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Chloroform 2018 Update

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2,847 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Embryotoxicity and fetal malformations of rats and mice due to maternally administered volatile anesthetics

Authors: Schwetz, BA; Becker, BA (1974) Anesthesiology. HERO ID: 4214575


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Embryo- and fetotoxicity of inhaled chloroform in rats

Authors: Schwetz, BA; Leong, BKJ; Gehring, PJ (1974) Toxicology and Applied Pharmacology 28:442-451. HERO ID: 65020

[Less] This study evaluated the effects of inhalation of subanesthetic concentrations of chloroform on rat . . . [More] This study evaluated the effects of inhalation of subanesthetic concentrations of chloroform on rat embryonal and fetal development. Pregnant Sprague-Dawley rats were exposed to 30, 100 or 300 ppm chloroform for 7hr/day on days 6 through 15 of gestation. Exposure to chloroform caused an apparent decrease in the conception rate and a high incidence of fetal resorption (300 ppm), retarded fetal development (30, 100, 300 ppm), decreased fetal body measurements (30, 300 ppm) and a low incidence of acaudate fetuses with imperforate anus (100 ppm). Chloroform was not highly teratogenic but was highly embryotoxic. The results of this study disclosed no relationship between maternal toxicity and embryo or fetotoxicity as the result of exposure to chloroform by inhalation.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Teratology studies on orally administered chloroform in the rat and rabbit

Authors: Thompson, DJ; Warner, SD; Robinson, VB (1974) Toxicology and Applied Pharmacology 29:348-357. HERO ID: 65024

[Less] The effect of orally administered chloroform on embryonal and fetal development was evaluated in the . . . [More] The effect of orally administered chloroform on embryonal and fetal development was evaluated in the rat and rabbit. Doses of 0, 20, 50, or 126 mg/kg/day in the rat, and 0, 20, 35, or 50 mg/kg/day in the rabbit were given on days 6–15 and 6–18 of gestation, respectively. Fetuses were removed by cesarean section 1 or 2 days prior to expected parturition and were examined for external, skeletal, and/or soft tissue abnormalities. The occurrence of anorexia and weight gain suppression in dams of both species, as well as subclinical nephrosis in the rat and hepatotoxicity in the rabbit, indicated that maximum tolerated doses of chloroform were used. Fetotoxicity in the form of reduced birth weights was observed at the highest dose level in both species. There was no evidence of teratogenicity in either species at any dose tested.

Journal Article
Journal Article

[Toxic damage of the liver by chloroform in chemical industry workers]

Authors: Bomski, H; Sobolewska, A; Strakowski, A (1967) Internationales Archiv für Gewerbepathologie und Gewerbehygiene 24:127-134. HERO ID: 65008

[Less] Bei 68 Betriebswerkern, beschäftigt in Umgang mit Chloroform, wurde in 25% der Fälle eine Lebervergrößerung . . . [More] Bei 68 Betriebswerkern, beschäftigt in Umgang mit Chloroform, wurde in 25% der Fälle eine Lebervergrößerung festgestellt. Der Gehalt an Chloroform in der Raumluft schwankte zwischen 0,01 and 1,0 mg/l Die Dauer der Arbeitstätigkeit der Untersuchungspersonen betrug 1–4 Jahre. — Bei 5,6% der Fälle wurde eine toxische Hepatitis festgestellt. Bei 20,6% der Fälle, wurde Verdacht auf eine toxische Fettleber erhoben. Bei den einer Einwirkung von Chloroform ausgesetzten Arbeitern wurde ein mehrzehnfach häufigeres Auftreten der Gelbsucht diagnostiziert. Es wird der Verdacht ausgesprochen, daß die als Folge einer Chloroformeinwirkung auftretenden toxischen Leberveränderungen bei diesen Fällen eine Virusinfektion begünstigten.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Report of 1500 chloroform anesthetics administered with a precision vaporizer

Authors: Whitaker, AM; Jones, CS (1965) Anesthesia and Analgesia 44:60-65. HERO ID: 4135258


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Chronic chloroform intoxication

Authors: Challen, PJR; Hickish, DE; Bedford, J (1958) Occupational and Environmental Medicine 15:243-249. HERO ID: 65010

[Less] Chloroform was discovered in 1831 by a French chemist, Soubeiran, and independently by the American, . . . [More] Chloroform was discovered in 1831 by a French chemist, Soubeiran, and independently by the American, Samuel Guthrie of Sachett's Harbour, in the State of New York (Duncum, 1947). Soubeiran obtained impure chloroform, which he provisionally called " bichloric ether ", by distilling a mixture of chloride of lime and alcohol. Liebig, in the following year, obtained a purer chloroform, which he named "liquid chloride of carbon", by a similar process. It was not until 1834 that Dumas succeeded in obtaining and correctly analysing pure chloroform and it was he who first gave it that name.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Induction of hepatomas in mice by repeated oral administration of chloroform, with observations on sex differences

Authors: Eschenbrenner, AB; Miller, E (1945) Journal of the National Cancer Institute 5:251-255. HERO ID: 59302

[Less] Repeated feeding of carbon tetrachloride in olive-oil solution in amounts sufficient. to produce liver . . . [More] Repeated feeding of carbon tetrachloride in olive-oil solution in amounts sufficient. to produce liver necrosis will induce hepatomas in mice (1-4). Chloroform produces central necrosis of the liver lobule, followed by regeneration of parenchymal cells in a manner similar to that produced with carbon tetrachloride and when given repeatedly will also induce hepatomas. In this report, experimental conditions leading to the induction of hepatomas with chloroform are given in detail while only a brief description of the tumors is given ince they appear to be indistinguishable from those induced with carbon tetrachloride. In a previous report ( 4), it was suggested that the cycles of repeated necrosis and repair in the liver might be an important factor in the induction of tumors with carbon tetrachloride. All reports (1-4), however, dealt only with the use of necrotizing doses. The use of a graded series of necrotizing and nonnecrotizing doses of chloroform has revealed an apparent necessity for the production of repeated liver necrosis in the induction of these tumors.