Health & Environmental Research Online (HERO)


Benzo(a)pyrene (BaP)


1,857 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Squamous epithelioma probably due to tar ointment in a case with psoriasis

Authors: Alexander, JOD; Macrosson, KI (1954) British Medical Journal 2:1089. HERO ID: 1390685

[Less] A case of squamous epithelioma arising on a patch of psoriasis in a 31 year old male was investigated. . . . [More] A case of squamous epithelioma arising on a patch of psoriasis in a 31 year old male was investigated. The patient presented with a 2 centimeter lump over the head of the right fibula. The lesion was raised 3 to 4 millimeters above the skin surface; the edge was firm and rolled, and the center showed slight ulceration without discharge. There was also a diffuse discoid psoriasis and a marked tar acne with one or two tar mollusca. No history of arsenic administration was found, and the only agent applied to the skin that might have been carcinogenic was an ointment containing salicylic-acid (69727), oleated-mercury (1191806), coal-tar, and an emulsifying base. Lesions appeared 14 days after initiation of tar ointment application. The patient used this ointment for 3 months before seeking medical advise. The epitheliomatous lesion was excised, and the diagnosis of squamous carcinoma was confirmed histologically. The author concludes that the continued insult to the skin of the tar ointment is the essential factor in the production of malignant change.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Protein measurement with the Folin phenol reagent

Authors: Lowry, OH; Rosebrough, NJ; Farr, AL; Randall, RJ (1951) Journal of Biological Chemistry 193:265-275. HERO ID: 2343674


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

On the susceptibility of the thymus, lung, subcutaneous and mammary tissues in strain street mice to direct application of small doses of four different carcinogenic hydrocarbons

Author: Rask-Nielsen, R (1950) British Journal of Cancer 4:108-116. HERO ID: 1011993


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Attempts to produce cancer in rhesus monkeys with carcinogenic hydrocarbons and estrogens

Authors: Pfeiffer, CA; Allen, E (1948) Cancer Research 8:97-127. HERO ID: 1011827


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Quantitative analysis of dose-response data obtained with three carcinogenic hydrocarbons in strain C3H male mice

Authors: Bryan, WR; Shimkin, MB (1943) Journal of the National Cancer Institute 3:503-531. HERO ID: 1012062

[Less] The quantitative relationship between dose and tumor morbidity were studied in 1,004 male C3H mice following . . . [More] The quantitative relationship between dose and tumor morbidity were studied in 1,004 male C3H mice following subcutaneous injections of 3-methylcholanthrene, dibenz(a,h)anthracene, or benzo(a)pyrene. Biomathematical procedures were used to determine both the tumor morbidity and latent-period responses with regard to the injected dose and relative carcinogenic potencies of these carcinogenic hydrocarbons. The results were as follows: The minimal average latent period in months (days/30) was 3.72 for dibenz(a,h)anthracene, 2.48 for 3-methylcholanthrene, and 3.02 for benzo(a)pyrene. The median tumor dose (TD-50) was 0.016mg. for dibenz (a,h)anthracene, 0.021 mg. for 3-r 24 ·lylcholanthrene, and 0.101 for benzo(a)pyrene. The 95% tumor dose (TD-95) was 0.084 Dlg. for dibenz(a,h)anthracene, 0.096 mg. for 3-methylcholanthrene, and 08.75 mg. for benzo(a)pyrene. The specific induction time in months (days/30) was 6.79 for dibenz(a,h)anthracene, 5.14 for 3-methylcholanthrene, and 5.23 for benzo(a)pyrene. The difference between the relative potencies of 3-methylcholanthrene, and dibenz{a,h)anthracene is not statistically significant, but both of these hydrocarbons differed significantly from benzo(a)pyrene. A total of 433 tumors at the site of injection was observed in the 957 surviving mice. Histologically, the tumors were spindle cell sarcoma (411), carcinoma (2}, or mixed carcinoma and sarcoma (2). Eighteen tumors were excluded in the absence of histological examination.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The production of cancer by pure hydrocarbons.--Part III

Authors: Barry, G; Cook, JW; Haslewood, GAD; Hewett, CL; Hieger, I; Kennaway, EL (1935) Proceedings of the Royal Society: Biological Sciences 117:318-351. HERO ID: 1012335

[Less] The carcinogenic activity of tetracyclic and pentacyclic aromatic hydrocarbons was investigated. Substances . . . [More] The carcinogenic activity of tetracyclic and pentacyclic aromatic hydrocarbons was investigated. Substances were applied in benzene solution to the interscapular region of mice twice weekly. Tests for the production of sarcoma were made by injecting the compound subcutaneously in a fatty medium, generally lard. Tetracyclic compounds including 3,4-benzpyrene (50328) (34BP) and 3,4-benzphenanthrene (217594) (34BPA), 20 simple homologues of 1,2-benzanthracene (56553) (12BA), 12 pentacyclic compounds including 1,2,5,6-dibenzanthracene (53703) (1256DB), 1,2-benzpyrene (192972), 20 simple derivatives of 1256DB, methylcholanthrene (56495), certain sterols and their derivatives, keto hydroxyoestrin (53167) and some derivatives, and allied compounds were tested. In all, 71 compounds not related in molecular structure to 12BA and 69 compounds related to 12BA were tested. Of those not related to 12BA, 34BPA, pyrene (129000), chrysene (218019), and their derivatives produced tumors. The most active of these, 34BPA, produced 7 epitheliomas and 5 papillomas in 20 mice tested. Of the 69 compounds related to 12BA, 25 were carcinogenic. In general, these active compounds were all derivatives of 12BA containing substituents at positions five or six or both, these substituents being alkyl groups, saturated rings, or an additional aromatic ring. Active compounds related to 12BA but not within these categories were 1,2-benzpyrene, 1,2,7,8-dibenzanthracene (224419), and its analogue 3,4,5,6-dibenzacridine (224533). Methylcholanthrene (56495), a benzanthracene hydrocarbon with substituents in positions five and six, was a potent carcinogen: in one series of 20 mice, 17 epitheliomas and 1 papilloma were produced in 180 days. The 44 compounds related to 12BA which were not carcinogenic were usually derivatives in which the substituents were attached to the molecule at positions other than five and six, or else compounds related to 1256DB by the attachment of additional benzene. The authors suggest that there is an optimum state of molecular complexity for carcinogenic activity.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

106. The isolation of a cancer-producing hydrocarbon from coal tar. Parts I, II, and III

Authors: Cook, JW; Hewett, CL; Hieger, I (1933) HERO ID: 1012331