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Methanol (Non-Cancer)

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The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Genome sequence of thermotolerant Bacillus methanolicus: features and regulation related to methylotrophy and production of L-lysine and L-glutamate from methanol

Authors: Heggeset, TM; Krog, A; Balzer, S; Wentzel, A; Ellingsen, TE; Brautaset, T (2012) Applied and Environmental Microbiology 78:5170-5181. HERO ID: 1444705

[Less] Bacillus methanolicus can utilize methanol as its sole carbon and energy source, and the scientific . . . [More] Bacillus methanolicus can utilize methanol as its sole carbon and energy source, and the scientific interest in this thermotolerant bacterium has focused largely on exploring its potential as a biocatalyst for the conversion of methanol into L-lysine and L-glutamate. We present here the genome sequences of the important B. methanolicus model strain MGA3 (ATCC 53907) and the alternative wild-type strain PB1 (NCIMB13113). The physiological diversity of these two strains was demonstrated by a comparative fed-batch methanol cultivation displaying highly different methanol consumption and respiration profiles, as well as major differences in their L-glutamate production levels (406 mmol liter(-1) and 11 mmol liter(-1), respectively). Both genomes are small (ca 3.4 Mbp) compared to those of other related bacilli, and MGA3 has two plasmids (pBM19 and pBM69), while PB1 has only one (pBM20). In particular, we focus here on genes representing biochemical pathways for methanol oxidation and concomitant formaldehyde assimilation and dissimilation, the important phosphoenol pyruvate/pyruvate anaplerotic node, the tricarboxylic acid cycle including the glyoxylate pathway, and the biosynthetic pathways for L-lysine and L-glutamate. Several unique findings were made, including the discovery of three different methanol dehydrogenase genes in each of the two B. methanolicus strains, and the genomic analyses were accompanied by gene expression studies. Our results provide new insight into a number of peculiar physiological and metabolic traits of B. methanolicus and open up possibilities for system-level metabolic engineering of this bacterium for the production of amino acids and other useful compounds from methanol.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Degradation of formaldehyde by advanced oxidation processes

Authors: Guimaraes, , JR; Turato Farah, CR; Maniero, MG; Fadini, PS (2012) Journal of Environmental Management 107:96-101. HERO ID: 1447381

[Less] The degradation of formaldehyde in an aqueous solution (400 mg L(-1)) was studied using photolysis, . . . [More] The degradation of formaldehyde in an aqueous solution (400 mg L(-1)) was studied using photolysis, peroxidation and advanced oxidation processes (UV/H(2)O(2), Fenton and photo-Fenton). Photolysis was the only process tested that did not reduce formaldehyde concentration; however, only advanced oxidation processes (AOPs) significantly decreased dissolved organic carbon (DOC). UV/H(2)O(2) and photo-Fenton AOPs were used to degrade formaldehyde at the highest concentrations (1200-12,000 mg L(-1)); the processes were able to reduce CH(2)O by 98% and DOC by 65%. Peroxidation with ultraviolet light (UV/H(2)O(2)) improved the efficiency of treatment of effluent from an anatomy laboratory. The effluent's CH(2)O content was reduced by 91%, DOC by 48%, COD by 46% and BOD by 53% in 420 min of testing.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Validation of a multiparameter flow cytometry method for the determination of phosphorylated extracellular-signal-regulated kinase and DNA in circulating tumor cells

Authors: Pluim, D; Devriese, L; Beijnen, J; Schellens, J (2012) Cytometry. Part A 81A:664-671. HERO ID: 1451397

[Less] A simple, selective, and sensitive multiparameter fluorescence activated cell sorting method utilizing . . . [More] A simple, selective, and sensitive multiparameter fluorescence activated cell sorting method utilizing density gradient centrifugation and magnetic antibody cell sorting was developed and validated for the determination of phosphorylated extracellular-signal-regulated kinase (pERK) and DNA in circulating tumor cells (CTCs). Cell preparation tubes (CPT) were used for peripheral blood collection and density gradient centrifugation, followed by phosphorylation of ERK with epidermal growth factor (EGF). After fixation with formaldehyde and methanol, magnetic anti epithelial cell adhesion molecule (EpCAM) micro-beads were used for the selective isolation of CTCs from the background, consisting of peripheral blood mononuclear cells and platelets. Subsequently, samples were stained with Hoechst 33342, and fluorescent antibodies against EpCAM, CD45, and pERK. Flow cytometry was used for identification and enumeration of CTCs and determination of their pERK and DNA content. The validation parameters included specificity, recovery, linearity, precision, sensitivity, and stability. The lower limit of quantification was two CTCs per 8 ml peripheral blood. Samples were stable for 4 months in storage at -80 degrees C. The applicability of the method was demonstrated by successful enumeration of CTCs, and the determination of DNA, and pERK before and after stimulation with EGF in 8 ml peripheral blood samples from patients with metastatic cancer. (c) 2012 International Society for Advancement of Cytometry

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Complete Quantitative Online Analysis of Methanol Electrooxidation Products via Electron Impact and Electrospray Ionization Mass Spectrometry

Authors: Zhao, Wei; Jusys, Z; Behm, RJ (2012) HERO ID: 1453597

[Less] We report on a novel approach for complete quantitative online product analysis in electrocatalytic . . . [More] We report on a novel approach for complete quantitative online product analysis in electrocatalytic reactions, combining electron impact ionization mass spectrometry (EI-MS) and electrospray ionization mass spectrometry (ESI-MS) for simultaneous detection of both volatile and nonvolatile reaction products. The potential of this method is demonstrated using continuous methanol oxidation in a flow cell. The overall reaction rate was followed via the Faradaic current; CO2 formation was monitored mass spectrometrically via a membrane inlet system, and formaldehyde and formic acid were detected by ESI-MS after a derivatization-extraction-separation procedure introduced recently (Zhao, W.; Jusys, Z.; Behm, R. J. Anal. Chem. 2010, 82, 2472-2479) providing quantitative data on the product distribution. In a more general sense, this approach is applicable for a wide range of reactions at the solid-liquid interface or in liquid phase.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Combinatorial Effects of Charge Characteristics and Hydrophobicity of Silk Fibroin on the Sorption and Release of Charged Dyes

Authors: Wongpanit, P; Rujiravanit, R (2011) Journal of Biomaterials Science, Polymer Edition. HERO ID: 1050990

[Less] The present study was designed to examine the influence of the charge characteristics of silk fibroin . . . [More] The present study was designed to examine the influence of the charge characteristics of silk fibroin on the sorption and release of charged dyes by varying the pH values of the sorption and release media as well as types of charged dyes. Negatively charged dyes (phenol red and chromotrope 2R) and positively charged dyes (crystal violet and indoine blue) were used as the model compounds. Silk fibroin films were prepared by using a solution casting technique. The prepared films were then treated with an aqueous methanol solution or annealed with water to control their conformation. The sorption behavior of the model compounds made by the methanol-treated and water-annealed silk fibroin films was investigated. Compared to the water-annealed silk fibroin films, a higher hydrophobicity of the methanol-treated silk fibroin films caused a higher sorption of the hydrophobic dyes. The dye molecules had a fairly high affinity to the silk fibroin film, even though the dye and the matrix possessed the same charge. However, in the presence of two charged groups in a single dye molecule, the electrostatic repulsion become more dominant. Stronger interaction was observed when the charges of the film and the dye were opposite. The results of dye sorption and release experiments showed that the degree of synergism or competition between electrostatic and hydrophobic interactions directly depended on the charges and chemical structure of the dye molecules and the environmental pH conditions of the existing silk fibroin film.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Improvement of dispersion state and charge separation efficiency of hybrid films of ZnO nanoparticle/conjugated polymers by utilizing methanol as a volatile dispersant

Authors: Tanita Hirunprateep; Nisanart Traiphol; Ruttayapon Potai; Rakchart Traiphol (2011) Synthetic Metals. HERO ID: 1000519

[Less] This contribution introduces an efficient method for fabricating hybrid films of ZnO nanoparticle/conjugated . . . [More] This contribution introduces an efficient method for fabricating hybrid films of ZnO nanoparticle/conjugated polymers with improved charge separation efficiency. Methanol is utilized as a volatile dispersant for promoting the dispersion of ZnO nanoparticles in chlorobenzene. The increase of methanol concentration from 0 to 20% (v/v) results in systematic improvement of the particle dispersion. The suspensions of ZnO nanoparticles in these solvents are used to prepare hybrid films of poly[2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) and regioregular poly(3-hexylthiophene) (P3HT). The morphologies and optical properties of the hybrid films, prepared by spin casting, are investigated by atomic force microscopy, UV/vis absorption and photoluminescence (PL) spectroscopy. The hybrid films obtained from all systems are continuous and exhibit relatively smooth surface. The extent of polymeric chain aggregation in the hybrid films is hardly affected by the variation of solvent. However, the drop of about 60% of PL intensity is detected when the methanol is added into ZnO/MEH-PPV solution prior to the film preparation. The drastic decrease of PL intensity indicates significant improvement of charge separation efficiency in the hybrid films. The investigation of ZnO/P3HT hybrid films shows consistent results. Our approach is very efficient because the methanol completely evaporates during the fabrication of hybrid film.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The promoting effect of adsorbed carbon monoxide on the oxidation of alcohols on a gold catalyst

Authors: Rodriguez, P; Kwon, Y; Koper, MT (2011) Nature Chemistry 4:177-182. HERO ID: 1038088

[Less] In heterogeneous catalysis and electrocatalysis, adsorbed carbon monoxide typically acts as a poison . . . [More] In heterogeneous catalysis and electrocatalysis, adsorbed carbon monoxide typically acts as a poison or poisoning intermediate in the oxidation of alcohols. However, gold as an (electro)catalyst often exhibits unexpected properties. Here we show that carbon monoxide irreversibly adsorbed on a Au(111) surface in aqueous alkaline media can act as a promoter for the electrocatalytic oxidation of certain alcohols, in particular methanol. In comparison with bare Au(111), the onset potential for methanol oxidation is significantly lower in the presence of adsorbed CO, and formation of the main methanol oxidation products-formaldehyde and formic acid-is enhanced. By studying the effect of adsorbed CO on the oxidation of other alcohols on gold, we conclude that the presence of adsorbed CO promotes beta-hydrogen elimination, that is, C-H bond breaking. Apart from its importance to gold catalysis, this is an unanticipated example of promotion effects by co-adsorbed small molecules in electrocatalysis.