Health & Environmental Research Online (HERO)


PFDS (335-77-3)


68 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Uncoupling of the liver monooxygenase system by perfluorocarbons in vivo

Authors: Obraztsov, VV; Shekhtman, DG; Sklifas, AN (1994) HERO ID: 3859497

[Less] BIOSIS COPYRIGHT: BIOL ABS. Administration of a perfluorodecalin (PFD) emulsion, the liver cytochrome . . . [More] BIOSIS COPYRIGHT: BIOL ABS. Administration of a perfluorodecalin (PFD) emulsion, the liver cytochrome P-450 II B12 inducer, to experimental animals is followed by a two-fold increase of the NADPH oxidation rate in liver microsomes. This phenomenon is caused by the presence in the cytochrome P-450 active center of PFD which uncouples microsomal hydroxylation. The high rate of NADPH oxidation in liver microsomes after administration of the fluorocarbon does not decrease the level of reduced pyridine nucleotides in the liver and does not change the glucose concentration in the plasma. It is suggested that the accelerated weight loss in starved animals following PFD administration is due to the energy dissipation in the fluorocarbon uncoupled monooxygenase reactions in the liver.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The effect of the cytochrome P-450 system inducers on the development of Drosophila melanogaster

Authors: Fuchs, SY; Spiegelman, VS; Belitsky, GA (1993) Journal of Biochemical Toxicology 8:83-88. HERO ID: 2135769

[Less] BIOSIS COPYRIGHT: BIOL ABS. D. melanogaster development was markedly retarded and its survival decreased . . . [More] BIOSIS COPYRIGHT: BIOL ABS. D. melanogaster development was markedly retarded and its survival decreased by larvae treatment with compounds being strong inducers of the cytochrome P-450 2B in mammals-phenobarbital (PB*), perfluorodecalin (PFD), trans-stilbene oxide (TSO), and triphenyldioxane (TPD). At the same time, the weak inducer hexobarbital or the selective cytochrome P-450 inducer in mice but not in rats 1,4-bis(2-(dichloropyridyl-oxy))-benzene (DPB) did not affect the larvae development. The cytochrome P-450 1A1 inducers benzo(a)anthracene (BA) and beta-naphthoflavone (BNF) were also not effective. The toxicity of phenobarbital was shown to be decreased by the cytochrome P450 inhibitor piperonyl butoxide by adding 20-hydroxyecdysone or by treatment with aminophylline-the indirect enhancer of ecdysone production in the larval prothoracic gland. The hypothesis of the moulting hormone degradation as the cause of elevated larvae mortality resulting from the induced high mixed function oxidase a

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Prevention of neutrophil-mediated injury to endothelial cells by perfluorochemical

Authors: Babbit, DG; Forman, MB; Jones, R; Bajaj, AK; Hoover, RL (1990) The American Journal of Pathology 136:451-460. HERO ID: 3859496

[Less] BIOSIS COPYRIGHT: BIOL ABS. Myocardial salvage after reperfusion may be limited by neutrophil-mediated . . . [More] BIOSIS COPYRIGHT: BIOL ABS. Myocardial salvage after reperfusion may be limited by neutrophil-mediated microvascular damage. The effect of the perfluorochemical, Fluosol-DA, and its various components on neutrophil adherence, cytotoxicity, and proteolytic enzyme release was examined on sheep large and small vessel endothelial cells in vitro. Cells were studied under normoxic (N) and anoxic conditions (A). Various concentrations of Fluosol (10%, 25%, and 50%) significantly reduced neutrophil adherence under both experimental conditions (mean 22 | 3.25% versus 7 | 0.8% (N) and 20 | 3.2% versus 7.5 | 0.9% (A); P and lt; 0.01). The perfluorocarbons, perfluorodecalin (PFD), and perfluoro-tripropylamine (PFTP) in a 50 volume/percent concentration exhibited profound effects on adherence, particularly on cells subjected to anoxia (51% and 69% reduction in adherence, respectively; P and lt; 0.01). No effect on adherence was observed with other components including the detergent, pluroinc F68. A 25% reduction (P and

Technical Report
Technical Report

Acute dermal toxicity in rabbits (OECD guidelines)

Author: Hazleton Laboratories (1988) (514-528). (8(e)/FYI ID Number: FYI-0500-01378 I. Document Control Number: 85000000010). St. Paul, MN: 3M Company. [TSCA Submission] HERO ID: 3927639

[Less] Study Title: FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment . . . [More] Study Title:
FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment is volume 1of 3. The whole file is also in the MF collection.

Study Information:
Acute/Subacute Toxicity
EF

Technical Report
Technical Report

Acute oral toxicity study in rats (OECD guidelines)

Author: Hazelton Lab (1988) (529-546). (8(e)/FYI ID Number: FYI-0500-01378 I. Document Control Number: 85000000010). St. Paul, MN: 3M Company. [TSCA Submission] HERO ID: 3927664

[Less] Study Title: FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment . . . [More] Study Title:
FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment is volume 1of 3. The whole file is also in the MF collection.

Study Information:
Acute/Subacute Toxicity
EF

Technical Report
Technical Report

Primary eye irritation/corrosion study in rabbits (OECD guidelines)

Author: Hazleton Laboratories (1987) (547-563). (8(e)/FYI ID Number: FYI-0500-01378 I. Document Control Number: 85000000010). St. Paul, MN: 3M Company. [TSCA Submission] HERO ID: 3927666

[Less] Study Title: FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment . . . [More] Study Title:
FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment is volume 1of 3. The whole file is also in the MF collection.

Study Information:
Acute/Subacute Toxicity
EF

Technical Report
Technical Report

Primary dermal irritation/corrosion study in rabbits (OECD guidelines)

Author: Hazleton Laboratories (1987) (564-572). (8(e)/FYI ID Number: FYI-0500-01378 I. Document Control Number: 85000000010). St. Paul, MN: 3M Company. [TSCA Submission] HERO ID: 3927681

[Less] Study Title: FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment . . . [More] Study Title:
FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment is volume 1of 3. The whole file is also in the MF collection.

Study Information:
Acute/Subacute Toxicity
EF

Technical Report
Technical Report

Odor detection thresholds in the rat for the vapors of 3 related perfluorocarbons and ethylene glycol dinitrate

Authors: Marshall, DA; Doty, RL; Lucero, DP; Slotnick, BM (1981) (421-434). (HEEP/83/02485). HERO ID: 3859499

[Less] HEEP COPYRIGHT: BIOL ABS. As a 1st step in ascertaining the feasibility of using laboratory rats for . . . [More] HEEP COPYRIGHT: BIOL ABS. As a 1st step in ascertaining the feasibility of using laboratory rats for explosive detection, their sensitivity to vapor-phase concentrations of the explosive ethylene glycol dinitrate (EGDN) and 3 homologous perfluorocarbons, perfluoromethylcyclohexane (PMCH) perfluorodimethylcyclohexane (PDCH) and perfluorodecalin (PFD) was evaluated. These perfluorocarbons are under evaluation by the USA Government as potential explosive taggants, substances added to explosives which identify their source of manufacture or distribution. The mean detection thresholds of these compounds, as determined in an operant discriminaton task using water reinforcement, were as follows: EGDN, 0.05 ppm (range 0.05-0.06); PDCH, 1.4 ppm (0.60-6.50); PMCH, 2.1 ppm (1.85-4.65); and PFD, 1.1 ppm (0.60-1.69). The 1st quantitative data on the olfactory sensitivity of rats to the vapors of explosive/taggant compounds was provided. The detection curves for such odorants may be fundamentally similar to those of other stimuli that were also evaluated.