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202697 
Journal Article 
Toxicological evaluation of the effect of water contaminated with lead, phenol and benzene on liver, kidney and colon of Albino rats 
Adeyemi, O; Ajayi, JO; Olajuyin, AM; Oloyede, OB; Oladiji, AT; Oluba, OM; Ololade, IA; Adebayo, EA 
2009 
Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351 
47 
885-887 
English 
The effect of water contaminated with phenol, benzene and lead on rats cellular system was investigated. Selected enzyme activity of the kidney and colon of rats was carried out. Standard enzyme assays were also conducted for selected liver enzymes such as alkaline and acid phosphatases, alanine and aspartate transaminases, and gamma glutamyl transpeptidase. Serum indices of liver and kidney function were also determined. The direct bilirubin of test rats were observed to be 3.2+/-0.2U/mol/l while that of control rat was 1.2+/-0.003 U/mol/l. The total bilirubin of test rats was found to be 8.4+/-0.8 U/mol/l while that of the control was 5.6+/-0.5 U/mol/l. Generally, enzymes activity in the tissues of test rats were found to be significantly (p<0.05) lower relative to control, while the enzyme activity of the serum of test rats was significantly (p<0.05) higher than control. It could be inferred that experimental data suggest possible damage to the tissues and that consumption of polluted water may account for increasing cases of renal and hepatic failure among people in developing countries. 
toxicology; water pollution; lead; phenol; benzene; liver; kidneys; colon; rats; animal models; kidney diseases; liver diseases; Internet resource 
NAAQS
• ISA-Lead
     Considered
     Health Effects
 
Alanine Transaminase 
Alkaline Phosphatase 
Animals 
Aspartate Aminotransferases 
Benzene 
Bilirubin 
Colon 
Creatinine 
Drinking 
Drug-Induced Liver Injury 
Kidney 
Kidney Diseases 
Kidney Function Tests 
L-Lactate Dehydrogenase 
Lead 
Liver 
Liver Diseases 
Liver Function Tests 
Male 
Phenol 
Rats 
Urea 
Water Pollutants, Chemical 
gamma-Glutamyltransferase 
 

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