Health & Environmental Research Online (HERO)


Methanol (Non-Cancer)

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148 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Scientific considerations for evaluating cancer bioassays conducted by the Ramazzini Institute: Supplemental material

Authors: Gift, JS; Caldwell, JC; Jinot, J; Evans, MV; Cote, I; Vandenberg, JJ (In Press) Environmental Health Perspectives. [Supplemental Data] HERO ID: 1983208

Abstract: Table S1: RI Control Group Rates for Lymphoma/Leukemia and references.

Archival Material
Archival Material

NTP historical controls for NTP-2000 diet

Author: NTP (2013) HERO ID: 1239473


Archival Material
Archival Material

Istituto Ramazzini - cooperatia sociale onlus

Author: Istituto Ramazzini (2013) Available online at http://www.ramazzini.it/. [Website] HERO ID: 1597270


Archival Material
Archival Material

Istituto Ramazzini - cooperatia sociale onlus; Centro di Saggio Europa, European experimental laboratory

Author: Istituto Ramazzini (2013) Available online at http://www.ramazzini.it/centro_di_saggio/. [Website] HERO ID: 1597271


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Scientific considerations for evaluating cancer bioassays conducted by the Ramazzini Institute

Authors: Gift, JS; Caldwell, JC; Jinot, J; Evans, MV; Cote, I; Vandenberg, JJ (2013) Environmental Health Perspectives. HERO ID: 1983117

[Less] Background: The Ramazzini Institute (RI) has completed nearly 400 cancer bioassays on over 200 compounds. . . . [More] Background: The Ramazzini Institute (RI) has completed nearly 400 cancer bioassays on over 200 compounds. Study design and protocol differences between RI and other laboratories have been suggested by the European Food Safety Authority (EFSA) and others to contribute to controversy regarding cancer hazard findings, principally lymphoma/leukemia diagnoses.

Objective: Evaluate RI study design, protocol differences, and accuracy of tumor diagnoses for their impact on carcinogenic hazard characterization.

Methods: We analyzed the findings from a recent Pathology Working Group (PWG) review of RI procedures and tumor diagnoses, evaluated consistency of RI and other laboratory findings for chemicals identified by RI as positive for lymphoma/leukemia, and examined evidence for a number of other issues raised regarding RI bioassays. The RI cancer bioassay design and protocols were evaluated in the context of relevant risk assessment guidance from International authorities.

Discussion: Although the PWG identified close agreement with RI diagnoses for most tumor types, it did not for lymphoma/leukemia of the respiratory tract and neoplasms of the inner ear and cranium. We discuss (1) the implications of the PWG findings, particularly lymphoma diagnostic issues, (2) differences between RI and other laboratory studies that are relevant to evaluating RI cancer bioassays and (3) future work that may help resolve some concerns.

Conclusions: We conclude that (1) issues related to respiratory tract infections have complicated diagnoses at that site (i.e., lymphoma/leukemia) and for neoplasms of the inner ear and cranium, and (2) there is consistency and value in RI studies for identification of other chemical-related neoplasia.

Archival Material
Archival Material

[Email to Jeff Gift, dated 5/30/2013, including graphs of mean survival and body weight in male and female Sprague-Dawley control rats from the colony of the CMCRC/RI]

Author: Belpoggi, F (2013) [Personal Communication] HERO ID: 1600861


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Two-year drinking water carcinogenicity study of methyl tertiary-butyl ether (MTBE) in Wistar rats

Authors: Dodd, D; Willson, G; Parkinson, H; Bermudez, E (2013) Journal of Applied Toxicology 33:593-606. HERO ID: 1070870

[Less] Methyl tertiary-butyl ether (MTBE) has been used as a gasoline additive to reduce tailpipe emissions . . . [More] Methyl tertiary-butyl ether (MTBE) has been used as a gasoline additive to reduce tailpipe emissions and its use has been discontinued. There remains a concern that drinking water sources have been contaminated with MTBE. A two-year drinking water carcinogenicity study of MTBE was conducted in Wistar rats (males, 0, 0.5, 3, 7.5 mg ml(-1) ; and females, 0, 0.5, 3, and 15 mg ml(-1) ). Body weights were unaffected and water consumption was reduced in MTBE-exposed males and females. Wet weights of male kidneys were increased at the end of two years of exposure to 7.5 mg ml(-1) MTBE. Chronic progressive nephropathy was observed in males and females, was more severe in males, and was exacerbated in the high MTBE exposure groups. Brain was the only tissue with a statistically significant finding of neoplasms. One astrocytoma (1/50) was found in a female rat (15 mg ml(-1) ). The incidence of brain astrocytomas in male rats was 1/50, 1/50, 1/50 and 4/50 for the 0, 0.5, 3 and 7.5 mg ml(-1) exposure groups, respectively. This was a marginally significant statistical trend, but not statistically significant when pairwise comparisons were made or when multiple comparisons were taken into account. The incidence of astrocytoma fell within historical control ranges for Wistar rats, and the brain has not been identified as a target organ following chronic administration of MTBE, ethyl tert-butyl ether, or tertiary butyl alcohol (in drinking water) to mice and rats. We conclude that the astrocytomas observed in this study are not associated with exposure to MTBE. Copyright © 2011 John Wiley & Sons, Ltd.

Technical Report
Technical Report

Update on Ramazzini Institute data in IRIS assessments

Author: U.S. EPA (2012) Washington, DC: U.S. Environmental Protection Agency. HERO ID: 1239456


Technical Report
Technical Report

Second amended pathology quality assessment review and pathology working group (PWG) coordinator’s report for lifetime carcinogenicity study of acrylonitrile in Sprague-Dawley rats conducted at the cancer research center, European RamazzinI foundation for oncology and environmental sciences, Bologna, Italy

Author: EPL (2012) Durham, NC: Experimental Pathology Laboratories. HERO ID: 1936533


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

MTBE: recent carcinogenicity studies

Authors: Burns, KM; Melnick, RL (2012) International Journal of Occupational and Environmental Health 18:66-69. HERO ID: 1239449

[Less] MTBE, a gasoline oxygenate, has contaminated drinking water sources for many years. Carcinogenicity . . . [More] MTBE, a gasoline oxygenate, has contaminated drinking water sources for many years. Carcinogenicity studies conducted in animals in the 1990s raised concerns of potential human health risks. Recent industry-sponsored studies have confirmed the carcinogenic effects of this agent and have identified additional sites of tumor induction (i.e., brain). However, the petroleum industry has attempted to portray these recent findings as demonstrating either no effect or no concern for humans. Our paper briefly summarizes the new findings and puts into perspective the totality of carcinogenic effects and health risks on this environmental chemical.