Inhalation Toxicity of Ammonium Perfluorooctanoate
Authors: Kennedy GL Jr; Hall, GT; Brittelli, MR; Barnes, , JR; Chen, HC
Food and Chemical Toxicology 24:1325-1329.
HERO ID: 3797575
The inhalational toxicity of ammonium-perfluorooctanoate (3825261) was studied in male rats using both . . .
The inhalational toxicity of ammonium-perfluorooctanoate (3825261) was studied in male rats using both acute (single dose) and repeated (ten dose) treatment schedules. Single 4 hour exposures ranged from 380 to 5700mg/m3. In subchronic studies, 0, 1, 8, or 84mg/m3 were used for 6 hour exposure/day for 5 days, 2 rest days, and 5 more exposure days. After single exposures, 11 deaths occurred within 48 hours of exposure. At higher doses, corneal opacity and corrosion was confirmed by fluorescein staining. Livers appeared enlarged, although they returned to normal size by the end of the 42 day recovery period. Microscopy revealed acute pulmonary edema. In subchronic experiments, body weights of rats exposed to 84mg/m3 were lower during the exposure period but had recovered by day 16 after exposure. Corneal changes were not observed. Focal or multifocal hepatocellular necrosis was found in two rats exposed to the high dose, in three in the intermediate group and in one control rat. Immediately after exposure, serum alkaline-phosphatase was significantly elevated at the higher doses. At the higher doses, liver weights, both absolute and relative, were also elevated. In all test groups, blood fluoride was elevated throughout the experiments and measurable amounts were found in controls. The authors conclude that the chemical is moderately toxic, with a median lethal concentration of 980mg/m3. Hepatic changes were reversible.