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Dibutyl Phthalate (DBP)

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  • 1.
    Technical Report
    Technical
    Report
    Phthalate Initiative

    Author: ,
    (2011)
    Minus Sign. Click to see only selected choices. The goal of this contract is to provide support of National Toxicology Program (NTP) or hazard assessment . . . Plus Sign. Click to expand choices. The goal of this contract is to provide support of National Toxicology Program (NTP) or hazard assessment activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. These studies will elucidate the developmental ontogeny of Peroxisome proliferorator receptor alpha (PPAR and #945;) in the rat and relationship to DEHP cancer (and other developmental toxicity) outcomes. In addition, the studies will provide the critical data to undertake mixture studies using various model approaches, to inform on potential cumulative and aggregate cancer and developmental toxicity risk. Recent data have indicated that because of similar modes of action in utero, phthalate esters do show dose addition when administered in combination and thus it would be appropriate to consider cumulative risk for the class, since human subjects (including fetuses) are typically exposed to multiple phthalates.
    Tagged With: Database Searches, LitSearch Jan 2017 - July 2017, Toxline

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  • 2.
    Journal Article
    Journal
    Article
    Di-(2-ethylhexyl) Phthalate-Induced Hippocampus-Derived Neural Stem Cells Proliferation

    Authors: Abdanipour, A; Noori-Zadeh, A; Mesbah-Namin, SA; Bakhtiyari, S; Nejatbakhsh, R; Anarkooli, IJ
    (2017) 19:166-172.
    Minus Sign. Click to see only selected choices. The brain and spinal cord have a limited capacity for self-repair under damaged conditions. One of the . . . Plus Sign. Click to expand choices. The brain and spinal cord have a limited capacity for self-repair under damaged conditions. One of the best options to overcome these limitations involves the use of phytochemicals as potential therapeutic agents. In this study, we have aimed to investigate the effects of di-(2-ethylhexyl) phthalate (DEHP) on hippocampus-derived neural stem cells (NSCs) proliferation to search phytochemical candidates for possible treatment of neurological diseases using endogenous capacity. In this experimental study, neonatal rat hippocampus-derived NSCs were cultured and treated with various concentrations of DEHP (0, 100, 200, 400 and 600 µM) and Cirsium vulgare (C. vulgare) hydroethanolic extract (0, 200, 400, 600, 800 and 1000 µg/ml) for 48 hours under in vitro conditions. Cell proliferation rates and quantitative Sox2 gene expression were evaluated using MTT assay and real-time reverse transcription polymerase chain reaction (RT-PCR). We observed the highest average growth rate in the 400 µM DEHP and 800 µg/ml C. vulgare extract treated groups. Sox2 expression in the DEHP-treated NSCs significantly increased compared to the control group. Gas chromatography/mass spectrometry (GC/ MS) results demonstrated that the active ingredients that naturally occurred in the C. vulgare hydroethanolic extract were 2-ethyl-1-hexanamine, n-heptacosane, 1-cyclopentanecarboxylic acid, 1-heptadecanamine, 2,6-octadien-1-ol,2,6,10,14,18,22-tetracosahexaene, and DEHP. DEHP profoundly stimulated NSCs proliferation through Sox2 gene overexpression. These results provide and opportunity for further use of the C. vulgure phytochemicals for prevention and/or treatment of neurological diseases via phytochemical mediated-proliferation of endogenous adult NSCs.
    Tagged With: Database Searches, WOS, Pubmed, LitSearch Jan 2017 - July 2017, WOS
  • 3.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Single, competitive, and dynamic adsorption on activated carbon of compounds used as plasticizers and herbicides

    Authors: Abdel daiem, MM; Rivera-Utrilla, J; Sánchez-Polo, M; Ocampo-Pérez, R
    (2015)
    Minus Sign. Click to see only selected choices. The main aim of this study was to investigate the single, competitive, and dynamic adsorption of phthalic . . . Plus Sign. Click to expand choices. The main aim of this study was to investigate the single, competitive, and dynamic adsorption of phthalic acid (PA), bisphenol A (BPA), diphenolic acid (DPA), 2,4-dichlorophenoxy-acetic acid (2,4-D), and 4-chloro-2-methylphenoxyacetic acid (MCPA) on two activated carbons with different chemical natures and similar textural characteristics. The adsorption mechanism was also elucidated by analyzing the influence of solution pH and ionic strength. The activated carbons demonstrated high adsorption capacity to remove all micropollutants due to the presence of active sites on their surfaces, which increase dispersive interactions between the activated carbon graphene layers and the aromatic ring of pollutants. The adsorption capacity of the activated carbons increased in the order: DPA<BPA<PA<2,4-D<MCPA, which is directly related to: i) molecular size of pollutants; ii) chemical structure of pollutants, and iii) chemical properties of adsorbents. In most cases, the adsorption of contaminants is favored at acid pH (pH<5) due to the establishment of attractive electrostatic interactions. In dynamic regime, the amount of pollutant adsorbed was much higher for PA, followed by DPA, and was approximately similar for BPA, 2,4-D, and MCPA. Finally, the amount of BPA and DPA adsorbed on activated carbon decreased by around 50% and 70% in the presence of DPA and BPA, respectively, indicating that both compounds are adsorbed on the same adsorption sites of the activated carbon.
    Tagged With: Excluded: No Primary Data on Health Effects, Use in sample prep or assay , Litsearch June 2015 - Jan 2016, Pubmed
  • 4.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Resveratrol and curcumin ameliorate di-(2-ethylhexyl) phthalate induced testicular injury in rats

    Authors: Abd El-Fattah, AA; Fahim, AT; Sadik, NA; Ali, BM
    (2016) General and Comparative Endrocrinology 225:45-54.
    Minus Sign. Click to see only selected choices. The present study aimed to evaluate the protective role of resveratrol and curcumin on oxidative testicular . . . Plus Sign. Click to expand choices. The present study aimed to evaluate the protective role of resveratrol and curcumin on oxidative testicular damage induced by di-(2-ethylhexyl) phthalate (DEHP). Male Wistar rats were divided into six groups; three groups received oral daily doses of DEHP (2g/kgBW) for 45days to induce testicular injury. Two of these groups received either resveratrol (80mg/kgBW) or curcumin (200mg/kgBW) orally for 30days before and 45days after DEHP administration. A vehicle-treated control group was also included. Another two groups of rats received either resveratrol or curcumin alone. Oxidative damage was observed by decreased levels of total antioxidant capacity (TAC) and glutathione (GSH) and increased malondialdehyde (MDA) level in the testes of DEHP-administered rats. Serum testosterone level as well as testicular marker enzymes activities; acid and alkaline phosphatases (ACP and ALP) and lactate dehydrogenase (LDH) showed severe declines. DEHP administration caused significant increases in the testicular gene expression levels of Nrf2, HO-1, HSP60, HSP70 and HSP90 as well as a significant decrease in c-Kit protein when compared with the control group. Histopathological observations provided evidence for the biochemical and molecular analysis. These DEHP-induced pathological alterations were attenuated by pretreatment with resveratrol and curcumin. We conclude that DEHP-induced injuries in biochemical, molecular and histological structure of testis were recovered by pretreatment with resveratrol and curcumin. The chemoprotective effects of these compounds may be due to their intrinsic antioxidant properties along with boosting Nrf2, HSP 60, HSP 70 and HSP 90 gene expression levels and as such may be useful potential tools in combating DEHP-induced testicular dysfunction.
    Tagged With: Database Searches, Excluded: No Primary Data on Health Effects, Not chemical specific , Use in sample prep or assay , Litsearch June 2015 - Jan 2016, Pubmed, Litsearch Jan 2016 - July 2016, Pubmed
  • 5.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Novel potentiometric sensors for the determination of the dinotefuran insecticide residue levels in cucumber and soil samples

    Authors: Abdel-Ghany, MF; Hussein, LA; El Azab, NF
    (2017)
    Minus Sign. Click to see only selected choices. Five new potentiometric membrane sensors for the determination of the dinotefuran levels in cucumber . . . Plus Sign. Click to expand choices. Five new potentiometric membrane sensors for the determination of the dinotefuran levels in cucumber and soil samples have been developed. Four of these sensors were based on a newly designed molecularly imprinted polymer (MIP) material consisting of acrylamide or methacrylic acid as a functional monomer in a plasticized PVC (polyvinyl chloride) membrane before and after elution of the template. A fifth sensor, a carboxylated PVC-based sensor plasticized with dioctyl phthalate, was also prepared and tested. Sensor 1 (acrylamide washed) and sensor 3 (methacrylic acid washed) exhibited significantly enhanced responses towards dinotefuran over the concentration range of 10(-7)-10(-2)molL(-1). The limit of detection (LOD) for both sensors was 0.35µgL(-1). The response was near-Nernstian, with average slopes of 66.3 and 50.8mV/decade for sensors 1 and 3 respectively. Sensors 2 (acrylamide non-washed), 4 (methacrylic acid non-washed) and 5 (carboxylated-PVC) exhibited non-Nernstian responses over the concentration range of 10(-7)-10(-3)molL(-1), with LODs of 10.07, 6.90, and 4.30µgL(-1), respectively, as well as average slopes of 39.1, 27.2 and 33mV/decade, respectively. The application of the proposed sensors to the determination of the dinotefuran levels in spiked soil and cucumber samples was demonstrated. The average recoveries from the cucumber samples were from 7.93% to 106.43%, with a standard deviation of less than 13.73%, and recoveries from soil samples were from 97.46% to 108.71%, with a standard deviation of less than 10.66%. The sensors were applied successfully to the determination of the dinotefuran residue, its rate of disappearance and its half-life in cucumbers in soil in which a safety pre-harvest interval for dinotefuran was suggested.
    Tagged With: Database Searches, LitSearch Jan 2017 - July 2017, Pubmed
  • 6.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Quercetin attenuates di-(2-ethylhexyl) phthalate-induced testicular toxicity in adult rats

    Authors: Abd-Ellah, MF; Aly, HA; Mokhlis, HA; Abdel-Aziz, AH
    (2016) Human and Experimental Toxicology 35:232-243.
    Minus Sign. Click to see only selected choices. The aim of the present study was to investigate the potential oxidative damage of di-(2-ethylhexyl) . . . Plus Sign. Click to expand choices. The aim of the present study was to investigate the potential oxidative damage of di-(2-ethylhexyl) phthalate (DEHP) in the rat testis and to further elucidate the potential modulatory effect of quercetin. DEHP was diluted in corn oil and given to rats by oral gavage at doses 0, 300, 600, and 900 mg/kg/day (groups I, III, IV, or V, respectively) for 15 consecutive days. Group VI was pretreated with quercetin (90 mg/kg), 24 h before starting the experiment and then treated with DEHP (900 mg/kg/day) for 15 consecutive days. Group II was treated with quercetin (90 mg/kg/day). The relative testes weight and sperm motility were significantly decreased by treatment with 900 mg/kg of DEHP. Both sperm count and daily sperm production were significantly decreased by DEHP treatment at doses of 600 and 900 mg/kg. Serum testosterone level and prostatic acid phosphatase (ACP) activity and testicular lactate dehydrogenase-X (LDH-X) activity were significantly decreased in animals treated with 900 mg/kg. Serum total ACP activity was significantly increased in animals treated with 600 and 900 mg/kg of DEHP. DEHP treatment induced oxidative stress and histopathological abnormality. These abnormalities were effectively normalized by pretreatment with quercetin except for LDH-X near normalcy. In conclusion, the findings of this study demonstrate that DEHP impairs testicular function at least, in part, by inducing oxidative stress and quercetin has a potent protective effect against DEHP-induced testicular toxicity in rats.
    Tagged With: Database Searches, Litsearch Jan 2016 - July 2016, Pubmed, Excluded: No Primary Data on Health Effects, Not chemical specific
  • 7.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Prenatal Exposures of Male Rats to the Environmental Chemicals Bisphenol A and Di(2-Ethylhexyl) Phthalate Impact the Sexual Differentiation Process

    Authors: Abdel-Maksoud, FM; Leasor, KR; Butzen, K; Braden, TD; Akingbemi, BT
    (2015) Endocrinology 156:4672-4683.
    Minus Sign. Click to see only selected choices. The increasing incidence of reproductive anomalies, described as testicular dysgenesis syndrome, is . . . Plus Sign. Click to expand choices. The increasing incidence of reproductive anomalies, described as testicular dysgenesis syndrome, is thought to be related to the exposure of the population to chemicals in the environment. Bisphenol A (BPA) and di(2-ethylhexyl)phthalate (DEHP), which have hormonal and antihormonal activity, have attracted public attention due to their presence in consumer products. The present study investigated the effects of BPA and DEHP on reproductive development. Timed-pregnant female rats were exposed to BPA and DEHP by gavage from gestational days 12 to 21. Results showed that prenatal exposures to test chemicals exerted variable effects on steroidogenic factor 1 and GATA binding protein 4 protein expression and increased (P < .05) sex-determining region Y-box 9 and antimüllerian hormone protein in the infantile rat testis compared with levels in the control unexposed animals. Pituitary LHβ and FSHβ subunit protein expression was increased (P < .05) in BPA- and DEHP-exposed prepubertal male rats but were decreased (P < .05) in adult animals relative to control. Exposure to both BPA and DEHP in utero inhibited (P < .05) global DNA hydroxymethylation in the adult testis in association with altered DNA methyltransferase protein expression. Together the present data suggest that altered developmental programming in the testes associated with chemical exposures are related to the disruption of sexual differentiation events and DNA methylation patterns. The chemical-induced effects impact the development of steroidogenic capacity in the adult testis.
    Tagged With: Pubmed, Excluded: No Primary Data on Health Effects, Not chemical specific , Use in sample prep or assay , Pubmed, Litsearch June 2015 - Jan 2016, Pubmed
  • 8.
    Journal Article
    Journal
    Article
    Preparation of Fluconazole β-Cyclodextrin Complex Ocuserts: In Vitro and In Vivo Evaluation

    Authors: Abdul Ahad, H; Sreeramulu, J; Padmaja, BS; Reddy, MN; Prakash, PG
    (2011)
    Minus Sign. Click to see only selected choices. The main purpose of the present study was to develop ocuserts of Fluconazole β-CD (beta-cyclodextrin) . . . Plus Sign. Click to expand choices. The main purpose of the present study was to develop ocuserts of Fluconazole β-CD (beta-cyclodextrin) complex and to evaluate both in vitro and in vivo. Fluconazole was made complex with β-CD, and the release rate was controlled by HPMC K(4)M and ethyl cellulose polymers using dibutyl Phthalate as permeability enhancer. Drug-polymer interactions were studied by Fourier transform infrared spectroscopic studies. The formulated ocuserts were tested for physicochemical parameters of in vitro release and in vivo permeation in rabbits. The optimized formulations (F-5 and F-8) were subjected to stability studies. The formulated ocuserts were found to have good physical characters, thickness, diameter, uniformity in weight, folding endurance, less moisture absorption, and controlled release of drug both in vitro and in vivo. The optimized formulations retained their characteristics even after stability studies. The study clearly showed that this technique was an effective way of formulating ocuserts for retaining the drug concentration at the intended site of action for a sufficient period of time and to elicit the desired pharmacological response.
    Tagged With: PubMed, Merged reference set, LitSearch Nov 2012, Excluded: No Primary Data on Health Effects, Manufacture/use , Database Searches, Pubmed
  • 9.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    The teratogenicity and behavioral teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-butyl Phthalate (DBP) in a chick model

    Authors: Abdul-Ghani, S; Yanai, J; Abdul-Ghani, R; Pinkas, A; Abdeen, Z
    (2012) Neurotoxicology and Teratology 34:56-62.
    Minus Sign. Click to see only selected choices. Phthalates are industrial chemicals widely used in consumer products, plastics and children toys, and . . . Plus Sign. Click to expand choices. Phthalates are industrial chemicals widely used in consumer products, plastics and children toys, and the risk of exposure to phthalates, especially prenatal exposure, is a growing concern justifying the development of an animal model to better understand their effect. The present study was designed to evaluate the suitability of a chick model for phthalate DEHP teratogenicity and neurobehavioral teratogenicity, a model which is simple and devoid of potential confounding factors such as maternal toxicity, maternal-fetal unit and maternal-neonatal interactions; major findings were confirmed in the DBP study. Prehatch exposure to DEHP in doses ranging from 20 to 100 mg/kg, reduced the percent hatching from 80% in control eggs to 65%, and increased late hatchings from 12.5% in control eggs to 29.4%. In addition it induced developmental defects characterized by an opening or weakening of abdominal muscles allowing internal organs to protrude externally with or without a sac, omphalocele or gastroschisis, respectively. The effect was dose dependent ranging from 8% with DEHP (20 mg/kg) to 22% (100 mg/kg). Similar treatment with DBP 100mg/kg has reduced percentage hatching to 57% and increased late hatching to 37.5%, with a 14% increase in gastroschisis. Biochemical evaluation revealed elevated levels of alkaline phosphatase, which reflects non-specific toxicity of DEHP at such a high dose. Behavioral evaluation using an imprinting test and locomotor activity on chicks pretreated with DEHP (100 mg/kg) has shown an abolishment of imprinting performance from the control (0.65) preference ratio. DNA damage measurements of the metabolite 8-hydroxydeoxyguanosine (8-OH-dG) in blood samples showed an increase of 39.7% after prehatch exposure to phthalates. This was statistically significant for DEHP and indicates genetic toxicity, since part of the teratogenic activity is associated with oxidative stress and DNA damage.
    Tagged With: Pubmed, WOS, PubMed, Database Searches, Pubmed, Pubmed, WOS, Web of Science, WOS, Toxnet, Merged reference set, Pubmed, WOS, Pubmed, WOS, LitSearch Nov 2012, PubMed, WOS, Merged reference set, LitSearch Dec 2012 - June 2013, Web of Science, Excluded: No Primary Data on Health Effects, Ecosystem effects
  • 10.
    Technical Report
    Technical
    Report
    Determination of the active ingredient in the herbicide toluine by gas-chromatography

    Authors: Abdullaev, S; Karimov, RK; Aripov KhN; Shakirov, TT
    (1979)
    Minus Sign. Click to see only selected choices. PESTAB. A gas-liquid chromatographic determination of the active ingredient of the herbicide toluine . . . Plus Sign. Click to expand choices. PESTAB. A gas-liquid chromatographic determination of the active ingredient of the herbicide toluine (N- methoxy- ethylchloro aceto-o- toluidide) in technical toluine and in a 30% wettable powder is described. The detectability of pure toluine and dibutylphthalate, used as the internal standard, in artificial mixtures was 98.4% and 98.8%, respectively. Detection of the active ingredient in a 30% wp formulation was 31.0%.
    Tagged With: Database Searches, Litsearch Jan 2016 - July 2016, Toxline, LitSearch Jan 2017 - July 2017, Toxline

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