Health & Environmental Research Online (HERO)


Libby Amphibole Asbestos (Draft, 2011)


1,032 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Continued spirometry changes after cessation of exposure in asbestos-cement workers

Authors: Swiątkowska, B; Wojciech, S; Szubert, Z; Szeszenia-Dąbrowska, N (2014) Journal of Occupational and Environmental Medicine 56:403-408. HERO ID: 2298131

[Less] OBJECTIVE:: To assess further progression of spirometry parameters among former asbestos-cement . . . [More] OBJECTIVE:: To assess further progression of spirometry parameters among former asbestos-cement plant workers.

METHODS:: The following parameters were assessed: forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the ratio (FEV1/FVC) using a linear regression model with mixed effects.

RESULTS:: The analysis included 3005 individuals. Spirometrically defined restrictive ventilatory defects were registered in 21.6% of the patients, obstructive defects in 8.3%, whereas mixed changes in 7%. Current smokers had significantly lower levels of FEV1, FVC, and FEV1/FVC and a steeper decline compared with nonsmokers. More rapid progression was also observed along with increasing termination of exposure. Having higher exposure was associated with a slower decline in FEV1 and FEV1/FVC ratios.

CONCLUSIONS:: This report indicates that asbestos-cement workers with higher cumulative exposure still had lower mean levels of spirometric parameters, despite cessation of asbestos exposure many years ago.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Asbestos exposure, pleural plaques and the risk of death from lung cancer

Authors: Pairon, JC; Andujar, P; Rinaldo, M; Ameille, J; Brochard, P; Chamming's, S; Clin, B; Ferretti, G; Gislard, A; Laurent, F; Luc, A; Wild, P; Paris, C (2014) American Journal of Respiratory and Critical Care Medicine 190:1413-1420. HERO ID: 2528298

[Less] Rationale: Although asbestos is a well-known lung carcinogen, the association between pleural plaques . . . [More] Rationale: Although asbestos is a well-known lung carcinogen, the association between pleural plaques and lung cancer remains controversial. Objective: The present study was designed to examine this association among asbestos-exposed workers. Methods and measurements: An 6-year follow-up was conducted to study lung cancer mortality in the 5,402 male subjects participating in an asbestos-related diseases screening program organized between October 2003 and December 2005 in four French regions. Chest computed tomography (CT) scan was performed in all subjects with randomized, independent, double reading of CT scans focusing on benign asbestos-related abnormalities. Survival regression based on the Cox model was used to model lung cancer mortality according to the presence of pleural plaques, with age as the main time variable adjusting for smoking and cumulative exposure index to asbestos. All statistical tests were two-sided. Main results: Thirty-six deaths from lung cancer were recorded. Lung cancer mortality was significantly associated with pleural plaques in the follow-up study in terms of both the unadjusted hazard ratio (HR) = 2.91 [95% confidence interval (CI) = 1.49 to 5.70 and the adjusted HR = 2.41 [95%CI = 1.21-4.85] after adjustment for smoking and cumulative exposure index to asbestos. Conclusions: The presence of pleural plaques may be an independent risk factor for lung cancer death in asbestos-exposed workers and could be used as an additional criterion in the definition of high-risk populations eligible for CT screening.

Technical Report
Technical Report

SEER cancer statistics review, 1975-2010

Authors: Howlader, N; Noone, AM; Krapcho, M; Garshell, J; Neyman, N; Altekruse, SF; Kosary, CL; Yu, M; Ruhl, J; Tatalovich, Z; Cho, ; Mariotto, A; Lewis, DR; Chen, HS: Feuer, EJ; Cronin, KA; (eds) (2013) Bethesda, MD: National Cancer Institute. HERO ID: 2238687


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A phase II clinical trial of the Vascular Disrupting Agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma

Authors: Nowak, AK; Brown, C; Millward, MJ; Creaney, J; Byrne, MJ; Hughes, B; Kremmidiotis, G; Bibby, DC; Leske, AF; Mitchell, PL; Pavlakis, N; Boyer, M; Stockler, MR (2013) HERO ID: 1937477

[Less] BNC105P is a tubulin polymerisation inhibitor that selectively disrupts tumour vasculature and suppresses . . . [More] BNC105P is a tubulin polymerisation inhibitor that selectively disrupts tumour vasculature and suppresses cancer cell proliferation. This agent has exhibited preclinical and phase I activity in Malignant Pleural Mesothelioma (MPM). This phase II, single arm trial investigated the efficacy and safety of BNC105P as second line therapy in MPM. Participants had progressive MPM after first line pemetrexed/platinum chemotherapy, ECOG PS 0-1, adequate organ function, and measurable disease. BNC105P 16mg/m(2) was administered intravenously on day 1 and 8 every 21 days until progression or undue toxicity. The primary endpoint was centrally reviewed objective response rate (RR). Tumour response was assessed every two cycles using modified RECIST. 30 patients were enrolled in 10 months, predominantly male (90%), ECOG PS 1 (77%), epithelioid histology (67%), and non-metastatic disease (67%). All patients received at least one dose of study drug, with a median of 2 cycles. No significant haematologic, biochemical, or cardiac adverse events (AEs) were observed. Grade 3 or 4 AEs occurred in 10 patients (33%). There were 2 deaths on study: 1 cardiorespiratory, the other to pneumonia. We observed 1 partial response (3%); 13 patients had stable disease (43%). Median progression free survival was 1.5 months (95% CI 1.4-2.4); median overall survival was 8.2 months (95% CI 3.8-11.9). BNC105P was safe and tolerable. The sole response was insufficient to warrant further research as a single agent.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Mechanisms of airway remodeling

Authors: Hirota, N; Martin, JG (2013) Chest 144:1026-1032. HERO ID: 1937480

[Less] Airway remodeling comprises the structural changes of airway walls, induced by repeated injury and repair . . . [More] Airway remodeling comprises the structural changes of airway walls, induced by repeated injury and repair processes. It is characterized by the changes of tissue, cellular, and molecular composition, affecting airway smooth muscle, epithelium, blood vessels, and extracellular matrix. It occurs in patients with chronic inflammatory airway diseases such as asthma, COPD, bronchiectasis, and cystic fibrosis. Airway remodeling is arguably one of the most intractable problems in these diseases, leading to irreversible loss of lung function. Current therapeutics can ameliorate inflammation, but there is no available therapy proven to prevent or reverse airway remodeling, although reversibility of airway remodeling is suggested by studies in animal models of disease. Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions. In this review, we consider the factors that may contribute to airway remodeling and discuss the current and potential therapeutic interventions.

Technical Report
Technical Report

Personal communication to EPA from Dr. James Lockey, July 2, 2013

Author: Lockey, J (2013) [Personal Communication] HERO ID: 2347064


Technical Report
Technical Report

SAB review of EPA’s draft assessment entitled toxicological review of Libby Amphibole Asbestos (August 2011)

Author: SAB (2013) HERO ID: 2325151


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Diffusing capacity and forced vital capacity in 5,003 asbestos-exposed workers: Relationships to interstitial fibrosis (ILO profusion score) and pleural thickening

Authors: Miller, A; Warshaw, R; Nezamis, J (2013) American Journal of Industrial Medicine 56:1383-1393. HERO ID: 2252658

[Less] BACKGROUND: Asbestosis is an interstitial lung disease whose radiographic severity . . . [More] BACKGROUND: Asbestosis is an interstitial lung disease whose radiographic severity has long been graded by the International Labour Office (ILO) profusion score. Its effect on pulmonary function is further impacted by asbestos related pleural thickening.

OBJECTIVES: This report aims to describe the relationships between radiographic grading of interstitial and pleural fibrosis and a key test of pulmonary function, the diffusing capacity, which measures gas exchange and has rarely been assessed in large groups, and to confirm the relationship to an independent test of pulmonary function, the vital capacity, which measures a mechanical property of the lungs.

METHODS: The data were derived from a survey during the period 1997-2004 of 5,003 workers (all white males) exposed to asbestos in various trades. Tests included chest radiographs read by a certified expert ("B") reader, forced vital capacity (FVC), and carbon monoxide diffusing capacity (DLco). Cigarette smoking was adjusted for in the predictive equation for DLCO . Workers were evaluated at a mobile facility at work sites in four southern states.

RESULTS: Both diffusing capacity and vital capacity were negatively correlated with profusion score over the full spectrum of radiographic severity. ILO profusion scores 0/1 (conventionally classified as normal) and 1/0 (conventionally classified as abnormal) were associated with similar diffusing capacity and vital capacity values. The highest profusion scores were associated with a greater proportionate decrease in diffusing capacity than in FVC. Both tests showed an effect of pleural fibrosis.

CONCLUSIONS: Both radiographic severity graded by the profusion score and pleural thickening are correlated with two independent measures of pulmonary function. FVC (which had been reported in smaller work forces) and DLCO (which has not been reported). Both measures show a decrease from normal to intermediate (0/1, 1/0) scores and a further decrease with greater scores, demonstrating the consistency of radiographic and functional assessments. Am. J. Ind. Med. 56:1383-1393, 2013. © 2013 Wiley Periodicals, Inc.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Lung function predicts mortality: 10-year follow-up after lung cancer screening among asbestos-exposed workers

Authors: Vehmas, T; Pallasaho, P; Piirilä, P (2013) International Archives of Occupational and Environmental Health 86:667-672. HERO ID: 1257853

[Less] PURPOSE: To assess the predictive value of lung function impairment on mortality among asbestos-exposed . . . [More] PURPOSE: To assess the predictive value of lung function impairment on mortality among asbestos-exposed workers. METHODS: A total of 590 workers originally screened for occupational lung disease including spirometry and pulmonary diffusing capacity measurements were followed up for mortality data (ICD-10 classification). The mean follow-up time was 10.5 years. Associations of different lung function parameters with mortality from all causes and from cardiovascular (I00-I99) and non-malignant respiratory diseases (J00-J99) were analysed. Factor analysis was used to create obstructive and restrictive factors. RESULTS: A total of 191 deaths were found altogether. Most measured lung function variables were associated with increased mortality when studied separately. Both decreased forced expiratory flow in one second (hazard ratio/measurement unit = 0.977, 95 % CI 0.969-0.988, p < 0.001) and impaired diffusing capacity (0.973, 0.965-0.981, p < 0.001) were independently associated with mortality from all causes, as well as from cardiovascular and non-malignant respiratory diseases. Both obstructive factor alone and the sum of obstructive and restrictive factors were associated with all studied mortality categories. The restrictive factor alone was associated with all-cause and respiratory mortality. CONCLUSIONS: Deteriorated lung function predicts deaths. The reasons for impaired lung function should be medically explored to enable restoring measures aiming thus to prevent premature deaths.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

All-cause mortality and cancer incidence among adults exposed to blue asbestos during childhood

Authors: Reid, A; Franklin, P; Olsen, N; Sleith, J; Samuel, L; Aboagye-Sarfo, P; de Klerk, N; Musk, AW (2013) American Journal of Industrial Medicine 56:133-145. HERO ID: 2088306

[Less] BACKGROUND: There are few data on the long-term health outcomes of exposure to asbestos . . . [More] BACKGROUND: There are few data on the long-term health outcomes of exposure to asbestos in childhood. This study investigated cancer and mortality of adults exposed to blue asbestos as children.

METHODS: Data linkage to relevant health registries was used to identify cancers and mortality in a cohort of adults (n = 2,460) that had lived in an asbestos mining town during their childhood (<15 years).

RESULTS: There were 217 (93 female) incident cancers and 218 (70 female) deaths among the cohort. Compared with the Western Australian population females had elevated mesothelioma, ovarian and brain cancers, and increased "all cause" and "all cancer" mortality. Males had elevated mesothelioma, leukemia, prostate, brain, and colorectal cancers, and excess mortality from "all causes," "all cancers," circulatory disease, diseases of the nervous system, and accidents.

CONCLUSION: Exposure to blue asbestos in childhood is associated with an increased risk of cancer and mortality in adults.