Health & Environmental Research Online (HERO)


PFDA (335-76-2)


784 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

STRUCTURE AND CONFORMATION ANALYSIS ON PERFLUORODECANOIC ACID AND ITS LITHIUM, SODIUM AND AMMONIUM-SALTS AS STUDIED BY RAMAN-SPECTROSCOPY

Authors: Dacosta, AMA; Santos, EBH (1983) Colloid and Polymer Science 261:58-63. HERO ID: 3858960


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids

Authors: Olson, CT; Andersen, ME (1983) Toxicology and Applied Pharmacology 70:362-372. HERO ID: 1290859

[Less] The acute toxicities of single ip injections of perfluorooctanoic (PFOA) and perfluorodecanoic (NDFDA) . . . [More] The acute toxicities of single ip injections of perfluorooctanoic (PFOA) and perfluorodecanoic (NDFDA) acids were evaluated in male Fischer rats. The LD50/30 day for PFOA was 189 (208-175) mg/kg and for NDFDA was 41 (47-34) mg/kg. All rats treated with lethal doses of PFOA died within the first 5 days; with NDFDA there was delayed lethality, with deaths in the second and third weeks after dosing. Four groups of rats were used for a more detailed study of toxicity and for analysis of fatty acids from liver, testes, and whole blood. One group received a single dose of 100 mg PFOA/kg; a second, a single dose of 2 ml of propylene glycol-water (1:1)/kg (vehicle control); a third, a single dose of 50 mg NDFDA/kg; the fourth was given 2 ml vehicle/kg and pair-fed with the NDFDA group. The first three groups were fed ad libitum. Rats from each group were killed at 2, 4, 8, and 16 days after dosing for fatty acid analysis. Rats dosed with NDFDA lost half their body weight in 16 days and ate virtually no food from Day 7 to Day 14 after dosing. Weight loss was less rapid in pair-fed controls. With PFOA there were transient decreases in food intake and body weight which were reversed by Day 7. Liver weights of PFOA rats were slightly greater than those from vehicle controls. With NDFDA, liver weights were much greater than those from pair-fed controls. In the livers of PFOA rats there were transient increases in oleic and palmitic acids and a decrease in stearic and docosahexaenoic acids. These changes were maximum by Day 2 and nearly resolved by Day 8. With NDFDA, similar changes were observed and arachidonic acid was also greatly decreased. These changes were quantitatively much larger and more persistent. NDFDA has unusually high toxic potency for a perfluorinated hydrocarbon, and some of the toxic effects caused by this acid are remarkably similar to those seen with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The acute toxicity of NDFDA may be due to an ability to interfere with fatty acid metabolism, and studies of its toxicity may be valuable in helping to understand mechanisms of action of TCDD.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Mutagenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin and perfluoro-n-decanoic acid in L5178Y mouse-lymphoma cells

Authors: Rogers, AM; Andersen, ME; Back, KC (1982) Mutation Research 105:445-449. HERO ID: 3858719

[Less] The toxicity and mutagenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD) and perfluoro-n-decanoic-acid . . . [More] The toxicity and mutagenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD) and perfluoro-n-decanoic-acid (335762) (PFDA) were examined using the mouse lymphoma cell line L5178Y. The cells were treated for 24 or 48 hours with 0.001 to 500 micrograms per milliliter (microg/ml) PFDA or TCDD respectively. Effects on cells in suspension and soft agar were considered. PFDA treatment had no effect on cell growth in suspension at concentrations below 50microg/ml and caused cell lysis at doses greater than 100microg/ml. TCDD had no effect on suspension growth at any concentration, but doses greater than 0.01microg/ml resulted in the formation of larger, less discrete cloning and reduced plating efficiency in soft agar experiments. PFDA at a dose of 0.5microg/ml also reduced plating efficiency. Five selective systems were used for testing mutation induction. These included ouabain, excess thymidine, methotrexate, cytosine-arabinoside, and thioguanine. TCDD significantly increased the frequency of mutations in the methotrexate, excess thymidine, and thioguanine systems but had no significant effect on the other two selective systems. PFDA treatment resulted in no significant mutation induction in any of the selective systems used. The authors concluded that TCDD but not PFDA was a direct acting mutagen in L5178Y cells.

Technical Report
Technical Report

THE TOXICITY AND MUTAGENICITY OF 2 3 7 8 TETRA CHLORO DI BENZO-P-DIOXIN AND SIMILAR ACTING COMPOUNDS

Authors: Rogers, AM; Andersen, ME; Back, KC (1982) (HEEP/84/03046). HERO ID: 2749382

Abstract: HEEP COPYRIGHT: BIOL ABS. ABSTRACT MOUSE L-5178Y LYMPHOMA CELL LINE PER FLUORO DECANOIC-ACID