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Methanol (Non-Cancer)

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The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Insight into the Structural Deformations of Beta-Cyclodextrin Caused by Alcohol Cosolvents and Guest Molecules

Authors: Zhang, H; Ge, C; van der Spoel, D; Feng, W; Tan, T (In Press) Journal of Physical Chemistry B. HERO ID: 1037930

[Less] Beta-cyclodextrin (β-CD) is an ideal candidate for a host molecule, and it is used as such in drug delivery . . . [More] Beta-cyclodextrin (β-CD) is an ideal candidate for a host molecule, and it is used as such in drug delivery and separation technology. The structural behavior of free β-CD and host-guest complexes of β-CD with two isoflavonoid isomers (puerarin and daidzin) in aqueous alcohol solutions, covering methanol, ethanol, 2-propanol, and 1-propanol, was investigated through molecular dynamics (MD) simulations. The MD results highlighted aspects of the structural flexibility and rigidity of β-CD in different alcohol solutions. The alcohol residence time within the β-CD cavity, solvent distribution around β-CD, and guest-induced structural changes were analyzed. Interaction with puerarin endowed β-CD with a more rigid structure than with daidzin and a weaker ternary complex β-CD/puerarin/alcohol was formed with a local participation of water molecules. The retention behavior of puerarin and daidzin on a β-CD-coupled medium was determined via chromatographic experiments and simulation results provided a structural explanation for such interactions.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Comparison of Accelerated Methods for the Extraction of Phenolic Compounds from Different Vine-Shoot Cultivars

Authors: Delgado-Torre, MP; Ferreiro-Vera, C; Priego-Capote, F; Pérez-Juan, PM; Luque de Castro, MD (In Press) Journal of Agricultural and Food Chemistry. HERO ID: 1038038

[Less] Most research on the extraction of high-priced compounds from vineyard/wine byproducts has traditionally . . . [More] Most research on the extraction of high-priced compounds from vineyard/wine byproducts has traditionally been focused on grape seeds and skins as raw materials. Vine-shoots can represent an additional source to those materials, the characteristics of which could depend on the cultivar. A comparative study of hydroalcoholic extracts from 18 different vineyard cultivars obtained by superheated liquid extraction (SHLE), microwave-assisted extraction (MAE), and ultrasound-assisted extraction (USAE) is here presented. The optimal working conditions for each type of extraction have been investigated by using multivariate experimental designs to maximize the yield of total phenolic compounds, measured by the Folin-Ciocalteu method, and control hydroxymethylfurfural because of the organoleptic properties of furanic derivatives and toxicity at given levels. The best values found for the influential variables on each extraction method were 80% (v/v) aqueous ethanol at pH 3, 180 °C, and 60 min for SHLE; 140 W and 5 min microwave irradiation for MAE; and 280 W, 50% duty cycle, and 7.5 min extraction for USAE. SHLE reported better extraction efficiencies as compared to the other two approaches, supporting the utility of SHLE for scaling-up the process. The extracts were dried in a rotary evaporator, reconstituted in 5 mL of methanol, and finally subjected to liquid-liquid extraction with n-hexane to remove nonpolar compounds that could complicate chromatographic separation. The methanolic fractions were analyzed by both LC-DAD and LC-TOF/MS, and the differences in composition according to the extraction conditions were studied. Compounds usually present in commercial wood extracts (mainly benzoic and hydroxycinnamic acids and aldehydes) were detected in vine-shoot extracts.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Catalytic reduction of NO with decomposed methanol on alumina-supported Mn-Ce catalysts

Authors: Spassova, I; Tsontcheva, T; Velichkova, N; Khristova, M; Nihtianova, D (In Press) Journal of Colloid and Interface Science. HERO ID: 1038060

[Less] A series of manganese-ceria supported on alumina catalysts with various Mn/Ce ratios are investigated . . . [More] A series of manganese-ceria supported on alumina catalysts with various Mn/Ce ratios are investigated in both methanol decomposition to CO and hydrogen and SCR of NO(x) with CO. The study is aimed at the potential application of both reactions in integrated devices, where NO(x) is reduced with the products of the decomposed methanol. The samples are characterized by nitrogen physisorption, XRD, TEM, XPS, UV-Vis, and TPR. It was established that manganese-ceria supported on alumina catalysts are perspective in both methanol decomposition and NO reduction at temperatures above 723K, which are typical for exhausted gases from the vehicles and some stationary stations. The best catalytic activity and selectivity to the desired products under these conditions was found for the samples with Mn/Mn+Ce ratio of 0.5 and 0.7. This superior catalytic performance is related to the formation of mixed valence Mn(3+)/Ce(4+) and Mn(4+)/Ce(3+) active sites.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Coke Formation and Carbon Atom Economy of Methanol-to-Olefins Reaction

Authors: Wei, Y; Yuan, C; Li, J; Xu, S; Zhou, Y; Chen, J; Wang, Q; Xu, L; Qi, Y; Zhang, Q; Liu, Z (In Press) ChemSusChem. HERO ID: 1038079

[Less] The methanol-to-olefins (MTO) process is becoming the most important non-petrochemical route for the . . . [More] The methanol-to-olefins (MTO) process is becoming the most important non-petrochemical route for the production of light olefins from coal or natural gas. Maximizing the generation of the target products, ethene and propene, and minimizing the production of byproducts and coke, are major considerations in the efficient utilization of the carbon resource of methanol. In the present work, the heterogeneous catalytic conversion of methanol was evaluated by performing simultaneous measurements of the volatile products generated in the gas phase and the confined coke deposition in the catalyst phase. Real-time and complete reaction profiles were plotted to allow the comparison of carbon atom economy of methanol conversion over the catalyst SAPO-34 at varied reaction temperatures. The difference in carbon atom economy was closely related with the coke formation in the SAPO-34 catalyst. The confined coke compounds were determined. A new type of confined organics was found, and these accounted for the quick deactivation and low carbon atom economy under low-reaction-temperature conditions. Based on the carbon atom economy evaluation and coke species determination, optimized operating conditions for the MTO process are suggested; these conditions guarantee high conversion efficiency of methanol.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Phosphorylation-dependent Pex11p and Fis1p interaction regulates peroxisome division

Authors: Joshi, S; Agrawal, G; Subramani, S (In Press) Molecular Biology of the Cell. HERO ID: 1038232

[Less] Peroxisome division is regulated by the conserved peroxin Pex11p. In Saccharomyces cerevisiae, induction . . . [More] Peroxisome division is regulated by the conserved peroxin Pex11p. In Saccharomyces cerevisiae, induction of the phosphoprotein, ScPex11p, coincides with peroxisome biogenesis. We show that the ScPex11p homolog in Pichia pastoris (PpPex11p) is phosphorylated at Serine(173). PpPex11p expression and phosphorylation are induced in oleate and coordinated with peroxisome biogenesis. PpPex11p transits to peroxisomes via the endoplasmic reticulum (ER). PpPex11p is unstable and ER-restricted in pex3Δ and pex19Δ cells, which are impaired in peroxisomal membrane protein biogenesis. In oleate medium, the P. pastoris mutants, pex11A (constitutively unphosphorylated - S173A) and pex11D (constitutively phosphorylated - S173D), exhibit juxtaposed elongated peroxisomes (JEPs) and hyper-divided forms respectively, although protein levels remain unchanged. In contrast with ScPex11p, the ER to peroxisome translocation in P. pastoris is phosphorylation-independent and the phosphorylation occurs at the peroxisome. Neither PpPex11p nor PpFis1p are necessary for peroxisome division in methanol medium. We show that PpPex11p interacts with the peroxisome fission machinery via PpFis1p and is regulated by phosphorylation because PpPex11p and PpPex11Dp interact more strongly with PpFis1p, as compared with PpPex11Ap. We propose a model for the role of PpPex11p in the regulation of peroxisome division through a phosphorylation-dependent interaction with the fission machinery, providing novel insights into peroxisome morphogenesis.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Comprehensive kinetic studies of acidic oil continuous esterification by cation-exchange resin in fixed bed reactors

Authors: Cheng, Y; Feng, Y; Ren, Y; Liu, X; Gao, A; He, B; Yan, F; Li, J (In Press) Bioresource Technology. HERO ID: 1038247

[Less] Biodiesel produced by esterification from molar ratio of methanol to free fatty acid (FFA) as 25:1 in . . . [More] Biodiesel produced by esterification from molar ratio of methanol to free fatty acid (FFA) as 25:1 in presence of triglyceride was carried out with cation-exchange resin as a heterogeneous catalyst in three different scales of fixed bed reactors from minireactor (6.8mm×110mm) to pilot scale reactor (70mm×1260mm) at 338K. The kinetic study of esterification was undertaken in terms of pseudo-homogeneous mechanism and performed as a first order reaction with elimination of the solid-liquid internal and external mass transfer resistances. Moreover, a kinetic model of FFA esterification was developed to illustrate the relationship between the FFA conversion and the catalyst bed height of fixed bed reactor. The model was also suitable for various resins in fixed bed reactor. The theoretical predictions were in agreement with the experimental data with root mean square (RMS) errors <10.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Characterization of Smallest Active Monomeric Lipase from Novel Rhizopus Strain: Application in Transesterification

Authors: Kantak, JB; Prabhune, AA (In Press) Applied Biochemistry and Biotechnology. HERO ID: 1038254

[Less] An extracellular lipase-producing fungus was isolated from oil-rich soil. This fungus belongs to the . . . [More] An extracellular lipase-producing fungus was isolated from oil-rich soil. This fungus belongs to the genus Rhizopus and clades with Rhizopus oryzae. Lipase was purified to homogeneity from this novel fungal source using ammonium sulphate precipitation followed by Q-Sepharose chromatography. The extracellular lipase was purified 8.6-fold, and enzymatic properties were studied. The molecular mass of the purified enzyme was estimated to be 17 kD by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and 16.25 kD by matrix-assisted laser desorption ionization/time-of-flight analysis. The native molecular mass was estimated to be 17.5 kD by gel filtration, indicating the protein to be monomer. The optimum pH and temperature for the enzyme catalysis were 7.0 °C and 40 °C, respectively. Enzyme was stable in pH range 6.0-7.0 and retains 95-100% activity when incubated at 50 °C for 1 h. The pI of the purified lipase was 4.2. Enzyme was stable in the organic solvents such as ethanol, hexane and methanol for 2 h. Purified enzyme was used for transesterification of oleic acid in the presence of ethanol for production of oleic acid ethyl ester with a conversion efficiency of 66% after 24 h at 30 °C.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Resveratrol-derived stilbenoids and biological activity evaluation of seed extracts of Cenchrus echinatus L

Authors: Silva, AA; Haraguchi, SK; Cellet, TS; Schuquel, IT; Sarragiotto, MH; Vidotti, GJ; de Melo, JO; Bersani-Amado, CA; Zanoli, K; Nakamura, CV (In Press) Natural Product Research. HERO ID: 1038470

[Less] A phytochemical study of the ethyl acetate fractions from the partition of seeds and roots methanol . . . [More] A phytochemical study of the ethyl acetate fractions from the partition of seeds and roots methanol extracts of Cenchrus echinatus L. led to the isolation of three resveratrol-derived stilbenoids: pallidol (1), carasiphenol C (2) and nepalensinol B (3). The results of a topic anti-inflammatory evaluation, DPPH assay and antiproliferative activity against adenocarcinoma cells (Caco 2) are described.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Enhanced solid-state citric acid bio-production using apple pomace waste through surface response methodology

Authors: Dhillon, GS; Brar, SK; Verma, M; Tyagi, RD (In Press) Journal of Applied Microbiology. HERO ID: 1040250

[Less] Aims:  To evaluate the potential of apple pomace (AP) supplemented with rice husk for hyper citric acid . . . [More] Aims:  To evaluate the potential of apple pomace (AP) supplemented with rice husk for hyper citric acid production through solid-state fermentation by Aspergillus niger NRRL-567. Optimization of two key parameters, such as moisture content and inducer (ethanol and methanol) concentration was carried out by response surface methodology. Methods and Results:  In this study, the effect of two crucial process parameters for solid-state citric acid fermentation by A. niger using AP waste supplemented with rice husk were thoroughly investigated in Erlenmeyer flasks through response surface methodology. Moisture and methanol had significant positive effect on citric acid production by A. niger grown on AP (P < 0·05). Higher values of citric acid on AP by A. niger (342·41 g kg(-1) and 248·42 g kg(-1) dry substrate) were obtained with 75% (v/w) moisture along with two inducers [3% (v/w) methanol and 3% (v/w) ethanol] with fermentation efficiency of 93·90% and 66·42%, respectively depending upon the total carbon utilized after 144 h of incubation period. With the same optimized parameters, conventional tray fermentation was conducted. The citric acid concentration of 187·96 g kg(-1) dry substrate with 3% (v/w) ethanol and 303·34 g kg(-1) dry substrate with 3% (v/w) methanol were achieved representing fermentation efficiency of 50·80% and 82·89% in tray fermentation depending upon carbon utilization after 120 h of incubation period. Conclusions:  Apple pomace proved to be the promising substrate for the hyper production of citric acid through solid-state tray fermentation, which is an economical technique and does not require any sophisticated instrumentation. Significance and Impact of the Study:  The study established that the utilization of agro-industrial wastes have positive repercussions on the economy and will help to meet the increasing demands of citric acid and moreover will help to alleviate the environmental problems resulting from the disposal of agro-industrial wastes.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Polyunsaturated fats in meat from Merino, first- and second-cross sheep slaughtered as yearlings

Authors: Ponnampalam, EN; Hopkins, DL; Butler, KL; Dunshea, FR; Sinclair, AJ; Warner, RD (In Press) Meat Science. HERO ID: 1040933

[Less] This study examined the level of long chain omega-3 and omega-6 polyunsaturated fats, the ratio of polyunsaturated . . . [More] This study examined the level of long chain omega-3 and omega-6 polyunsaturated fats, the ratio of polyunsaturated fat to saturated fat (PUFA/SFA) and the ratio of omega-6 to omega-3 (n-6/n-3) fat in sheep grown under grazing conditions in Australia. The sheep genotypes used were Poll Dorset(growth)xBorder Leicester Merino (PDgxBLM), Poll Dorset(growth)xMerino (PDgxM), Poll Dorset(muscling)xMerino (PDmxM), Border LeicesterxMerino (BLxM) and MerinoxMerino (MxM). Loin muscles (Longissimus lumborum) collected from 40 ewe and wether sheep slaughtered at 14months of age were processed for fatty acid determination. After frozen storage, 20g samples were minced and a 7g homogenate was processed for muscle lipid extraction using a chloroform:methanol (2:1) procedure. There was an increase in PUFA/SFA as the proportion of Merino genetics increased in the progeny (second-cross<first-cross<Merino), but this was not shown in the n-6/n-3 ratio. The PUFA/SFA trend appeared to be associated with an increase in the level of total polyunsaturated fats, but not a decrease in the level of total saturated fats. The results demonstrate that there is a need to improve the PUFA/SFA content in first- and second-cross animals which are mainly used for meat production in Australia so as to maintain the healthy lipids in meat. Nutritional manipulation through feeding systems or selection of sires for greater heritability of omega-3 fat deposition may be suitable pathways to elevate the ratio of polyunsaturated fatty acids, and in particular omega-3.