Health & Environmental Research Online (HERO)


Libby Amphibole Asbestos (Draft, 2011)


1,032 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Asbestos exposure, pleural plaques and the risk of death from lung cancer

Authors: Pairon, JC; Andujar, P; Rinaldo, M; Ameille, J; Brochard, P; Chamming's, S; Clin, B; Ferretti, G; Gislard, A; Laurent, F; Luc, A; Wild, P; Paris, C (2014) American Journal of Respiratory and Critical Care Medicine 190:1413-1420. HERO ID: 2528298

[Less] Rationale: Although asbestos is a well-known lung carcinogen, the association between pleural plaques . . . [More] Rationale: Although asbestos is a well-known lung carcinogen, the association between pleural plaques and lung cancer remains controversial. Objective: The present study was designed to examine this association among asbestos-exposed workers. Methods and measurements: An 6-year follow-up was conducted to study lung cancer mortality in the 5,402 male subjects participating in an asbestos-related diseases screening program organized between October 2003 and December 2005 in four French regions. Chest computed tomography (CT) scan was performed in all subjects with randomized, independent, double reading of CT scans focusing on benign asbestos-related abnormalities. Survival regression based on the Cox model was used to model lung cancer mortality according to the presence of pleural plaques, with age as the main time variable adjusting for smoking and cumulative exposure index to asbestos. All statistical tests were two-sided. Main results: Thirty-six deaths from lung cancer were recorded. Lung cancer mortality was significantly associated with pleural plaques in the follow-up study in terms of both the unadjusted hazard ratio (HR) = 2.91 [95% confidence interval (CI) = 1.49 to 5.70 and the adjusted HR = 2.41 [95%CI = 1.21-4.85] after adjustment for smoking and cumulative exposure index to asbestos. Conclusions: The presence of pleural plaques may be an independent risk factor for lung cancer death in asbestos-exposed workers and could be used as an additional criterion in the definition of high-risk populations eligible for CT screening.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Impact of body mass index on the detection of radiographic localized pleural thickening

Authors: Larson, TC; Franzblau, A; Lewin, M; Goodman, AB; Antao, VC (2014) Academic Radiology 21:3-10. HERO ID: 2225734

[Less] RATIONALE AND OBJECTIVES: Subpleural fat can be difficult to distinguish from localized . . . [More] RATIONALE AND OBJECTIVES: Subpleural fat can be difficult to distinguish from localized pleural thickening (LPT), a marker of asbestos exposure, on chest radiographs. The aims of this study were to examine the influence of body mass index (BMI) on the performance of radiograph readers when classifying LPT and to model the risk of false test results with varying BMI.

MATERIALS AND METHODS: Subjects (n = 200) were patients being screened or treated for asbestos-related health outcomes. A film chest radiograph, a digital chest radiograph, and a high-resolution computed tomography (HRCT) chest scan were collected from each subject. All radiographs were independently read by seven B readers and scored using the International Labour Office system. HRCT scans, read by three experienced thoracic radiologists, served as the gold standard for the presence of LPT. We calculated measures of radiograph reader performance, including sensitivity and specificity, for each image modality. We also used logistic regression to estimate the probability of a false-positive and a false-negative result while controlling for covariates.

RESULTS: The proportion of false-positive readings correlated with BMI. While controlling for covariates, regression modeling showed the probability of a false-positive result increased with increasing BMI category, younger age, not having pleural calcification, and among subjects not reporting occupational or household contact asbestos exposure.

CONCLUSIONS: Clinicians should be cautious when evaluating radiographs of younger obese persons for the presence of asbestos-related pleural plaque, particularly in populations having an anticipated low or background prevalence of LPT.

Technical Report
Technical Report

SEER cancer statistics review, 1975-2010

Authors: Howlader, N; Noone, AM; Krapcho, M; Garshell, J; Neyman, N; Altekruse, SF; Kosary, CL; Yu, M; Ruhl, J; Tatalovich, Z; Cho, ; Mariotto, A; Lewis, DR; Chen, HS: Feuer, EJ; Cronin, KA; (eds) (2013) Bethesda, MD: National Cancer Institute. HERO ID: 2238687


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A phase II clinical trial of the Vascular Disrupting Agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma

Authors: Nowak, AK; Brown, C; Millward, MJ; Creaney, J; Byrne, MJ; Hughes, B; Kremmidiotis, G; Bibby, DC; Leske, AF; Mitchell, PL; Pavlakis, N; Boyer, M; Stockler, MR (2013) HERO ID: 1937477

[Less] BNC105P is a tubulin polymerisation inhibitor that selectively disrupts tumour vasculature and suppresses . . . [More] BNC105P is a tubulin polymerisation inhibitor that selectively disrupts tumour vasculature and suppresses cancer cell proliferation. This agent has exhibited preclinical and phase I activity in Malignant Pleural Mesothelioma (MPM). This phase II, single arm trial investigated the efficacy and safety of BNC105P as second line therapy in MPM. Participants had progressive MPM after first line pemetrexed/platinum chemotherapy, ECOG PS 0-1, adequate organ function, and measurable disease. BNC105P 16mg/m(2) was administered intravenously on day 1 and 8 every 21 days until progression or undue toxicity. The primary endpoint was centrally reviewed objective response rate (RR). Tumour response was assessed every two cycles using modified RECIST. 30 patients were enrolled in 10 months, predominantly male (90%), ECOG PS 1 (77%), epithelioid histology (67%), and non-metastatic disease (67%). All patients received at least one dose of study drug, with a median of 2 cycles. No significant haematologic, biochemical, or cardiac adverse events (AEs) were observed. Grade 3 or 4 AEs occurred in 10 patients (33%). There were 2 deaths on study: 1 cardiorespiratory, the other to pneumonia. We observed 1 partial response (3%); 13 patients had stable disease (43%). Median progression free survival was 1.5 months (95% CI 1.4-2.4); median overall survival was 8.2 months (95% CI 3.8-11.9). BNC105P was safe and tolerable. The sole response was insufficient to warrant further research as a single agent.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Mechanisms of airway remodeling

Authors: Hirota, N; Martin, JG (2013) Chest 144:1026-1032. HERO ID: 1937480

[Less] Airway remodeling comprises the structural changes of airway walls, induced by repeated injury and repair . . . [More] Airway remodeling comprises the structural changes of airway walls, induced by repeated injury and repair processes. It is characterized by the changes of tissue, cellular, and molecular composition, affecting airway smooth muscle, epithelium, blood vessels, and extracellular matrix. It occurs in patients with chronic inflammatory airway diseases such as asthma, COPD, bronchiectasis, and cystic fibrosis. Airway remodeling is arguably one of the most intractable problems in these diseases, leading to irreversible loss of lung function. Current therapeutics can ameliorate inflammation, but there is no available therapy proven to prevent or reverse airway remodeling, although reversibility of airway remodeling is suggested by studies in animal models of disease. Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions. In this review, we consider the factors that may contribute to airway remodeling and discuss the current and potential therapeutic interventions.

Technical Report
Technical Report

Personal communication to EPA from Dr. James Lockey, July 2, 2013

Author: Lockey, J (2013) [Personal Communication] HERO ID: 2347064


Technical Report
Technical Report

SAB review of EPA’s draft assessment entitled toxicological review of Libby Amphibole Asbestos (August 2011)

Author: SAB (2013) HERO ID: 2325151


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes

Authors: Kukkonen, MK; Tiili, E; Vehmas, T; Oksa, P; Piirila, P; Hirvonen, Ari (2013) BMC Pulmonary Medicine 13. HERO ID: 2248435

[Less] Background: The imbalance between proteases and antiproteases has been proposed to participate to the . . . [More] Background: The imbalance between proteases and antiproteases has been proposed to participate to the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. Gene level variation in different metalloproteinases, metalloproteinase inhibitors, and cytokines affecting them may contribute to this imbalance and destruction of the lung parenchyma. We investigated whether polymorphisms in selected protease-antiprotease balance pathway genes predispose to different emphysema subtypes (centrilobular, paraseptal, panlobular, and bullae) and airflow limitation among Finnish construction workers.

Methods: Eleven single nucleotide polymorphisms (SNPs) from seven genes (GC: rs7041 and rs4588; MMP1: rs1799750; MMP9: rs3918242; MMP12: rs652438; TIMP2: rs2277698; TNF: rs1799724 and rs1800629; TGFB1: rs1800469, rs1800470, and rs2241718) were analyzed from 951 clinically and radiologically characterized construction workers. The genotype and haplotype data was compared to different emphysematous signs confirmed with high resolution computed tomography (HRCT), forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and maximal expiratory flow at 50% of FVC (MEF50) by using linear and logistic regression analyses, adjusted for potential confounders.

Results: The TIMP2 rs2277698 SNP was associated with overall (p = 0.022) and paraseptal (p = 0.010) emphysema, as well as with FEV1/FVC ratio (p = 0.035) and MEF50 (p = 0.008). The TGFB1 rs2241718 and MMP9 rs3918242 SNPs were associated with centrilobular emphysema (p = 0.022 and p = 0.008), and the TNF rs1800629 SNP with paraseptal emphysema (p = 0.017). In stratified analysis, individuals with at least one TIMP2 rs2277698 or TNF rs1800629 variant allele were found to be at around two-fold risk for pathological paraseptal changes (OR 1.94, 95% CI 1.14-3.30; OR 2.10, 95% CI 1.24-3.56). On the contrary, the risk for pathological centrilobular changes was halved for individuals with at least one MMP9 rs3918242 (OR 0.51, 95% CI 0.30-0.86) or TGFB1 rs2241718 (OR 0.53, 95% CI 0.30-0.90) variant allele, or TGFB1 rs1800469-rs1800470 AT-haplotype (OR 0.55, 95% CI 0.33-0.93). MEF50, in turn, was significantly reduced among individuals with at least one TIMP2 rs2277698 variant allele (p = 0.011).

Conclusion: Our findings strengthen the hypothesis of the importance of protease-antiprotease balance in pathogenesis of emphysema and shed light on the aetiology of different emphysema subtypes by associating MMP9 and TGFB1 to centrilobular emphysema, and TIMP2 and TNF to paraseptal emphysema and/or airflow obstruction.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Longitudinal decline in lung function in former asbestos exposed workers

Authors: Algranti, E; Mendonça, EM; Hnizdo, E; De Capitani, EM; Freitas, JB; Raile, V; Bussacos, MA (2013) Occupational and Environmental Medicine 70:15-21. HERO ID: 2078956

[Less] BACKGROUND: This study was designed to assess the effect of asbestos exposure on longitudinal . . . [More] BACKGROUND: This study was designed to assess the effect of asbestos exposure on longitudinal lung function decline.

METHODS: A group of 502 former asbestos-cement workers with at least two spirometry tests 4 years apart. Repeated evaluations included respiratory symptoms questionnaire, spirometry and chest imaging. Asbestos exposure was ascertained as years of exposure, an index of cumulative exposure and latency time. The mixed effects model was used to evaluate the effect of exposure on the level and rate of change in forced expiratory volume in 1 s (FEV(1)) and forced vital capacity (FVC).

RESULTS: Mean age at entry was 51 (SD 9.9) years, mean latency time 25.6 (SD 10.0) years, mean follow-up time 9.1 (SD 2.8) years and mean number of spirometry tests 3.5. The FEV(1) level was significantly related to pack-years of smoking at entry and during the follow-up, the index of cumulative asbestos exposure at entry, and the presence of asbestosis at follow-up. The FVC level was significantly related to pack-years of smoking during the follow-up, cumulative asbestos exposure at entry, asbestosis and pleural thickening at follow-up, and body mass index at entry. Asbestos exposure was not associated with increasing rates of FEV(1) and FVC decline. However, FEV(1) regression slopes with age, estimated by terciles of cumulative exposure, showed significant differences. Combined effects of smoking and exposure conferred further acceleration in lung function decline.

CONCLUSIONS: Occupational exposure in asbestos-cement industry was a risk factor for increased lung function decline. The effect seems to be mostly concentrated during the working period. Smoking and exposure had synergic effects.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Low levels exposure to Libby amphibole asbestos and localized pleural thickening

Authors: Christensen, KY; Bateson, TF; Kopylev, L (2013) Journal of Occupational and Environmental Medicine 55:1350-1355. [Review] HERO ID: 2088643

[Less] OBJECTIVE:: To explore the relationship between low levels of exposure to Libby amphibole . . . [More] OBJECTIVE:: To explore the relationship between low levels of exposure to Libby amphibole asbestos (LAA) and pleural abnormalities, specifically localized pleural thickening (LPT).

METHODS:: Three studies presenting the risks associated with quantitative LAA exposure estimates were reviewed, paying particular attention to lower exposure ranges.

RESULTS:: Studies reviewed were conducted among workers exposed to LAA at mining and milling operations in Libby, Montana, at a vermiculite processing facility in Marysville, Ohio, and community residents exposed to LAA from a vermiculite processing facility in Minneapolis, Minnesota. Pleural abnormalities were evaluated using radiographs. Despite differences in study populations and design, each study found that cumulative inhalation LAA exposure was associated with increased risk of LPT even at low levels of exposure.

CONCLUSIONS:: Inhalation exposure to LAA is associated with increased risk of LPT even at the lowest levels of exposure in each study.