Health & Environmental Research Online (HERO)


Dibutyl sebacate (109-43-3)


112 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Studies on the toxicity and skin effects of compounds used in the rubber and plastics industries: II. Plasticizers

Authors: Mallette, FS; Von Haam, E (1952) AMA Archives of Industrial Hygiene and Occupational Medicine 6:231-236. HERO ID: 675304

[Less] The toxicities and skin effects of plasticizers used in rubber and plastic industries were studied in . . . [More] The toxicities and skin effects of plasticizers used in rubber and plastic industries were studied in laboratory animals and humans. Twenty five compounds used as plasticizers of synthetic resins were investigated. Rats were administered the compounds by various routes, and mortality was recorded. All animals were necropsied. The compounds were tested for skin irritancy and sensitization in rabbits and humans. Five compounds dioctyl-phthalate (117817), butylbenzyl-phthalate, santicizer-140 (66770443), santicizer-141 (1241947), and flexol-8N8 (61461776) were moderately toxic in doses of 0.6 to 2.4 grams per kilogram (g/kg), generally as a result of intraperitoneal administration. Toxic effects were usually seen in the erythrocytes, blood capillaries, and the central nervous system. The other 20 compounds were essentially nontoxic. All animals supported intraperitoneal injections of 6g/kg or more with no signs of toxic effects. Five compounds showed no skin irritation or sensitization in humans and rabbits: di-2-ethylhexyl-adipate (103231), dibutoxyethyl-diglycol-carbonate, dibutoxyethyl-phthalate (117839), dioctyl-sebacate (122623), and dibutyl-sebacate (109433). Seventeen plasticizers were slight or moderate skin irritants, three were severe skin irritants, and five were moderate sensitizers.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Range-finding toxicity data: List IV

Authors: Smyth, HF, Jr; Carpenter, CP; Weil, CS (1951) AMA Archives of Industrial Hygiene and Occupational Medicine 4:119-122. HERO ID: 94779

[Less] The toxicity of 92 commercially used chemicals was determined in rabbits and rats. Minimum and maximum . . . [More] The toxicity of 92 commercially used chemicals was determined in rabbits and rats. Minimum and maximum dose concentrations for oral toxicity, skin penetration, vapor inhalation, and skin and eye irritation were found. Single oral dose toxicity for rats after 14 days ranged from 0.089 milligrams per kilograms (mg/kg) for 1,4-dichloro-2-butene (31423924) to 22.8mg/kg for 1,3-butanediol (25265752). Penetration of rabbit skin was not measurable in some chemicals, but as high as 17.3 milliliters per kilogram for tetrahydronaphthalene (119642). Lowest daily subacute dose ranged from trace amounts of acrolein (107028) to 10.3 grams per kilogram (gm/kg) tetrabutyl-thiodisuccinate (10042894). Trace amounts of aldol (107891) reduced growth; 5.33gm/kg dichloral-urea reduced appetite. Trace amounts of aldol allyl-alcohol and 2.92gm/kg di(2)-ethylhexyl)-adipate (103231) altered liver or kidney weight; trace amounts of 15 chemicals and 10.3gm/kg tetrabutyl-thiodisuccinate produced microscopic lesions; trace amounts of monoisopropanolamine (78966) and 10.3gm/kg tetrabutyl-thiodisuccinate caused death. The authors recommend changing the rabbit eye injury test as it exaggerates the hazard from certain materials, adding some expression for the rate of healing, and dropping the microscopic study of tissues from the subacute dosesseries since the technique is not sufficiently sensitive to justify its cost.