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30 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The embryo-fetal toxicity and teratogenic potential of ammonium perfluorooctanoate (APFO) in the rat

Authors: Staples, RE; Burgess, BA; Kerns, WD (1984) Fundamental and Applied Toxicology 4:429-440. HERO ID: 1332669

[Less] Ammonium perfluorooctanoate (APFO, greater than 95% pure) was administered to Sprague-Dawley rats from . . . [More] Ammonium perfluorooctanoate (APFO, greater than 95% pure) was administered to Sprague-Dawley rats from Days 6 through 15 of gestation by inhalation as a dust (whole body exposure) for 6 hr/day at 0, 0.1, 1, 10, and 25 mg/m3, or by gavage at 100 mg/kg body wt/day in corn oil. Maternal deaths occurred in the groups given the highest level of APFO by each route and overt toxicity was evident among the surviving dams of these groups and among those of the 10-mg/m3 group. The fetuses were examined for external, visceral, and skeletal alterations and for APFO-related macroscopic and microscopic alterations of the eyes. In the postpartum period, pups from additional control and experimental dams were examined externally and ophthalmoscopically, and the usual fertility and viability indices were calculated. A teratogenic response was not demonstrated. Toxic effects on the conceptus were noted only in the groups given the highest level of APFO by each route. Hence, APFO was not demonstrated to represent a unique hazard to the conceptus of the rat.

Technical Report
Technical Report

Primary skin irritation test with T-3371 in albino rabbits.

Author: Riker Labs (1983) HERO ID: 4467669


Technical Report
Technical Report

FOSA; perfluorooctanesulfonamide: Primary skin irritation test with T-3421 in Albino rabbits. Project No. 0883AR0288, 3M Reference No. T-3421 (KTZ-15)

Author: Riker Labs (1983) (137-145). (8(e)/FYI ID Number: FYI-0500-01378 I. Document Control Number: 85000000010). St. Paul, MN: 3M Company. [TSCA Submission] HERO ID: 3981200

[Less] Study Title: FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment . . . [More] Study Title:
FYI-01378 I - Consists of three extremely large PDFs in the RAD collection. The attachment is volume 1of 3. The whole file is also in the MF collection.

Study Information:
Skin irritation

Technical Report
Technical Report

Repeat application 28 day percutaneous absorption study with T-2618CoC in albino rabbits

Authors: O’Malley, KD; Ebbins, KL (1981) (USEPA Administrative Record 226-0446). St. Paul, MN: Riker Laboratories, Inc.. HERO ID: 4471529


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Animal toxicity studies with ammonium perfluorooctanoate

Authors: Griffith, FD; Long, JE (1980) American Industrial Hygiene Association Journal 41:576-583. HERO ID: 1424955

[Less] These studies were conducted to evaluate the potential toxicity of ammonium perfluorooctanoate, a commercial . . . [More] These studies were conducted to evaluate the potential toxicity of ammonium perfluorooctanoate, a commercial surfactant. They include acute and subchronic feeding studies with rabbits, mice, rats and monkeys as well as in vitro mutagenicity assays with Salmonella typhimurium and Saccharomyces cerevisiae. The compound was non-irritating to the skin and moderately irritating to the eyes of rabbits. The rat oral LD50 was 540 mg/kg; no deaths resulted from a one hour rat inhalation exposure at a nominal concentration of 18.6 mg/L. All in vitro assays were negative. The liver was the target organ in rodents in both the 28 day and 90 day feeding studies with males showing a greater response than females. Serum and liver concentrations of organic fluorine were greater in male than in female rats. In a 90 day oral study in rhesus monkeys the gastrointestinal tract and the reticuloendothelial system were the sites of toxic effects. The gastrointestinal effects were attributed to the potent surface activity of the compound. Histopathological effects wer noted in the spleen, lymph nodes and bone marrow. Unlike the rats, sex related differences were not evident in the monkeys. Toxicological evaluations of ammonium perfluorooctanoate are continuing.

Technical Report
Technical Report

An acute inhalation toxicity study of T2306 CoC in the rat

Authors: Rusch, GM; Rinehart, WE; Bozak, CA (1979) Boston, MA: Bio/dynamics Inc.. HERO ID: 4467671


Technical Report
Technical Report

Primary eye irritation study in rabbits, Report 226-0426

Author: Gabriel, K (1976) (226-0426). Biosearch, Inc. HERO ID: 4442368


Technical Report
Technical Report

Primary skin irritation study in rabbits

Author: Gabriel, K (1976) (226-0423). Biosearch, Inc. HERO ID: 4442371


Technical Report
Technical Report

Primary eye irritation study in rabbits, Report 226-0422

Author: Gabriel, K (1976) (226-0422). Biosearch, Inc. HERO ID: 4442370


Technical Report
Technical Report

Eye and skin irritation report on sample T-1117

Authors: Biesemeier, JA; Harris, DL (1974) HERO ID: 4467668