Studies on the carcinogenic activity of protein-denaturing agents: Hepatocarcinogenicity of dioxane
Authors: Argus, MF; Arcos, JC; Hoch-Ligeti, C
Journal of the National Cancer Institute 35:949-958.
HERO ID: 17009
The carcinogenic activity of diethylformamide, diethylacetamide, N,N'-dimethyl-N,N'-dinitrosophthalamide, . . .
The carcinogenic activity of diethylformamide, diethylacetamide, N,N'-dimethyl-N,N'-dinitrosophthalamide, heptylamine, and dioxane, compounds selected both because of their potency to denature proteins and their structural resemblance to nitrosamine derivatives, was investigated. Dioxane, when administered orally, was found to be a hepatic carcinogen, producing hepatomas in 6 of 26 rats. Diethylacetamide ingestion produced a transitional cell carcinoma of the kidney in 1 of 30 rats. Dioxane, diethylacetamide, and N,N'-dimethyl-N,N'-dinitrosophthalamide caused severe kidney damage. The possible relationship between the carcinogenic activity of dioxane and its capacity to alter cellular metabolic control sites by virtue of its protein-denaturing ability is discussed.