Health & Environmental Research Online (HERO)


BBP (Butyl benzyl phthalate)


1,614 References Were Found:

Technical Report
Technical Report

Final report subacute feeding: Albino rats

Author: Hazleton Laboratories (1958) (878213590). Falls Church, VA: Hazelton Laboratories. HERO ID: 678609

[Less] Subchronic toxicity was evaluated in 2 groups of 20 Charles River albino rats (10 male and 10 female) . . . [More] Subchronic toxicity was evaluated in 2 groups of 20 Charles River albino rats (10 male and 10 female) ingesting Santicizer 160 (butyl benzyl phthalate) via the diet for 13 weeks. The first group ingested test article at a dietary concentration of 0.5% throughout the treatment period. The second group received weekly adjustments in dietary levels, starting at 0.5% and increasing incrementally by 0.5% until a concentration of 2.0% was reached; animals were then maintained at this level for the remainder of the test. Mortality was observed in 3 males in the control group, in one female in the 0.5% dose group, and in one male in the 2.0% dose group during the treatment period. A statistically significant (analysis of variance, p < 0.05) decrease in body weight gain was observed in males and females in the 2.0% dose group, but not in the 0.5% dose group. Liver to body weight, and kidney to body weight ratios were significantly (p < 0.05) increased in males and females in the 2.0% dose group; however, the investigators attributed this to the decreased (see above) body weight of these animals. Necropsy of animals that died or survived to the end of the 90 day treatment period did not reveal gross pathology that could be attributed to the effect of the test articl e. Additionally, microscopic analysis of the liver, spleen, kidneys, adrenals, stomach, and large and small intestines did not reveal test article induced pathology.

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Peer Reviewed Journal Article

Studies on the toxicity and skin effects of compounds used in the rubber and plastics industries: II. Plasticizers

Authors: Mallette, FS; Von Haam, E (1952) AMA Archives of Industrial Hygiene and Occupational Medicine 6:231-236. HERO ID: 675304

[Less] The toxicities and skin effects of plasticizers used in rubber and plastic industries were studied in . . . [More] The toxicities and skin effects of plasticizers used in rubber and plastic industries were studied in laboratory animals and humans. Twenty five compounds used as plasticizers of synthetic resins were investigated. Rats were administered the compounds by various routes, and mortality was recorded. All animals were necropsied. The compounds were tested for skin irritancy and sensitization in rabbits and humans. Five compounds dioctyl-phthalate (117817), butylbenzyl-phthalate, santicizer-140 (66770443), santicizer-141 (1241947), and flexol-8N8 (61461776) were moderately toxic in doses of 0.6 to 2.4 grams per kilogram (g/kg), generally as a result of intraperitoneal administration. Toxic effects were usually seen in the erythrocytes, blood capillaries, and the central nervous system. The other 20 compounds were essentially nontoxic. All animals supported intraperitoneal injections of 6g/kg or more with no signs of toxic effects. Five compounds showed no skin irritation or sensitization in humans and rabbits: di-2-ethylhexyl-adipate (103231), dibutoxyethyl-diglycol-carbonate, dibutoxyethyl-phthalate (117839), dioctyl-sebacate (122623), and dibutyl-sebacate (109433). Seventeen plasticizers were slight or moderate skin irritants, three were severe skin irritants, and five were moderate sensitizers.

Technical Report
Technical Report

Analytical Procedures for the Measurement and Characterization of Phthalate Esters

Authors: Banerjee, S; Dombrowski, AE; Scala, AJ; Howard, PH (1900) (1533-05). (NIOSH/00189527). BIO/DYNAMICS INC. HERO ID: 1316111

[Less] Analytical procedures for analyzing and characterizing phthalate esters were evaluated. Hexane solutions . . . [More] Analytical procedures for analyzing and characterizing phthalate esters were evaluated. Hexane solutions containing 1000 parts per million (ppm) dimethyl-phthalate (131113), diethyl-phthalate (84662), di-n-butyl-phthalate (84742), butyl-benzyl-phthalate (85687) (BBP), dihexyl-phthalate (84753), butyl-2-ethylhexyl-phthalate (85698), a mixture of dihexyl-phthalate plus di-n-octyl-phthalate (117840), plus di-n-decyl-phthalate (84775), di-(2-ethylhexyl)phthalate (117817), diisooctyl-phthalate (27554263), diisononyl-phthalate (28553120), a mixture of di-heptyl-phthalate (3648213) plus dinonyl-phthalate (84764) plus di-undecyl-phthalate (3648202), diisodecyl-phthalate (26761400), di-undecyl-phthalate, and ditridecyl-phthalate (119062) were analyzed by gas chromatography (GC) using a flame ionization detector or GC/mass spectrometry (GC). The mass spectrometer was operated in the chemical ionization mode with methane as the reagent gas and in the electron impact mode. Acetonitrile solutions containing 1000ppm of the compounds were also analyzed by high performance liquid chromatography (HPLC) using an ultraviolet detector set at 200 nanometers. Sample chromatograms and mass spectra of the compounds were given. HPLC was more sensitive than GC; however GC provided better resolution. A program to measure the solubility of the compounds in water at 25 degrees-C by HPLC was underway. Sample data for BBP indicated an aqueous solubility of 3.2ppm. The authors conclude that HPLC is probably the method of choice for making physical measurements on phthalate esters. GC or GC/MS is best suited for degradation studies where separation and identification of products are important./CHEMISTRY

Technical Report
Technical Report

MSDS Extract concerning physico chemical properties of BBP

Author: Bayer AG HERO ID: 2131453