Health & Environmental Research Online (HERO)


FtS 6:2 (27619-97-2)


59 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Determination of adsorbable organic fluorine from aqueous environmental samples by adsorption to polystyrene-divinylbenzene based activated carbon and combustion ion chromatography

Authors: Wagner, A; Raue, B; Brauch, HJ; Worch, E; Lange, FT (2013) Journal of Chromatography A 1295:82-89. HERO ID: 2324806

[Less] A new method for the determination of trace levels of adsorbable organic fluorine (AOF) in water is . . . [More] A new method for the determination of trace levels of adsorbable organic fluorine (AOF) in water is presented. Even if the individual contributing target compounds are widely unknown, this surrogate parameter is suited to identify typical organofluorine contaminations, such as with polyfluorinated chemicals (PFCs), and represents a lower boundary of the organofluorine concentration in water bodies. It consists of the adsorption of organofluorine chemicals on a commercially available synthetic polystyrene-divinylbenzene based activated carbon (AC) followed by analysis of the loaded AC by hydropyrolysis combustion ion chromatography (CIC). Inorganic fluorine is displaced by excess nitrate during the extraction step and by washing the loaded activated carbon with an acidic sodium nitrate solution. Due to its high purity the synthetic AC had a very low and reproducible fluorine blank (0.3 μg/g) compared to natural ACs (up to approximately 9 μg/g). Using this AC, fluoride and the internal standard phosphate could be detected free of chromatographic interferences. With a sample volume of 100 mL and 2× 100 mg of AC packed into two extraction columns combined in series, a limit of quantification (LOQ), derived according to the German standard method DIN 32645, of 0.3 μg/L was achieved. The recoveries of six model PFCs were determined from tap water and a municipal wastewater treatment plant (WWTP) effluent. Except for the extremely polar perfluoroacetic acid (recovery of approximately 10%) the model substances showed fairly good (50% for perfluorobutanoic acid (PFBA)) to very good fluorine recoveries (100±20% for perfluorooctanoic acid (PFOA), perfluorobutanesulfonate (PFBS), 6:2 fluorotelomersulfonate (6:2 FTS)), both from tap water and wastewater matrix. This new analytical protocol was exemplarily applied to several surface water and groundwater samples. The obtained AOF values were compared to the fluorine content of 19 target PFCs analyzed by high performance liquid chromatography-electrospray tandem mass spectrometry (HPLC-(-)ESI-MS/MS). In groundwater contaminated by PFC-containing aqueous film-forming foams (AFFFs) up to 50% of the AOF could be attributed to PFC target chemicals, while in diffuse contaminated samples only <5% of the AOF could be identified by PFC analysis.

Book/Book Chapter
Book/ Chapter

PERFLUORINATED ALKYL SUBSTANCES, CHLOROPARAFFINS AND BFRs IN SOIL, SEDIMENTS AND TERRESTRIAL/MARINE BIOTA IN NORWAY AND THE ARCTIC

Authors: Harju, M; Herzke, D; Katsoyiannis, A; Borgen, A; Sagerup, K; Gabrielsen, GW (2013) HERO ID: 3860083

[Less] A screening study was made on the occurrence of chloroparaffins and BFRs in soil, sediments and the . . . [More] A screening study was made on the occurrence of chloroparaffins and BFRs in soil, sediments and the terrestrial/marine biota in Northern Norway and The Arctic. The terrestrial environment was sampled for soil, sediments and biota such as moose, mouse, brown trout and perch at the freshwater lake in Dalsvatn, Telemark, Norway. The marine environment of Lofoten and Troms and Finnmark in Northern Norway was sampled for sediments and biota such as Common eider and Herring gull eggs, Cod liver, mussels and seal liver. Seven species from Svalbard was collected in 2007 to 2009; Blood from Polar bear, Ringed Seal and Glaucous gull, eggs from Common Eider and Black-legged Kittiwake and liver from Cod and whole Polar cod was sampled. Pentabromophenol was generally below the detection limits in terrestrial and marine samples in Norway and Arctic samples, while 2,4,6-tribromophenol was found in almost all samples. The relatively new BFRs, Decabromodiphenyl-ethane was detected in the majority of mainland marine samples in Norway and the Arctic while Bis(2-ethylhexyl)tetrabromophthalate generally was below or close to the detection limits. The short chained (C10-13) and medium chained (C14-17) chlorinated paraffins on the other hand were only analyzed for in Arctic biota and were detected in the majority of samples. In order to distinguish between pollution levels caused by long-range transport and point sources, to establish a base line for time- and spatial trends and have a general knowledge about background levels in the Norwegian environment, samples representing all important ecosystems collected at remote locations were analyzed.

The reported levels are very valuable data on background levels for a variety of compounds. With this knowledge future changes can be assessed as well as the impact of point sources and new exposure routes. We managed to determine background levels for a number of pollutants of concern in the abiotic and biotic parts of the terrestrial and marine ecosystem representing the Norwegian mainland and the Arctic. Since most of the target compounds are potential substitutes for already regulated chemicals, the collected data can give information on whether they already pose a threat to the environment as well and to assess eventual future risks.

From the 17 analysed PFAS only 10 were detected. Lowest PFAS levels were found in abiota samples and highest PFAS levels were found in seal liver, plasma and eggs of marine birds and polar bear plasma. No considerable differences were found for sumPFAS levels collected at the Norwegian mainland and Svalbard with the exception of PFOS which contributes more to mainland samples. Perfluorinated carboxylacids are mostly contributing to terrestrial samples whilst perfluorinated sulfonates are more important in marine biota. Found PFAS levels are in good agreement with background data described in literature. However, since different time trends are observed for different PFAS, comparison of data is challenging. In general do PFCAs have a much more diverse use and emission pattern, making it more difficult to assess their sources and fate. The finding of dominating PFCAs in some cases is very interesting since it has been barely observed before and might be a sign of parallel decreasing PFOS- and increasing PFCA trends also in Norwegian background locations. The PFOS substitutes 6:2 FTS and PFDcS were only detected very occasionally and at levels very close to the quantification limit, mostly field mouse liver and soil. The rare findings indicate either only limited use of these chemicals or that they are not stable enough to reach remote locations. In contrast are FTOHs and FT(U)CAs widely used chemicals which seem to be either to volatile to be taken up by organisms or too chemical reactive to reach remote areas.

Of the 5 analysed BFR PBDE 47 and DBDPE were the most detected BFRs within this study, with DBDPE dominating over the PBDE 47 in a number of cases. This is indicating the continuation of the decreasing trend of PBDE 47 in Norwegian environment due to the ban of this chemical. TBP was detected in a broad range of samples as well opposite to PBP which was only detected very sparsely. Since TBP can be formed naturally in the marine environment as well conclusion of eventual sources are difficult. Both SCCPs and MCCPs were detected in the majority of the Arctic samples with the exception of only 10% detection of MCCPS in cod liver. SCCP > MCCP for polar bear and seal plasma, kittiwake eggs, cod liver and polar cod. The opposite is the case for glaucous gull plasma and eider duck eggs.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Bioconcentration of aqueous film-forming foam (AFFF) in juvenile rainbow trout (Oncorhyncus mykiss)

Authors: Yeung, LW; Mabury, SA (2013) Environmental Science and Technology 47:12505-12513. HERO ID: 2851296

[Less] This work investigated the bioconcentration of PFASs in juvenile rainbow trout by exposing the fish . . . [More] This work investigated the bioconcentration of PFASs in juvenile rainbow trout by exposing the fish in separate tanks under flow-through conditions to water continuously spiked with either of the AFFFs FC-203CF light water AFFF 3% (3M) or Niagara 1-3 (Angus Fire); a nonspiked tank served as the control. Three fish in each tank were collected after 1, 3, 6, and 11 days of exposure, and 3, 7, 14, and 25 days of depuration. Liver and carcass homogenate samples were analyzed for 20 PFASs using LC-MS/MS. PFDS, PFOS, PFHxS, and EtFOSAA were detected in fish exposed to the 3M foam, while 6:2 and 8:2 FTSASs, 6:2 and 8:2 FTSAs, 5:3 and 7:3 FTCAs were measured in fish exposed to Angus Fire foam. Bioconcentration factors and rate constants for uptake and depuration were calculated. Total and extractable organofluorine were measured in the fish samples. After fish were exposed to AFFFs, not only known PFASs but also other unknown organofluorines were bioconcentrated. Compared to the control group, significantly greater amounts (at least 10-fold) and proportion of unidentified PFASs were found in both liver and carcass homogenate ranging from ∼50% in 3M foam up to 95% in the Angus Fire foam at the end of exposure.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Detections of Commercial Fluorosurfactants in Hong Kong Marine Environment and Human Blood: A Pilot Study

Authors: Loi, EIH; Yeung, LWY; Mabury, SA; Lam, PKS (2013) Environmental Science and Technology 47:4677-4685. HERO ID: 3353947

[Less] Previously, much of the perfluoroalkyl and polyfluoroalkyl substance (PFAS) research has focused on . . . [More] Previously, much of the perfluoroalkyl and polyfluoroalkyl substance (PFAS) research has focused on perfluoroallcyl carboxylates (PFCAs) or perfluoroalkane sulfonates (PFSAs). Recent studies indicate that known PFCAs and PFSAs accounted for 5-95% of the organofluorine (OF) in human and wild rat blood samples suggesting that a relatively large proportion of OF remained unknown. Until recently, some studies reported commercially available compounds such as polyfluoroalkyl phosphate diesters (diPAPs) and fluorotelomer sulfonates (FTSAs) in human blood and sludge samples. The present investigation is a pilot study aiming at surveying some newly identified PFASs such as diPAPs, FTSAs, and perfluorinated phosphinates (PFPiAs) in different environmental samples including surface water, sediment, sewage treatment plant influent and effluent, sludge, benthic worm, and human blood from Hong Kong. DiPAPs (6:2, 6:2/8:2, and 8:2) were detected in some of the samples at part-per-billion (ppb) levels in sludge, sub ppb levels in influent and effluent, sediment, worm, and human blood samples, and sub part-per-trillion (ppt) levels in surface waters. Sub ppt to ppb levels of 6:2 and 8:2 FTSAs were observed in worm, surface water, and human blood samples. PFPiAs were only observed in worm samples. The detected "new PFASs" accounted for a minor proportion (less than 5%) of the total PFASs in benthic worm and human blood, but up to 95% in sewage sludge samples from Hong Kong. This is the first report of commercial fluorosurfactants (PFPiAs, diPAPs, and FTSAs) in the samples from the environment and human blood in Hong Kong; further information on the distribution, fate, and transport of "new PFASs" in other Asian cities, as well as toxicity, is needed for further assessing the human exposure and risk.

Technical Report
Technical Report

Extract of opinion of 22 April 2013 of the French Agency for Food, Environmental and Occupational Health & Safety on the application for authorisation to use 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonic acid (CAS No. 27619-97-2) and its potassium salt (CAS No. 59587-38-1) in the manufacture of organic materials intended to come into contact with drinking water

Author: French Agency for Food, Environmental and Occupational Health & Safety (2012) (Request No. 2012-SA-0235). Paris, France: French Agency for Food, Environmental and Occupational Health & Safety. HERO ID: 3980914


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer

Authors: Laheru, D; Shah, P; Rajeshkumar, NV; Mcallister, F; Taylor, G; Goldsweig, H; Le, DT; Donehower, R; Jimeno, A; Linden, S; Zhao, M; Song, D; Rudek, MA; Hidalgo, M (2012) HERO ID: 3860072

[Less] PURPOSE: S-trans,trans-Farnesylthiosalicylic Acid (FTS, salirasib) inhibits Ras-dependent . . . [More] PURPOSE: S-trans,trans-Farnesylthiosalicylic Acid (FTS, salirasib) inhibits Ras-dependent cell growth by dislodging all isoforms of Ras, including mutant Ras, from the plasma membrane. This study evaluated the activity, safety, and toxicity of salirasib in preclinical models and patients with metastatic pancreatic adenocarcinoma (PDA).

PATIENTS AND METHODS: In the preclinical study, salirasib was tested, alone and in combination with gemcitabine, in patient derived xenografts (PDX) of PDA. In the clinical study, treatment-naïve patients with advanced, metastatic PDA were treated with a standard dose schedule of gemcitabine and salirasib 200-800 mg orally (PO) twice daily (bid) for 21 days every 28 days. Tissue from preclinical models and patients' biopsies were collected pre-treatment and on Cycle (C) 1, Day (D) 9 to characterize the effect of gemcitabine and salirasib on activated Ras protein levels. Plasma samples for pharmacokinetics were collected for salirasib administered alone and in combination.

RESULTS: Salirasib inhibited the growth of 2/14 PDX models of PDA and modulated Ras signaling in these tumors. Nineteen patients were enrolled. No DLTs occurred. Common adverse events included hematologic and gastrointestinal toxicities and fatigue. The median overall survival was 6.2 months and the 1 year survival 37 %. In 2 patients in whom paired tissue biopsies were available, Ras and KRas protein levels were decreased on C1D9. Salirasib exposure was not altered by gemcitabine and did not correlate with PD outcomes.

CONCLUSION: The combination of gemcitabine and salirasib appears well-tolerated, with no alteration of salirasib exposure, and exerted clinical and PD activity in PDA.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Aerobic soil biodegradation of 8:2 fluorotelomer stearate monoester

Authors: Dasu, K; Liu, J; Lee, LS (2012) Environmental Science and Technology 46:3831-3836. HERO ID: 1311549

[Less] A laboratory investigation on the biotransformation of 8:2 fluorotelomer stearate monoester (8:2 FTS) . . . [More] A laboratory investigation on the biotransformation of 8:2 fluorotelomer stearate monoester (8:2 FTS) in aerobic soils was conducted by monitoring the loss of 8:2 FTS, production of 8:2 fluorotelomer alcohol (8:2 FTOH) and stearic acid, which would be released by cleavage of the ester linkage, and subsequent degradation products from FTOH for 80 d. Soil microcosms were extracted with ethyl acetate followed by two heated 90/10 v/v acetonitrile/200 mM NaOH extractions. 8:2 FTS was degraded with an observed half-life (t(1/2)) of 10.3 d. The rate of 8:2 FTS biotransformation substantially decreased after 20 d with 22% of 8:2 FTS still remaining on day 80. No biotransformation of 8:2 FTS occurred in autoclaved soil controls, which remained sterile with 102 ± 6% recovery, through day 20. 8:2 FTOH was generated with cleavage of the ester linkage of 8:2 FTS followed by a rapid decline (t(1/2) ~ 2 d) due to subsequent biodegradation. All the expected 8:2 FTOH degradation products were detected including 8:2 fluorotelomer unsaturated and saturated carboxylic acids, 7:2s FTOH, 7:3 acid, and three perfluoroalkyl carboxylic acids with the most prominent being perfluorooctanoic acid (PFOA). PFOA consistently increased over time reaching 1.7 ± 0.07 mol % by day 80. Although cleavage of the ester linkage was evidenced by 8:2 FTOH production, an associated trend in stearic acid concentrations was not clear because of complex fatty acid metabolism dynamics in soil. Further analysis of mass spectrometry fragmentation patterns and chromatography supported the conclusion that hydrolysis of the ester linkage is predominantly the first step in the degradation of 8:2 FTS with the ultimate formation of terminal products such as PFOA.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Occurrence, fate, and fluxes of perfluorochemicals (PFCs) in an urban catchment: Marina Reservoir, Singapore

Authors: Nguyen, VT; Gin, KY; Reinhard, M; Liu, C (2012) Water, Science and Technology 66:2439-2446. HERO ID: 3859614

[Less] A study was carried out to characterize the occurrence, sources and sinks of perfluorochemicals (PFCs) . . . [More] A study was carried out to characterize the occurrence, sources and sinks of perfluorochemicals (PFCs) in the Marina Catchment and Reservoir, Singapore. Salinity depth profiles indicated the reservoir was stratified with lower layers consisting of sea water (salinity ranging from 32 to 35 g L(-1)) and a brackish surface layer containing approximately 14-65% seawater. The PFC mixture detected in catchment waters contained perfluoroalkyl carboxylates (PFCAs), particularly perfluorooctanoate (PFOA), perfluorohexanoate (PFHpA), perfluorooctane sulfonate (PFOS) and PFC transformation products. PFC concentrations in storm runoff were generally higher than those in dry weather flow of canals and rivers. PFC concentration profiles measured during storm events indicated 'first flush' behavior, probably because storm water is leaching PFC compounds from non-point sources present in the catchment area. Storm runoff carries high concentrations of suspended solids (SS), which suggests that PFC transport is via SS. In Marina Bay, PFCs are deposited in the sediments along with the SS. In sediments, the total PFC concentration was 4,700 ng kg(-1), approximately 200 times higher than in the bottom water layers. Total perfluoroalkyl sulfonates (PFSAs), particularly PFOS and 6:2 fluoro telomer sulfonate (6:2 FtS) were dominant PFCs in the sediments. PFC sorption by sediments varied with perfluorocarbon chain length, type of functional group and sediment characteristics. A first approximation analysis based on SS transport suggested that the annual PFC input into the reservoir was approximately 35 ± 12 kg y(-1). Contributions of SS, dry weather flow of river/canals, and rainfall were approximately 70, 25 and 5%, respectively. This information will be useful for improving strategies to protect the reservoir from PFC contamination.

Technical Report
Technical Report

Declassification Activity - TSCA §8(e) Submission; Originally assigned 8EHQ Number: 8EHQ-07-16986 (letter dated 10.30.07); Originally Assigned Bar Code: 88080000029; CAS number: 27619-97-2; Supplemental submission - revised public copy of submission: 1 -Octanesulfonic acid, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-; CAS # 27619-97-2; Generic Name: Polyfluorosulfonic Acid [Letter: re: two genotoxicity tests: In vitro mammalian chromosome aberration test using Chinese Hamster Ovary cells & In vivo unscheduled DNA synthesis in primary cultures of rat hepatocytes]

Author: Company Sanitized, (2011) (8EHQ-07-16986. DCN: 89110000183). Submitted under TSCA section 8E. [TSCA Submission] HERO ID: 3980907


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Determination of per- and polyfluorinated substances in airborne particulate matter by microwave-assisted extraction and liquid chromatography-tandem mass spectrometry

Authors: Beser, MI; Pardo, O; Beltrán, J; Yusà, V (2011) Journal of Chromatography A 1218:4847-4855. HERO ID: 1256375

[Less] A sensitive and confirmatory analytical method has been developed for the determination of 12 ionic . . . [More] A sensitive and confirmatory analytical method has been developed for the determination of 12 ionic per- and polyfluorinated alkyl substances (PFAS) in fine airborne particulate matter (PM2.5) at trace levels. The proposed method includes extraction of PM2.5-bound PFAS by microwave-assisted extraction (MAE) followed by centrifugation and injection into the liquid chromatograph coupled to a triple quadrupole tandem mass spectrometry system (LC-MS/MS). The main parameters affecting the performance of MAE were optimised using statistical design of experiments (DoE). Recoveries ranged from 83 to 120% and the method quantification limit (MQL) was 1.4 pg m(-3), when air volumes of 720 m(3) were sampled. This method was successfully applied to 41 samples collected from five stations of the monitoring network of the Valencian Regional Government (Spain) during April-July 2010. Eight out of 12 PFCs investigated were quantified in at least one sample (PFBA, PFPeA, PFHxS, 6:2 FTS, PFOA, PFNA, PFOS and PFDA). The measured concentrations ranged from 1.4 to 34.3 pg m(-3).