Jump to main content.

Contact Us

Health & Environmental Research Online (HERO)

You are here: EPA Home Research NCEA HERO Reproductive toxicity of acrylamide and related compounds in mice- effects on fertility and sperm morphology

Please wait while we submit your request.
This may take several minutes...


224442 
Journal Article 
Reproductive toxicity of acrylamide and related compounds in mice- effects on fertility and sperm morphology 
Sakamoto, J; Hashimoto, K 
1986 
Yes 
Archives of Toxicology
ISSN: 0340-5761
EISSN: 1432-0738 
59 
201-205 
English 
Acrylamide and its three neurotoxic analogues, which are known to induce testicular damage in animals, were tested for reproductive toxicity in male and female mice and for the effect on germ cells in males, after subchronic treatment. After mating the treated males with untreated females, a decrease in fertility rate for all analogues except for N-hydroxymethylacrylamide, and an increase in the number of resorptions/dam for all test compounds were found. When untreated males were mated with treated females, an increase in the number of resorptions/dam was seen only after acrylamide dosing without any effect on the fertility rate. The reproductive toxicity appeared with only slight or no testicular atrophy, and without any apparent neurotoxicity after treatment with all test compounds. High doses of all test compounds produced both a decreased sperm count and an increase in abnormal sperm morphology. 
Acrylamide; N-hydroxymethylacrylamide; N-methylacrylamide; N-isopropylacrylamide; Reproduction; Sperm; Mice 
Acrylamides 
Animals 
Body Weight 
Embryo Loss 
Female 
Fertility 
Genitalia, Male 
Male 
Mice 
Nervous System Diseases 
Organ Size 
Pregnancy 
Reproduction 
Sperm Count 
Spermatozoa 
 

Jump to main content.

page loading graphic