Health & Environmental Research Online (HERO)


ISA-PM (current)


14,002 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Fetal physiologically-based pharmacokinetic models: systems information on fetal biometry and gross composition

Authors: Abduljalil, K; Johnson, TN; Rostami-Hodjegan, A (2018) Clinical Pharmacokinetics 57:1149-1171. HERO ID: 4470812

[Less] BACKGROUND: Postulating fetal exposure to xenobiotics has been based on animal studies; . . . [More] BACKGROUND: Postulating fetal exposure to xenobiotics has been based on animal studies; however, inter-species differences can make this problematic. Physiologically-based pharmacokinetic models may capture the rapid changes in anatomical, biochemical, and physiological parameters during fetal growth over the duration of pregnancy and help with interpreting laboratory animal data. However, these models require robust information on the longitudinal variations of system parameter values and their covariates.

OBJECTIVE: The objective of this study was to present an extensive analysis and integration of the available biometric data required for creating a virtual human fetal population by means of equations that define the changes of each parameter with gestational age.

METHODS: A comprehensive literature search was carried out on the parameters defining the growth of a fetus during in-utero life including weight, height, and body surface area in addition to other indices of fetal size, body fat, and water. Collated data were assessed and integrated through a meta-analysis to develop mathematical algorithms to describe growth with fetal age.

RESULTS: Data for the meta-analysis were obtained from 97 publications, of these, 15 were related to fetal height or length, 32 to fetal weight, 4 to fetal body surface area, 8 to crown length, 5 to abdominal circumference, 12 to head circumference, 14 to body fat, and 12 to body water. Various mathematical algorithms were needed to describe parameter values from the time of conception to birth.

CONCLUSION: The collated data presented in this article enabled the development of mathematical functions to describe fetal biometry and provide a potentially useful resource for building anthropometric features of fetal physiologically-based pharmacokinetic models.

Technical Report
Technical Report

Supplemental material: Chapter 9 (reproductive and developmental effects) of the integrated science assessment for particulate matter

Author: U.S. EPA (2018) HERO ID: 4442365


Technical Report
Technical Report

Supplemental material: Chapter 6 (cardiovascular effects) of the integrated science assessment for particulate matter

Author: U.S. EPA (2018) HERO ID: 4442361


Technical Report
Technical Report

Supplemental material: Chapter 5 (respiratory effects) of the integrated science assessment for particulate matter

Author: U.S. EPA (2018) HERO ID: 4566668


Technical Report
Technical Report

Supplemental material: Chapter 7 of the integrated science assessment for particulate matter – health criteria

Author: U.S. EPA (2018) HERO ID: 4434892


Technical Report
Technical Report

Supplemental material: Chapter 8 of the integrated science assessment for particulate matter – health criteria

Author: U.S. EPA (2018) HERO ID: 4414073


Technical Report
Technical Report

Supplemental material: Chapter 10 (cancer) of the integrated science assessment for particulate matter

Author: U.S. EPA (2018) HERO ID: 4417285


Technical Report
Technical Report

Supplemental material: Chapter 11 (mortality) of the integrated science assessment for particulate matter

Author: U.S. EPA (2018) HERO ID: 4442366


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The development of a pregnancy PBPK Model for Bisphenol A and its evaluation with the available biomonitoring data

Authors: Sharma, RP; Schuhmacher, M; Kumar, V (2018) Science of the Total Environment 624:55-68. HERO ID: 4471201

[Less] Recent studies suggest universal fetal exposure to Bisphenol A (BPA) and its association with the adverse . . . [More] Recent studies suggest universal fetal exposure to Bisphenol A (BPA) and its association with the adverse birth outcomes. Estimation of the fetal plasma BPA concentration from the maternal plasma BPA would be highly useful to predict its associated risk to this specific population. The objective of current work is to develop a pregnancy-physiologically based pharmacokinetic (P-PBPK) model to predict the toxicokinetic profile of BPA in the fetus during gestational growth, and to evaluate the developed model using biomonitoring data obtained from different pregnancy cohort studies. To achieve this objective, first, the adult PBPK model was developed and validated with the human BPA toxicokinetic data. This validated human PBPK model was extended to develop a P-PBPK model, which included the physiological changes during pregnancy and the fetus sub-model. The developed model would be able to predict the BPA pharmacokinetics (PKs) in both mother and fetus. Transplacental BPA kinetics parameters for this study were taken from the previous pregnant mice study. Both oral and dermal exposure routes were included into the model to simulate total BPA internal exposure. The impact of conjugation and deconjugation of the BPA and its metabolites on fetal PKs was investigated. The developed P-PBPK model was evaluated against the observed BPA concentrations in cord blood, fetus liver and amniotic fluid considering maternal blood concentration as an exposure source. A range of maternal exposure dose for the oral and dermal routes was estimated, so that simulation concentration matched the observed highest and lowest mother plasma concentration in different cohorts' studies. The developed model could be used to address the concerns regarding possible adverse health effects in the fetus being exposed to BPA and might be useful in identifying critical windows of exposure during pregnancy.

Technical Report
Technical Report

Probe and monitoring path siting criteria for ambient air quality monitoring

Author: U.S. EPA (2018) § 40 CFR Part 58, Appendix 58, 2018 (Goverment Publishing Office). HERO ID: 4445192

[Less] (a) This appendix contains specific location criteria applicable to SLAMS, NCore, and PAMS ambient air . . . [More] (a) This appendix contains specific location criteria applicable to SLAMS, NCore, and PAMS ambient air quality monitoring probes, inlets, and optical paths after the general location has been selected based on the monitoring objectives and spatial scale of representation discussed in appendix D to this part. Adherence to these siting criteria is necessary to ensure the uniform collection of compatible and comparable air quality data.

(b) The probe and monitoring path siting criteria discussed in this appendix must be followed to the maximum extent possible. It is recognized that there may be situations where some deviation from the siting criteria may be necessary. In any such case, the reasons must be thoroughly documented in a written request for a waiver that describes how and why the proposed siting deviates from the criteria. This documentation should help to avoid later questions about the validity of the resulting monitoring data. Conditions under which the EPA would consider an application for waiver from these siting criteria are discussed in section 10 of this appendix.

(c) The pollutant-specific probe and monitoring path siting criteria generally apply to all spatial scales except where noted otherwise. Specific siting criteria that are phrased with a “must” are defined as requirements and exceptions must be approved through the waiver provisions. However, siting criteria that are phrased with a “should” are defined as goals to meet for consistency but are not requirements.