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Methanol (Non-Cancer)

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The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Controlling Size, Amount, and Crystalline Structure of Nanoparticles Deposited on Graphenes for Highly Efficient Energy Conversion and Storage

Authors: Choi, BG; Park, HS (In Press) ChemSusChem. HERO ID: 1037655

[Less] A facilitated electrochemical reaction at the surface of electrodes is crucial for highly efficient . . . [More] A facilitated electrochemical reaction at the surface of electrodes is crucial for highly efficient energy conversion and storage. Herein, various nanoparticles (NPs) including Au, Pt, Pd, Ru, and RuO(2) , were synthesized in situ and directly deposited on the ionic liquid (IL)-functionalized reduced graphene oxides (RGOs) in a controlled manner. The size, amount, and crystalline structures of discrete NPs were readily controlled, giving rise to enhanced methanol oxidation and pseudocapacitance. The well-defined nanostructure of decorated NPs and the favorable interaction between ILs and RGOs (or NPs) facilitated the electrochemical reaction, where NPs acted as electrocatalysts for energy conversion and played the role of redox-active electrodes for energy storage.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Electronic Modulation of a Copper/Zinc Oxide Catalyst by a Heterojunction for Selective Hydrogenation of Carbon Dioxide to Methanol

Authors: Liao, F; Zeng, Z; Eley, C; Lu, Q; Hong, X; Tsang, SC (In Press) Angewandte Chemie (International Edition). HERO ID: 1037709

[Less] Methanol from CO(2) : For the hydrogenation of carbon dioxide a marked increase in the methanol selectivity . . . [More] Methanol from CO(2) : For the hydrogenation of carbon dioxide a marked increase in the methanol selectivity was observed when the reaction was catalyzed by Cu/rod-shaped ZnO/CdSe with heterojunction structure. Diffusion reflectance, photoluminescence, and ESR spectroscopies clearly indicated an increase in the electron density because of the incorporation of CdSe in the core-shell morphology of Cu/rod-shaped ZnO.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Observation of Methanol Behavior in Fuel Cells In Situ by NMR Spectroscopy

Authors: Han, OH; Han, KS; Shin, CW; Lee, J; Kim, SS; Um, MS; Joh, HI; Kim, SK; Ha, HY (In Press) Angewandte Chemie (International Edition). HERO ID: 1037739

[Less] The chemical conversion of methanol in direct methanol fuel cells was followed in situ by NMR spectroscopy. . . . [More] The chemical conversion of methanol in direct methanol fuel cells was followed in situ by NMR spectroscopy. Comparing data of the methanol oxidation on Pt and PtRu anode catalysts allowed the role of Ru in both Faradaic and non-Faradaic reactions to be investigated. The spatial distributions of chemicals could also be determined. (Picture: T1-T4=inlet and outlet tubes.).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Radical-mediated nitrile translocation as the key step in the stereoselective transformation of 2-(4-chloro-2-cyanobutyl)aziridines to methyl cis-(1-arylmethyl-4-phenylpiperidin-2-yl)acetates

Authors: Vervisch, K; D'hooghe, M; Törnroos, KW; De Kimpe, N (In Press) Organic and Biomolecular Chemistry. HERO ID: 1037740

[Less] Non-activated 2-(4-chloro-2-cyano-2-phenylbutyl)aziridines were used as building blocks for the stereoselective . . . [More] Non-activated 2-(4-chloro-2-cyano-2-phenylbutyl)aziridines were used as building blocks for the stereoselective synthesis of novel cis-2-cyanomethyl-4-phenylpiperidines via a microwave-assisted aziridine to piperidine ring expansion followed by a radical-induced nitrile translocation through initial formation and subsequent cleavage of intermediate bicyclic iminyl radicals. Furthermore, these 2-(cyanomethyl)piperidines were shown to be eligible substrates for the preparation of methyl cis-(1-arylmethyl-4-piperidin-2-yl)acetates through a Pinner reaction using gaseous HCl in methanol.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Preparation and PEGylation of exendin-4 peptide secreted from yeast Pichia pastoris

Authors: Zhou, J; Cai, ZH; Li, L; Kou, C; Gao, YF (In Press) European Journal of Pharmaceutics and Biopharmaceutics. HERO ID: 1043501

[Less] Exendin-4, a peptide analogue of glucagon-like peptide (GLP-1), has been developed for treatment of . . . [More] Exendin-4, a peptide analogue of glucagon-like peptide (GLP-1), has been developed for treatment of type 2 diabetes. Herein, the secretive exendin-4 peptide, expressed by methanol induction in Pichia pastoris, was purified to near homogeneity by Ni-NTA agarose chromatography. 103.6 mg of protein was obtained from 1 L of the supernatant and its purity was 96.1%. Subsequently, the PEGylated exendin-4 was prepared. The bioactivity of exendin-4 was determined by examining the glucose-lowering and insulin-releasing ability in plasma. Then, a safety evaluation was performed by histological examination of the main organs (liver, kidney and pancreas). PEGylated exendin-4 displayed glucose-lowering and insulin-stimulating action in vivo without obvious damage to the above organs. The results suggest that the P. pastoris expression could be used to produce large quantities of exendin-4 and PEGylation is a useful tool to maintain and enhance bioactivity of the peptide.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Photo-degradation products of pramipexole

Authors: Nishimura, E; Kugimiya, A; Naoki, H; Hamanaka, N (In Press) Bioorganic and Medicinal Chemistry Letters. HERO ID: 1037692

[Less] Two pyrrolidine compounds (1 and 2) were isolated from photo-degradation of Bi-Sifrol tablets. Compound . . . [More] Two pyrrolidine compounds (1 and 2) were isolated from photo-degradation of Bi-Sifrol tablets. Compound 1 was esterified to p-bromophenacyl ester as single-crystal, and then the structure was elucidated by single-crystal X-ray study. Compound 2 was determined by 2D NMR and mass spectra. Otherwise, we established that the photo-degradation of pramipexole was smoothly carried out in the methanol solution, and elucidate the degradation mechanism.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

NMR assignment of the absolute configuration of C-25 in furostanol steroidal saponins

Authors: Challinor, VL; Piacente, S; De Voss, JJ (In Press) Steroids. HERO ID: 1038074

[Less] The chemical shifts of the geminal proton resonances of H(2)-26 (δ(a) and δ(b)) are a widely used predictor . . . [More] The chemical shifts of the geminal proton resonances of H(2)-26 (δ(a) and δ(b)) are a widely used predictor of C-25 stereochemistry in furostanol steroidal saponins, being in general more resolved in 25S than 25R compounds. Unexpectedly, we found that application of this empirical rule in different solvents led to conflicting assignments of stereochemistry. An experimental survey revealed that, while the chemical shifts of H(2)-26 exhibit a dependence on C-25 configuration, it is less pronounced in methanol-d(4) than pyridine-d(5) solvent, and thus the general rule derived for pyridine-d(5) fails when NMR spectra are acquired in methanol-d(4). We propose a modified empirical method for the direct assignment of C-25 stereochemistry in furostanol saponins in methanol-d(4) (Δ(ab)=0.45-0.48ppm for 25S; Δ(ab)=0.33-0.35ppm for 25R), and provide several detailed examples. In addition, the absolute configuration of compound 8, a steroidal saponin isolated in previous work from Ruscus colchicus, is corrected from 25R to 25S stereochemistry.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Stabilization of High-Valence Ruthenium with Silicotungstate Ligands: Preparation, Structural Characterization, and Redox Studies of Ruthenium(III)-Substituted α-Keggin-Type Silicotungstates with Pyridine Ligands, [SiW(11) O(39) Ru(III) (Py)](5-)

Authors: Sadakane, M; Moroi, S; Iimuro, Y; Izarova, N; Kortz, U; Hayakawa, S; Kato, K; Ogo, S; Ide, Y; Ueda, W; Sano, T (In Press) Chemistry - An Asian Journal. HERO ID: 1038308

[Less] Ruthenium(III)-substituted α-Keggin-type silicotungstates with pyridine-based ligands, [SiW(11) O(39) . . . [More] Ruthenium(III)-substituted α-Keggin-type silicotungstates with pyridine-based ligands, [SiW(11) O(39) Ru(III) (Py)](5-) , (Py: pyridine (1), 4-pyridine-carboxylic acid (2), 4,4'-bipyridine (3), 4-pyridine-acetamide (4), and 4-pyridine-methanol (5)) were prepared by reacting [SiW(11) O(39) Ru(III) (H(2) O)](5-) with the pyridine derivatives in water at 80 °C and then isolated as their hydrated cesium salts. These compounds were characterized using cyclic voltammetry (CV), UV/Vis, IR, and (1) H NMR spectroscopy, elemental analysis, titration, and X-ray absorption near-edge structure (XANES) analysis (Ru K-edge and L(3) -edge). Single-crystal X-ray analysis of compounds 2, 3, and 4 revealed that Ru(III) was incorporated in the α-Keggin framework and was coordinated by pyridine derivatives through a RuN bond. In the solid state, compounds 2 and 3 formed a dimer through ππ interaction of the pyridine moieties, whereas they existed as monomers in solution. CV indicated that the incorporated Ru(III) -Py was reversibly oxidized into the Ru(IV) -Py derivative and reduced into the Ru(II) -Py derivative.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Evaluation of medicinal plant extracts and isolated compound epicatechin from Ricinus communis against Paramphistomum cervi

Authors: Zahir, AA; Rahuman, AA; Bagavan, A; Geetha, K; Kamaraj, C; Elango, G (In Press) Parasitology Research. HERO ID: 1047232

[Less] The purpose of this study is to determine the efficacies of hexane, chloroform, ethyl acetate, acetone, . . . [More] The purpose of this study is to determine the efficacies of hexane, chloroform, ethyl acetate, acetone, and methanol leaf extracts of Euphorbia hirta L., Psidium guajava L., Ricinus communis L., Solanum trilobatum L., and Tridax procumbens L. against sheep fluke Paramphistomum cervi (Digenea: Paramphistomatidae). All plant extracts showed moderate effects after 24 h of exposure; however, the highest parasite mortality was found in the methanol extract of R. communis. In the present study, bioassay-guided fractionation of methanol extract of R. communis led to the separation and identification of epicatechin as a potential new compound (LC(50) = 31.2; LC(90) = 105.0 ppm) against P. cervi. The structures were established from infrared, ultraviolet, (1)H-nuclear magnetic resonance (NMR), (13)C-NMR, and mass spectral data which confirmed the identification of the compound epicatechin from R. communis. Results of this study showed that the methanol extract of R. communis may be considered as a potent source and epicatechin as a new natural parasitic agent.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Pomegranate extract demonstrate a selective estrogen receptor modulator profile in human tumor cell lines and in vivo models of estrogen deprivation

Authors: Sreeja, S; Santhosh Kumar, TR; Lakshmi, BS; Sreeja, S (In Press) Journal of Nutritional Biochemistry. HERO ID: 1047242

[Less] Selective estrogen receptor modulators (SERMs) are estrogen receptor (ER) ligands exhibiting tissue-specific . . . [More] Selective estrogen receptor modulators (SERMs) are estrogen receptor (ER) ligands exhibiting tissue-specific agonistic or antagonistic biocharacter and are used in the hormonal therapy for estrogen-dependent breast cancers. Pomegranate fruit has been shown to exert antiproliferative effects on human breast cancer cells in vitro. In this study, we investigated the tissue-specific estrogenic/antiestrogenic activity of methanol extract of pericarp of pomegranate (PME). PME was evaluated for antiproliferative activity at 20-320 μg/ml on human breast (MCF-7, MDA MB-231) endometrial (HEC-1A), cervical (SiHa, HeLa), ovarian (SKOV3) carcinoma and normal breast fibroblast (MCF-10A) cells. Competitive radioactive binding studies were carried out to ascertain whether PME interacts with ER. The reporter gene assay measured the estrogenic/antiestrogenic activity of PME in MCF-7 and MDA MB-231 cells transiently transfected with plasmids coding estrogen response elements with a reporter gene (pG5-ERE-luc) and wild-type ERα (hEG0-ER). PME inhibited the binding of [(3)H] estradiol to ER and suppressed the growth and proliferation of ER-positive breast cancer cells. PME binds ER and down-regulated the transcription of estrogen-responsive reporter gene transfected into breast cancer cells. The expressions of selected estrogen-responsive genes were down-regulated by PME. Unlike 17β-estradiol [1 mg/kg body weight (BW)] and tamoxifen (10 mg/kg BW), PME (50 and 100 mg/kg BW) did not increase the uterine weight and proliferation in ovariectomized mice and its cardioprotective effects were comparable to that of 17β-estradiol. In conclusion, our findings suggest that PME displays a SERM profile and may have the potential for prevention of estrogen-dependent breast cancers with beneficial effects in other hormone-dependent tissues.