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088823 
Technical Report 
Supplemental guidance for assessing susceptibility from early-life exposure to carcinogens 
U.S. Environmental Protection Agency :: U.S. EPA 
2005 
U.S. Environmental Protection Agency, Risk Assessment Forum 
Washington, DC 
EPA/630/R-03/003F 
U.S. Environmental Protection Agency (EPA or the Agency) cancer risk assessments may be conducted differently than envisioned in this Supplemental Guidance for many reasons including, for example, new information, new scientific understanding, or different science policy judgment. The practice of risk assessment with respect to accounting for early-life exposures to toxicants continues to develop, and specific components of this Supplemental Guidance may become outdated or may otherwise require modification in individual settings. It is EPA’s intent to use, to the extent practicable and consistent with Agency statutes and regulations, the best available science in its risk assessments and regulatory actions, and this Supplemental Guidance is not intended to provide any substantive or procedural obstacle in achieving that goal. Therefore, the Supplemental Guidance has no binding effect on EPA or on any regulated entity. Where EPA does use the approaches in the Supplemental Guidance in developing risk assessments, it will be because EPA has decided in the context of that risk assessment that the approaches from the Supplemental Guidance are suitable and appropriate. This judgment will be tested through peer review, and the risk assessment will be modified to use different approaches if appropriate. 
• Ammonia
     Considered References
          Other Studies
     Cited References
          Guidance, Notices
• Benzo(a)pyrene (BaP)
     Considered
     Cited
          Guidance
          Carcinogenicity
• Biphenyl
     Considered
     Cited References
          Guidance
• tert-Butanol
     Cited in Document
• Chromium VI
     Cited in Document
• DCM (Dichloromethane) (Final, 2011)
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• Libby Amphibole Asbestos (Draft, 2011)
• Methanol (Non-Cancer)
     Cited in Final (2013)
     Cited in External Review Draft (2013)
     Ramazzini
• RDX (121-82-4)
     Additional strategies
          References added during assessment development
     Secondary Sources of Health Effects Information
          References added during assessment development
• Tetrachloroethylene (Perc) (Final, 2012)
• Trichloroacetic acid (TCA) (Final, 2011)
• Trichloroethylene (TCE) (Final, 2011)
     All References
     Hazard
     Kidney
     Liver
     Respiratory
     Susceptibility
     Dose-Response
     Cancer
• Trimethylbenzenes (TMB)
     Considered Studies
          Other
     Cited Studies
          Guidance
          EPA
     Cited in Tox Review – Revised TMBs Draft
     Cited in Revised TMBs Draft - All
• Ramazzini Institute
 
Adolescent 
Adult 
Aging 
Animals 
Carcinogens 
Child 
Child Development 
Child, Preschool 
Disease Susceptibility 
Environmental Exposure 
Humans 
Infant 
Infant, Newborn 
Mutagens 
Neoplasms 
Risk Assessment 
 

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