration (53.6 vs.72.5 million/mL; p = 0.025); percent progressive motility (33.2% vs. 40.8%; p < 0.001); total motile sperm count (44.2 vs. 77.5 × 106; p = 0.018); estradiol (76.2 vs. 95.9 pmol/L; p = 0.001); and an increase in follicle-stimulating hormone (FSH; 3.58 vs. 2.98 IU/L; p = 0.055). Forty-four
men (mean age at exposure, 13.2 years; median serum TCDD, 164 ppt) at 32?39 years of age showed increased total sperm count (272 vs. 191.9 × 106; p = 0.042), total motile sperm count (105 vs. 64.9 × 106; p = 0.036), FSH (4.1 vs. 3.2 UI/L; p = 0.038), and reduced estradiol (74.4 vs. 92.9 pmol/L; p < 0.001). No effects were observed in 20 men, 40?47 years of age, who were exposed to TCDD (median, 123 ppt) as adults (mean age at exposure, 21.5 years).
CONCLUSIONS: Exposure to TCDD in infancy reduces sperm concentration and motility, and an opposite effect is seen with exposure during puberty. Exposure in either period leads to permanent reduction of estradiol and increased FSH. These effects are permanent and occur at TCDD concentrations < 68 ppt, which is within one order of magnitude of those in the industrialized world in the 1970s and 1980s and may be responsible at least in part for the reported decrease in sperm quality, especially in younger men. 
dioxin; endocrine disruption; environmental contaminants; human sperm quality; reproductive hormones; TCDD 
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