Health & Environmental Research Online (HERO)


Methylmercury


43,976 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Metals, hormones and sexual maturation in Flemish adolescents in three cross-sectional studies (2002–2015)

Authors: De Craemer, S; Croes, K; Van Larebeke, N; De Henauw, S; Schoeters, G; Govarts, E; Loots, I; Nawrot, T; Nelen, V; Den Hond, E; Bruckers, L; Gao, Y; Baeyens, W HERO ID: 3789105

[Less] Abstract rmone levels and timing of sexual maturation are considered important markers for health status . . . [More] Abstract rmone levels and timing of sexual maturation are considered important markers for health status of adolescents in puberty, and previous research suggests they might be influenced by metal exposure. In three campaigns of the Flemish Environment and Health Study (FLEHS I 2002–2006; FLEHS II 2007–2011 and FLEHS III 2012–2015), data were collected on internal exposure to metals (Cd, Cu, Pb, Cr, Mn, Tl, Ni, Sb, Hg, As and As species) and sexual maturation in 2671 14–15 years old adolescents. All metals were measured in blood and/or urine, except total- and methylmercury which were measured in hair samples. Sex hormone levels were measured in blood serum of adolescent males of the cohorts of FLEHS I and FLESH II. The use of a uniform methodology in successive campaigns allows to confirm associations between exposure and health in different cohorts and over time. Furthermore, mathematical and statistical density correction methods using creatinine or specific gravity were tested for urinary markers. icant associations between sex hormones and maturity markers were observed in the FLEHS I and II campaigns, when both were assessed together. Regardless of the applied correction method, creatinine correction systematically introduced bias due to associations of creatinine with sex hormones and maturation markers, especially in adolescent males, while this is not the case for specific gravity. A series of exposure-response associations were found, but several involving Cd, Pb, As, Tl and Cu persisted in different FLEHS campaigns. The effects of Pb and Cu on luteinizing hormone, (free) testosterone, (free) oestradiol and maturation support a xenoestrogenic agonistic action on the feedback of oestradiol to the hypothalamus-pituitary-gonadal axis. sults suggest that specific care should be taken when selecting urine density correction for investigating associations with hormonal and maturation markers in adolescent males. Furthermore, the possibility of xenoestrogenic effects of certain metals in environmentally exposed adolescents warrants further investigation.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Methylmercury induces an initial increase in GABA-evoked currents in Xenopus oocytes expressing α1 and α6 subunit-containing GABAA receptors

Authors: Tsai, T; Yuan, Y; Hajela, RK; Philips, SW; Atchison, WD HERO ID: 3789168

[Less] Abstract onset effects of methylmercury (MeHg) on recombinant α1β2γ2S or α6β2γ2S subunit-containing . . . [More] Abstract onset effects of methylmercury (MeHg) on recombinant α1β2γ2S or α6β2γ2S subunit-containing GABAA receptors were examined. These are two of the most prevalent receptor types found in cerebellum–a consistent target of MeHg-induced neurotoxicity. Heterologously expressed receptors were used in order to: (1) isolate receptor-mediated events from extraneous effects of MeHg due to stimulation of the receptor secondary to increased release of GABA seen with MeHg in neurons in situ and (2) limit the phenotypes of GABAA receptors present at one time. Initial changes in IGABA in Xenopus laevis oocytes expressing either α1β2γ2S or α6β2γ2S receptors were compared during continuous bath application of MeHg. A time-dependent increase in IGABA mediated by both receptor subtypes occurred following the first 25–30 min of MeHg (5 μM) exposure. In α6β2γ2S containing receptors, the MeHg-induced increase in IGABA was less pronounced compared to that mediated by α1β2γ2S containing receptors, although the pattern of effects was generally similar. Washing with MeHg-free solution reversed the increase in current amplitude. Application of bicuculline at the time of peak potentiation of IGABA rapidly and completely reversed the MeHg-induced currents. Therefore these MeHg-increased inward currents are mediated specifically by the two subtypes of GABAA receptors and appear to entail direct actions of MeHg on the receptor. However bicuculline did not affect stimulation by MeHg of oocyte endogenous Cl− -mediated current, which presumably results from increased [Ca2+]i. Thus, MeHg initially potentiates IGABA in oocytes expressing either α1β2γ2S or α6β2γ2S receptors prior to its more defined later effects, suggesting that MeHg may initially interact directly with GABAA receptors in a reversible manner to cause this potentiation.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Identification of exposure to environmental chemicals in children and older adults using human biomonitoring data sorted by age: Results from a literature review

Authors: Choi, J; Knudsen, LE; Mizrak, S; Joas, A HERO ID: 3789265

[Less] Abstract biomonitoring (HBM) provides the tools for exposure assessment by direct measurements of biological . . . [More] Abstract biomonitoring (HBM) provides the tools for exposure assessment by direct measurements of biological specimens such as blood and urine. HBM can identify new chemical exposures, trends and changes in exposure, establish distribution of exposure among the general population, and identify vulnerable groups and populations with distinct exposures such as children and older adults. The objective of this review is to demonstrate the use of HBM to identify environmental chemicals that might be of concern for children or older adults due to higher body burden. To do so, an extensive literature search was performed, and using a set of defined criteria, ten large-scale, cross-sectional national HBM programs were selected for data review and evaluation. A comparative analysis of the age-stratified data from these programs and other relevant HBM studies indicated twelve chemicals/classes of chemicals with potentially higher body burden in children or older adults. Children appear to have higher body burden of bisphenol A (BPA), some phytoestrogens, perchlorate, and some metabolites of polycyclic aromatic hydrocarbons and benzene. On the other hand, older adults appear to have higher body burden of heavy metals and organochlorine pesticides. For perfluoroalkyl substances, polybrominated diphenyl ethers, parabens, and phthalates, both children and older adults have higher body burden depending on the specific biomarkers analyzed, and this might be due to the exposure period and/or sources from different countries. Published data from the DEMOCOPHES project (a pilot study to harmonize HBM efforts across Europe) also showed elevated exposures to BPA and some phthalate metabolites in children across several European countries. In summary, age-stratified HBM data can provide useful knowledge of identifying environmental chemicals that might be of concern for children and older adults, which, combined with additional efforts to identify potential sources of exposure, could assist policy makers in prioritizing their actions in order to reduce chemical exposure and potential risks of adverse health effects.

Journal Article
Journal Article

Multiple marine ecological disturbance assessments for latin american and caribbean large marine ecosystems

Author: Sherman, BH HERO ID: 3789266

[Less] Abstract ative assessment of pollution and ecosystem health among the Large Marine Ecosystems (LMEs) . . . [More] Abstract ative assessment of pollution and ecosystem health among the Large Marine Ecosystems (LMEs) of Latin America and the Caribbean requires tracking of shifting food- chain associations, loss of habitat, toxic and anoxic impacts to species, diseases, harmful algal blooms and vulnerability to climate extremes, invasive species, and overfishing. Meta-data search and extraction techniques help researchers consolidate disturbance observations into one of eight multiple marine disturbance (MMED) categories important for the creation of place specific disturbance regimes. By measuring the changing baseline condition of impact-sensitive indicator species involved in these MMED events, resource managers can better compare, mitigate, and track changes in marine ecosystem health.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A review of antimony (Sb) isotopes analytical methods and application in environmental systems

Authors: Wen, B; Zhou, J; Zhou, A; Liu, C; Li, L HERO ID: 3789385

[Less] Abstract ny (Sb) is a metalloid element with potential toxicity and carcinogenicity, and is ubiquitous . . . [More] Abstract ny (Sb) is a metalloid element with potential toxicity and carcinogenicity, and is ubiquitous in our living environment. Sb pollution has become a serious global problem, which has been induced by combustion of fossil fuel and Sb-containing waste as well as mining activities. However, Sb geochemical cycle in environment systems and its inherent hazards to human and ecosystem health are poorly known. Sb isotope technology provides a novel method to counter this challenge. Sb isotopic ratio could not be measured precisely until the introduction of the multiple-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) at the beginning of the 20th century. This paper systematically reviewed the analytical methods of Sb isotopes, including pre-concentration and separation methods of thiol cotton fiber (TCF) and ion-exchange chromatography, measurement techniques of MC-ICP-MS with hydride generation (HG) and metal doping. Additionally, the Sb isotope fractionation mechanism was summarized in biological, reduction, adsorption, evaporation, precipitation and mixing processes. The Sb isotope application research status is also reviewed, such as illustrating Sb sources and its characteristics of migration and transformation in hydrologic system. Finally, future prospects for Sb isotopes in environmental systems have been proposed, which will promote the advances in the study of Sb pollution and its prevention significantly.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Reducing Marine Mammal Bycatch in Global Fisheries: An economics approach

Authors: Lent, R; Squires, D HERO ID: 3789453

[Less] Abstract oader ecosystem impacts of fishing continue to present a challenge to scientists and resource . . . [More] Abstract oader ecosystem impacts of fishing continue to present a challenge to scientists and resource managers around the world. Bycatch is of greatest concern for marine mammals, for which fishery bycatch and entanglement is the number one cause of direct mortality. Climate change will only add to the challenge, as marine species and fishing practices adapt to a changing environment, creating a dynamic pattern of overlap between fishing and species (both target and bycatch). Economists suggest policy instruments for reducing bycatch that move away from top-down, command-and-control measures (e.g. effort reduction, time/area closures, gear restrictions, bycatch quotas) towards an approach that creates incentives to reduce bycatch (e.g. transferable bycatch allowances, taxes, and other measures). The advantages of this flexible, incentive-oriented approach are even greater in a changing and increasingly variable environment, as regulatory measures would have to be adapted constantly to keep up with climate change. Unlike the regulatory process, individual operators in the fishery sector can make adjustments to their harvesting practices as soon as the incentives for such changes are apparent and inputs or operations can be modified. This paper explores policy measures that create economic incentives not only to reduce marine mammal bycatch, but also to increase compliance and induce technological advances by fishery operators. Economists also suggest exploration of direct economic incentives as have been used in other conservation programs, such as payments for economic services, in an approach that addresses marine mammal bycatch as part of a larger conservation strategy. Expanding the portfolio of mandatory and potentially, voluntary, measures to include novel approaches will provide a broader array of opportunities for successful stewardship of the marine environment.