Health & Environmental Research Online (HERO)


Glycols (25265-71-8, 110-98-5, & 24800-44-0)


220 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Structure‐activity relationships for skin sensitisation potential of diacrylates and dimethacrylates

Author: Roberts, DW (1987) Contact Dermatitis 17:281-289. HERO ID: 1322754

[Less] Apparently conflicting guinea pig sensitisation data on diacrylates and dimethacrylates published by . . . [More] Apparently conflicting guinea pig sensitisation data on diacrylates and dimethacrylates published by 3 groups of authors, are analysed in terms of the RAJ model. This model, correlating sesitisation score with a combination of induction dose, chemical reactivity and lipophilicity, enables the major discrepancies to be rationalised. The data provide a striking example of the overload effect, in that some of the diacrylates have failed to show sensitisation when tested at high induction doses, but are revealed as strong sensitisers when tested by other authors at lower induction doses.

Technical Report
Technical Report

Health hazard evaluation report no. MHETA-87-039-1837, Old Ben Coal Company, Benton, Illinois

Authors: Cornwell, RJ; Stark, G (1987) (296-300). (NIOSH/00175413). HERO ID: 2301139

[Less] In response to a request from the Deputy Administrator, Occupational Health, of the United Mine Workers . . . [More] In response to a request from the Deputy Administrator, Occupational Health, of the United Mine Workers of America, a study was made of possible worker exposure to two hydraulic fluids at the Old Ben Coal Company (SIC-1111) located in Benton, Illinois. Employees using Solcenic-3A hydraulic fluid or working near its area of use had reported eye, skin, or respiratory irritation. Solcenic-2 fluid produced no symptoms. Chemical analysis revealed that Solcenic-3A contained dipropylene-glycol isomers and a small amount of ethanolamine (141435) which were not present in Solcenic-2. The authors suggest that these components may lower the Solcenic-3A odor threshold. Area air evaluations indicated no harmful exposures to the component methyl-isobutyl-carbinol (108112), with exposures of 1.4 and 3.4mg/m3 determined for two of 11 samples (American Conference of Governmental Industrial Hygienists threshold limit value, 100mg/m3). No excessive exposure to the component napthenic-mineral-oil was found; it was considered that workers were exposed to it only during hydraulic line ruptures or fluid spills. Of 13 workers reporting symptoms, nine of 11 interviewed had symptoms possibly due to skin or inhalation exposure to Solcenic-3A. The authors suggest that inhalation symptoms are a reaction to its strong vapor. They conclude that there is no health hazard, but they recommend use of protective equipment, proper disposal of waste, and use of nonirritating Solcenic-2.

Technical Report
Technical Report

Support for chemical nomination and selection process of the national toxicology program. Executive summary of data: dipropylene glycol.

Author: Dynamac (1987) Bethesda, MD: National Toxicology Program. National Institutes of Health.. HERO ID: 4940386


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Metabolism and disposition of glycol ethers

Author: Miller, RR (1987) Drug Metabolism Reviews 18:1-22. [Review] HERO ID: 1620742


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Toxicity of mixtures of heavy metals and petrochemicals to Xenopus laevis

Authors: De Zwart, D; Slooff, W (1987) Bulletin of Environmental Contamination and Toxicology 38:345-351. HERO ID: 1580138

Abstract: BIOSIS COPYRIGHT: BIOL ABS. RRM WATER POLLUTION LC-50

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Final report on the safety assessment of butylene glycol, hexylene glycol, ethoxydiglycol, and dipropylene glycol

Author: CIR (1985) Journal of the American College of Toxicology 4:223-248. HERO ID: 4941420

[Less] Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol are viscous liquids used in . . . [More] Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol are viscous liquids used in the cosmetic industry as humectants, emulsifiers, plasticizers, and solvents. The results of acute, subchronic, and chronic oral toxicity studies using a variety of animal species indicate low order of toxicity for the Glycols. Butylene Glycol, Ethoxydiglycol, and Dipropylene Glycol caused minimal to mild irritation of rabbit skin, whereas Hexylene Glycol was moderately irritating. The Glycols produced mild to severe ocular irritation when tested in rabbit, with Hexylene Glycol producing the most severe irritation. Human skin patch tests on undiluted Butylene Glycol and undiluted Hexylene Glycol produced a very low order of primary skin irritation. A repeated insult patch test on Butylene Glycol produced no evidence of skin sensitization. It is concluded the Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol are safe as presently used in cosmetics.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Metabolism and disposition of dipropylene glycol monomethyl ether (DPGME) in male rats

Authors: Miller, RR; Hermann, EA; Calhoun, LL; Kastl, PE; Zakett, D (1985) Fundamental and Applied Toxicology 5:721-726. HERO ID: 4946615

[Less] Male Fischer 344 rats were given a single oral dose of approximately 1289 mg/kg (8.7 mmol/kg) of ( super(14)C)DPGME. . . . [More] Male Fischer 344 rats were given a single oral dose of approximately 1289 mg/kg (8.7 mmol/kg) of ( super(14)C)DPGME. After dosing, expired air, excreta, and tissues were analyzed for super(14)C activity, and metabolites in urine were isolated and identified. Approximately 60% of the administered super(14)C activity was excreted in urine, while 27% was eliminated as super(14)CO sub(2) within 48 hr after dosing. DPGME, PGME, dipropylene glycol, propylene glycol, as well as sulfate and glucuronide conjugates of DPGME were identified in urine of animals given ( super(14)C)DPGME. Results of the study indicate that DPGME is metabolized via the same routes to the same general types of metabolites as previously identified for propylene glycol monomethyl ether (PGME).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Dipropylene glycol monomethyl ether: A 13-week inhalation toxicity study in rats and rabbits

Authors: Landry, TD; Yano, BL (1984) Fundamental and Applied Toxicology 4:612-617. HERO ID: 4946620

[Less] Fischer 344 rats (10/sex/exposure concentration) and New Zealand white rabbits (7/sex/exposure concentration) . . . [More] Fischer 344 rats (10/sex/exposure concentration) and New Zealand white rabbits (7/sex/exposure concentration) were exposed to 0, 15, 50, or 200 ppm (0, 91, 303, or 1212 mg/m super(3)) of dipropylene glycol monomethyl ether (DPGME) for 6 hr/day, 5 days/week for 13 weeks. Criteria of response included general observations, body weights, clinical chemistry, hematology, urinalyses (rats only), necropsy, organ weights, and histopathology. There were no effects attributed to exposure to DPGME at any exposure concentration in either male or female rats or rabbits. Based on the low vapor pressure of DPGME, and results in this 13-week study, DPGME appears to have a low subchronic vapor inhalation toxicity hazard.

Technical Report
Technical Report

The toxicology of glycol ethers and its relevance to man: An up-dating of ECETOC technical report No.4

Author: ECETOC (1984) (CIS/85/01358). Bruxelles, Belgium: European Chemical Industry Ecology and Toxicology Centre. HERO ID: 628230

[Less] This report is an update of ECETOC Technical Report No.4 (see CIS 84-1084). Contents: haematological . . . [More] This report is an update of ECETOC Technical Report No.4 (see CIS 84-1084). Contents: haematological and testicular effects; teratological, embryotoxic and foetotoxic effects; neurologic and behavioural effects; genetic toxicity; carcinogenicity; skin absorption; metabolism; human exposure (exposure limits, environmental control, testing of effects on man); discussion; general conclusions. This update covers more of the glycol ethers than does Report No.4. It also includes their acetates.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The sensitizing capacity of multifunctional acrylates in the guinea pig

Author: Bjorkner, B (1984) Contact Dermatitis 11:236-246. HERO ID: 2745927

[Less] HEEP COPYRIGHT: BIOL ABS. The multifunctional acrylates used in UV curable resins act as cross-linkers . . . [More] HEEP COPYRIGHT: BIOL ABS. The multifunctional acrylates used in UV curable resins act as cross-linkers and diluents. They are usually based on di(meth)acrylate esters of dialcohols of tri- and tetra-acrylate esters of polyalcohols. In UV-curable coatings, the most commonly used are pentaerythritol triacylate (PETA), trimethylolpropane triacrylate (TMPTA) and 1,6-hexanediol diacrylate (HDDA). In other uses, such as dental composite resin materials, the dimethacrylic monomers based on n-ethylene glycol are the most useful. The sensitizing capacity of various multifunctional acrylats and their cross-reactivity pattern were investigated with the guinea pig maximization test. BUDA (1,4-butanediol diacrylate) and HDDA evidently are moderate to strong sensitizers and they probably cross-react with each other. The n-ethylene glycol diacrylates and methacrylates tested are weak or nonsensitizers. Tripropylene glycol diacrylate (TPGDA) is a moderate and neopentyl glycol diacrylate (NPGDA) a strong sensitizer, whereas neopentyl glycol dimethacrylate is a nonsensitizer. The commercial PETA is a mixture of pentaerythritol tri- and tetra-acrylate (PETA-3 and PETA-4). PETA-3 is a much stronger sensitizer than PETA-4. Simultaneous reactions were seen between PETA-3, PETA-4 and TMPTA. The oligotriacrylate OTA 480 is a moderate sensitizer, but no concomitant reactions were seen with PETA-3, PETA-4 or TMPTA. Of the multifunctional acrylates tested, the di- and triacrylic compounds should be regarded as potent sensitizers. The methacrylated multifunctional acrylic compounds are weak or nonsensitizers.