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086237 
Technical Report 
Guidelines for carcinogen risk assessment 
U.S. Environmental Protection Agency :: U.S. EPA 
2005 
U.S. Environmental Protection Agency, Risk Assessment Forum 
Washington, DC 
EPA/630/P-03/001F 
166 
is supplemented by 412939 and supplemental guidance for assessing susceptibility from early-life exposure to carcinogens
These guidelines revise and replace the U.S. Environmental Protection Agency’s Guidelines for Carcinogen Risk Assessment, published in 51 FR 33992, September 24, 1986 (U.S. EPA, 1986a) and the 1999 interim final guidelines (U.S. EPA, 1999a; see U.S. EPA 2001b). They provide EPA staff with guidance for developing and using risk assessments. They also provide basic information to the public about the Agency's risk assessment methods. 
Risk; Risk Assessment 
NAAQS
• ISA-Lead
     Cited
          2nd Draft
          3rd Draft
          Final
• ISA-NOx
     Cited
          1st Draft
• ISA-Ozone (2012)
     Considered
     Cited
          1st Draft
          2nd Draft
          3rd Draft
          Final
     Health Effects
• ISA-PM
     2009 Final
• Ammonia
     Considered References
          Other Studies
     Cited References
          Guidance, Notices
• Arsenic
     Test Mode of Action Clusters
     Cited in Draft Public Meeting
• Benzo(a)pyrene (BaP)
     Considered
     Cited
          Guidance
          Carcinogenicity
• Biphenyl
     Considered
     Cited References
          Other studies
               Dose-response assessment
          Guidance
• tert-Butanol
     Cited in Document
• DCM (Dichloromethane) (Final, 2011)
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• ETBE
     Cited in Document
     Not in Lit Search
• Libby Amphibole Asbestos (Draft, 2011)
• Methanol (Non-Cancer)
     Cited in Final (2013)
     Cited in External Review Draft (2013)
     Ramazzini
• RDX (121-82-4)
     Additional strategies
          References added during assessment development
     Secondary Sources of Health Effects Information
          References added during assessment development
• Tetrachloroethylene (Perc) (Final, 2012)
     Hazard
          Genotox
• Trichloroacetic acid (TCA) (Final, 2011)
• Trichloroethylene (TCE) (Final, 2011)
     All References
     Hazard
     Cancer Epi
     Genotox
     Kidney
     Liver
     Respiratory
     Dose-Response
     Non-Cancer
     Cancer
     Liver Issues
• Trimethylbenzenes (TMB)
     Considered Studies
          Other
     Cited Studies
          Guidance
          EPA
     Cited in Tox Review – Revised TMBs Draft
     Cited in Revised TMBs Draft - All
• Vanadium Pentoxide (Draft, 2011)
• Mouse Lung Tumor
• Nanoscale Carbon
     All References Cited
     External Review Draft
          Impacts
     Peer Reviewed Draft
          Impacts
               Lower Priority Areas: Appendices G and H
     Final Case Study
          Product Life Cycle
               Lower Priority Areas: Appendices G and H
          Transport & Fate
               Lower Priority Areas: Appendices G and H
          Exposure, Uptake, and Dose
               Lower Priority Areas: Appendices G and H
          Impacts
               Lower Priority Areas: Appendices G and H
• Nanoscale Silver
     External Review Draft
     Final Case Study
          Exposure, Uptake and Dose
          Effects
• Ramazzini Institute
 
PB2005-105899 

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