Jump to main content.

Contact Us

Health & Environmental Research Online (HERO)

You are here: EPA Home Research NCEA HERO Methods for derivation of inhalation reference concentrations and application of inhalation dosimetry

Please wait while we submit your request.
This may take several minutes...


6488 
Technical Report 
Methods for derivation of inhalation reference concentrations and application of inhalation dosimetry 
U.S. Environmental Protection Agency :: U.S. EPA 
1994 
U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office 
Research Triangle Park, NC 
EPA/600/8-90/066F 
409 
This document describes the U .S . Environmental Protection Agency (EPA) methodology for estimation of inhalation reference concentrations (RfCs) (earlier terminology was "inhalation reference dose" or "RfDi") as benchmark estimates of the quantitative doseresponse assessment of chronic noncancer toxicity for individual inhaled chemicals. Noncancer toxicity refers to adverse health effects other than cancer and gene mutations. This overview chapter discusses general principles of dose-response assessment for noncancer toxicity, the development of the RfC methodology, and its role within the context of the risk assessment process. Subsequent chapters of the document discuss criteria and information to be considered in selecting key studies for RfC derivation, provide an overview of the respiratory system and its intra- and interspecies variables, and discuss areas of uncertainty and data gaps in relation to the proposed methodology. 
• Ammonia
     Considered References
          Other Studies
     Cited References
          Guidance, Notices
• Benzo(a)pyrene (BaP)
     Considered
     Cited
          Guidance
• Biphenyl
     Considered
     Cited References
          Other studies
               Dose-response assessment
          Guidance
• n-Butanol
     Additional Strategies
     Source – January 2013 (private)
          Additional strategies - 1/2013
          Merged reference set - 1/2013
     Secondary Sources of Health Effects Information
          Regulatory documents
     Cited in Document
• DCM (Dichloromethane) (Final, 2011)
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• ETBE
     Cited in Document
     Not in Lit Search
• Libby Amphibole Asbestos (Draft, 2011)
• Libby Amphibole Asbestos (Revision 2013)
• Methanol (Non-Cancer)
     Cited in Final (2013)
     Cited in External Review Draft (2013)
     Cited in External Review Draft (2011)
• RDX (121-82-4)
     Additional strategies
          References added during assessment development
     Secondary Sources of Health Effects Information
          References added during assessment development
• Tetrachloroethylene (Perc) (Final, 2012)
     All References
• Trichloroacetic acid (TCA) (Final, 2011)
• Trichloroethylene (TCE) (Final, 2011)
     All References
     Dose-Response
     Non-Cancer
     Cancer
• Trimethylbenzenes (TMB)
     Considered Studies
          Other
     Cited Studies
          Guidance
          EPA
     Cited in Tox Review – Revised TMBs Draft
     Cited in Revised TMBs Draft - All
• Vanadium Pentoxide (Draft, 2011)
NAAQS
• ISA-NOx
     2008 Final
 

Jump to main content.

page loading graphic