Health & Environmental Research Online (HERO)


BBP (Butyl benzyl phthalate)


189 References Were Found:

Data/Software
Data/ Software

Substance information: Benzyl butyl phthalate

Author: ECHA (2017) HERO ID: 3663960


Data/Software
Data/ Software

Substance information: 1-methyl-2-pyrrolidone

Author: ECHA (2017) HERO ID: 3827462


Technical Report
Technical Report

Substance information: Carbon tetrachloride

Author: ECHA (2017) Helsinki, Finland: European Chemicals Agency. HERO ID: 3839957


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A review of human biomonitoring data used in regulatory risk assessment under Canada's Chemicals Management Program

Authors: Zidek, A; Macey, K; Mackinnon, L; Patel, M; Poddalgoda, D; Zhang, Y (2017) International Journal of Hygiene and Environmental Health 220:167-178. [Review] HERO ID: 3469257

[Less] As a part of the Chemicals Management Plan launched in 2006, the Government of Canada is assessing and . . . [More] As a part of the Chemicals Management Plan launched in 2006, the Government of Canada is assessing and managing, where appropriate, the potential health and ecological risks associated with approximately 4300 substances under the Canadian Environmental Protection Act (1999). Since that time, nearly 3000 substances have been assessed, with human biomonitoring (HBM) data playing an increasingly important role for some substances. Case studies are presented, including both inorganic and organic substances (i.e., selenium, triclosan, phthalates), which highlight the impact and overall role HBM has had in regulatory decision making in Canada for these three substances as well as criteria used in the application of HBM data in human health risk assessment. An overview of its limitations in terms of how and when HBM data can be applied, when assessing human health in a regulatory setting, is discussed as well as the role HBM data can play in priority setting.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Multiple exposures to indoor contaminants: Derivation of benchmark doses and relative potency factors based on male reprotoxic effects

Authors: Fournier, K; Tebby, C; Zeman, F; Glorennec, P; Zmirou-Navier, D; Bonvallot, N (2016) Regulatory Toxicology and Pharmacology 74:23-30. HERO ID: 3070939

[Less] Semi-Volatile Organic Compounds (SVOCs) are commonly present in dwellings and several are suspected . . . [More] Semi-Volatile Organic Compounds (SVOCs) are commonly present in dwellings and several are suspected of having effects on male reproductive function mediated by an endocrine disruption mode of action. To improve knowledge of the health impact of these compounds, cumulative toxicity indicators are needed. This work derives Benchmark Doses (BMD) and Relative Potency Factors (RPF) for SVOCs acting on the male reproductive system through the same mode of action. We included SVOCs fulfilling the following conditions: detection frequency (>10%) in French dwellings, availability of data on the mechanism/mode of action for male reproductive toxicity, and availability of comparable dose-response relationships. Of 58 SVOCs selected, 18 induce a decrease in serum testosterone levels. Six have sufficient and comparable data to derive BMDs based on 10 or 50% of the response. The SVOCs inducing the largest decrease in serum testosterone concentration are: for 10%, bisphenol A (BMD10 = 7.72E-07 mg/kg bw/d; RPF10 = 7,033,679); for 50%, benzo[a]pyrene (BMD50 = 0.030 mg/kg bw/d; RPF50 = 1630), and the one inducing the smallest one is benzyl butyl phthalate (RPF10 and RPF50 = 0.095). This approach encompasses contaminants from diverse chemical families acting through similar modes of action, and makes possible a cumulative risk assessment in indoor environments. The main limitation remains the lack of comparable toxicological data.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

The effects of phthalates in the cardiovascular and reproductive systems: A review

Authors: Mariana, M; Feiteiro, J; Verde, I; Cairrao, E (2016) Environment International 94:758-776. [Review] HERO ID: 3469538

[Less] Every year millions of tons of plastic are produced around the world and humans are increasingly exposed . . . [More] Every year millions of tons of plastic are produced around the world and humans are increasingly exposed to them. This constant exposure to plastics has raised some concerns against human health, particularly when it comes to phthalates. These compounds have endocrine-disrupting properties, as they have the ability to bind molecular targets in the body and interfere with hormonal function and quantity. The main use of phthalates is to give flexibility to polyvinyl chloride (PVC) polymers. Phthalates are found in a variety of industrial and consumer products, and as they are not covalently bound to the plastic, phthalates contaminate the environment from which human exposure occurs. Studies in human and animal populations suggest a correlation between phthalate exposure and adverse health outcomes, particularly at the reproductive and cardiovascular systems, however there is much less information about the phthalate toxicity of the later. Thus, the main purpose of this review is to present the studies relating the effects already stated of phthalates on the cardiovascular and reproductive systems, and also present the link between these two systems.

Technical Report
Technical Report

Update of Human Health Ambient Water Quality Criteria: Butylbenzyl Phthalate 85-68-7. Office of Water, Office of Science and Technology, EPA 820-R-15-022. Available online at https://www.regulations.gov/document?D=EPA-HQ-OW-2014-0135-0213

Author: Epa, US (2015) HERO ID: 3664465


Technical Report
Technical Report

Butyl benzyl phthalate – Priority Existing Chemical. Assessment Report No. 40. Department of Health, National Industrial Chemicals Notification and Assessment Scheme. Available online at https://www.nicnas.gov.au/search?query=85-68-7&collection=nicnas-meta

Author: Government, A (2015) HERO ID: 3664467


Technical Report
Technical Report

Human health tier II assessment for C4-6 side chain transitional phthalates. Department of Health, National Industrial Chemicals Notification and Assessment Scheme. Available online at https://www.nicnas.gov.au/chemical-information/imap-assessments/imap-group-assessment-report?assessment_id=1126#cas-A_85-68-7

Author: Government, A (2015) HERO ID: 3664468


Journal Article
Journal Article

ENDOCRINE DISRUPTOR CHEMICALS

Authors: Andrady, AL; Andrady, AL (2015) HERO ID: 3683218