Arsenic MOA
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1. MOA Literature Screening - 5649 references close open
- MOA Seeds - 378 references
- Health Effect Screening - 549 references
- MOA Cluster - 5038 references
- Susceptibility Screening - 422 references
2. Electronic Discard - 981 references close open
3. Excluded - 2475 references close open
- Non Peer Reviewed - 64 references
- Other not relevant - 2336 references
4. Adverse Outcome Pathways - 2251 references close open
- ADME - 214 references
- Cell viability, cell proliferation, cell cycle changes (unrelated to regenerative proliferation) - 437 references
- Cellular differentiation and malignant transformation - 95 references
- Gene expression changes - 240 references
- Immune mechanisms - 99 references
- Endocrine mechanisms - 78 references
- Epigenetic mechanisms - 99 references
- Non-oxidative DNA/ chromosomal damage - 237 references
- Specific proteotoxicity - 29 references
- Oxidative stress related effects (includes non-specific SH reactions) - 663 references
- Regenerative proliferation - 17 references
- Vascular mechanisms - 97 references
- Other MOA - 276 references
5. Health Effect - 1398 references close open
- Bladder Effects - 107 references
- Cardiovascular disease - 115 references
- Developmental Effects including Neurodevelopmental - 76 references
- Digestive System Effects - 18 references
- Endocrine System Effects including Diabetes - 71 references
- Hematology, Hematopoietic System - 87 references
- Immune System and Lymphatic Effects - 152 references
- Liver Effects - 261 references
- Nervous System Effects - 127 references
- Renal Effects - 100 references
- Reproductive System Effects including Pregnancy Outcomes - 84 references
- Respiratory Effects - 121 references
- Skin Diseases - 173 references
- Cancer - 517 references