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Nanoscale Carbon

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334 References Were Found:

Data/Software
Data/ Software

ChemIDplus - a TOXNET database

Author: ChemIDplus (2018) National Institutes of Health, U.S. Library of Medicine. HERO ID: 4235826


Data/Software
Data/ Software

ChemIDplus - a TOXNET database

Author: NLM (2016) Bethesda, MD: National Institutes of Health, U.S. Library of Medicine. HERO ID: 2991424


Technical Report
Technical Report

Multi-Walled Carbon Nanotubes (MWCNT), synthetic graphite in tubular shape

Author: ECHA (2013) European Chemicals Agency. HERO ID: 1578615


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems

Authors: Kato, T; Totsuka, Y; Ishino, K; Matsumoto, Y; Tada, Y; Nakae, D; Goto, S; Masuda, S; Ogo, S; Kawanishi, M; Yagi, T; Matsuda, T; Watanabe, M; Wakabayashi, K (2013) Nanotoxicology 7:452-461. HERO ID: 1071837

[Less] Abstract The genotoxic effects of multi-walled carbon nanotubes (MWCNTs) were examined by using in vitro . . . [More] Abstract The genotoxic effects of multi-walled carbon nanotubes (MWCNTs) were examined by using in vitro and in vivo assays. MWCNTs significantly induced micronuclei in A549 cells and enhanced the frequency of sister chromatid exchange (SCE) in CHO AA8 cells. When ICR mice were intratracheally instilled with a single dose (0.05 or 0.2 mg/animal) of MWCNTs, DNA damage of the lungs, analysed by comet assay, increased in a dose-dependent manner. Moreover, DNA oxidative damage, indicated by 8-oxo-7,8-dihydro-2'-deoxyguanosine and heptanone etheno-deoxyribonucleosides, occurred in the lungs of MWCNT-exposed mice. The gpt mutation frequencies significantly increased in the lungs of MWCNT-treated gpt delta transgenic mice. Transversions were predominant, and G:C to C:G was clearly increased by MWCNTs. Moreover, many regions immunohistochemically stained for inducible NO synthase and nitrotyrosine were observed in the lungs of MWCNT-exposed mice. Overall, MWCNTs were shown to be genotoxic both in in vitro and in vivo tests; the mechanisms probably involve oxidative stress and inflammatory responses.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

Authors: Nel, A; Xia, T; Meng, H; Wang, X; Lin, S; Ji, Z; Zhang, H (2013) Accounts of Chemical Research 46:607-621. HERO ID: 1239939

[Less] The production of engineered nanomaterials (ENMs) is a sci-entific breakthrough in material design and . . . [More] The production of engineered nanomaterials (ENMs) is a sci-entific breakthrough in material design and the development of new consumer products. While the successful implementation of nanotechnology is important for the growth of the global economy, we also need to consider the possible environmental health and safety (EHS) impact as a result of the novel physicochemical properties that could generate hazardous biological outcomes. In order to assess ENM hazard, reliable and reproducible screening approaches are needed to test the basic materials as well as nanoenabled products. A platform is required to investigate the potentially endless number of biophysicochemical interactions at the nano/bio interface, in response to which we have developed a predictive toxicological approach. We define a predictive toxicological approach as the use of mechanisms-based high-throughput screening in vitro to make predictions about the physicochemical properties of ENMs that may lead to the generation of pathology or disease outcomes in vivo. The in vivo results are used to validate and improve the in vitro high-throughput screening (HTS) and to establish structure-activity relationships (SARs) that allow hazard ranking and modeling by an appropriate combination of in vitro and in vivo testing. This notion is in agreement with the landmark 2007 report from the US National Academy of Sciences, "Toxicity Testing in the 21st Century: A Vision and a Strategy" ( http://www.nap.edu/catalog.php?record_id=11970 ), which advocates increased efficiency of toxicity testing by transitioning from qualitative, descriptive animal testing to quantitative, mechanistic, and pathway-based toxicity testing in human cells or cell lines using high-throughput approaches. Accordingly, we have implemented HTS approaches to screen compositional and combinatorial ENM libraries to develop hazard ranking and structure-activity relationships that can be used for predicting in vivo injury outcomes. This predictive approach allows the bulk of the screening analysis and high-volume data generation to be carried out in vitro, following which limited, but critical, validation studies are carried out in animals or whole organisms. Risk reduction in the exposed human or environmental populations can then focus on limiting or avoiding exposures that trigger these toxicological responses as well as implementing safer design of potentially hazardous ENMs. In this Account, we review the tools required for establishing predictive toxicology paradigms to assess inhalation and environmental toxicological scenarios through the use of compositional and combinatorial ENM libraries, mechanism-based HTS assays, hazard ranking, and development of nano-SARs. We will discuss the major injury paradigms that have emerged based on specific ENM properties, as well as describing the safer design of ZnO nanoparticles based on characterization of dissolution chemistry as a major predictor of toxicity.

Archival Material
Archival Material

Marina: Managing risks of nanomaterials

Author: IOM (2013) HERO ID: 1592174

[Less] The aim of MARINA is to develop and validate the Risk Management Methods for Nanomaterials. To do . . . [More] The aim of MARINA is to develop and validate the Risk Management Methods for Nanomaterials.

To do this, MARINA will address the four central themes for the Risk Assessment and Management of Nanomaterials: Materials, Exposure, Hazard, and Risk. In MARINA we will develop beyond state-of-the-art referential tools from each of these themes and integrate them into a Risk Management Toolbox and Strategy for both human and environmental health.

There is a need to evaluate and develop specific reference methods for all the fundamental steps in managing the potential risk of ENM. The methods must be integrated in an overarching, coherent strategy for regulators and industry to adapt them. Thus, a safe and environmentally responsible nanotechnology will safeguard current and future global investments and will be the key to the sustainability of this industry.

Archival Material
Archival Material

Ecological State of the Science Report on decabromodiphenyl ether (decaBDE): Summary

Author: Environment Canada (2013) Available online at https://www.canada.ca/en/environment-climate-change/services/canadian-environmental-protection-act-registry/publications/ecological-state-science-report-decabromodiphenyl.html. [Website] HERO ID: 4158871

Abstract: Table of contents for EC SOS on Decabromodiphenyl Ether (decaBDE)

Technical Report
Technical Report

Flame retardants: Textile finishes for flame resistant fabrics

Author: Textile Exchange (2012) HERO ID: 1065584


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice

Authors: Fujitani, T; Ohyama, K; Hirose, A; Nishimura, T; Nakae, D; Ogata, A (2012) Journal of Toxicological Sciences 37:81-89. HERO ID: 1071956

[Less] A possible teratogenicity of multi-wall carbon nanotube (MWCNT) was assessed using ICR mice. MWCNTs . . . [More] A possible teratogenicity of multi-wall carbon nanotube (MWCNT) was assessed using ICR mice. MWCNTs were suspended in 2% carboxymethyl cellulose and given intraperitoneally or intra-tracheally to pregnant ICR mice on day 9 of the gestation. All fetuses were removed from the uterus on day 18 of the gestation, and were examined for external and skeletal anomalies. In the intraperitoneal study, various types of malformation were observed in all MWCNT-treated groups (2, 3, 4 and 5 mg/kg body weight, intraperitoneal). In contrast, such malformations were observed in groups given 4 or 5 mg/kg body weight, but not in that treated with 3 mg/kg in the intratracheal study. In either study, the number of litters having fetuses with external malformation and that of litters having fetuses with skeletal malformations were both increased in proportion to the doses of MWCNT. The present results are the first to report that MWCNT possesses the teratogenicity at least under the present experimental conditions. Mechanism(s) to result such malformations is yet unclear and further experiment is necessary.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Different cellular response mechanisms contribute to the length-dependent cytotoxicity of multi-walled carbon nanotubes

Authors: Liu, D; Wang, L; Wang, Z; Cuschieri, A (2012) HERO ID: 1325230

[Less] To date, there has not been an agreement on the best methods for the characterisation of multi-walled . . . [More] To date, there has not been an agreement on the best methods for the characterisation of multi-walled carbon nanotube (MWCNT) toxicity. The length of MWCNTs has been identified as a factor in in vitro and in vivo studies, in addition to their purity and biocompatible coating. Another unresolved issue relates to the variable toxicity of MWCNTs on different cell types. The present study addressed the effects of MWCNTs' length on mammalian immune and epithelial cancer cells RAW264.7 and MCF-7, respectively. Our data confirm that MWCNTs induce cytotoxicity in a length- and cell type-dependent manner. Whereas, longer (3 to 14 μm) MWCNTs exert high toxicity, especially to RAW264.7 cells, shorter (1.5 μm) MWCNTs are significantly less cytotoxic. These findings confirm that the degree of biocompatibility of MWCNTs is closely related to their length and that immune cells appear to be more susceptible to damage by MWCNTs. Our study also indicates that MWCNT nanotoxicity should be analysed for various components of cellular response, and cytotoxicity data should be validated by the use of more than one assay system. Results from chromogenic-based assays should be confirmed by trypan blue exclusion.