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Mouse Lung Tumor

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580 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Survey of mortality among employees engaged in the manufacture of styrene and polystyrene at the BASF Ludwigshafen works

Authors: Frentzel-Beyme, R; Thiess, AM; Wieland, R (1978) Scandinavian Journal of Work, Environment and Health 2:231-239. HERO ID: 73441

[Less] A mortality survey of 1,960 employees currently or previously exposed to styrene at work has shown that . . . [More] A mortality survey of 1,960 employees currently or previously exposed to styrene at work has shown that the observed number of deaths from cancer or other causes is no higher than the number expected in the German population or in a group of BASF employees. Analyses of deaths occurring after a minimum period of five years in groups exposed for different durations (5 years, 10 years, 15 years, more than 15 years) indicated no increase in mortality with exposure time. This latter observation also applied to malignant tumors; therefore it may be inferred that prolonged exposure to styrene is not a cancer hazard.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Chromosome aberrations in lymphocytes of workers exposed to styrene

Authors: Meretoja, T; Jarventaus, H; Sorsa, M; Vainio, H (1978) Scandinavian Journal of Work, Environment and Health 2:259-264. HERO ID: 73487

[Less] Workers exposed to styrene in the reinforced plastics industry show a significant increase of chromosome . . . [More] Workers exposed to styrene in the reinforced plastics industry show a significant increase of chromosome aberrations, mainly chromosome breaks, in peripheral blood lymphocytes. The high incidence of aberrant lymphocytes (mean 15.1 ± 4.8%; referents 2.0 ± 1.3%) was retained when the same men were reexamined one year later (mean 16.2 ± 2.9 %) However, the frequency of sister chromatid exchanges (SCE), a newly developed sensitive parameter for the detection of recombinational exchanges linked with DNA repair, was not significantly increased (mean 5.3 ± 1.0 SCE/cell) in comparison to the referents (mean 4.4 ± 0.6 SCE/cell. This finding suggests a specific role of styrene or its metabolites in inducing genetic lesions mainly manifesting themselves as chromosomal breaks.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Mortality experience of styrene-polystyrene polymerization workers: initial findings

Authors: Nicholson, WJ; Selikoff, IJ; Seidman, H (1978) Scandinavian Journal of Work, Environment and Health 2:247-252. HERO ID: 73495

[Less] A group of 560 individuals has been identified as employed on 1 May 1960 with at least five years seniority . . . [More] A group of 560 individuals has been identified as employed on 1 May 1960 with at least five years seniority in a plant manufacturing styrene and polystyrene. In this plant workplace exposures included styrene, benzene and ethylbenzene, among other materials. All of the 560 individuals have been traced through 1975 and their vital status determined. Expected and observed deaths, by cause, were determined from 1 May 1960 or the tenth anniversary of employment in the plant through 31 December 1975. Over this relatively short period of time a deficit of deaths compared to that of the general population was observed (106.41 expected versus 83 observed). Among the 83 deaths, one was of leukemia, one of lymphoma and an additional death was accompanied by leukemia. A review of 361 additional death certificates revealed five additional cases of leukemia and four of lymphoma. The available information from the limited follow-up in time of the cohort and from the randomly collected death certificates, while suggestive of a possible risk, is not definitive.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Enhancement of urethan tumorigenesis in mouse lung by butylated hydroxytoluene

Authors: Witschi, H; Williamson, D; Lock, S (1977) Journal of the National Cancer Institute 58:301-305. HERO ID: 626379

[Less] Intraperitoneal injection of the antioxidant butylated hydroxytoluene (BHT) produces cell proliferation . . . [More] Intraperitoneal injection of the antioxidant butylated hydroxytoluene (BHT) produces cell proliferation in mouse lungs within 2-4 days. We examined whether the presence of an increased number of proliferating lung cells would influence urethan tumorigenesis. Male Swiss-Webster mice were treated with 1 mg urethan/g before, during, or after BHT-stimulated cell growth in the lung. The number of pulmonary tumors found 13-15 weeks later was not different in BHT-treated mice compared to that in controls. On the other hand, repeated stimulation of cell growth after urethan treatment enhanced tumorigenesis. Male Swiss-Webster and A/J mice were given a single dose of urethan (1 mg/g) and, beginning 7 days later, weekly injections of BHT or corn oil. Repeated injections of BHT significantly increased the yield of lung tumors in both strains. Weekly injections of BHT into mice pretreated with 0.9% NaCl reduced the number of spontaneous pulmonary adenomas.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Experimental study of the pathogenesis of carcinoma

Authors: Yamagiwa, K; Ichikawa, K (1977) CA: A Cancer Journal for Clinicians 27:174-181. HERO ID: 1597255


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Toxicologic, industrial hygiene and epidemiologic considerations in the possible association between SBR manufacturing and neoplasms of lymphatic and hematopoietic tissues

Authors: Spirtas, R; Van Ert, M; Gamble, JF; Wolf, P; McMichael, AJ (1976) HERO ID: 73528


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Mutagenicity of industrial compounds: styrene and its possible metabolite styrene oxide

Authors: Loprieno, N; Abbondandolo, A; Barale, R; Baroncelli, S; Bonatti, S; Bronzetti, G; Cammellini, A; Corsi, C; Corti, G; Frezza, D; Leporini, C; Mazzaccaro, A; Nieri, R; Rosellini, D; Rossi, AM (1976) Mutation Research 40:317-324. HERO ID: 95518

[Less] Summary Styrene and its presumed metabolite, styrene oxide, were tested for their mutagenic effect . . . [More] Summary Styrene and its presumed metabolite, styrene oxide, were tested for their mutagenic effect on a forward mutation system of yeast and of Chinese hamster cells, and on a gene-conversion system of yeast. Experiments with liver microsomal preparations and host-mediated assay with yeast were also carried out. Styrene oxide was mutagenic in all test systems. Styrene was mutagenic only in the host-mediated assay.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Tumours of the respiratory tract

Authors: Pour, P; Stanton, MF; Kuschner, M; Laskin, S; Shabad, LM (1976) IARC Scientific Publications 1-40. [Review] HERO ID: 2221336


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Mortality among rubber workers: Relationship to specific jobs

Authors: McMichael, AJ; Spirtas, R; Gamble, JF; Tousey, PM (1976) Journal of Occupational Medicine 18:178-185. HERO ID: 62362

[Less] This study has examined the ten-year mortality in a single-plant population of 6678 male rubber workers, . . . [More] This study has examined the ten-year mortality in a single-plant population of 6678 male rubber workers, in terms of the association of specific causes of death with a history of having worked in certain categories of jobs within the rubber industry. The work-histories of individual study subjects were analyzed, in detail, for all workers dying of selected causes of death. Comparison was made with the work-histories of a 22% age-stratified random sample of the total population. Age-adjusted exposure ratios (Tables 3 and 4) were calculated for all nine case groups in all 16 work areas, using differing exposure criteria (i.e. duration and calendar period). These ratios provide an approximation of the increased mortality risk associated with particular work areas. The risk ratios (with their associated confidence intervals), in Table 5, provide more rigorous estimates of these instances of increased mortality risk. For each cause of death studied, there were statistically significant associations with several work areas. For the cancers, the strongest associations tended to be with work areas at the front end of the production line (especially compounding and mixing), where the likelihood of contact with dusts, chemical ingredients, and vapors containing the early reaction byproducts, is high. The reclaim operation and the synthetic plant were each associated with several cancers (respiratory and bladder, and stomach and lymphato-hematopoietic cancers, respectively). The lymphatic leukemias were associated with solvent-exposure areas, especially inspection, finishing, and repair. Ischemic heart disease deaths, at ages 40-54, were strongly associated with having worked in extrusion and tread cementing, and in the synthetic plant. Deaths from diabetes mellitus were strongly associated with the janitoring-trucking category, and with jobs in the inspection, finishing and repair area. These observed associations, calculated after controlling for the variables sex and age, were apparently not due to confounding by smoking and race differences between work areas. The role of selective transfer of sick individuals (into, say janitoring or trucking) warrants further investigation. However, this mechanism is unlikely to be involved in the great majority of the observed associations. Another possible source of spurious inferences of increased risk would be correlation, within work-histories, between two job categories, one of which actually involved increased risk, while the other did not. Such associations could occur if certain job sequency trends existed within this working population. (Preliminary analyses indicate that this likelihood is not great; however, further analysis is planned.) Detailed study of specific environmental agents, historically and cross-sectionally, is currently underway, in an attempt to identify the work-environment agents responsible for the associations reported here.

Technical Report
Technical Report

Final report on carcinogens background document for styrene-7,8-oxide

Author: NTP Research Triangle Park, NC: National Toxicology Program. [NTP] HERO ID: 2347334