Jump to main content.

Contact Us

Health & Environmental Research Online (HERO)

You are here: EPA Home Research NCEA HERO Realgar, cinnabar and An-Gong-Niu-Huang Wan are much less chronically nephrotoxic than common arsenicals and mercurials

Please wait while we submit your request.
This may take several minutes...


1017270 
Journal Article 
Realgar, cinnabar and An-Gong-Niu-Huang Wan are much less chronically nephrotoxic than common arsenicals and mercurials 
Lu, YF; Wu, Q; Yan, JW; Shi, JZ; Liu, J; Shi, JS 
2011 
Experimental Biology and Medicine
ISSN: 1535-3702
EISSN: 1535-3699 
Society for Experimental Biology and Medicine, 195 W. Spring Valley Avenue Maywood NJ 07607-1727 USA 
236 
233-239 
WOS:000290122600015 
Realgar (As(4)S(4)) and cinnabar (HgS) are frequently included in traditional Chinese medicines and Indian Ayurvedic medicines. Both As and Hg are well known for toxic effects, and their safety is of concern. The aim of this study was to compare chronic nephrotoxicity of An-Gong-Niu-Huang Wan (AGNH), realgar and cinnabar with common arsenicals and mercurials. Mice were orally administrated with AGNH (3 g/kg, 6-fold of clinical dose), cinnabar (0.3 g/kg, amount in AGNH) and realgar (0.3 g/kg, amount in AGNH), HgCl(2) (0.118 mmol/kg, 1/10 of cinnabar), MeHg (0.012 mmol/kg, 1/100 of cinnabar), NaAsO(2) (As(3+) 0.028 mmol/kg, 1/100 of realgar) or Na(2)HAsO(4) (As(5+) 0.056 mmol/kg, 1/50 of realgar), daily for six weeks, and nephrotoxicity was examined. Animal body weights were decreased by MeHg and HgCl(2). Blood urea nitrogen and creatinine levels were elevated by MeHg. Renal pathology was severe in the MeHg and HgCl(2) groups, moderate in the arsenite, arsenate and realgar groups and mild in the cinnabar and AGNH groups. Renal Hg accumulation in the MeHg and HgCl(2) groups was 50-200 folds higher than the cinnabar group. Expressions of metallothionein-1 and heme oxygenase-1, biomarkers for metal toxicity, were increased 2-5 folds by arsenite, arsenate, MeHg and HgCl(2), but not by realgar, cinnabar and AGNH. The chemokine and glutathione-S transferase-α4, markers for inflammation, were also increased by MeHg and HgCl(2). Expressions of cell adhesion gene S100a9 and E-cadherin were altered by HgCl(2), arsenite and realgar. Taken together, chemical forms of mercury and arsenic are major determinants in their disposition and toxicity. 
Mercury; Heme oxygenase (decyclizing); Urea; Nitrogen; Blood; Heavy metals; E-Cadherin; Traditional Chinese Medicine; Chemokines; Arsenite; biomarkers; Disposition; Body weight; Cell adhesion; Arsenic; Toxicity; Creatinine; Kidney; Inflammation 
IRIS
• Arsenic
     Initial Lit Search
          PubMed
          WOS
          ToxNet
     Considered
     Cluster Filter
     Source Characterization
          Not Relevant
 
Animals 
Arsenic Poisoning 
Arsenicals 
Blood Urea Nitrogen 
Body Weight 
Creatinine 
Diet 
Histocytochemistry 
Kidney Diseases 
Mercury Compounds 
Mercury Poisoning 
Mice 
Microscopy 
Plant Extracts 
Plants, Medicinal 
Sulfides 
 

Jump to main content.

page loading graphic