Health & Environmental Research Online (HERO)


BBP (Butyl benzyl phthalate)


435 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Occurrence and Profiles of Phthalates in Foodstuffs from China and Their Implications for Human Exposure

Authors: Guo, Y; Zhang, Z; Liu, L; Li, Y; Ren, N; Kannan, K (In Press) Journal of Agricultural and Food Chemistry. HERO ID: 1311703

[Less] Phthalate esters are used in a wide variety of consumer products, and human exposure to this class of . . . [More] Phthalate esters are used in a wide variety of consumer products, and human exposure to this class of compounds is widespread. Nevertheless, studies on dietary exposure of humans to phthalates are limited. In this study, nine phthalate esters were analyzed in eight categories of foodstuffs (n = 78) collected from Harbin and Shanghai, China, in 2011. Dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP), benzyl butyl phthalate (BzBP), and diethylhexyl phthalate (DEHP) were frequently detected in food samples. DEHP was the major compound found in most of the food samples, with concentrations that ranged from below the limit of quantification (LOQ) to 762 ng/g wet weight (wt). The concentrations of phthalates in food samples from China were comparable to concentrations reported for several other countries, but the profiles were different; DMP was found more frequently in Chinese foods than in foods from other countries. The estimated daily dietary intake of phthalates (EDI(diet)) was calculated based on the concentrations measured and the daily ingestion rates of food items. The EDI(diet) values for DMP, DEP, DIBP, DBP, BzBP, and DEHP (based on mean concentrations) were 0.092, 0.051, 0.505, 0.703, 0.022, and 1.60 μg/kg-bw/d, respectively, for Chinese adults. The EDI(diet) values calculated for phthalates were below the reference doses suggested by the United States Environmental Protection Agency (EPA). Comparison of total daily intakes, reported previously based on a biomonitoring study, with the current dietary intake estimates suggests that diet is the main source of DEHP exposure in China. Nevertheless, diet accounted for only <10% of the total exposure to DMP, DEP, DBP, and DIBP, which suggested the existence of other sources of exposure to these phthalates.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Isolation and characterization of two n-butyl benzyl phthalate degrading bacteria

Authors: Yang, Xue; Zhang, Can; He, Z; Hu, X; Guo, Jia; Zhong, Qiu; Wang, J; Xiong, Li; Liu, D (2013) International Biodeterioration & Biodegradation 76:8-11. HERO ID: 1465057

[Less] nButyl benzyl phthalate (BBP) is a phthalic acid ester (PAE) used extensively in the manufacturing . . . [More] nButyl benzyl phthalate (BBP) is a phthalic acid ester (PAE) used extensively in the manufacturing of plastics that contributes to the environmental pollution. It easily released to the environment and resistant to degradation. Bioremediation has been proposed for removal of PAEs from contaminated sites. Studies showed that the biodegradation of PAEs was slow if the lateral chain was longer and more complex. Two BBP degrading bacterial strains, HS-B1, HS-B2, were isolated from contaminated sludge in the river of Jingzhou in Hubei province. The two bacteria were identified as Acinetobacter sp. and Arthrobacter sp. by morphology and 16S rDNA sequence analysis. BBP at 500 mg L-1 in the culture medium was tested and after 24 h of culture, chloroform was used to extract the BBP in the culture medium. The initial and the final concentrations of BBP were assessed by UV-visible spectrophotometer. The results showed that the bacterium could grow well on BBP as the sole source of carbon and energy. The degradation of 500 mg L-1 BBP by strains HS-B1 and HS-B2 was 28% and 59% after 24 h, respectively. The rate of degradation increased to 40%, 75% respectively with addition of 0.1% LB in 24 h, suggesting that additional sources of growth factors enhanced biodegradation. This study is helpful to the development of microbial resources for bioremediation. (C) 2012 Elsevier Ltd. All rights reserved.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Assessment of Adult Human Exposure to Phthalate Esters in the Urban Centre of Paris (France)

Authors: Martine, B; Marie-Jeanne, T; Cendrine, D; Fabrice, A; Marc, C (2013) Bulletin of Environmental Contamination and Toxicology 90:91-96. HERO ID: 1315297

[Less] Human exposure to phthalates was assessed through digestive and respiratory intakes. Six phthalates . . . [More] Human exposure to phthalates was assessed through digestive and respiratory intakes. Six phthalates (DMP, DEP, DnBP, BBP, DEHP, DnOP) were investigated in drinking water, in current foodstuff and in ambient air. Digestive intake was prevailing (92 %) with a major contribution of food (95.5 %). Phthalate intake from water was mainly due to bottled water (60 %) in spite of the minor volume absorbed daily. From the respiratory tract, it was dominated by DEP: 30.3 ng kg(-1) bw day(-1) and the part played by indoor air prevailed. Total intake were as ng kg(-1) bw day(-1), for DEHP: 1458, DnBP: 191.8, BBP: 164.3, DEP: 107.7, DMP: 79.1.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A rapid and sensitive gas chromatography-mass spectrometry method for the quality control of perfumes: simultaneous determination of phthalates

Authors: Lopez-Nogueroles, M; Benede, JL; Chisvert, A; Salvador, A (2013) Analytical Methods 5:409-415. HERO ID: 1464953

[Less] A rapid and sensitive analytical gas chromatography-mass spectrometry (GC-MS) method for perfume analysis . . . [More] A rapid and sensitive analytical gas chromatography-mass spectrometry (GC-MS) method for perfume analysis to determine the phthalates banned by the European Union Regulation on cosmetic samples is presented. This method has been tested in commercial alcoholic perfume samples for the determination of the following seven phthalates: dibutyl phthalate, bis(2-ethylhexyl) phthalate, bis(2-methoxyethyl) phthalate, n-pentyl-isopentylphthalate, di-n-pentyl phthalate, diisopentylphthalate and benzyl butyl phthalate. Sample evaporation and redissolution in ethanol is carried out before GC-MS analysis, with no dilution of the sample. External calibration and standard addition calibration are compared to detect possible matrix effects. External calibration could provide good results in some cases but standard addition calibration is recommended as matrix effects are observed in many cases in the determination of the target phthalates. The accuracy of the method has been proven by the analysis of quality control samples prepared from commercial free phthalate perfumes after spiking with known concentrations of the analytes. Accurate results were obtained with limits of detection in the ng mL(-1) range and good repeatability (relative standard deviations lower than 6%). The method was satisfactorily applied to the analysis of commercial perfume samples, and the results revealed considerable amounts of dibutyl phthalate and bis(2-ethylhexyl) phthalate in some of the analyzed samples.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Study of Photocatalytic Degradation mechanism of Butyl enzyl phthalate ester

Authors: Lu, Yan; Xi, L (2012) HERO ID: 1464954

[Less] Under ultraviolet radiation, the photocatalytic degradation mechanism of Butyl enzyl phthalate ester . . . [More] Under ultraviolet radiation, the photocatalytic degradation mechanism of Butyl enzyl phthalate ester (BBP) was studied with TiO2 as the catalyst. As a result, BBP could be degraded efficiently, and the efficiency was 85% after 6h degradation. During the degradation process, the acidity of the degradation system changed obviously. The initial pH of the solution was 6.0, and it increased to 6.23 after 15min degradation, however it decreased to 3.89 after 6h degradation. Some photodegradation intermediates in the different photocatalytic steps were examined and analyzed by means of GC-MS. For the BBP, the photocatalytic degradation firstly reacted on the benzyloxy chain, and new material occured by the recomposition of the educts in the degradation.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Determination of Selected Endocrine Disrupter Compounds at Trace Levels in Sewage Sludge Samples

Authors: Sonmez, MS; Muz, M; Komesli, OT; Bakirdere, S; Gokcay, CF (2012) HERO ID: 1465025

[Less] Simultaneous determination of endocrine disrupter compounds (EDCs), namely diltiazem, progesterone, . . . [More] Simultaneous determination of endocrine disrupter compounds (EDCs), namely diltiazem, progesterone, benzylbutylphthalate (BBP), estrone, and carbamazepine (Cbz) were performed by using high performance LC-electrospray tandem MS. The ultrasound-aided sequential extraction of sludge samples was optimized to increase extraction efficiencies of the analytes; ranging between 93.0-98.3% recovery. The limit of detection values for diltiazem, progesterone, BBP, estrone, and Cbz were found as 0.78, 0.72, 0.24, 0.75, and 0.72 mu g/kg, respectively. Sludge samples taken from Ankara Tatlar; Hurma, Lara and Kemer of Antalya, and Middle East Technical University-vacuum rotating membrane wastewater treatment plant (WWTP) aeration tanks were analyzed for their EDCs contents under optimized conditions. Diltiazem was found in all the samples in the range between 116.4-180.8 ng/g while progesterone and estrone were not detected in any of the samples analyzed with the exception of Tatlar WWTP. The BBP concentration was between beyond detection and 9195.5 ng/g. In addition, Cbz was found in all the samples ranging from 25.6 to 118.8 ng/g.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

n-Butyl benzyl phthalate promotes breast cancer progression by inducing expression of lymphoid enhancer factor 1

Authors: Hsieh, TH; Tsai, CF; Hsu, CY; Kuo, PL; Hsi, E; Suen, JL; Hung, CH; Lee, JN; Chai, CY; Wang, SC; Tsai, EM (2012) PLoS ONE 7:e42750. HERO ID: 1337049

[Less] Environmental hormones play important roles in regulating the expression of genes involved in cell proliferation, . . . [More] Environmental hormones play important roles in regulating the expression of genes involved in cell proliferation, drug resistance, and breast cancer risk; however, their precise role in human breast cancer cells during cancer progression remains unclear. To elucidate the effect of the most widely used industrial phthalate, n-butyl benzyl phthalate (BBP), on cancer progression, we evaluated the results of BBP treatment using a whole human genome cDNA microarray and MetaCore software and selected candidate genes whose expression was changed by more than ten-fold by BBP compared with controls to analyze the signaling pathways in human breast cancer initiating cells (R2d). A total of 473 genes were upregulated, and 468 were downregulated. Most of these genes are involved in proliferation, epithelial-mesenchymal transition, and angiogenesis signaling. BBP induced the viability, invasion and migration, and tube formation in vitro, and Matrigel plug angiogenesis in vivo of R2d and MCF-7. Furthermore, the viability and invasion and migration of these cell lines following BBP treatment was reduced by transfection with a small interfering RNA targeting the mRNA for lymphoid enhancer-binding factor 1; notably, the altered expression of this gene consistently differentiated tumors expressing genes involved in proliferation, epithelial-mesenchymal transition, and angiogenesis. These findings contribute to our understanding of the molecular impact of the environmental hormone BBP and suggest possible strategies for preventing and treating human breast cancer.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The Study of Biodegradation of Butyl Benzyl Phthalate by Phanerochaete Chrysosporium

Authors: Yang, Y; Fang, Wei; Hu, X; Ren, Na; Liang, D (2012) Advanced Materials Research 343-344:513-518. HERO ID: 1341860

[Less] In this study, the microbial degradation characteristics of butyl benzyl phthalate (BBP) were studied . . . [More] In this study, the microbial degradation characteristics of butyl benzyl phthalate (BBP) were studied by using Phanerochaete chrysosporium. Results showed Phanerochaete chrysosporium can effectively degrade BBP and the degradation efficiency can reach 90% in 2 days. This strain can use BBP as sole carbon source. The biodegradation of BBP by Phanerochaete chrysosporium fits for first-order kinetics (Inc=-K(b)t+a), which are Inc = - 0.0445x + 4.4235, Inc = -0.0404x + 5.1221, Inc = -0.0389x + 5.6363, respectively, for the concentration of 100mg/L, 300mg/L, 500mg/L. The biodegradation rate constants are 0.0445 d(-1) 0.0404 d(-1), 0.0389 d(-1), respectively. The biodegradation rate constant reduces with the increase of the concentration of BBP, indicating BBP has inhibitory effect on Phanerochaete chrysosporium, especially under high concentration. The high performance liquid chromatography (HPLC) profile of the metabolites indicated the accumulation of two major products except for phthalic acid (PA). These two products were characterized by high performance liquid chromatography mass spectrometry (HPLC/MS) as mono-n-butyl phthalate (MBuP) and monobenzyl phthalate (MBzP).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Phthalates induce proliferation and invasiveness of estrogen receptor-negative breast cancer through the AhR/HDAC6/c-Myc signaling pathway

Authors: Hsieh, T-H; Tsai, C-F; Hsu, C-Y; Kuo, P-L; Lee, J-N; Chai, C-Y; Wang, S-C; Tsai, E-M (2012) FASEB Journal 26:778-787. HERO ID: 1249834

[Less] The environmentally present group of chemical phthalates, or phthalate esters, has been recognized as . . . [More] The environmentally present group of chemical phthalates, or phthalate esters, has been recognized as a rising threat to public health, including cancer. While most studies have addressed the estrogenic effects of phthalates in malignancies of the breast and the prostate, little is known about their role in the etiology of hormone-independent cancer. Here we show that treatments with the phthalates n-butyl benzyl phthalate (BBP) and dibutyl phthalate (DBP) at 1 μM induced proliferation (BBP, 3.2-fold; DBP, 3.2-fold), migration (BBP, 2.6-fold; DBP, 2.6-fold), invasion (BBP, 2.7-fold; DBP, 3.1-fold), and tumor formation (EC(50): BBP, 0.12 μM; DBP, 0.22 μM) in estrogen receptor (ER)-negative breast cancer cells (MDA-MB-231). We further demonstrate that phthalates stimulated the cell surface aryl hydrocarbon receptor (AhR) and triggered the downstream cyclic AMP (cAMP)-PKA-CREB1 signaling cascade. The pathway led to increased expression of HDAC6, which facilitated nuclear assembly of the β-catenin-LEF1/TCF4 transcriptional complex and transactivation of the c-Myc oncogene. This nongenomic pathway emanated from the phthalate-induced AhR promoted tumorigenesis of ER-negative breast cancer. Collectively, our findings revealed a novel oncogenic mechanism of phthalates in breast cancer independent from their estrogenic activities.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Extraction of Phthalate Esters in Environmental Water Samples Using Layered-Carbon Magnetic Hybrid Material as Adsorbent Followed by Their Determination with HPLC

Authors: Wang, W; Wu, Q; Zang, X; Wang, C; Wang, Zhi (2012) Bulletin of the Korean Chemical Society 33:3311-3316. HERO ID: 1465047

[Less] In this paper, a layered-carbon-Fe3O4 (LC-Fe3O4) hybrid material was synthesized through a facile one-pot . . . [More] In this paper, a layered-carbon-Fe3O4 (LC-Fe3O4) hybrid material was synthesized through a facile one-pot solvothermal method and used as the adsorbent for the preconcentration of some phthalate esters (dimethyl phthalate, diethyl phthalate, diallyl phthalate, diisobutyl phthalate and benzyl butyl phthalate) in water samples. The effects of the adsorbent dosage, extraction time, the solution pH and salinity on the adsorption of the phthalate esters (PAEs) were investigated. The magnetic nanocomposite adsorbent could remove and enrich the PAEs from water samples efficiently. After the adsorption, the analytes were desorbed and then determined by high performance liquid chromatography-ultraviolet detection. Under the optimum conditions, the enrichment factors of the method for the analytes were in the range from 161 to 180. A linear response with peak area as the quantification signal was observed in the concentration range from 0.5 to 100 ng mL(-1). The limits of detection (S/N = 3) of the method were between 0.08 and 0.1 ng mL(-1). The method was suitable for the determination of trace phthalate esters in environmental water samples.