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Dibutyl Phthalate (DBP)

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  • 1.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Article
    Single, competitive, and dynamic adsorption on activated carbon of compounds used as plasticizers and herbicides

    Authors: Abdel daiem, MM; Rivera-Utrilla, J; Sánchez-Polo, M; Ocampo-Pérez, R
    (2015)
    Minus Sign. Click to see only selected choices. The main aim of this study was to investigate the single, competitive, and dynamic adsorption of phthalic . . . Plus Sign. Click to expand choices. The main aim of this study was to investigate the single, competitive, and dynamic adsorption of phthalic acid (PA), bisphenol A (BPA), diphenolic acid (DPA), 2,4-dichlorophenoxy-acetic acid (2,4-D), and 4-chloro-2-methylphenoxyacetic acid (MCPA) on two activated carbons with different chemical natures and similar textural characteristics. The adsorption mechanism was also elucidated by analyzing the influence of solution pH and ionic strength. The activated carbons demonstrated high adsorption capacity to remove all micropollutants due to the presence of active sites on their surfaces, which increase dispersive interactions between the activated carbon graphene layers and the aromatic ring of pollutants. The adsorption capacity of the activated carbons increased in the order: DPA<BPA<PA<2,4-D<MCPA, which is directly related to: i) molecular size of pollutants; ii) chemical structure of pollutants, and iii) chemical properties of adsorbents. In most cases, the adsorption of contaminants is favored at acid pH (pH<5) due to the establishment of attractive electrostatic interactions. In dynamic regime, the amount of pollutant adsorbed was much higher for PA, followed by DPA, and was approximately similar for BPA, 2,4-D, and MCPA. Finally, the amount of BPA and DPA adsorbed on activated carbon decreased by around 50% and 70% in the presence of DPA and BPA, respectively, indicating that both compounds are adsorbed on the same adsorption sites of the activated carbon.
    Tagged With: Excluded: No Primary Data on Health Effects, Use in sample prep or assay , Litsearch June 2015 - Jan 2016, Pubmed
  • 2.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
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    Article
    Resveratrol and curcumin ameliorate di-(2-ethylhexyl) phthalate induced testicular injury in rats

    Authors: Abd El-Fattah, AA; Fahim, AT; Sadik, NA; Ali, BM
    (2016) General and Comparative Endrocrinology 225:45-54.
    Minus Sign. Click to see only selected choices. The present study aimed to evaluate the protective role of resveratrol and curcumin on oxidative testicular . . . Plus Sign. Click to expand choices. The present study aimed to evaluate the protective role of resveratrol and curcumin on oxidative testicular damage induced by di-(2-ethylhexyl) phthalate (DEHP). Male Wistar rats were divided into six groups; three groups received oral daily doses of DEHP (2g/kgBW) for 45days to induce testicular injury. Two of these groups received either resveratrol (80mg/kgBW) or curcumin (200mg/kgBW) orally for 30days before and 45days after DEHP administration. A vehicle-treated control group was also included. Another two groups of rats received either resveratrol or curcumin alone. Oxidative damage was observed by decreased levels of total antioxidant capacity (TAC) and glutathione (GSH) and increased malondialdehyde (MDA) level in the testes of DEHP-administered rats. Serum testosterone level as well as testicular marker enzymes activities; acid and alkaline phosphatases (ACP and ALP) and lactate dehydrogenase (LDH) showed severe declines. DEHP administration caused significant increases in the testicular gene expression levels of Nrf2, HO-1, HSP60, HSP70 and HSP90 as well as a significant decrease in c-Kit protein when compared with the control group. Histopathological observations provided evidence for the biochemical and molecular analysis. These DEHP-induced pathological alterations were attenuated by pretreatment with resveratrol and curcumin. We conclude that DEHP-induced injuries in biochemical, molecular and histological structure of testis were recovered by pretreatment with resveratrol and curcumin. The chemoprotective effects of these compounds may be due to their intrinsic antioxidant properties along with boosting Nrf2, HSP 60, HSP 70 and HSP 90 gene expression levels and as such may be useful potential tools in combating DEHP-induced testicular dysfunction.
    Tagged With: Database Searches, Excluded: No Primary Data on Health Effects, Not chemical specific , Use in sample prep or assay , Litsearch June 2015 - Jan 2016, Pubmed, Litsearch Jan 2016 - July 2016, Pubmed
  • 3.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
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    Reviewed
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    Article
    Quercetin attenuates di-(2-ethylhexyl) phthalate-induced testicular toxicity in adult rats

    Authors: Abd-Ellah, MF; Aly, HA; Mokhlis, HA; Abdel-Aziz, AH
    (2016) Human and Experimental Toxicology 35:232-243.
    Minus Sign. Click to see only selected choices. The aim of the present study was to investigate the potential oxidative damage of di-(2-ethylhexyl) . . . Plus Sign. Click to expand choices. The aim of the present study was to investigate the potential oxidative damage of di-(2-ethylhexyl) phthalate (DEHP) in the rat testis and to further elucidate the potential modulatory effect of quercetin. DEHP was diluted in corn oil and given to rats by oral gavage at doses 0, 300, 600, and 900 mg/kg/day (groups I, III, IV, or V, respectively) for 15 consecutive days. Group VI was pretreated with quercetin (90 mg/kg), 24 h before starting the experiment and then treated with DEHP (900 mg/kg/day) for 15 consecutive days. Group II was treated with quercetin (90 mg/kg/day). The relative testes weight and sperm motility were significantly decreased by treatment with 900 mg/kg of DEHP. Both sperm count and daily sperm production were significantly decreased by DEHP treatment at doses of 600 and 900 mg/kg. Serum testosterone level and prostatic acid phosphatase (ACP) activity and testicular lactate dehydrogenase-X (LDH-X) activity were significantly decreased in animals treated with 900 mg/kg. Serum total ACP activity was significantly increased in animals treated with 600 and 900 mg/kg of DEHP. DEHP treatment induced oxidative stress and histopathological abnormality. These abnormalities were effectively normalized by pretreatment with quercetin except for LDH-X near normalcy. In conclusion, the findings of this study demonstrate that DEHP impairs testicular function at least, in part, by inducing oxidative stress and quercetin has a potent protective effect against DEHP-induced testicular toxicity in rats.
    Tagged With: Database Searches, Litsearch Jan 2016 - July 2016, Pubmed, Excluded: No Primary Data on Health Effects, Not chemical specific
  • 4.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    Prenatal Exposures of Male Rats to the Environmental Chemicals Bisphenol A and Di(2-Ethylhexyl) Phthalate Impact the Sexual Differentiation Process

    Authors: Abdel-Maksoud, FM; Leasor, KR; Butzen, K; Braden, TD; Akingbemi, BT
    (2015) Endocrinology 156:4672-4683.
    Minus Sign. Click to see only selected choices. The increasing incidence of reproductive anomalies, described as testicular dysgenesis syndrome, is . . . Plus Sign. Click to expand choices. The increasing incidence of reproductive anomalies, described as testicular dysgenesis syndrome, is thought to be related to the exposure of the population to chemicals in the environment. Bisphenol A (BPA) and di(2-ethylhexyl)phthalate (DEHP), which have hormonal and antihormonal activity, have attracted public attention due to their presence in consumer products. The present study investigated the effects of BPA and DEHP on reproductive development. Timed-pregnant female rats were exposed to BPA and DEHP by gavage from gestational days 12 to 21. Results showed that prenatal exposures to test chemicals exerted variable effects on steroidogenic factor 1 and GATA binding protein 4 protein expression and increased (P < .05) sex-determining region Y-box 9 and antimüllerian hormone protein in the infantile rat testis compared with levels in the control unexposed animals. Pituitary LHβ and FSHβ subunit protein expression was increased (P < .05) in BPA- and DEHP-exposed prepubertal male rats but were decreased (P < .05) in adult animals relative to control. Exposure to both BPA and DEHP in utero inhibited (P < .05) global DNA hydroxymethylation in the adult testis in association with altered DNA methyltransferase protein expression. Together the present data suggest that altered developmental programming in the testes associated with chemical exposures are related to the disruption of sexual differentiation events and DNA methylation patterns. The chemical-induced effects impact the development of steroidogenic capacity in the adult testis.
    Tagged With: Pubmed, Excluded: No Primary Data on Health Effects, Not chemical specific , Use in sample prep or assay , Pubmed, Litsearch June 2015 - Jan 2016, Pubmed
  • 5.
    Journal Article
    Journal
    Article
    Preparation of Fluconazole β-Cyclodextrin Complex Ocuserts: In Vitro and In Vivo Evaluation

    Authors: Abdul Ahad, H; Sreeramulu, J; Padmaja, BS; Reddy, MN; Prakash, PG
    (2011)
    Minus Sign. Click to see only selected choices. The main purpose of the present study was to develop ocuserts of Fluconazole β-CD (beta-cyclodextrin) . . . Plus Sign. Click to expand choices. The main purpose of the present study was to develop ocuserts of Fluconazole β-CD (beta-cyclodextrin) complex and to evaluate both in vitro and in vivo. Fluconazole was made complex with β-CD, and the release rate was controlled by HPMC K(4)M and ethyl cellulose polymers using dibutyl Phthalate as permeability enhancer. Drug-polymer interactions were studied by Fourier transform infrared spectroscopic studies. The formulated ocuserts were tested for physicochemical parameters of in vitro release and in vivo permeation in rabbits. The optimized formulations (F-5 and F-8) were subjected to stability studies. The formulated ocuserts were found to have good physical characters, thickness, diameter, uniformity in weight, folding endurance, less moisture absorption, and controlled release of drug both in vitro and in vivo. The optimized formulations retained their characteristics even after stability studies. The study clearly showed that this technique was an effective way of formulating ocuserts for retaining the drug concentration at the intended site of action for a sufficient period of time and to elicit the desired pharmacological response.
    Tagged With: PubMed, Merged reference set, LitSearch Nov 2012, Excluded: No Primary Data on Health Effects, Manufacture/use , Database Searches, Pubmed
  • 6.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    The teratogenicity and behavioral teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-butyl Phthalate (DBP) in a chick model

    Authors: Abdul-Ghani, S; Yanai, J; Abdul-Ghani, R; Pinkas, A; Abdeen, Z
    (2012) Neurotoxicology and Teratology 34:56-62.
    Minus Sign. Click to see only selected choices. Phthalates are industrial chemicals widely used in consumer products, plastics and children toys, and . . . Plus Sign. Click to expand choices. Phthalates are industrial chemicals widely used in consumer products, plastics and children toys, and the risk of exposure to phthalates, especially prenatal exposure, is a growing concern justifying the development of an animal model to better understand their effect. The present study was designed to evaluate the suitability of a chick model for phthalate DEHP teratogenicity and neurobehavioral teratogenicity, a model which is simple and devoid of potential confounding factors such as maternal toxicity, maternal-fetal unit and maternal-neonatal interactions; major findings were confirmed in the DBP study. Prehatch exposure to DEHP in doses ranging from 20 to 100 mg/kg, reduced the percent hatching from 80% in control eggs to 65%, and increased late hatchings from 12.5% in control eggs to 29.4%. In addition it induced developmental defects characterized by an opening or weakening of abdominal muscles allowing internal organs to protrude externally with or without a sac, omphalocele or gastroschisis, respectively. The effect was dose dependent ranging from 8% with DEHP (20 mg/kg) to 22% (100 mg/kg). Similar treatment with DBP 100mg/kg has reduced percentage hatching to 57% and increased late hatching to 37.5%, with a 14% increase in gastroschisis. Biochemical evaluation revealed elevated levels of alkaline phosphatase, which reflects non-specific toxicity of DEHP at such a high dose. Behavioral evaluation using an imprinting test and locomotor activity on chicks pretreated with DEHP (100 mg/kg) has shown an abolishment of imprinting performance from the control (0.65) preference ratio. DNA damage measurements of the metabolite 8-hydroxydeoxyguanosine (8-OH-dG) in blood samples showed an increase of 39.7% after prehatch exposure to phthalates. This was statistically significant for DEHP and indicates genetic toxicity, since part of the teratogenic activity is associated with oxidative stress and DNA damage.
    Tagged With: Pubmed, WOS, PubMed, Database Searches, Pubmed, Pubmed, WOS, Web of Science, WOS, Toxnet, Merged reference set, Pubmed, WOS, Pubmed, WOS, LitSearch Nov 2012, PubMed, WOS, Merged reference set, LitSearch Dec 2012 - June 2013, Web of Science, Excluded: No Primary Data on Health Effects, Ecosystem effects
  • 7.
    Technical Report
    Technical
    Report
    Determination of the active ingredient in the herbicide toluine by gas-chromatography

    Authors: Abdullaev, S; Karimov, RK; Aripov KhN; Shakirov, TT
    (1979)
    Minus Sign. Click to see only selected choices. PESTAB. A gas-liquid chromatographic determination of the active ingredient of the herbicide toluine . . . Plus Sign. Click to expand choices. PESTAB. A gas-liquid chromatographic determination of the active ingredient of the herbicide toluine (N- methoxy- ethylchloro aceto-o- toluidide) in technical toluine and in a 30% wettable powder is described. The detectability of pure toluine and dibutylphthalate, used as the internal standard, in artificial mixtures was 98.4% and 98.8%, respectively. Detection of the active ingredient in a 30% wp formulation was 31.0%.
    Tagged With: Database Searches, Litsearch Jan 2016 - July 2016, Toxline

    Details
       
  • 8.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
    Journal
    Article
    A study to investigate and compare the physicomechanical properties of experimental and commercial temporary crown and bridge materials

    Authors: Abdulmohsen, B; Parker, S; Braden, M; Patel, MP
    (2015) Dental Materials.
    Minus Sign. Click to see only selected choices. OBJECTIVES: To develop two experimental temporary crown and bridge materials with improved . . . Plus Sign. Click to expand choices. OBJECTIVES: To develop two experimental temporary crown and bridge materials with improved physicomechanical properties.

    METHODS: Commercial materials: Trim (TR, monomethacrylate, Bosworth) and Quicktemp2 (QT, dimethacrylate, Schottlander).

    EXPERIMENTAL MATERIALS: isobutyl methacrylate/poly(ethyl methacrylate) (IBMA/PEM) and n-butyl methacrylate/PEM (nBMA/PEM), both monomethacrylates. For water absorption/desorption studies rectangular samples (40mm×10mm×1mm) of each material were prepared, immersed in deionized water (DW, control) and artificial saliva (AS), and weighed at regular time intervals. %solubility and diffusion coefficients (D) for uptake/loss processes were calculated and compared with theoretical predictions. Polymerization exotherm (cylindrical samples 10mm×18mm) and flexural moduli were measured (three point bending; rectangular samples 80mm×10mm×4mm, dry and after 9 days storage in DW). The data were compared statistically.

    RESULTS: QT and nBMA/PEM had lower %equilibrium uptakes/loss in DW (0.68%/0.884% and 0.64%/0.895% respectively). QT had the lowest water absorption/desorption D (P<0.05) compared to the three monomethacrylates, in DW and AS. %solubility for all systems showed no differences in DW (P>0.05), but a difference for QT in AS (P<0.05). QT reached its maximum temperature rapidly (∼2min; 3 monomethacrylates ∼7-13min). The commercial materials exhibited high peak temperatures (∼51°C, P<0.05; experimental materials ∼43°C). QT had a higher flexural modulus (∼4GPa; 3 monomethacrylates ∼0.7-1GPa) for dry and wet samples. The moduli for commercial materials reduced significantly after immersion in DW; there was no difference between the dry and wet experimental materials samples (P>0.05).

    SIGNIFICANCE: The experimental materials merit further studies since they presented with lower setting exotherms, and contained no phthalate plasticizer, thus being less of a risk to patients.
    Tagged With: Database Searches, Excluded: No Primary Data on Health Effects, Use in sample prep or assay , Litsearch June 2015 - Jan 2016, Pubmed, Litsearch Jan 2016 - July 2016, Pubmed
  • 9.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
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    Article
    Electrospun nanofiber SLIPS exhibiting high total transparency and scattering

    Authors: Abe, J; Tenjimbayashi, M; Shiratori, S
    (2016)
    Minus Sign. Click to see only selected choices. Antifouling coatings are important in fields such as mobility, architecture, power generation devices, . . . Plus Sign. Click to expand choices. Antifouling coatings are important in fields such as mobility, architecture, power generation devices, and medical devices, where energy efficiency is required to be maximized. Slippery liquid-infused porous surfaces (SLIPS) are an antifouling approach inspired by nature from the pitcher plant, and have recently received widespread attention in many fields. SLIPS can repel various liquids, including organic solvents with low contact angle hystereses, but require further development to extend their application. We previously reported a fast and straight-forward process for preparing SLIPS called Gel-SLIPS. SLIPS were prepared by the non-solvent-induced phase separation (NIPS) of a poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP)/di-n-butyl phthalate solution. In the current study, SLIPS were prepared by electrospinning to give nanofiber SLIPS. These exhibited high scattering (50%), high total transmittance (93.2%), and a low sliding angle (<= 10 degrees). These properties resulted from the nanofiber non-woven structure of the PVDF-HFP. Nanofiber SLIPS provide control over scattering by altering the under layer density, all while maintaining the total transparency. These characteristics are useful for energy efficient optical devices such as solar cells and street lighting.
    Tagged With: Database Searches, LitSearch Jul 2016 - Jan 2017, Considered new, WoS, WOS, WOS
  • 10.
    The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
    Peer
    Reviewed
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    Article
    Determination of Trihexyphenidyl hydrochloride drug in tablets and urine using a potentiometric carbon paste electrode

    Authors: Abu Shawish, HM; Elhabiby, M; Abu Aziz, HS; Saadeh, SM; Tbaza, A
    (2016)
    Tagged With: Database Searches, LitSearch Jul 2016 - Jan 2017, Considered new, WoS
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