Health & Environmental Research Online (HERO)


Gluconates (527-07-1, 299-27-4, 526-95-4, 90-80-2, & 299-28-5)


198 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

General acid-base catalysis of alpha-glucan phosphorylases: stereospecific glucosyl transfer from D-glucal is a pyridoxal 5'-phosphate and orthophosphate (arsenate) dependent reaction

Authors: Klein, HW; Palm, D; Helmreich, EJ (1982) Biochemistry 21:6675-6684. HERO ID: 1029322

[Less] D-Glucal, containing a highly reactive double bond, can replace glucose 1-phosphate as the glucosyl . . . [More] D-Glucal, containing a highly reactive double bond, can replace glucose 1-phosphate as the glucosyl donor in phosphorylase-catalyzed glucosyl transfer to a suitable oligo- or polysaccharide acceptor: D-glucal + Pi + (glucose)Pi leads to n 2-deoxy-alpha-D-glucosyl(glucose)n in equilibrium 2-deoxy-alpha-D-glucose-1-P + (glucose)n. This reaction is catalyzed by alpha-glucan phosphorylases from rabbit skeletal muscle, potato tuber, and Escherichia coli. D-Glucal is only measurably consumed by alpha-glucan phosphorylases when orthophosphate or arsenate is present. With saturating concentrations of these anions and a glucosyl acceptor, the D-glucal reaction proceeds at rates comparable with the rates of glucosyl transfer from glucose 1-phosphate and of phosphorolysis or arsenolysis of poly- or oligosaccharides. Furthermore, for the reaction to proceed, the enzyme must be in the active conformation containing the cofactor pyridoxal 5'-phosphate in its dianionic form. On the basis of proton nuclear magnetic resonance spectra, it is proposed that protonation at C-2 of D-glucal gives rise to a hypothetical 2-deoxy-beta-D-glucose intermediate, yielding as a final product (2-deoxy-alpha-D-[2(e)-2H]glucose)n alpha (1 leads to 4) saccharides. These 2-deoxy-alpha-D-glucose oligo- or polysaccharides are degraded by alpha-glucan phosphorylases by phosphorolysis or arsenolysis like natural linear and branched alpha-glucans. The absolute requirement of the D-glucal reaction for phosphate (or arsenate) and its dependency on the dianionic form of the pyridoxal 5'-phosphate bound to phosphorylase are rationalized in terms of a proton transfer relay involving juxtaposed phosphates. Phosphate--phosphate interactions were postulated by Withers et al. [Withers, S. G., Madsen, N. B., Sykes, B. D., Takagi, M., Shimomura, S., & Fukui, T. (1981) J. Biol. Chem. 256, 10759-10762].

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (trade-named "vitamin B15")

Authors: Herbert, V; Gardner, A; Colman, N (1980) American Journal of Clinical Nutrition 33:1179-1182. HERO ID: 700296

[Less] Dichloroacetate demonstrates low grade mutagenicity in the Ames Salmonella/mammaltan microsome mutagenicity . . . [More] Dichloroacetate demonstrates low grade mutagenicity in the Ames Salmonella/mammaltan microsome mutagenicity test. This evidence of probable carcinogenicity must be considered in any proposed use of dichloroacetate or of preparations of pangamic acid (trade-named "vitamin B15") containing dichloroacetate.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Modulation of plasma 1,25-dihydroxyvitamin D in man by stimulation and suppression tests

Authors: Eisman, JA; Wark, JD; Prince, RL; Moseley, JM (1979) The Lancet 2:931-933. HERO ID: 4947545

[Less] In normal volunteers infusion of parathyroid extract raised plasma 1,25-dihydroxyvitamin D (1,25-[OH]2D) . . . [More] In normal volunteers infusion of parathyroid extract raised plasma 1,25-dihydroxyvitamin D (1,25-[OH]2D) levels by 80% (peak 8--40 h after infusion) without producing any significant change in plasma calcium, phosphate, or magnesium. An oral calcium load suppressed plasma 1,25-(OH)2D to 63% of control values within 48--72 h. These responses will be useful in the diagnosis and management of disturbances of calcium and mineral metabolism in which vitamin D metabolism is abnormal.

Technical Report
Technical Report

Potassium gluconate: basic toxicokinetics

Author: ECHA (1979) HERO ID: 4940231


Technical Report
Technical Report

D-glucono-1,5-lactone: basic toxicokinetics

Author: ECHA (1979) HERO ID: 4940243


Technical Report
Technical Report

D-gluconic acid: repeated dose toxicity: oral: 001 key | read-across (structural analogue/surrogate)

Author: ECHA (1978) HERO ID: 4940241


Technical Report
Technical Report

D-glucono-1,5-lactone: repeated dose toxicity: oral: 001 key | experimental result

Author: ECHA (1978) HERO ID: 4940253

[Less] The authors of this study reported that compound-related effects were observed in the stomach of rats . . . [More] The authors of this study reported that compound-related effects were observed in the stomach of rats and consisted of thickening of the stratified squamous epithelieum at the anterior stomach, which is perceived to pertain to the rat forestomach. The area particularly affected was the transitional area continuous with the pyloric stomach, which is consistent with a description of the limiting ridge. The effect was observed in all dose groups and was reported with dose dependency in frequency and severity, and therefore, a NOAEL for glucono delta lactone could not be determined based on the results of this study. However, given that the forestomach and limiting ridge are structures unique to the rodent, the effects observed in the stomach of rats in this study are not relevant to humans. It should be noted that the results reported herein were taken from a partial English translation of a study report written in Japanese.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Independent effects of oral calcium gluconate on gastric-acid secretion and serum gastrin concentration in man

Authors: Brodie, MJ; Fine, A; Ganguli, PC; Thomson, TJ (1976) Journal of Physiology 257:P39-P40. [Abstract] HERO ID: 4946680


Technical Report
Technical Report

Mutagenic evaluation of compound FDA 73-5, calcium gluconate

Author: Litton Bionetics (1975) HERO ID: 4947764

Abstract: Mutagenic test results are reported in microbial and mammalian cell systems.

Technical Report
Technical Report

Mutagenic evaluation of compounds FDA 75-5, 000527-07-1, sodium gluconate, FCC, fine granular

Author: Litton Bionetics, Inc. (1975) HERO ID: 4947765

Abstract: Mutagenic test results are reported in microbial and mammalian cell systems.