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Technical Report 
Supplemental guidance for assessing susceptibility from early-life exposure to carcinogens 
U.S. Environmental Protection Agency :: U.S. EPA 
U.S. Environmental Protection Agency, Risk Assessment Forum 
Washington, DC 
U.S. Environmental Protection Agency (EPA or the Agency) cancer risk assessments may be conducted differently than envisioned in this Supplemental Guidance for many reasons including, for example, new information, new scientific understanding, or different science policy judgment. The practice of risk assessment with respect to accounting for early-life exposures to toxicants continues to develop, and specific components of this Supplemental Guidance may become outdated or may otherwise require modification in individual settings. It is EPA’s intent to use, to the extent practicable and consistent with Agency statutes and regulations, the best available science in its risk assessments and regulatory actions, and this Supplemental Guidance is not intended to provide any substantive or procedural obstacle in achieving that goal. Therefore, the Supplemental Guidance has no binding effect on EPA or on any regulated entity. Where EPA does use the approaches in the Supplemental Guidance in developing risk assessments, it will be because EPA has decided in the context of that risk assessment that the approaches from the Supplemental Guidance are suitable and appropriate. This judgment will be tested through peer review, and the risk assessment will be modified to use different approaches if appropriate. 
Child Development 
Child, Preschool 
Disease Susceptibility 
Environmental Exposure 
Infant, Newborn 
Risk Assessment 
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