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Journal Article 
Mutagenic, antimutagenic, cytotoxic, and apoptotic activities of extracts from Pituranthos tortuosus 
Abdelwahed, A; Skandrani, I; Kilani, S; Neffati, A; Sghaier, MB; Bouhlel, I; Boubaker, J; Ammar, RB; Mahmoud, A; Ghedira, K; Chekir-Ghedira, L 
Drug and Chemical Toxicology
ISSN: 0148-0545
EISSN: 1525-6014 
Mutagenic and antimutagenic activities against direct acting mutagens, nifuroxazide (NF) and sodium azide (SA), and indirect acting mutagen aflatoxin B1 (AFB1) of extracts prepared from aerial parts of Pituranthos tortuosus were investigated in bacterial assay systems (i.e., the Ames test with Salmonella typhimurium TA100, TA98, TA1538, TA1535, and the SOS chromotest with Escherichia coli PQ 37). It was found that all extracts obtained from P. tortuosus decreased the mutagenicity induced by AFB1 (10 microg/assay), SA (1.5 microg/assay), and NF (20 microg/assay). Ethyl acetate, acetone, methanol, and total oligomer flavenoid extracts exhibited the highest inhibition level of mutagenicity induced by the indirect mutagen AFB1. In addition, antiproliferative and apoptotic properties of these extracts have also been reported using two leukemia cell lines, L1210 and K562. The results revealed that all extracts showed a significant cytotoxic effect on these cell lines, and the effect was greater in the presence of human K562 chronic myelogenous leukemia cells, whereas they do not induce apoptosis. 
• Methanol (Non-Cancer)
     Search 2012
Aflatoxin B1 
Antimutagenic Agents 
Antineoplastic Agents, Phytogenic 
Cell Proliferation 
Cell Survival 
DNA Fragmentation 
DNA, Bacterial 
Dose-Response Relationship, Drug 
Escherichia coli 
Hydroxybenzoic Acids 
K562 Cells 
Plant Components, Aerial 
Plant Extracts 
Salmonella typhimurium 
Sodium Azide 

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