Health & Environmental Research Online (HERO)


8:2 diPAP (678-41-1)


34 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Production of perfluorinated carboxylic acids (PFCAs) from the biotransformation of polyfluoroalkyl phosphate surfactants (PAPS): exploring routes of human contamination

Authors: D'Eon, JC; Mabury, SA (2007) Environmental Science and Technology 41:4799-4805. HERO ID: 3859267

[Less] Perfluorinated acids are detected in human blood world-wide, with increased levels observed in industrialized . . . [More] Perfluorinated acids are detected in human blood world-wide, with increased levels observed in industrialized areas. The origin of this contamination is not well understood. A possible route of exposure, which has received little attention experimentally, is indirect exposure to perfluorinated acids through ingestion of chemicals applied to food contact paper packaging. The current investigation quantified the load of perfluorinated acids to Sprague-Dawley rats upon exposure to polyfluoroalkyl phosphate surfactants (PAPS), nonpolymeric fluorinated surfactants approved for application to food contact paper products. The animals were administered a single dose at 200 mg/kg by oral gavage of 8:2 fluorotelomer alcohol (8:2 FTOH) mono-phosphate (8:2 monoPAPS), or the corresponding di-phosphate (8:2 diPAPS), with blood taken over 15 days post-dosing to monitor uptake, biotransformation, and elimination. Upon completion of the time-course study the animals were redosed using an identical dosing procedure, with sacrifice and necropsy 24 h after the second dosing. Increased levels of perfluorooctanoic acid (PFOA), along with both 8:2 PAPS congeners, were observed in the blood of the dosed animals. In the 8:2 monoPAPS-dosed animals, 8:2 monoPAPS and PFOA blood concentrations peaked at 7900 +/- 1200 ng/g and 34 +/- 4 ng/g respectively. In the 8:2 diPAPS-dosed animals, 8:2 diPAPS peaked in concentration at 32 +/- 6 ng/g, and 8:2 monoPAPS and PFOA peaked at 900 +/- 200 ng/g and 3.8 +/- 0.3 ng/g, respectively. Several established polyfluorinated metabolites previously identified in 8:2 FTOH metabolism studies were also observed in the dosed animals. Consistent with other fluorinated contaminants, the tissue distributions showed increased levels of both PFOA and the 8:2 PAPS congeners in the liver relative to the other tissues measured. Previous investigations have found that PAPS can migrate into food from paper packaging. Here we link ingestion of PAPS with in vivo production of perfluorinated acids.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Effects of IMAGENT on pulmonary hemodynamics and gas exchange in dogs

Authors: Kirkton, SD; Wagner, H; Landicho, MM; Struthers, JJ; Busan, N; Wagner, PD (2006) HERO ID: 3875535

[Less] Imagent is an IV injected contrast echocardiography agent designed to image the left ventricle after . . . [More] Imagent is an IV injected contrast echocardiography agent designed to image the left ventricle after traversing the pulmonary circulation. We examined the effect of Imagent on pulmonary function by injecting either Imagent (n = 8) or equivalent volume of saline (n = 7) IV in randomly ordered 1, 8 and 16 mg/kg doses in dogs with preexisting pulmonary hypertension. We found that Imagent had no effects on cardiac output, pulmonary gas exchange, lung wet:dry ratio or static compliance. However, the 16 mg/kg dose of Imagent increased both pulmonary artery pressure (PAP) transiently by an average of 5.7 mmHg (p < 0.05) 2 to 3 min after injection and pulmonary vascular resistance (PVR) by 5.9 mmHg per l/min (p < 0.05) 4 min after injection before returning to preinjection levels. The lower doses of Imagent did not affect PAP or PVR. These results imply that the approved clinical dose of Imagent (0.125 mg/kg) will not affect pulmonary hemodynamics, gas exchange or mechanical properties in dogs with preexisting pulmonary hypertension.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Beneficial effects of perfluorotributylamine/pluronic F-68 stem-emulsion (FC43se) on discordant lung xenografts

Authors: Okada, K; Wada, S; Kajihara, H; Sueda, T; Matsuura, Y (1997) HERO ID: 3878957

[Less] The aim of this study was to assess the effectiveness of Perfluorotributylamine/Pluronic F-68 Stem-Emulsion . . . [More] The aim of this study was to assess the effectiveness of Perfluorotributylamine/Pluronic F-68 Stem-Emulsion (FC43se) against hyperacute rejection in rabbit-pig xenodiscordant transplantation in an ex-vivo lung model. Rabbits were divided into two groups. In Group 1 (control), after extraction, the lungs were connected directly to the experimental circuit as soon as possible. The lungs were then perfused with 100 ml of pig blood only. In Group 2 (FC(+) Group), after extraction, the lungs were connected to the same circuit as soon as possible. The lungs were then perfused with 10 ml of FC43se plus 90 ml of pig blood. The duration of perfusion was defined from when the perfusion started until the PAP reached 50 mmHg. Significant differences in survival were seen between Group 1 and Group 2: in Group 1, the survival time was 51.9 +/- 16.8 min, whereas in Group 2 the survival time was 76.9 +/- 12.4 min (p < 0.01). The wet-to-dry weight ratio after 30 min of perfusion in Group 2 was significantly lower than that of Group 1 and the mean pulmonary artery pressure of Group 2 at 35, 40 and 45 min after perfusion was significantly lower than that of Group 1. Histological examination revealed that FC43se suppressed the adhesion of leukocytes to the surfaces of endothelial cells, and also attenuated the intimal edematous changes accompanying leukocyte infiltration. Therefore, FC43se has a beneficial effect on suppressing hyperacute rejection in xenogeneic discordant lung transplantation.

Journal Article
Journal Article

[Effect of perfluorochemicals on experimental cerebral ischemia]

Authors: Yamashita, K; Yamaguchi, S; Kobayashi, S (1989) HERO ID: 3878958

[Less] It has been noted that perfluorochemicals (PFC) which were developed as artificial blood substitutes, . . . [More] It has been noted that perfluorochemicals (PFC) which were developed as artificial blood substitutes, protect against ischemic brain injury by their ability to serve as oxygen carriers. It is also known that normovolemic hemodilution (HD) improves cerebral blood flow (CBF) and neurological symptoms in cerebral infarction. However, there are few reports concerning the effect of PFC on the collateral circulation via pial anastomoses in cases of middle cerebral artery (MCA) occlusion. The ability to record the pial arterial blood pressure (PAP) without interfering blood flow now makes it possible to measure the segmental resistance of cerebral vessels. By using this method, one can measure collateral vessel resistance through pial anastomoses following MCA occlusion. In this paper, we studied the protective effects of PFC combined with HD on ischemic brain injury with the focus on the collateral circulation via pial anastomoses following occlusion of the MCA. Twenty adult cats were studied: control, 8; HD, 5; Fluosol (Fluosol-DA), 7. The systemic arterial pressure (SAP) and PeCO2 were continuously monitored. Subsequently the MCA was occluded via the transorbital approach. CBF in the ectosylvian gyrus (central area of the ischemic lesion) was measured by the hydrogen clearance method. A small pial artery about 100 microns in diameter on the exposed ectosylvian gyrus was punctured nonocclusively with a micropipette filled with 2 M sodium chloride which was connected to a servo-null micropressure system (Model 900, W-P Instruments, Inc. U.S.A.). The electroencephalogram (EEG) was recorded from the ectosylvian gyrus.(ABSTRACT TRUNCATED AT 250 WORDS)