Health & Environmental Research Online (HERO)


Squalane (111-01-3)


106 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Metabolism of beta-hexachlorocyclohexane-14C in rats following low dosing in the daily diet

Authors: Lay, JP; Klein, W; Korte, F; Richter, E (1981) HERO ID: 4968805

[Less] beta-Hexachlorocyclohexane-14C (1.5 ppm) was administered in the diet to rats for one week. During the . . . [More] beta-Hexachlorocyclohexane-14C (1.5 ppm) was administered in the diet to rats for one week. During the elimination phase three therapeutic agents were fed to enhance the clearance. Renal and fecal excreted radioactive products were collected for 8 weeks and extracted. Although significant differences in the total excreted amount of radioactivity were registered between controls and treated rats, there were no quantitative differences in the extractability of the excreta and no differences in the chemical nature of metabolites found. Radioactivity in urine consisted to 100% of conversion products, about 30% of which were unextractable residues. In the organic soluble fraction the 2,4,6-trichlorophenol was the major metabolite in urine and the only metabolite detected in feces. Minor conversion products of beta-HCH in urine were a trichlorohydroxyme-thoxybenzene, a dichlorophenol and a trace of a tetrachlorocyclohexane-isomer.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Some biochemical effects of isopropyl myristate and squalane on rabbit skin

Authors: Komatsu, H; Asaba, K; Suzuki, M (1979) Journal of the Society of Cosmetic Chemists 30:263-278. HERO ID: 1619553

[Less] A biochemical method was employed to study the response of rabbit skin to isopropyl myristate, squalane, . . . [More] A biochemical method was employed to study the response of rabbit skin to isopropyl myristate, squalane, and decane. The results showed that decane damaged the skin so severely that the biosyntheses of lipids, RNA and DNA were reduced markedly for the first 3 days after application, but increased rapidly after that due to the repair. The effect of squalane was found to be weaker than that of isopropyl myristate, though both oils induced the stimulation of biosynthese in the epidermis. The magnitude of the biochemical effects of the 3 oils on the skin was increased in the order of squalane, isopropyl myristate and decane, which was consistent with the results of macroscopic and histological observations. From the profiles of the effects, it is postulated that the repairing processes are controlled by some feedback mechanisms.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Safety evaluation of cosmetic raw materials

Authors: Guillot, JP; Martini, MC; Giauffret, JY (1977) Journal of the Society of Cosmetic Chemists 28:377-393. HERO ID: 1619655

[Less] IPA COPYRIGHT: ASHP The toxicity of 26 cosmetics excipients was evaluated using a rabbit test. The . . . [More] IPA COPYRIGHT: ASHP The toxicity of 26 cosmetics excipients was evaluated using a rabbit test. The ocular and cutaneous effects were evaluated using official French methods with some additions. The results show that 13 samples gave adverse reactions after repeated skin exposures; 8 of them appeared to be significantly more irritant--4 isopropyl myristates and 4 oleyl alcohols each from different sources. Eleven excipients were well tolerated when applied undiluted during 60 days and 2 gave uncertain results. Compounds tested included squalane, caprylic triglycerides, isopropyl myristate and palmitate, decyl oleate, octyl palmitate and stearate, oleyl alcohol and polyoxyethylene sorbitan stearate.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Assimilation of selected cosmetic ingredients by microorganisms

Authors: Yanagi, M; Onishi, G (1971) Journal of the Society of Cosmetic Chemists 22:851-865. HERO ID: 1621432

[Less] IPA COPYRIGHT: ASHP A study was made of the possible assimilation by various microorganisms of ingredients . . . [More] IPA COPYRIGHT: ASHP A study was made of the possible assimilation by various microorganisms of ingredients commonly used in the formulation of cosmetic products. Hydrocarbons, high molecular weight alcohols, esters and fatty acids, and silicones were studied. Microorganisms used in this study were isolated from cosmetic products. Some species of Penicillium, Candida, and Pseudomonas were noted to demonstrate strong ability to assimilate some of these ingredients. Of the materials tested, mineral oil, oleyl alcohol, stearyl alcohol, propylene glycol, isopropyl myristate, 2-hexyldecyl myristate, oleic acid, and stearic acid were found to be utilized as the sole source of carbon by most of the test organisms. Solid paraffin, multiwax, camellian, squalane, silicones, hexadecyl alcohol, polyethylene glycol, and di(2-hexyldecyl) adipate were not utilized by the organisms. The relationship between microbial assimilation and chemical structure of substrate was also determined by the use of different esters.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Absorption of aliphatic hydrocarbons by rats

Authors: Albro, PW; Fishbein, L (1970) Biochimica et Biophysica Acta 219:437-446. HERO ID: 4829875


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene

Authors: Wepierre, J; Cohen, Y; Valette, G (1968) European Journal of Pharmacology 3:47-51. HERO ID: 3044744

[Less] Percutaneous absorption of ethyl-alcohol (64175), perhydrosqualene (111013), and p-cymene (99876) was . . . [More] Percutaneous absorption of ethyl-alcohol (64175), perhydrosqualene (111013), and p-cymene (99876) was investigated. Male albino-mice were treated topically with 0.1 milliliter of radio labeled solutions of one of the test agents. In some tests with ethyl-alcohol and perhydrosqualene, the stratum corneum was removed before treatment. At selected times, the skin was removed and analyzed for radioactivity. Absorption rates were 10.5 and 0.12 nanomoles per square centimeter per minute for ethyl-alcohol and perhydrosqualene, respectively, for nonabraded skin. When the stratum corneum was removed, ethyl-alcohol penetration rate increased to 200 nanomoles per square centimeter per minute, but the rate for perhydrosqualene did not change. The penetration rate of p-cymene was 32 nanomoles per square centimeter per minute over 1 hour. The authors conclude that dermal absorption is affected by the epidermal barrier and the removal capacity of the blood. The liposolubility of the agent also affects its penetration through the epidermal stratum.