Health & Environmental Research Online (HERO)


Propylene glycol ethers (88917-22-0 & 55934-93-5)


132 References Were Found:

Technical Report
Technical Report

1-butoxypropan-2-ol: toxicity to microorganisms: 001 key | experimental result

Author: ECHA (2009) HERO ID: 4985117


Technical Report
Technical Report

[(butoxymethylethoxy)methylethoxy]propan-1-ol: toxicity to aquatic algae and cyanobacteria: 001 key | experimental result

Author: ECHA (2009) HERO ID: 4985112


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Final report on the safety assessment of PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate

Authors: Robinson, V; Bergfeld, WF; Belsito, DV; Klaassen, CD; Marks, JG; Shank, RC; Slaga, TJ; Snyder, PW; Cosmetic Ingredient Review Expert Panel; Andersen, FA (2009) International Journal of Toxicology 28:162S-74S. HERO ID: 2530089

[Less] PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are used in cosmetics as fragrance . . . [More] PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are used in cosmetics as fragrance ingredients and/or solvents at concentrations of 0.4% to 2%. Propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure, but the inhalation toxicity of PPG-2 methyl ether vapor, for example, is low. Aerosols, such as found with hair sprays, produce particle sizes that are not respirable. Because these ingredients are highly water-soluble, they are likely to be absorbed through the human skin only at slow rates, resulting in low blood concentrations and rapid removal by the kidney. These ingredients are not genotoxic and are not reproductive or developmental toxicants. Overall the data are sufficient to conclude that PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are safe as used in cosmetics.

Technical Report
Technical Report

1-(2-butoxy-1-methylethoxy)propan-2-ol: Toxicity to reproduction: 001 Key | Experimental result

Author: ECHA (2006) HERO ID: 5077929


Technical Report
Technical Report

The toxicology of glycol ethers and its relevance to man (fourth edition). Volume II - Substance profiles

Author: ECETOC (2005) HERO ID: 5077937


Technical Report
Technical Report

Propylene glycol ethers: SIDS initial assessment report for SIAM 17: Arona, Italy, 11-14 November 2003

Author: OECD (2003) (SIDS Initial Assessment Meeting (SIAM) 17). UNEP Publications. HERO ID: 4956637

[Less] The category contains four structurally related propylene glycol ethers: - Propylene Glycol n-Butyl . . . [More] The category contains four structurally related propylene glycol ethers:
- Propylene Glycol n-Butyl Ether (PnB, 5131-66-8, major (“alpha”) isomer, 29387-86-8 isomeric mixture)
- Dipropylene Glycol n-Butyl Ether (DPnB, 29911-28-2 major isomer or 35884-42-5 isomeric mixture))
- Dipropylene Glycol Methyl Ether Acetate (DPMA, 88917-22-0 isomeric mixture)
- Tripropylene Glycol Methyl Ether (TPM, 20324-33-8 one of the isomers and 25498-49-1 isomeric mixture)

The alpha (secondary alcohol) form is kinetically favored during synthesis. PnB is available as the isomeric mixture in which the alpha isomer is the predominant isomer (ca. 95%. DPnB, DPMA and TPM are commercially produced as mixtures of isomeric components in which the internal ether linkages may be adjacent to either primary or secondary carbon atoms. Thus, for DPMA and DPnB the commercially produced products may contain up to 4 such isomers. In the case of TPM, the commercially produced product may contain up to 8 such isomers.

Data for these propylene glycol ethers are supplemented with data from three propylene glycol ethers that are closely related to the category members in molecular structure, physicochemical properties and toxicity and thus extend the category. These compounds are:
- Propylene Glycol Methyl Ether (PM; CAS No. 107-98-2)
- Propylene Glycol Methyl Ether Acetate (PMA; CAS No. 108-65-6)
- Dipropylene Glycol Methyl Ether (DPM; CAS No. 34590-94-8 isomeric mixture and 20324-32-7 major isomer)

PM and PMA were reviewed at SIAM 11 and DPM was reviewed at SIAM 12. All were assigned as low priority for further work.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Biodegradation of potential diesel oxygenate additives: dibutyl maleate (DBM), and tripropylene glycol methyl ether (TGME)

Authors: Marchetti, AA; Knize, MG; Chiarappa-Zucca, ML; Pletcher, RJ; Layton, DW (2003) Chemosphere 52:861-868. HERO ID: 44187

[Less] The addition of oxygen-bearing compounds to diesel fuel considerably reduces particulate emissions. . . . [More] The addition of oxygen-bearing compounds to diesel fuel considerably reduces particulate emissions. TGME and DBM have been identified as possible diesel additives based on their physicochemical characteristics and performance in engine tests. Although these compounds will reduce particulate emissions, their potential environmental impacts are unknown. As a means of characterizing their persistence in environmental media such as soil and groundwater, we conducted a series of biodegradation tests of DBM and TGME. Benzene and methyl tertiary butyl ether (MTBE) were also tested as reference compounds. Primary degradation of DBM fully occurred within 3 days, while TGME presented a lag phase of approximately 8 days and was not completely degraded by day 28. Benzene primary degradation occurred completely by day 3 and MTBE did not degrade at all. The total mineralized fractions of DBM and TGME achieved constant values as a function of time of approximately 65% and approximately 40%, respectively. Transport predictions show that, released to the environment, DBM and TGME would concentrate mostly in soils and waters with minimal impact to air. From an environmental standpoint, these results combined with the transport predictions indicate that DBM is a better choice than TGME as a diesel additive.

Technical Report
Technical Report

1-butoxypropan-2-ol: short-term toxicity to aquatic invertebrates: 002 supporting | experimental result

Author: ECHA (2002) HERO ID: 4985115


Technical Report
Technical Report

[(butoxymethylethoxy)methylethoxy]propan-1-ol: short-term toxicity to aquatic invertebrates: 002 supporting | experimental result

Author: ECHA (2002) HERO ID: 4985123


Technical Report
Technical Report

[(butoxymethylethoxy)methylethoxy]propan-1-ol: biodegradation in water: screening tests: 002 supporting | experimental result

Author: ECHA (2002) HERO ID: 4985134