Jump to main content.

Contact Us

Health & Environmental Research Online (HERO)

You are here: EPA Home Research NCEA HERO Developmental dental aberrations after the dioxin accident in Seveso

Please wait while we submit your request.
This may take several minutes...


197142 
Journal Article 
Developmental dental aberrations after the dioxin accident in Seveso 
Alaluusua, S; Calderara, P; Gerthoux, PM; Lukinmaa, PL; Kovero, O; Needham, L; Patterson, , Jr; Tuomisto, J; Mocarelli, P 
2004 
Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924 
112 
13 
1313-1318 
WOS:000224547000032 
Children's developing teeth may be sensitive to environmental dioxins, and in animal studies developing teeth are one of the most sensitive targets of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Twenty-five years after the dioxin accident in Seveso, Italy, 48 subjects from the contaminated areas (zones A and B) and in patches lightly contaminated (zone R) were recruited for the examination of dental and oral aberrations. Subjects were randomly invited from those exposed in their childhood and for whom frozen serum samples were available. The subjects were frequency matched with 65 subjects from the surrounding non-ABR zone for age, sex, and education. Concentrations of TCDD in previously analyzed plasma samples (zone ABR subjects only) ranged from 23 to 26,000 ng/kg in serum lipid. Ninety-three percent (25 of 27) of the subjects who had developmental enamel defects had been < 5 years of age at the time of the accident. The prevalence of defects in this age group was 42% (15 of 36) in zone ABR subjects and 26% (10 of 39) in zone non-ABR subjects, correlating with serum TCDD levels (p = 0.016). Hypodontia was seen in 12.5% (6 of 48) and 4.6% (3 of 65) of the zone ABR and non-ABR subjects, respectively, also correlating with serum TCDD level (p = 0.05). In conclusion, developmental dental aberrations were associated with childhood exposure to TCDD. In contrast, dental caries and periodontal disease, both infectious in nature, and oral pigmentation and salivary flow rate were not related to the exposure. The results support our hypothesis that dioxins can interfere with human organogenesis. 
Accidents, Occupational 
Adult 
Anodontia 
Case-Control Studies 
Dental Enamel 
Environmental Pollutants 
Female 
Humans 
Italy 
Male 
Tetrachlorodibenzodioxin 
Tooth 
Tooth Abnormalities 
 

Jump to main content.

page loading graphic