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Dibutyl Phthalate (DBP)

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397 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Comparative toxicity, oxidative stress and endocrine disruption potential of plasticizers in JEG-3 human placental cells

Authors: Pérez-Albaladejo, E; Fernandes, D; Lacorte, S; Porte, C (2017) Toxicology In Vitro 38:41-48. HERO ID: 3469255

[Less] Plasticizers are suspected to be toxic and/or to modulate or disrupt the endocrine system of humans . . . [More] Plasticizers are suspected to be toxic and/or to modulate or disrupt the endocrine system of humans and to cross the placental barrier, being embryonic and fetal development a particularly vulnerable period. This work investigates the comparative toxicity and ability to interfere with the synthesis of steroids and to generate reactive oxygen species (ROS) of a selected number of plasticizers, including bisphenol A (BPA), nonyl- (NP) and octylphenol (OP), benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), di(2-ethylhexyl)phthalate (DEHP) and dimethyl phthalate (DMP), in the human placenta JEG-3 cells. Moreover, the bioavailability of chemicals in culture medium has been investigated. After 24h exposure, OP and NP showed the highest cytotoxicity (EC50: 36-40μM) followed by BPA (138-219μM), whereas no significant toxicity was observed for phthalates. Notwithstanding, BBP and DBP significantly decreased P450 aromatase activity (experimental IC50: 14-15μM), while NP and OP (20μM) increased the activity. Overall, this study evidences the differential toxicity and ability to modulate placental aromatase activity of some of the compounds nowadays used as plasticizers, and highlights the need of an accurate determination of the bioavailability of chemicals to improve the sensitivity of in-vitro tests.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A molecular imprinting-based multifunctional chemosensor for phthalate esters

Authors: Gong, CB; Ou, XX; Liu, S; Jin, YL; Huang, HR; Tang, Q; Lam, MHW; Chow, CF; Tang, Q (2017) Dyes and Pigments 137:499-506. HERO ID: 3479969

[Less] This paper reports a molecular imprinting-based fluorescent and solvatochromic multifunctional chemosensor . . . [More] This paper reports a molecular imprinting-based fluorescent and solvatochromic multifunctional chemosensor for phthalate esters (PAEs). The multifunctional chemosensor was fabricated through precipitation polymerization using 4-[(1E)-4-(2-hydroxyphenyl) ethenyl]-1-allylpyridinium bromide (HPEAPB) as the functional monomer and phthalamide-4,4′-dibutyl dimethyl ester (PDDB) as the mimic template. The molecular imprinting-based chemosensor shows specific affinity toward PDDB and dibutyl phthalate (DBP) in ethanol. Of note is that the molecular imprinting-based chemosensor shows turn-off fluorescent response toward PAEs in an ethanol solution with a limit of detection of 2.0 × 10−6 mol L-1 (0.7 ppm) when HPEAPB is in the protonated form (chemosensor 1), and shows solvatochromic properties, fluorescent enhancement and a colorimetric (from orange to bright yellow) response toward PAEs in an ethanol solution with a limit of detection of 4.0 × 10−5 mol L-1 by the naked eye when HPEAPB is in the deprotonated form (chemosensor 2). This multifunctional chemosensor is promising for the simple, accurate and low-cost detection of trace PAEs.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles

Authors: Connor, LM; Tang, SC; Cognard, E; Ochiai, S; Hilligan, KL; Old, SI; Pellefigues, C; White, RF; Patel, D; Smith, AA; Eccles, DA; Lamiable, O; Mcconnell, MJ; Ronchese, F (2017) Journal of Experimental Medicine 214:125-142. HERO ID: 3502713

[Less] The dendritic cell signals required for the in vivo priming of IL-4-producing T cells are unknown. We . . . [More] The dendritic cell signals required for the in vivo priming of IL-4-producing T cells are unknown. We used RNA sequencing to characterize DCs from skin LN of mice exposed to two different Th2 stimuli: the helminth parasite Nippostrongylus brasiliensis (Nb) and the contact sensitizer dibutyl phthalate (DBP)-FITC. Both Nb and DBP-FITC induced extensive transcriptional changes that involved multiple DC subsets. Surprisingly, these transcriptional changes were highly distinct in the two models, with only a small number of genes being similarly regulated in both conditions. Pathway analysis of expressed genes identified no shared pathways between Nb and DBP-FITC, but revealed a type-I IFN (IFN-I) signature unique to DCs from Nb-primed mice. Blocking the IFN-I receptor at the time of Nb treatment had little effect on DC migration and antigen transport to the LN, but inhibited the up-regulation of IFN-I-induced markers on DCs and effectively blunted Th2 development. In contrast, the response to DBP-FITC was not affected by IFN-I receptor blockade, a finding consistent with the known dependence of this response on the innate cytokine TSLP. Thus, the priming of Th2 responses is associated with distinct transcriptional signatures in DCs in vivo, reflecting the diverse environments in which Th2 immune responses are initiated.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Occurrence of phthalate esters in over-the-counter medicines from China and its implications for human exposure

Authors: Jia, LL; Lou, XY; Guo, Y; Leung, KS; Zeng, EY (2017) Environment International 98:137-142. HERO ID: 5540627

[Less] Food, air, personal care products and indoor dust have been recognized as the main routes of exposure . . . [More] Food, air, personal care products and indoor dust have been recognized as the main routes of exposure to phthalates in Chinese population, but other sources may have been overlooked, e.g., medicines. To fill the knowledge gap, phthalate esters were measured in 96 over-the-counter medicines made in China, including selected 71 Chinese patented medicines and 25 western medicines. It was found that none of the medicines was free of phthalates. The mean concentrations of individual phthalates ranged from 0.001μg/g (dicyclohexyl phthalate) to 5.85μg/g (diethyl phthalate). Among 9 targeted phthalates, di-n-butyl phthalate was the dominant congener, accounting for > 65% of the total phthalates in all medicine samples, followed by di-(2-ethylhexyl) phthalate and diethyl phthalate. Phthalates in medicines appeared to derive from gastroresistant film coatings, plastic packing materials or phthalate contaminated rural herbal plants (especially for Chinese patented medicines). Daily human exposure to phthalates was estimated for local patients for one treatment cycle (e.g., one week) based on suggested consumption dosage and phthalate concentrations. Almost all exposure levels were below the guidelines suggested by the United States Environmental Protection Agency or European Food Safety Authority, indicating low health risk with phthalates from consumption of the medicines. In addition, concentration levels of phthalates in patients would increase upon administration but are expected to decrease to the same values as those in patients before they took medicines in several days. Because the number of medicine samples was limited and the concentrations of phthalates varied in a large range, further investigations are needed to acquire more data for better assessment of human health effects for Chinese population. Capsule: Distribution of phthalate esters in over-the-counter medicines and related exposure for Chinese population are examined.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Prenatal phthalate biomarker concentrations and performance on the Bayley Scales of Infant Development-II in a population of young urban children

Authors: Doherty, BT; Engel, SM; Buckley, JP; Silva, MJ; Calafat, AM; Wolff, MS (2017) Environmental Research 152:51-58. HERO ID: 3469358

[Less] INTRODUCTION: Evidence suggests prenatal phthalate exposures may have neurodevelopmental . . . [More] INTRODUCTION: Evidence suggests prenatal phthalate exposures may have neurodevelopmental consequences. Our objective was to investigate prenatal exposure to phthalates and cognitive development in a cohort of young urban children.

MATERIALS AND METHODS: We recruited pregnant women in New York City from 1998 to 2002 and measured concentrations of nine phthalate metabolites in urine collected in late pregnancy. We administered a neurodevelopmental screening instrument, the Bayley Scales of Infant Development II (BSID-II), to children who returned for follow-up at approximately 24 months (n=276). We estimated associations between phthalate metabolite concentrations in maternal urine and BSID-II indices (Mental Development Index (MDI), Psychomotor Development Index (PDI)).

RESULTS: We observed no associations between phthalate metabolite concentrations and performance on the MDI or PDI in boys and girls combined. We did, however, observe evidence of effect measure modification by sex. We observed several negative associations between metabolite concentrations and both MDI and PDI scores among girls, suggesting poorer performance across multiple metabolites, with estimates equal to a 2-3 point decrease in score per ln-unit increase in creatinine-standardized metabolite concentration. Conversely, we observed multiple weakly positive associations among boys, equal to a 1-2 point increase in score per ln-unit increase in metabolite concentration. The strongest associations were for the metabolites mono-n-butyl phthalate, mono-isobutyl phthalate, monobenzyl phthalate, and mono(3-carboxylpropyl) phthalate (MCPP).

CONCLUSIONS: Girls of mothers with higher urinary concentrations of MCPP and metabolites of dibutyl phthalates had lower MDI scores on the BSID-II. These same biomarker concentrations were often associated with improved scores among boys. We observed similar results for MnBP, MCPP, and MBzP on the PDI. Given the prevalence of phthalate exposures in reproductive aged women, the implications of potential neurotoxicity warrant further investigation.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Non-target analysis of household dust and laundry dryer lint using comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometry

Authors: Ouyang, X; Weiss, JM; de Boer, J; Lamoree, MH; Leonards, PE (2017) Chemosphere 166:431-437. HERO ID: 3455857

[Less] Household dust and laundry dryer lint are important indoor environmental matrices that may have notable . . . [More] Household dust and laundry dryer lint are important indoor environmental matrices that may have notable health effects on humans due to chronic exposure. However, due to the sample complexity the studies conducted on these sample matrices until now were almost exclusively on the basis of target analysis. In this study, comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometry (LC × LC-ToF MS) was applied, to enable non-target analysis of household dust as well as laundry dryer lint for the first time. The higher peak capacity and good orthogonality of LC × LC, together with reduced ion suppression in the MS enabled rapid identification of environmental contaminants in these complex sample matrices. A number of environmental contaminants were tentatively identified based on their accurate masses and isotopic patterns, including plasticizers, flame retardants, pesticides, drug metabolites, etc. The identity of seven compounds: tris(2-butoxyethyl) phosphate, tris(2-chloropropyl) phosphate, n-benzyl butyl phthalate, dibutyl phthalate, tributyl phosphate, triethyl phosphate and N, N-diethyl-meta-toluamide was confirmed using two-dimensional retention alignment and their concentrations in the samples were semi-quantitatively determined.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Assessing the concentration of phthalate esters (PAEs) and bisphenol A (BPA) and the genotoxic potential of treated wastewater (final effluent) in Saudi Arabia

Authors: Al-Saleh, I; Elkhatib, R; Al-Rajoudi, T; Al-Qudaihi, G (2017) Science of the Total Environment 578:440-451. HERO ID: 3469247

[Less] Plasticizers such as phthalate esters (PAEs) and bisphenol A (BPA) are highly persistent organic pollutants . . . [More] Plasticizers such as phthalate esters (PAEs) and bisphenol A (BPA) are highly persistent organic pollutants that tend to bio-accumulate in humans through the soil-plant-animal food chain. Some studies have reported the potential carcinogenic and teratogenic effects in addition to their estrogenic activities. Water resources are scarce in Saudi Arabia, and several wastewater treatment plants (WTPs) have been constructed for agricultural and industrial use. This study was designed to: (1) measure the concentrations of BPA and six PAEs, dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), butyl benzyl phthalate (BBP), bis (2-ethylhexyl) phthalate (DEHP) and dioctyl phthalate (DOP), in secondary- and tertiary-treated wastewater collected from five WTPs in three Saudi cities for four to five weeks and (2) test their potential genotoxicity. Three genotoxicological parameters were used: % tail DNA (%T), tail moment (TM) and percentage micronuclei (%MN). Both DBP and DEHP were detected in all treated wastewater samples. DMP, DEP, BBP, DOP, and BPA were found in 83.3, 84.2, 79, 73.7 and 97.4% of the samples, respectively. The levels of DMP (p<0.001), DOP (p<0.001) and BPA (p=0.001) were higher in tertiary- treated wastewater than secondary-treated wastewater, perhaps due to the influence of the molecular weight and polarity of the chemicals. Both weekly sampling frequency and WTP locations significantly affected the variability in our data. Treated wastewater from Wadi Al-Araj was able to induce DNA damage (%T and TM) in human lymphoblastoid TK6 cells that was statistically higher than wastewater from all other WTPs and in untreated TK6 cells (negative control). %MN in samples from both Wadi Al-Araj and Manfouah did not differ statistically but was significantly higher than in the untreated TK6 cells. This study also showed that the samples of tertiary-treated wastewater had a higher genotoxicological potential to induce DNA damage than the samples of secondary-treated wastewater. BPA and some PAEs in the treated wastewater might have the potential to induce genetic damage, despite their low levels. Genotoxicity, however, may also have been due to the presence of other contaminants. Our preliminary findings should be of concern to Saudi agriculture because long-term irrigation with treated wastewater could lead to the accumulation of PAEs and BPA in the soil and ultimately reach the human and animal food chain. WTPs need to remove pollutants more efficiently. Until then, a cautious use of treated wastewater for irrigation is recommended to avoid serious health impacts on local populations.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Phenyl-functionalized mesoporous silica materials for the rapid and efficient removal of phthalate esters

Authors: Fan, J; Wang, X; Teng, W; Yang, J; Ran, X; Gou, X; Bai, N; Lv, M; Xu, H; Li, G; Zhang, W; Zhao, D (2017) Journal of Colloid and Interface Science 487:354-359. HERO ID: 3491078

[Less] Phthalate esters (PAEs) are a group of endocrine disrupting compounds, which have been widely used as . . . [More] Phthalate esters (PAEs) are a group of endocrine disrupting compounds, which have been widely used as plasticizers. To alleviate the environmental and health threats from water resources polluted by PAEs, we prepared phenyl functionalized mesoporous silica materials (ph-SBA-15) were synthesized by a simple post-modification approach for rapid and efficient removal of low concentration of di-n-butyl phthalate (DBP) from aqueous solution. Mesostructure, texture, surface chemistry and surface charges were systemically characterized. The obtained ph-SBA-15 possesses a highly ordered mesostructure, a high surface area (418m(2)/g), uniform mesopores (6.5nm) and high-density organic groups around 11wt.%. Batch adsorption experiments revealed that phenyl modified SBA-15 had an excellent ability to remove DBP with the maximum adsorption capacity up to ∼40mg/g at 25°C. The thermodynamics and kinetics for the adsorption were also investigated, demonstrating an exothermic, multi-layer and fast adsorption process. In addition, DBP adsorption was found to be sensitive to the pH and the uptake was observed to be greatest at around pH 7.0. Furthermore, this material can be effectively regenerated by ethanol.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Enhanced biodegradation of di-n-butyl phthalate by Acinetobacter species strain LMB-5 coated with magnetic nanoparticles

Authors: Wang, J; Jiang, L; Zhou, Y; Ye, BCe (2017) International Biodeterioration & Biodegradation 116:184-190. HERO ID: 3502600

[Less] Phthalate acid esters (PAEs) are widely present in a variety of consumer products and they pose a . . . [More] Phthalate acid esters (PAEs) are widely present in a variety of consumer products and they pose a public health concern due to the high mobility and hazards. In this study, we designed an immobilized method to eliminate phthalates by using Fe3O4@NH2 nanoparticles (NPs). The surface-modified NPs showed a good dispersion property, and the particle size was approximately 230 nm. The results showed that Acinetobacter sp. strain LMB-5 could be coated by the prepared magnetic particles allowing easy separation from solution by applying an external magnetic field. The coated cells possessed adaptability to a wide range of pH and high tolerance towards toxic substances. More importantly, when the temperature was elevated to 60 degrees C, the coated cells also exhibited remarkable degradability. There was no change in the main metabolites during the biodegradation between the free cells and immobilized ones through GC/MS analysis to detect the degradation intermediates. These results show that immobilization method using magnetic nanoparticles is a promising way for degradation of phthalates in application. (C) 2016 Elsevier Ltd. All rights reserved.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Phthalate levels and related factors in children aged 6-12 years

Authors: Wu, W; Zhou, F; Wang, Y; Ning, Y; Yang, JY; Zhou, YK (2017) Environmental Pollution 220:990-996. HERO ID: 3469193

[Less] Although previous studies showed that children are widely exposed to phthalates, the sources of phthalate . . . [More] Although previous studies showed that children are widely exposed to phthalates, the sources of phthalate exposure for school-aged children in China are not well understood. This study aimed to assess phthalate metabolite levels and explore the factors influencing exposure in children. We collected demographic data and biological samples from 336 children aged 6-12 years. We calculated urinary concentrations of 14 mono-phthalate metabolites and conducted chi-square (χ(2)) tests and logistic regression analysis to determine the variables associated with phthalate levels. Mono-n-butyl phthalate (MnBP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) were the most abundant urinary phthalate metabolites. In addition, housing type, decorating materials in the home, and frequency of canned food consumption were associated with exposure to low molecular weight phthalates. Water source, duration of time spent playing with toys, residential area, and frequency of canned food consumption were associated with exposure to high molecular weight phthalates. Based on these results, potential strategies to reduce exposure to phthalates include avoiding plastic food containers and chemical fragrances as well as eating fewer processed foods, especially canned foods, and foods in plastic packaging.