Analytical Procedures for the Measurement and Characterization of Phthalate Esters
Authors: Banerjee, S; Dombrowski, AE; Scala, AJ; Howard, PH
(1533-05). (NIOSH/00189527). BIO/DYNAMICS INC.
HERO ID: 1316111
Analytical procedures for analyzing and characterizing phthalate esters were evaluated. Hexane solutions . . .
Analytical procedures for analyzing and characterizing phthalate esters were evaluated. Hexane solutions containing 1000 parts per million (ppm) dimethyl-phthalate (131113), diethyl-phthalate (84662), di-n-butyl-phthalate (84742), butyl-benzyl-phthalate (85687) (BBP), dihexyl-phthalate (84753), butyl-2-ethylhexyl-phthalate (85698), a mixture of dihexyl-phthalate plus di-n-octyl-phthalate (117840), plus di-n-decyl-phthalate (84775), di-(2-ethylhexyl)phthalate (117817), diisooctyl-phthalate (27554263), diisononyl-phthalate (28553120), a mixture of di-heptyl-phthalate (3648213) plus dinonyl-phthalate (84764) plus di-undecyl-phthalate (3648202), diisodecyl-phthalate (26761400), di-undecyl-phthalate, and ditridecyl-phthalate (119062) were analyzed by gas chromatography (GC) using a flame ionization detector or GC/mass spectrometry (GC). The mass spectrometer was operated in the chemical ionization mode with methane as the reagent gas and in the electron impact mode. Acetonitrile solutions containing 1000ppm of the compounds were also analyzed by high performance liquid chromatography (HPLC) using an ultraviolet detector set at 200 nanometers. Sample chromatograms and mass spectra of the compounds were given. HPLC was more sensitive than GC; however GC provided better resolution. A program to measure the solubility of the compounds in water at 25 degrees-C by HPLC was underway. Sample data for BBP indicated an aqueous solubility of 3.2ppm. The authors conclude that HPLC is probably the method of choice for making physical measurements on phthalate esters. GC or GC/MS is best suited for degradation studies where separation and identification of products are important./CHEMISTRY