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Journal Article 
Aspartame induces lymphomas and leukaemias in rats 
Soffritti, M; Belpoggi, F; Esposti, DD; Lambertini, L 
European Journal of Oncology
ISSN: 1128-6598 
Aspartame, a widely used artificial sweetener, was administered with feed to male and female Sprague- Dawley rats (100-150/sex/group), 8 weeks-old at the start of the experiment, at concentrations of 100,000; 50,000; 10,000; 2,000; 400; 80 and 0 ppm. Treatment lasted until spontaneous death of the animals. In this report we present the first results showing that aspartame, in our experimental conditions, causes a statistically significant, dose-related increase in lymphomas and leukaemias in females. No statistically significant increase in malignant brain tumours was observed among animals from the treated groups as compared to controls. 

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