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The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function

Authors: Byon, JCH; Chen, J; Doty, RT; Abkowitz, JL (In Press) Blood. HERO ID: 2064237

[Less] Heme is a pleiotropic molecule that is important for oxygen and oxidative metabolism, most notably as . . . [More] Heme is a pleiotropic molecule that is important for oxygen and oxidative metabolism, most notably as the prosthetic group of hemoglobin and cytochromes. Since, excess free intracellular heme is toxic, organisms have developed mechanisms to tightly regulate its concentration. One mechanism is through active heme export by FLVCR. Previously, we have shown that FLVCR is necessary for embryonic and post-natal erythropoiesis. However, FLVCR is also expressed in numerous other tissues, including hematopoietic stem cells (HSCs). To explore a possible role for FLVCR in HSC function, we performed serial, competitive repopulation transplant experiments using FLVCR-deleted and control bone marrow cells, along with wild-type competitor cells. Loss of FLVCR did not impact HSC function under steady-state or myelotoxic stress conditions (such as arsenic or radiation exposure), nor did FLVCR deletion result in alterations in the various progenitor compartments. However, even when 95% of the donor bone marrow cells lacked FLVCR, all red cells in recipient mice were wild-type. This is due to the increased apoptosis of FLVCR-deleted proerythroblasts. Also, remarkably, loss of FLVCR increased megakaryocyte ploidy. Together, these findings show FLVCR is redundant in stem cells, but has critical and contrasting stage-specific roles in discrete hematopoietic lineages.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Second-generation everolimus-eluting stents compared to first-generation drug-eluting stents in patients treated for multivessel disease

Authors: Minha, S; Barbash, IM; Dvir, D; Loh, JP; Badr, S; Kitabata, H; Pendyala, LK; Pichard, AD; Torguson, R; Waksman, R (In Press) Journal of Interventional Cardiology. HERO ID: 2064243

[Less] OBJECTIVE: This study aimed to compare the safety and efficacy of everolimus-eluting . . . [More] OBJECTIVE: This study aimed to compare the safety and efficacy of everolimus-eluting stents (EES) to first-generation drug-eluting stents (DES) in multivessel disease (MVD).

BACKGROUND: Second-generation EES have demonstrated superiority over first-generation DES for single-vessel disease, although the merits of EES in MVD are less established.

METHODS: A cohort of 1,285 patients (3,124 lesions) with ≥2 diseased vessels were treated with either first-generation DES (n = 1,002) or EES (n = 283). The rates of death, myocardial infarction, target lesion revascularization, target vessel revascularization, definite stent thrombosis, and major adverse cardiac events (MACE), defined as the combined incidence of target vessel revascularization, death, and non-fatal myocardial infarction, were compared at 1 year.

RESULTS: Baseline characteristics were similar except for a lower left ventricular ejection fraction and a lower incidence of stable angina pectoris in the first-generation DES group (P = 0.001 and 0.013, respectively). At 1 year, the MACE rate was lower in the EES group (9.5P% vs. 15.7%; P = 0.01). Multivariable analysis demonstrated that EES use predicted a higher chance of freedom from MACE at 1 year (hazard ratio 0.58 [0.38-0.87]; P = 0.009; 95% confidence interval).

CONCLUSIONS: The use of EES in patients with MVD is safe with signals for improved effectiveness compared to first-generation DES. Randomized trials comparing new-generation DES to coronary artery bypass grafting surgery are warranted.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Evaluation of short-term and long-term results after laparoscopic antireflux surgery: Esophageal manometry and 24-h pH monitoring versus quality of life index

Authors: Blazejczyk, K; Hoene, A; Glitsch, A; Busemann, A; Heidecke, CD; Patrzyk, M (In Press) Langenbeck's Archives of Surgery. HERO ID: 2064247

[Less] PURPOSE: The objective of this long-term study is to compare data on postoperative . . . [More] PURPOSE: The objective of this long-term study is to compare data on postoperative quality of life with objective functional measurements in patients with gastroesophageal reflux disease who have undergone laparoscopic antireflux surgery.

METHODS: Between 1995 and 2005, 162 patients with gastroesophageal reflux disease underwent laparoscopic surgery. A minimum of 4 years after surgery, 60 patients were contacted at random, 29 of whom agreed to follow-up examination. The following examinations were performed preoperatively, 6 months postoperatively, and 4-12 years postoperatively: esophageal manometry, 24-h gastroesophageal pH-metry, and assessment of patient quality of life based on the gastrointestinal quality of life index (GIQLI).

RESULTS: The number of postsurgical reflux episodes was reduced significantly, both at 6 months and at 4 or more years after surgery. The number of episodes dropped from 183 before surgery to 58 at 6 months after surgery and remained constant ≥4 years later. Surgery also produced a significant drop in reflux time, seen both 6 months and ≥4 years later. Six months after surgery, the median reflux time had fallen from 134 min (preoperatively) to 27 min, and at ≥ 4 years it was still significantly reduced at 35 min. Sphincter length (median preoperative length, 3 cm; median postoperative length (at 6 months and at ≥4 years), 4 cm) and sphincter pressure (median preoperative pressure, 3 mmHg; median at 6 months, 12 mmHg; median at ≥4 years, 10.9 mmHg) were significantly improved by surgery as well. Finally, surgery produced an improvement in quality of life. The median preoperative GIQLI was 102, while at 6 months after surgery it was 113 and at ≥4 years after surgery it was 124.

CONCLUSION: Laparoscopic fundoplication guarantees long-term improvement in symptoms and quality of life for patients suffering from gastroesophageal reflux disease. The effectiveness of reflux surgery can thus be demonstrated by long-term quality of life assessments and postoperative functional measurements. No statistically significant correlation between total score (DeMeester) and GIQLI could be demonstrated.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A comparison of epididymectomy with vasectomy reversal for the surgical treatment of postvasectomy pain syndrome

Authors: Lee, JY; Cho, KS; Lee, SH; Cho, HJ; Cho, JM; Oh, CY; Han, JH; Lee, KS; Kim, TH; Lee, SW (In Press) International Urology and Nephrology. HERO ID: 2064264

[Less] PURPOSE: To compare the outcome of epididymectomy and vasectomy reversal (VR) in patients . . . [More] PURPOSE: To compare the outcome of epididymectomy and vasectomy reversal (VR) in patients with postvasectomy pain syndrome (PVPS) who required surgical treatment.

METHODS: A total of 50 patients with PVPS who underwent epididymectomy or VR between January 2000 and January 2010 were included retrospectively. Of these, 36 (72.0 %) patients completed the study questionnaire. These 36 patients completed the questionnaire either during attendance at the outpatient clinic or during a telephone interview. Twenty patients (22 cases) underwent epididymectomy, and sixteen patients (17 cases) underwent VR. Analyses were performed for (1) preoperative clinical findings, (2) preoperative and postoperative visual analogue pain scale (VAPS) scores, (3) patency and pregnancy rate in VR group, and (4) patient satisfaction with surgical treatment.

RESULTS: The mean age was 48.28 ± 11.27 years, and the mean period of follow-up was 3.58 years (0.15-10.03). The mean VAPS score was 6.78 ± 0.93 preoperatively and 1.13 ± 0.72 postoperatively (p < 0.001). The difference in the mean preoperative and postoperative VAPS scores was 6.00 ± 1.34 (3-8) in the epididymectomy group and 5.50 ± 1.03 (4-8) in the VR group. However, this difference was not statistically significant (p = 0.227). No significant difference in satisfaction with surgical outcome was observed between the epididymectomy and the VR groups (p = 0.124).

CONCLUSIONS: In PVPS patients requiring surgical treatment, no significant difference was observed between the epididymectomy and VR groups in either the reduction in pain or the degree of patient satisfaction with surgical outcome. Selection of the optimal surgical procedure may be dependent on specific patient characteristics.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Sub-microscopic gametocyte carriage in febrile children living in different areas of Gabon

Authors: Mawili-Mboumba, DP; Nikiéma, R; Bouyou-Akotet, MK; Bahamontes-Rosa, N; Traoré, A; Kombila, M (In Press) HERO ID: 2088478

[Less] BACKGROUND: Considering malaria prevalence declines in parts of sub-Saharan Africa, . . . [More] BACKGROUND: Considering malaria prevalence declines in parts of sub-Saharan Africa, such as Gabon, identification of the human infectious reservoir is important for successful malaria control. Microscopic and sub-microscopic parasites contribute to malaria transmission. The aim of the present study was to evaluate the proportion of microscopic and sub-microscopic gametocyte carriers among febrile patients in two different areas of Gabon.

METHODS: Samples from febrile children aged less than 11 years old were collected from February 2008 to January 2009 at two health centres of Gabon. Patients were screened for the presence of asexual Plasmodium falciparum parasites. Gametocyte carriage was determined by microscopy and QT-NASBA.

RESULTS: Gametocytes were detected in 5.3% (n = 16/304) of children by microscopy compared to 45.7% (n = 139/304) by QT-Nasba. Sub-microscopic gametocyte carriage (ie microscopy negative and QT-Nasba positive) was found in 89.2% (n = 124/139) of patients. Among patients with microscopically detected trophozoites, the proportion of sub-microscopic gametocyte (SMG) carriers was 58.4% (n = 118/202) and 6% in samples from children with negative slides (p < 0.01). In Oyem, where malaria prevalence is three-fold higher than in Owendo, SMG carriage was more frequent (49.0% vs 32.6% in Owendo; p < 0.01).

CONCLUSION: Sub-microscopic gametocytaemia is common among Gabonese febrile children. They might strongly contribute to maintain malaria transmission. However, further analysis of sub-microscopic parasite carriage among asymptomatic individuals will be helpful to better characterize malaria transmission.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A vibrational spectroscopic study of the silicate mineral ardennite-(As)

Authors: Frost, RL; López, A; Xi, Y; Scholz, R; Gandini, AL (In Press) Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. HERO ID: 2088488

[Less] We have used a combination of scanning electron microscopy with EDX and vibrational spectroscopy to . . . [More] We have used a combination of scanning electron microscopy with EDX and vibrational spectroscopy to study the mineral ardennite-(As). The mineral ardennite-(As) of accepted formula Mn4(2+)(Al,Mg)6(Si3O10)(SiO4)2(AsO4,VO4)(OH)6 is a silicate mineral which may contain arsenate and/or vanadates anions. Because of the oxyanions present, the mineral lends itself to analysis by Raman and infrared spectroscopy. Qualitative chemical analysis shows a homogeneous phase, composed by Si, Mn, Al and As. Ca and V were also observed in partial substitution for Mn and As. Raman bands at 1197, 1225, 1287 and 1394cm(-1) are assigned to SiO stretching vibrations. The strong Raman bands at 779 and 877cm(-1) are assigned to the AsO4(3-) antisymmetric and symmetric stretching vibrations. The Raman band at 352cm(-1) is assigned to the ν2 symmetric bending vibration. The series of Raman bands between 414 and 471cm(-1)are assigned to the ν4 out of plane bending modes of the AsO4(3-) units. Intense Raman bands observed at 301 and 314cm(-1) are attributed to the MnO stretching and bending vibrations. Raman bands at 3041, 3149, 3211 and 3298cm(-1) are attributed to the stretching vibrations of OH units. There is vibrational spectroscopic evidence for the presence of water adsorbed on the ardennite-(As) surfaces.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

A conserved protein with AN1 zinc-finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway

Authors: Sá-Moura, B; Funakoshi, M; Tomko, RJ, Jr; Dohmen, RJ; Wu, Z; Peng, J; Hochstrasser, M (In Press) Journal of Biological Chemistry. HERO ID: 2088548

[Less] Regulated protein degradation mediated by the ubiquitin-proteasome system (UPS) is critical to eukaryotic . . . [More] Regulated protein degradation mediated by the ubiquitin-proteasome system (UPS) is critical to eukaryotic protein homeostasis. Often vital to degradation of protein substrates is their disassembly, unfolding, or extraction from membranes. These processes are catalyzed by the conserved AAA-ATPase Cdc48 (also known as p97). Here we characterize the Cuz1 protein (Cdc48-associated UBL/zinc-finger protein-1), encoded by a previously uncharacterized arsenite-inducible gene in budding yeast. Cuz1, like its human ortholog ZFAND1, has both an AN1-type zinc finger (Zf_AN1) and a divergent ubiquitin-like domain (UBL). We show that Cuz1 modulates Cdc48 function in the UPS. The two proteins directly interact, and the Cuz1 UBL, but not Zf_AN1, is necessary for binding to the Cdc48 N-terminal domain. Cuz1 also associates, albeit more weakly, with the proteasome, and the UBL is dispensable for this interaction. Cuz1-proteasome interaction is strongly enhanced by exposure of cells to the environmental toxin arsenite, and in a proteasome mutant, loss of Cuz1 enhances arsenite sensitivity. Whereas loss of Cuz1 alone causes only minor UPS degradation defects, its combination with mutations in the Cdc48(Npl4-Ufd1) complex leads to substantial further impairment. Cuz1 helps limit the accumulation of ubiquitin conjugates on both the proteasome and Cdc48, suggesting a possible role in the transfer of ubiquitylated substrates from Cdc48 to the proteasome or in their release from these complexes.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Histopathology predicts clinical outcome in advanced epithelial ovarian cancer patients treated with neoadjuvant chemotherapy and debulking surgery

Authors: Muraji, M; Sudo, T; Iwasaki, S-I; Ueno, S; Wakahashi, S; Yamaguchi, S; Fujiwara, K; Nishimura, R (In Press) Gynecologic Oncology. HERO ID: 2088566

[Less] OBJECTIVE: To analyze the factors prognostic of survival in patients with advanced . . . [More] OBJECTIVE: To analyze the factors prognostic of survival in patients with advanced epithelial ovarian cancer (EOC) treated with neoadjuvant chemotherapy (NAC) followed by interval debulking surgery.

METHODS: Outcomes were retrospectively in patients with advanced EOC or peritoneal cancer who received neoadjuvant paclitaxel and carboplatin chemotherapy every 3weeks for three to four cycles, followed by interval debulking surgery and three additional cycles of the same regimens from January 2001 to November 2010. Therapeutic response was assessed histopathologically as grade 0 to 3, based on the degree of disappearance of cancer cells, displacement by necrotic and fibrotic tissue, and tumor-induced inflammation. Factors prognostic of progression-free survival (PFS) and overall survival (OS) were calculated.

RESULTS: The 124 enrolled patients had a median age of 62years (range, 35-79years). Viable cancer cells were observed in specimens resected from 72 patients (58%) at interval debulking surgery after NAC. Multivariate analysis using the Cox proportional hazard model showed that advanced (stage IV) disease (hazard ratio [HR]=1.94, p=0.003), residual cancer at the end of surgery ≥1cm (HR=3.78, p<0.001), and histological grade 0-1 (HR=1.65, p=0.03) were independent predictors of decreased OS. Grade 0-1 was also an independent predictor of increased risk of relapse within 6months (odds ratio=8.42, p=0.003).

CONCLUSIONS: Residual disease of ≥1cm, advanced stage, and the presence of more viable disease in resected specimens are prognostic factors for survival in advanced EOC patients receiving NAC followed by interval debulking surgery.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Dicopper(II) metallacyclophanes with electroswitchable polymethyl-substituted para-phenylene spacers

Authors: Ferrando-Soria, J; Castellano, M; Ruiz-García, R; Cano, J; Julve, M; Lloret, F; Ruiz-Pérez, C; Pasán, J; Cañadillas-Delgado, L; Armentano, D; Journaux, Y; Pardo, E (In Press) HERO ID: 1797800

[Less] Double-stranded anionic dinuclear copper(II) metallacyclic complexes of the paracyclophane type [Cu2 . . . [More] Double-stranded anionic dinuclear copper(II) metallacyclic complexes of the paracyclophane type [Cu2 L2 ](4-) have been prepared by the Cu(II) -mediated self-assembly of different para-phenylenebis(oxamato) bridging ligands with either zero-, one-, or four-electron-donating methyl substituents (L=N,N'-para-phenylenebis(oxamate) (ppba; 1), 2-methyl- N,N'-para-phenylenebis(oxamate) (Meppba; 2), and 2,3,5,6-tetramethyl- N,N'-para-phenylenebis(oxamate) (Me4 ppba; 3)). These complexes have been isolated as their tetra-n-butylammonium (1 a-3 a), lithium(I) (1 b-3 b), and tetraphenylphosphonium salts (1 c-3 c). The X-ray crystal structures of 1 a and 3 c show a parallel-displaced π-stacked conformation with a smaller deviation from perpendicularity between the two benzene rings and the basal planes of the square planar Cu(II) ions when increasing the number of methyl substituents (average dihedral angles (ϕ) of 58.72(7) and 73.67(5)° for 1 a and 3 c, respectively). Variable-temperature (2.0-300 K) magnetic-susceptibility measurements show an overall increase of the intramolecular antiferromagnetic coupling with the number of methyl substituents onto the para-phenylene spacers (-J=75-95, 100-124, and 128-144 cm(-1) for 1 a-c, 2 a-c, and 3 a-c, respectively; H=-JS1 ×S2 ). Cyclic voltammetry (CV) measurements show a reversible one-electron oxidation of the double polymethyl-substituted para-phenylenediamidate bridging skeleton at a relatively low formal potential that decreases with the number of methyl substituents (E1 =+0.33, +0.24, and +0.15 V vs. SCE for 1-3, respectively). The monooxidized dicopper(II) π-radical cation species 3' prepared by the chemical oxidation of 3 with bromine exhibits intense metal-to-ligand charge-transfer (MLCT) transitions in the visible and near-IR (λmax =595 and 875 nm, respectively) regions together with a rhombic EPR signal with a seven-line splitting pattern due to hyperfine coupling with the nuclear spin of the two Cu(II) ions. Density functional (DF) calculations for 3' evidence a characteristic iminoquinonoid-type short-long-short alternating sequence of CN and CC bonds for both tetramethyl-para-phenylenediamidate bridges and a large amount of spin density of negative sign mainly delocalized along each of the four benzene C atoms directly attached to the amidate N atoms, which is in agreement with a fully delocalized π-stacked monoradical ligand description. Hence, the spins of the two Cu(II) ions (SCu =1/2) that are antiparallel aligned in 3 (OFF state) become parallel in 3' (ON state). Further developments may be then envisaged for this new permethylated dicopper(II) paracyclophane with a redox noninnocent ligand as a prototype for molecular magnetic electroswitch.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Effect of text messaging to deter early resumption of sexual activity after male circumcision for HIV prevention: A randomized controlled trial

Authors: Odeny, TA; Bailey, RC; Bukusi, EA; Simoni, JM; Tapia, KA; Yuhas, K; Holmes, KK; McClelland, RS (In Press) . HERO ID: 1797836

[Less] Background: Resumption of sex before complete wound healing after male circumcision may increase risk . . . [More] Background: Resumption of sex before complete wound healing after male circumcision may increase risk of postoperative surgical complications, and HIV acquisition and transmission. We aimed to determine the effect of text messaging to deter resumption of sex before 42 days postcircumcision. Methods: We conducted a randomized trial where men older than18 years who owned mobile phones and had just undergone circumcision were randomized to receive a series of text messages (n = 600) or usual care (n = 600). The primary outcome was self-reported resumption of sex before 42 days. Results: Sex before 42 days was reported by 139 of 491 (28.3%) men in the intervention group and 124 of 493 (25.2%) men in the control group [relative risk = 1.13, 95% confidence interval (CI): 0.91 to 1.38, P = 0.3]. Men were more likely to resume early if they were married or had a live-in sexual partner [adjusted relative risk (aRR) 1.57, 95% CI: 1.18 to 2.08, P < 0.01]; in the month before circumcision had 1 (aRR: 1.50, 95% CI: 1.07 to 2.12, P = 0.02) or more than 1 (aRR: 1.81, 95% CI: 1.24 to 2.66, P < 0.01) sexual partner(s); had primary school or lower education (aRR: 1.62, 95% CI: 1.33 to 1.97, P< 0.001); were employed (aRR: 1.35, 95% CI: 1.05 to 1.72, P = 0.02); or were 21–30 years old (aRR: 1.58, 95% CI: 1.01 to 2.47, P = 0.05), 31–40 years old (aRR: 1.91, 95% CI: 1.18 to 3.09, P < 0.01), or older than 40 years (aRR: 1.76, 95% CI: 1.04 to 2.97, P = 0.03) compared with younger than 21 years. Conclusions: Text messaging as used in this trial did not reduce early resumption of sex after circumcision. We identified key risk factors for early resumption that need to be considered in circumcision programs.