Health & Environmental Research Online (HERO)


tert-Amyl ethyl ether (TAEE)


210 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The yeast test: an alternative method for the testing of acute toxicity of drug substances and environmental chemicals

Authors: Koch, HP; Hofeneder, M; Bohne, B (1993) Methods and Findings in Experimental and Clinical Pharmacology 15:141-152. HERO ID: 817389

[Less] A novel testing procedure has been developed with the aim to replace the traditional LD50 test in vertebrates . . . [More] A novel testing procedure has been developed with the aim to replace the traditional LD50 test in vertebrates by a method using a non-pain sensitive organism. Several years of practical experience have proven this method to be a rather quick, simple, inexpensive, outstandingly well reproducible and reliable experimental technique which yields an estimate for the acute toxicity of drugs, environmental chemicals, solvents, food additives, pesticides, industrial and waste products, and the like. The model is equivalent to the customary LD50 test in mice, rats and other laboratory animals. The yeast test, as it has been briefly named, employs ordinary yeast (Saccharomyces cerevisiae) in a thermostatized incubation mixture with nutrients and trace elements. The test substance is added to this mixture by increasing concentration, and the effect upon the growth rate of the yeast cells is monitored at 30, 90, 150 and 210 min after beginning the experiment by counting the cell number, either in a simple counting chamber under the microscope or, more conveniently, by using an electronic Coulter counter. The effect is expressed as percent growth of the cells in relation to the untreated control. Evaluation of the experimental data leads to a general toxicity parameter, the mean inhibitory concentration or IC50 value of the compound under test. Hitherto it was found that the IC50 values of approx. 160 common drugs and other chemicals correlate well with the known LD50 values found in animals with the same substances.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Effects of l-arginine and d-arginine and some related esters on the cytosolic mechanisms of alpha-thrombin-induced human platelet activation

Authors: Failli, P; Cecchi, E; Ruocco, C; Fazzini, A; Giotti, A (1993) British Journal of Pharmacology 110:213-218. HERO ID: 3258168

[Less] 1. In Fura-2 preloaded human platelets, the increase in cytosolic calcium induced by alpha-thrombin . . . [More] 1. In Fura-2 preloaded human platelets, the increase in cytosolic calcium induced by alpha-thrombin was reduced by some L- and D-arginine ester compounds the IC50 (microM) values of which were 7.4 for TAEE, 56.9 for BAEE, 77.6 for TAME, 560 for T(d)AME, 656.3 for L-ArgOMe and 2206.7 for D-ArgOMe. alpha-tosyl-L-Arginine, L- and D-arginine were inactive. 2. The inhibitory activity of the L-arginine esters was not modified when platelets were pretreated with 100 microM N omega-monomethyl-L-arginine. 3. The L-arginine esters did not increase cyclic GMP content in platelets either in the presence or absence of indomethacin and apyrase at rest and after alpha-thrombin stimulation. 4. The kinetic parameters of platelet Na+/H+ antiporter (amiloride-inhibitable, evaluated after cytosolic nigericin-induced acidification) were modified by L- and D-arginine esters, while the native amino acids were ineffective. 5. The inhibitory effects of the L- and D-arginine esters on platelet activation appear to be mainly due to their inhibitory effect on Na+/H+ antiporter.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

[The yeast test: an alternative method for determination of acute toxicity of drugs and environmental chemicals]

Author: Koch, HP (1992) Die Pharmazie 47:531-537. HERO ID: 817386

[Less] Starting point for this study was the urgent need for replacement of the contemporary mode of acute . . . [More] Starting point for this study was the urgent need for replacement of the contemporary mode of acute toxicity testing of chemicals in vertebrates (LD50-test) by an experimental model with equal power that can be performed on non-pain sensitive matter. For this purpose, a testing procedure ought to be developed using a non-pathogenic microorganism as testing object that is available at any time, easy to cultivate, and in its indicative power equivalent to the LD50 test in mice, rats, and other laboratory animals. Such an organism has been found with ordinary yeast (baker's yeast, brewer's yeast, Saccharomyces cerevisiae) which can always be obtained in good quality. This procedure (shortly denominated as 'yeast test' offers several advantages: It is rather simple, inexpensive, outstandingly well reproducible, and it can be carried out conveniently also in routine experiments. The results correlate well with those furnished by the customary methods of acute toxicity testing.

Technical Report
Technical Report

Initial Submission: Tertiary Amyl Alcohol: Subchronic Toxicity and Pharmacokinetics in Cd-1 Mice, Fischer 344 Rats and Male Beagle Dogs with Cover Letter dated 043092

Author: Dow Chemical Co (1992) HERO ID: 817406


Technical Report
Technical Report

IARC Monographs on the evaluation of carcinogenic risk to humans (Deltamethrin)

Author: IARC (1991) (251-267). (53). Geneva, Switzerland: International Agency for Research on Cancer, WHO. HERO ID: 3108884


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The effects of alcohols in vitro on the nervous cell membrane measured by changes in the (Ca2+ / Mg2+) ATPase activity and fluidity of the synaptosomal membrane

Authors: Edelfors, S; Ravn-Jonsen, A (1990) Pharmacology and Toxicology 67:56-60. HERO ID: 32267

[Less] The effect of various alkanols on the central nervous system was studied by using rat brain synaptosomal . . . [More] The effect of various alkanols on the central nervous system was studied by using rat brain synaptosomal membranes as an in vitro model. The activity of (Ca2+/Mg2+)ATPase and the membrane fluidity were determined. The n-alkanols exhibited an increased molar inhibition of the ATPase activity with an increase in the carbon chain length up to 1-octanol. 1-octanol and 1-decanol caused a biphasic effect on the ATPase activity depending on the alkanol concentration, whereas 1-dodecanol caused a stimulation of the ATPase activity. All alkanols studied caused an increased fluidity of the membrane. Our results indicate that the effect of alkanols on the ATPase activity depends on changes in the border layer between the membrane and the surrounding medium and on a binding of the alkanols to the enzyme molecule. Furthermore, the two-way effect of 1-octanol and 1-decanol and the stimulatory effect of 1-dodecanol indicate that more mechanisms are involved. In addition, the results indicate that changes in the membrane fluidity do not seem to be a prerequisite of the ATPase inhibition.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Quantitative structure-activity relationships in a series of alcohols exhibiting inhibition of cytochrome P-450-mediated aniline hydroxylation

Author: Lewis, DFV (1987) Chemico-Biological Interactions 62:271-280. HERO ID: 31650

[Less] The results of Molecular Orbital (MO) calculations by the MINDO/3 method are reported, together with . . . [More] The results of Molecular Orbital (MO) calculations by the MINDO/3 method are reported, together with the results of multiple regression analysis of electronic and structural parameters with inhibition of aniline hydroxylation by a series of 22 alcohols. The most significant correlations show the relationships between molecular length, frontier electron density of the alpha-carbon and hydroxyl oxygen, nucleophilic superdelocalizability of the hydroxyl hydrogen, energy of the highest occupied MO and biological activity involving binding to microsomal cytochromes P-450. Using the data of Cohen and Mannering (Mol. Pharmacol., 9 (1973) 383), Testa, (Chem.-Biol. Interact., 34 (1981) 287) has shown that the inhibition of aniline hydroxylation by a series of alcohols can be related to their electronic structure and hydrophobicity (measured by log P, the octanol-water partition coefficient). The mode of binding and effect on spin-state equilibria in cytochrome P-450 by alcohols has been elucidated by Testa, whereas an alternative hypothesis based on connectivity correlations has been reported by Sabljic and Sabljic (Mol. Pharmacol., 23 (1983) 213). The present work shows that the biological response can be explained by calculated electronic structure and molecular shape parameters. Also, one compound (the only tertiary alcohol) from the original set that was not included in Testa's calculations and analysis, is included in this work and its activity successfully calculated. The latter authors, Sabljic and Sabljic, were led to exclude the data for this compound and one other (phenyl methanol) in order to achieve a good correlation with their calculated parameters of molecular structure.

Technical Report
Technical Report

Guidelines for carcinogen risk assessment

Author: U.S. EPA (1986) (33993-34003). (EPA/630/R-00/004). Washington, DC: U.S. Environmental Protection Agency, Risk Assessment Forum. [EPA Report] HERO ID: 199530


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

[Amyl alcohols or pentanols]

Author: FNRaS (1985) Cahiers de Notes Documentaires 118:143-146. HERO ID: 817407

[Less] Structural formulae and synonyms, uses, physical and chemical properties, methods of detection and determination . . . [More] Structural formulae and synonyms, uses, physical and chemical properties, methods of detection and determination in air, fire hazards. Effects: acute and chronic experimental toxicity; mutagenic, carcinogenic and metabolic effects; toxicity in man; the TWA for 3-methyl-1-butanol established by the ACGIH (USA) is 100ppm (360mg/m|3|). Regulations: OSH (in France) and transport (in France and internationally). Technical and medical recommendations.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The role of hydroxyl radical scavengers in preventing DNA strand breaks induced by X irradiation of toluene-treated Escherichia coli

Author: Billen, D (1984) Radiation Research 97:626-629. HERO ID: 817388