Health & Environmental Research Online (HERO)


BBP (Butyl benzyl phthalate)


1,590 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications

Authors: Jahreis, S; Trump, S; Bauer, M; Bauer, T; Thürmann, L; Feltens, R; Wang, Q; Gu, L; Grützmann, K; Röder, S; Averbeck, M; Weichenhan, D; Plass, C; Sack, U; Borte, M; Dubourg, V; Schüürmann, G; Simon, JC; Martin Von, B; Hackermüller, J; Eils, R; Lehmann, I; Polte, T (2018) Journal of Allergy and Clinical Immunology 141:741-753. HERO ID: 5490441

[Less] Background Prenatal and early postnatal exposures to environmental factors are considered responsible . . . [More] Background Prenatal and early postnatal exposures to environmental factors are considered responsible for the increasing prevalence of allergic diseases. Although there is some evidence for allergy-promoting effects in children because of exposure to plasticizers, such as phthalates, findings of previous studies are inconsistent and lack mechanistic information. Objective We investigated the effect of maternal phthalate exposure on asthma development in subsequent generations and their underlying mechanisms, including epigenetic alterations. Methods Phthalate metabolites were measured within the prospective mother-child cohort Lifestyle and Environmental Factors and Their Influence on Newborns Allergy Risk (LINA) and correlated with asthma development in the children. A murine transgenerational asthma model was used to identify involved pathways. Results In LINA maternal urinary concentrations of mono-n-butyl phthalate, a metabolite of butyl benzyl phthalate (BBP), were associated with an increased asthma risk in the children. Using a murine transgenerational asthma model, we demonstrate a direct effect of BBP on asthma severity in the offspring with a persistently increased airway inflammation up to the F2 generation. This disease-promoting effect was mediated by BBP-induced global DNA hypermethylation in CD4+T cells of the offspring because treatment with a DNA-demethylating agent alleviated exacerbation of allergic airway inflammation. Thirteen transcriptionally downregulated genes linked to promoter or enhancer hypermethylation were identified. Among these, the GATA-3 repressor zinc finger protein 1(Zfpm1)emerged as a potential mediator of the enhanced susceptibility for TH2-driven allergic asthma. Conclusion These data provide strong evidence that maternal BBP exposure increases the risk for allergic airway inflammation in the offspring by modulating the expression of genes involved in TH2 differentiation through epigenetic alterations.

Data/Software
Data/ Software

Substance information: Benzyl butyl phthalate

Author: ECHA (2017) HERO ID: 3663960


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Comparative toxicity, oxidative stress and endocrine disruption potential of plasticizers in JEG-3 human placental cells

Authors: Pérez-Albaladejo, E; Fernandes, D; Lacorte, S; Porte, C (2017) Toxicology In Vitro 38:41-48. HERO ID: 3469255

[Less] Plasticizers are suspected to be toxic and/or to modulate or disrupt the endocrine system of humans . . . [More] Plasticizers are suspected to be toxic and/or to modulate or disrupt the endocrine system of humans and to cross the placental barrier, being embryonic and fetal development a particularly vulnerable period. This work investigates the comparative toxicity and ability to interfere with the synthesis of steroids and to generate reactive oxygen species (ROS) of a selected number of plasticizers, including bisphenol A (BPA), nonyl- (NP) and octylphenol (OP), benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), di(2-ethylhexyl)phthalate (DEHP) and dimethyl phthalate (DMP), in the human placenta JEG-3 cells. Moreover, the bioavailability of chemicals in culture medium has been investigated. After 24h exposure, OP and NP showed the highest cytotoxicity (EC50: 36-40μM) followed by BPA (138-219μM), whereas no significant toxicity was observed for phthalates. Notwithstanding, BBP and DBP significantly decreased P450 aromatase activity (experimental IC50: 14-15μM), while NP and OP (20μM) increased the activity. Overall, this study evidences the differential toxicity and ability to modulate placental aromatase activity of some of the compounds nowadays used as plasticizers, and highlights the need of an accurate determination of the bioavailability of chemicals to improve the sensitivity of in-vitro tests.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The plasticizer BBP selectively inhibits epigenetic regulator sirtuin during differentiation of C3H10T1/2 stem cell line

Authors: Zhang, J; Choudhury, M (2017) Toxicology In Vitro 39:75-83. HERO ID: 3519887

[Less] Exposure to environmental chemicals can perturb an individual's metabolic set point, especially during . . . [More] Exposure to environmental chemicals can perturb an individual's metabolic set point, especially during critical periods of development, and as a result increase his or her propensity towards obesity that is manifested later in life and possibly in successive generations. We hypothesized that benzyl butyl phthalate (BBP), a widespread endocrine disruptor, may impair one important epigenetic regulator, sirtuin, in mesenchymal stem cells and induce adipogenesis. Our results showed that gene expression of two well-known adipogenic markers, aP2 and PPARγ, were significantly increased from day 2 to day 8 under 50μM BBP exposure when compared to control in C3H10T1/2 stem cells (p<0.05) and induced adipogenesis. Sirt1 gene expression was also significantly decreased at day 2, 4, 6, and 8 (p<0.05). However, Sirt7 gene expression was decreased only at day 2 and 8 (p<0.05) while other sirtuin transcriptional levels remained unaltered throughout. Furthermore, Sirt1 and Sirt3 protein expression was decreased (p<0.05) and overall protein hyperacetylation was observed at day 8. Furthermore, FOXO1 and β-catenin, Sirt1 targets and adipogenesis regulators, were hyperacetylated at day 8. PGC1α, NRF1, NRF2, and Tfam, were also significantly decreased (p<0.05). In conclusion, our study suggests for the first time that BBP, a potential epigenetic disruptor, can lead to increased adipogenesis and metabolic dysregulation by impairing vital epigenetic regulators.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Determination of phthalate esters in distillates by ultrasound-vortex-assisted dispersive liquid-liquid micro-extraction (USVADLLME) coupled with gas chromatography/mass spectrometry

Authors: Montevecchi, G; Masino, F; Zanasi, L; Antonelli, A (2017) Food Chemistry 221:1354-1360. HERO ID: 3515158

[Less] A method for the extraction of phthalate esters (PAEs) by Ultrasound-Vortex-Assisted Dispersive Liquid-Liquid . . . [More] A method for the extraction of phthalate esters (PAEs) by Ultrasound-Vortex-Assisted Dispersive Liquid-Liquid Micro-Extraction (USVADLLME) approach was optimised and applied for the first time to a historical series of brandies. These contaminants are widely spread in the environment as a consequence of about half century of use in different fields of applications. The concern about these substances and the recent legal restrictions of China in distillates import need a quick and sensitive method for their quantification. The proposed method, moreover, is environmentally oriented due to the disposal of micro-quantities of solvent required. In fact, sub-ppm-limits of detection were achieved with a solvent volume as low as 160μL. The analysed samples were within the legal limits, except for some very ancient brandies whose contamination was probably due to a PAEs concentration effect as a consequence of long ageing and for the use of plastic pipelines no more operative.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction

Authors: Buñay, J; Larriba, E; Moreno, RD; Del Mazo, J (2017) Scientific Reports 7:3373. HERO ID: 3860092

[Less] Humans are environmentally exposed not only to single endocrine-disrupting chemicals (EDCs) but to mixtures . . . [More] Humans are environmentally exposed not only to single endocrine-disrupting chemicals (EDCs) but to mixtures that affect their reproductive health. In reproductive tissues, microRNAs (miRNAs) are emerging as key targets of EDCs. Here, we analysed changes in the testis "miRNome" (and their biogenesis mechanism) in chronically exposed adult mice to a cocktail of five EDCs containing 0.3 mg/kg-body weight (BW)/day of each phthalate (DEHP, DBP, BBP) and 0.05 mg/kg-BW/day of each alkylphenol (NP, OP), from conception to adulthood. The testis "miRNome" was characterised using next-generation sequencing (NGS). Expression levels of genes involved in miRNA biogenesis were measured by RT-qPCR, as well as several physiological and cytological parameters. We found two up-regulated, and eight down-regulated miRNAs and thirty-six differentially expressed isomiRs along with an over-expression of Drosha, Adar and Zcchc11. A significant decrease of intratesticular estradiol but not testosterone was detected. Functional analysis showed altered spermatogenesis, germ cell apoptosis and negative correlation of miR-18a-5p with Nr1h2 involved in the deregulation of the steroidogenesis pathway. Here, we present the first association between miRNA/isomiRs deregulation, their mechanisms of biogenesis and histopathological and hormonal alterations in testes of adult mice exposed to a mixture of low-dose EDCs, which can play a role in male infertility.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Quantification of Six Phthalates and One Adipate in Luxembourgish Beer Using HS-SPME-GC/MS

Authors: Carnol, L; Schummer, C; Moris, G (2017) Food Analytical Methods 10:298-309. HERO ID: 3860093

[Less] A simple, low-cost and sensitive method for the determination of six phthalate acid esters (dimethyl . . . [More] A simple, low-cost and sensitive method for the determination of six phthalate acid esters (dimethyl phthalate, diethyl phthalate, dibutyl phthalate, benzyl butyl phthalate, bis(2-ethylhexyl) phthalate and dioctyl phthalate) and one adipate (bis(2-ethylhexyl) adipate) in beer has been developed using head-space solid-phase microextraction (HS-SPME) followed by gas chromatography coupled to mass spectrometry (GC/MS). SPME conditions were optimised, and optimum extraction parameters were found to be 95 A degrees C at 100 min, without addition of NaCl. Matrix interference was avoided by using a deuterated internal standard (ISTD). Limits of detection ranged from 0.006 to 0.590 mu g/L. The method showed good linearity with coefficients of determination ranging from 0.963 to 0.999 and satisfactory accuracy (74-101 %) and repeatability (3.56-27.86 %) values. The method was applied to 15 samples of beer from Luxembourgish breweries, stored in different containers (can, glass and aluminium bottle), and phthalates were detected in all samples with concentrations as high as 61.56 mu g/L for total phthalates. The exact origins of phthalates in beer were difficult to determine from the data in this study, though the brewing and bottling process seems to be a major contributor.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Ionic Liquid-Based Surfactant Extraction Coupled with Magnetic Dispersive mu-Solid Phase Extraction for the Determination of Phthalate Esters in Packaging Milk Samples by HPLC

Authors: Wang, M; Yang, Fan; Liu, Le; Cheng, C; Yang, Y (2017) Food Analytical Methods 10:1745-1754. HERO ID: 3860098

[Less] A highly selective sample cleanup procedure combining ionic liquid-based surfactant extraction (ILSE) . . . [More] A highly selective sample cleanup procedure combining ionic liquid-based surfactant extraction (ILSE) and magnetic dispersive mu-solid phase extraction (MD-mu-SPE) was triumphantly developed for the synchronously extraction of four phthalate acid esters (PAEs) in packaging milk samples prior to high-performance liquid chromatography coupled with photodiode array detector (HPLC-DAD). In this ionic liquid (IL)-based surfactant method, 1-octyl-3-methylimidazolium hexafluorophosphate ([C8MIM] [PF6]) was used as extraction solvent, anionic surfactant sodium linear alkylbenzene sulfonate (LAS) was used as auxiliary extraction solvent, and then sodium chloride (NaCl) was mixed to drive phase separation. The synthesized hydrophobic diatomaceous earth-supported Fe3O4 magnetic nanoparticles (DSMNPs) were applied as an efficient adsorbent to retrieve the analyte-containing IL and LAS. Under the optimal extraction situations, good linearity of the approach was obtained in the concentration range from 10 to 1000 ng/mL for target analytes, and the preconcentration process was rapidly accomplished in 5 min. The limits of detection (LODs) based on a signal-to-noise ratio (S/N = 3) were ranged from 1.42 to 3.57 ng/mL with the relative standard deviations (RSDs) over the range of 1.84-3.56% (n = 5). The above-mentioned method was applied to the trace analysis of four PAEs including benzyl butyl phthalate (BBP), dicyclohexyl phthalate (DCHP), di-n-butyl phthalate (DBP), and di-n-octyl phthalate (DNOP) in packaging milk samples, and recoveries were between 89.8 and 99.7%.

Data/Software
Data/ Software

Substance information: 1-methyl-2-pyrrolidone

Author: ECHA (2017) HERO ID: 3827462


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Endocrine disruption: In silico interactions between phthalate plasticizers and corticosteroid binding globulin

Authors: Sheikh, IA; Beg, MA (2017) Journal of Applied Toxicology 37:1471-1480. HERO ID: 5618172

[Less] Endocrine disruption is a phenomenon when a man-made or natural compound interferes with normal hormone . . . [More] Endocrine disruption is a phenomenon when a man-made or natural compound interferes with normal hormone function in human or animal body systems. Endocrine-disrupting compounds (EDCs) have assumed considerable importance as a result of industrial activity, mass production of synthetic chemicals and environmental pollution. Phthalate plasticizers are a group of chemicals used widely and diversely in industry especially in the plastic industry, and many of the phthalate compounds have endocrine-disrupting properties. Increasing evidence indicates that steroid nuclear receptors and steroid binding proteins are the main targets of endocrine disruption. Corticosteroid-binding globulin (CBG) is a steroid binding protein that binds and transports cortisol in the blood circulation and is a potential target for endocrine disruption. An imbalance of cortisol in the body leads to many health problems. Induced fit docking of nine important and environmentally relevant phthalate plasticizers (DMP, BBP, DBP, DIBP, DnHP, DEHP, DINP, DnOP, DIDP) showed interactions with 10-19 amino acid residues of CBG. Comparison of the interacting residues of CBG with phthalate ligands and cortisol showed an overlapping of the majority (53-82%) of residues for each phthalate. Five of nine phthalate compounds and cortisol shared a hydrogen bonding interaction with the Arg-252 residue of CBG. Long-chain phthalates, such as DEHP, DINP, DnOP and DIDP displayed a higher binding affinity and formed a number of interactions with CBG in comparison to short-chain phthalates. The similarity in structural binding characteristics of phthalate compounds and native ligand cortisol suggested potential competitive conflicts in CBG-cortisol binding function and possible disruption of cortisol and progesterone homeostasis. Phthalates as endocrine-disrupting compounds (EDC) have assumed considerable importance as a result of environmental pollution. Corticosteroid-binding globulin (CBG) transports cortisol in the blood circulation and is a potential target for endocrine disruption. An imbalance of cortisol in the body leads to many health problems. Induced fit docking of important phthalate plasticizers revealed similarity in structural binding characteristics of phthalate compounds and native ligand cortisol. These results suggest competitive conflicts in CBG-cortisol binding function and potential disruption of cortisol homeostasis.