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ETBE

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181 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Optimal design and effective control of the tent-amyl methyl ether production process using an integrated reactive dividing wall and pressure swing columns

Authors: Yang, Ao; Lv, L; Shen, W; Dong, L; Li, Jie; Xiao, Xin (2017) Industrial and Engineering Chemistry Research 56:14565-14581. HERO ID: 4662554

[Less] Design of the tert-amyl methyl ether (TAME) production process has received much attention because TAME . . . [More] Design of the tert-amyl methyl ether (TAME) production process has received much attention because TAME is an important oxygenated gasoline additive with much fewer environmental and health issues than methyl tert-butyl ether. Although a reactive dividing wall column where reaction and separation take place in one vessel has been developed with less capital and operating cost, little work on its application to TAME production has been reported. In this paper, we propose a new overall procedure for optimal design of the TAME production process through an integrated reactive dividing wall and pressure swing columns, which includes screening of the best dividing wall configuration, thermodynamic feasible insight, and process simulation and optimization using the sensitivity analysis tool in Aspen Plus. The computational results demonstrate that the optimal design of the TAME production process through an integrated reactive dividing wall and pressure swing column is successfully obtained to achieve desired TAME purity of 99.958 mol %, significantly reducing the total annualized cost by 43.58% and decreasing the exergy loss by 48.24% compared to the existing TAME production process using reactive distillation. Finally, an effective control strategy including tray temperature control is proposed to ensure the operating conditions are well controlled at or close to their set points in a desired time when disturbances occur.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Physiological and genetic screening methods for the isolation of methyl tert-butyl ether-degrading bacteria for bioremediation purposes

Authors: Guisado, IM; Purswani, J; Gonzalez-Lopez, J; Pozo, C (2015) HERO ID: 2849963

[Less] Bioremediation of groundwater contaminated with methyl tert-butyl ether (MTBE) has been widely described . . . [More] Bioremediation of groundwater contaminated with methyl tert-butyl ether (MTBE) has been widely described since their cost/efficient ratios are lower than other physic-chemical methodologies. The present study focused on the isolation and selection of MTBE degrading microorganisms from contaminated soil and groundwater samples based on results from growth on mineral media amended with MTBE and BTEX, presence or absence of the monooxygenase genes and specific ability to degrade MTBE. Three bacterial strains were selected and identified as Rhodococcus ruber, strains EE1 (CECT 8555), EE6 (CECT 8612) and A5 (CECT 8556), showing the ability to degrade 60.0, 36.0 and '10.0 mg l(-1) MTBE, respectively. Moreover, all the R. ruber strains showed the presence of genes encoding MTBE-degrading enzymes. One isolated strain was identified as Paenibacillus sp. SH7 (CECT 8558) and demonstrated the greatest MTBE degradation value (100 mg l(-1)), but together with the last strain selected and identified as Agrobacterium sp. MS2 (CECT 8557) did not result in positive amplification of any of the monooxygenase primers tested. The lowest toxicity (as EC50) was observed after 4-days growth of R. ruber EE6 on MTBE-supplemented mineral medium. The potential application of these strains in bioremediation processes is discussed. (C) 2014 Elsevier Ltd. All rights reserved.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Molecular structure and thermal stability of the oxide-supported phosphotungstic Wells-Dawson heteropolyacid

Authors: Matkovic, SR; Collins, SE; Bonivardi, AL; Banares, MA; Briand, LE (2015) HERO ID: 2849959

[Less] We present, for the first time in the literature, a systematic study of the molecular structure of the . . . [More] We present, for the first time in the literature, a systematic study of the molecular structure of the Wells-Dawson heteropolyacid H6P2W18O62 center dot 24H(2)O (HPA) dispersed on TiO2, SiO2, ZrO2 and Al2O3. The heteropolyacid-based materials were synthesized through a conventional impregnation method (in aqueous and ethanol media) at a loading that corresponds to the theoretical "monolayer'' coverage (dispersion limit loading). The combination of Raman and infrared studies demonstrates the presence of crystals of HPA (regardless of the nature of the medium used during the synthesis) suggesting that the dispersion limit loading was greatly exceeded. In situ temperature programmed spectroscopy analyses demonstrated that the Raman shift of the distinctive W=O Raman mode of the phosphotungstic Wells-Dawson heteropolyacid is sensitive to the local environment, that is, the amount of water molecules associated with the structure. Moreover, the aqueous based species associated with such structures are recognizable through infrared spectroscopy.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Novel antioxidant capacity assay for lipophilic compounds using electron paramagnetic resonance spectroscopy

Authors: Takahashi, Y; Ichimori, K; Okano, M; Goto, H (2015) HERO ID: 2849947

[Less] A novel antioxidant capacity assay for lipophilic compounds was developed using electron paramagnetic . . . [More] A novel antioxidant capacity assay for lipophilic compounds was developed using electron paramagnetic resonance (EPR) spectroscopy. The assay is based on antioxidant's scavenging ability against the tert-butoxyl radical generated photolytically from di-tert-butyl peroxide in ethyl acetate, and named the tert-butoxyl-based antioxidant capacity (BAC) assay. The radical was trapped by spin trap, 5,5-dimethyl-1-pyrroline-N-oxide, and EPR signal intensity of the spin adduct was used as a quantitative marker of radical levels. Signal intensity decreased in a dose-dependent manner in the presence of an antioxidant that competitively reacts with the radical, which was utilized to evaluate BAC values. The BAC method enabled the accurate estimation of antioxidant capacity for lipophilic materials that may counteract lipid peroxidation in biological membranes. The BAC values for quercetin and caffeic acid are 0.639 ± 0.020 and 0.118 ± 0.012 trolox equivalents, respectively, which are much smaller than values obtained by other aqueous methods such as H-ORAC and ORAC-EPR. Thus, antioxidants present in a non-aqueous environment should be evaluated using a non-aqueous system. In combination with in situ ascorbate reduction, the BAC method was capable of accurately determining the antioxidant capacity of water-insoluble materials that may be reduced in living cells.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Gastroprotective activity of ethyl-4-[(3,5-di-tert-butyl-2-hydroxybenzylidene) amino]benzoate against ethanol-induced gastric mucosal ulcer in rats

Authors: Halabi, MF; Shakir, RM; Bardi, DA; Al-Wajeeh, NS; Ablat, A; Hassandarvish, P; Hajrezaie, M; Norazit, A; Abdulla, MA (2014) PLoS ONE 9:e95908. HERO ID: 2367099

[Less] BACKGROUND: The study was carried out to determine the cytotoxic, antioxidant and gastro-protective . . . [More] BACKGROUND: The study was carried out to determine the cytotoxic, antioxidant and gastro-protective effect of ethyl-4-[(3,5-di-tert-butyl-2-hydroxybenzylid ene)amino] benzoate (ETHAB) in rats.

METHODOLOGY/PRINCIPAL FINDINGS: The cytotoxic effect of ETHAB was assessed using a MTT cleavage assay on a WRL68 cell line, while its antioxidant activity was evaluated in vitro. In the anti-ulcer study, rats were divided into six groups. Group 1 and group 2 received 10% Tween 20 (vehicle). Group 3 received 20 mg/kg Omeprazole. Groups 4, 5 and 6 received ETHAB at doses of 5, 10, and 20 mg/kg, respectively. After an hour, group 1 received the vehicle. Groups 2-6 received absolute ethanol to induce gastric mucosal lesions. In the WRL68 cell line, an IC50 of more than 100 µg/mL was observed. ETHAB results showed antioxidant activity in the DPPH, FRAP, nitric oxide and metal chelating assays. There was no acute toxicity even at the highest dosage (1000 mg/kg). Microscopy showed that rats pretreated with ETHAB revealed protection of gastric mucosa as ascertained by significant increases in superoxide dismutase (SOD), pH level, mucus secretion, reduced gastric lesions, malondialdehyde (MDA) level and remarkable flattened gastric mucosa. Histologically, pretreatment with ETHAB resulted in comparatively better gastric protection, due to reduction of submucosal edema with leucocyte infiltration. PAS staining showed increased intensity in uptake of Alcian blue. In terms of immunohistochemistry, ETHAB showed down-expression of Bax proteins and over-expression of Hsp70 proteins.

CONCLUSION/SIGNIFICANCE: The gastroprotective effect of ETHAB may be attributed to antioxidant activity, increased gastric wall mucus, pH level of gastric contents, SOD activity, decrease in MDA level, ulcer area, flattening of gastric mucosa, reduction of edema and leucocyte infiltration of the submucosal layer, increased PAS staining, up-regulation of Hsp70 protein and suppressed expression of Bax.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The carbomethylation of arylacrylamides leading to 3-ethyl-3-substituted indolin-2-one by cascade radical addition/cyclization

Authors: Dai, Q; Yu, J; Jiang, Y; Guo, S; Yang, H; Cheng, J (2014) HERO ID: 2849943

[Less] An FeCl2-promoted carbomethylation of arylacrylamides by di-tert-butyl peroxide (DTBP) is achieved, . . . [More] An FeCl2-promoted carbomethylation of arylacrylamides by di-tert-butyl peroxide (DTBP) is achieved, leading to 3-ethyl-3-substituted indolin-2-one in high yield. The reaction tolerates a series of functional groups, such as cyano, nitro, ethyloxy carbonyl, bromo, chloro, and trifluoromethyl groups. The radical methylation and arylation of the alkenyl group are involved in this reaction.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Syntheses of thiol and selenol esters by oxidative coupling reaction of aldehydes with RYYR (Y = S, Se) under metal-free conditions

Authors: He, C; Qian, X; Sun, P (2014) HERO ID: 2849951

[Less] Thiol and selenol esters were synthesized by a direct oxidative coupling reaction of aldehydes with . . . [More] Thiol and selenol esters were synthesized by a direct oxidative coupling reaction of aldehydes with disulfides or diselenides in ethyl acetate under metal-free conditions. Among the oxidants examined, tert-butyl peroxide (TBP) was shown to give the best results. For the substrates with both electron-donating and electron-withdrawing substituents, the reaction proceeded smoothly and gave moderate to good yields. Compared with the previous method, the present route is very simple, atom-economical and environmentally friendly.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

1-(1H-Indol-3-yl)ethanamine Derivatives as Potent Staphylococcus aureus NorA Efflux Pump Inhibitors

Authors: Hequet, A; Burchak, ON; Jeanty, M; Guinchard, X; Le Pihive, E; Maigre, L; Bouhours, P; Schneider, D; Maurin, M; Paris, JM; Denis, JN; Jolivalt, C (2014) ChemMedChem. HERO ID: 2321095

[Less] The synthesis of 37 1-(1H-indol-3-yl)ethanamine derivatives, including 12 new compounds, was achieved . . . [More] The synthesis of 37 1-(1H-indol-3-yl)ethanamine derivatives, including 12 new compounds, was achieved through a series of simple and efficient chemical modifications. These indole derivatives displayed modest or no intrinsic anti-staphylococcal activity. By contrast, several of the compounds restored, in a concentration-dependent manner, the antibacterial activity of ciprofloxacin against Staphylococcus aureus strains that were resistant to fluoroquinolones due to overexpression of the NorA efflux pump. Structure-activity relationships studies revealed that the indolic aldonitrones halogenated at position 5 of the indole core were the most efficient inhibitors of the S. aureus NorA efflux pump. Among the compounds, (Z)-N-benzylidene-2-(tert-butoxycarbonylamino)-1-(5-iodo-1H-indol-3-yl)ethanamine oxide led to a fourfold decrease of the ciprofloxacin minimum inhibitory concentration against the SA-1199B strain when used at a concentration of 0.5 mg L(-1) . To the best of our knowledge, this activity is the highest reported to date for an indolic NorA inhibitor. In addition, a new antibacterial compound, tert-butyl (2-(3-hydroxyureido)-2-(1H-indol-3-yl)ethyl)carbamate, which is not toxic for human cells, was also found.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

Authors: Basavapathruni, A; Olhava, EJ; Daigle, SR; Therkelsen, CA; Jin, L; Boriack-Sjodin, PA; Allain, CJ; Klaus, CR; Raimondi, A; Scott, MP; Dovletoglou, A; Richon, VM; Pollock, RM; Copeland, RA; Moyer, MP; Chesworth, R; Pearson, PG; Waters, NJ (2014) Biopharmaceutics and Drug Disposition. HERO ID: 2321106

[Less] EPZ-5676 ((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol) . . . [More] EPZ-5676 ((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol) is a novel DOT1L histone methyltransferase inhibitor currently in clinical development for the treatment of MLL-rearranged leukemias. In this report, we describe the preclinical pharmacokinetics and metabolism of EPZ-5676, an aminonucleoside analog with exquisite target potency and selectivity that has shown robust and durable tumor growth inhibition in preclinical models. The in vivo pharmacokinetics in mouse, rat and dog were characterized following IV and PO administration; EPZ-5676 had moderate to high clearance, low oral bioavailability with a steady-state volume of distribution 2-3 fold higher than total body water. EPZ-5676 showed biexponential kinetics following IV administration, giving rise to terminal t1/2 of 1.1, 3.7 and 13.6 h in mouse, rat and dog respectively. Corresponding in vitro ADME parameters were also studied and utilized for in vitro - in vivo extrapolation purposes. There was good agreement between microsomal clearance and in vivo clearance implicating hepatic oxidative metabolism as the predominant elimination route in preclinical species. Furthermore, low renal clearance was observed in mouse, approximating to fu-corrected GFR and thus passive glomerular filtration. The metabolic pathways across species were studied in liver microsomes in which EPZ-5676 was metabolized to three monohydroxylated metabolites (M1, M3 and M5), one N-dealkylated product (M4) as well as an N-oxide (M6). This article is protected by copyright. All rights reserved.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Bifurcation analysis of dynamic process models using Aspen Dynamics (R) and Aspen Custom Modeler (R)

Authors: Restrepo, JB; Olivar, G; Cardona, CA (2014) Computers & Chemical Engineering 62:10-20. HERO ID: 2321113