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Arsenic Hazard ID

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The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

An arsenic-contaminated field trial to assess the uptake and translocation of arsenic by genotypes of rice

Authors: Lei, M; Tie, B; Zeng, M; Qing, P; Song, Z; Williams, PN; Huang, Y (In Press) Environmental Geochemistry and Health. HERO ID: 1337505

[Less] Compared to other cereals, rice has particular strong As accumulation. Therefore, it is very important . . . [More] Compared to other cereals, rice has particular strong As accumulation. Therefore, it is very important to understand As uptake and translocation among different genotypes. A field study in Chenzhou city, Hunan province of China, was employed to evaluate the effect of arsenic-contaminated soil on uptake and distribution in 34 genotypes of rice (including unpolished rice, husk, shoot, and root). The soil As concentrations ranged from 52.49 to 83.86 mg kg(-1), with mean As concentration 64.44 mg kg(-1). The mean As concentrations in rice plant tissues were different among the 34 rice genotypes. The highest As concentrations were accumulated in rice root (196.27-385.98 mg kg(-1) dry weight), while the lowest was in unpolished rice (0.31-0.52 mg kg(-1) dry weight). The distribution of As in rice tissue and paddy soil are as follows root ≫ soil > shoot > husk > unpolished rice. The ranges of concentrations of inorganic As in all of unpolished rice were from 0.26 to 0.52 mg kg(-1) dry weight. In particular, the percentage of inorganic As in the total As was more than 67 %, indicating that the inorganic As was the predominant species in unpolished rice. The daily dietary intakes of inorganic As in unpolished rice ranged from 0.10 to 0.21 mg for an adult, and from 0.075 to 0.15 mg for a child. Comparison with tolerable daily intakes established by FAO/WHO, inorganic As in most of unpolished rice samples exceeded the recommended intake values. The 34 genotypes of rice were classified into four clusters using a criteria value of rescaled distance between 5 and 10. Among the 34 genotypes, the genotypes II you 416 (II416) with the lowest enrichment of As and the lowest daily dietary intakes of inorganic As could be selected as the main cultivar in As-contaminated field.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Association of arsenic levels in soil and water with urinary arsenic concentration of residents in the vicinity of closed metal mines

Authors: Cho, Y; Seo, S; Choi, S-H; Lee, S; Kim, K; Kim, H-J; Choi, J-W (In Press) International Journal of Hygiene and Environmental Health. HERO ID: 1248978

[Less] Arsenic (As) pollution in the surroundings of metal mines has been observed, and may induce serious . . . [More] Arsenic (As) pollution in the surroundings of metal mines has been observed, and may induce serious health problems, in particular cancer. Health hazard attributed to As in contaminated soil and water in the vicinity of closed or abandoned metal mines may be high. Little is known about how environmental exposure to As has affected the health of resident near closed metal mines. The objectives of this study were to compare the urinary level of As for those living near closed metal mines (the exposed group) with that of non-exposed group; and to investigate the correlation between As levels in soil (Soil(As)) and water (Water(As)) and the urinary levels (Urine(As)) of residents in the exposed group. Data for Soil(As) and Water(As) were obtained from the national environmental survey performed between 2003 and 2005 by the Ministry of Environment in Korea. To measure Urine(As), 2674 and 237 subjects were selected from 67 closed metal mines (exposed areas) and two rural areas (non-exposed areas), respectively. Five milliliters of urine samples were taken, and graphite furnace atomic absorption spectrometry was used to analyze Urine(As). Of all the exposed areas, high Soil(As) and Water(As) areas that exceed the Korean standards of As in soil (6mg/kg-soil) and stream or groundwater (0.05mg/l-water) were classified to evaluate the health risks in high polluted areas. Also, high Urine(As) group was defined as 20μg/g creatinine or more. Student's t-test was performed to compare the Urine(As) level between the exposed and non-exposed groups. The odds ratio (OR) was calculated by a logistic analysis to evaluate the risk for high Urine(As) level from high Soil(As) and Water(As) areas. The mean of urinary As were 8.90±8.34μg/g-creatinine for the exposed group and 7.68±4.98μg/g creatinine for the non-exposed group, respectively; and the significant difference of urinary As level was observed between both groups (p<0.05). Moreover, the means for urinary As of people in areas with high As level in soil and water were significantly higher than that for the control areas (p<0.001), and these differences were more pronounced for the As level in water. The odds of subjects with high Urine(As) were positively and significantly associated with living in the areas with high As level in soil (OR=1.62; 95% C.I.=1.13-2.31). These associations were much stronger for the areas with high Water(As) (OR=3.79; 95% C.I.=2.32-6.19). These results indicate that the high level of As in environment may increase the risk of having high urinary As level of people in the exposed areas.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Optimal time interval between neoadjuvant chemoradiotherapy and surgery for rectal cancer

Authors: Sloothaak, DAM; Geijsen, DE; van Leersum, NJ; Punt, CJA; Buskens, CJ; Bemelman, WA; Tanis, PJ; Dutch Surgical Colorectal Audit (In Press) British Journal of Surgery. HERO ID: 1519025

[Less] BACKGROUND: Neoadjuvant chemoradiotherapy (CRT) has been proven to increase local control in rectal . . . [More] BACKGROUND: Neoadjuvant chemoradiotherapy (CRT) has been proven to increase local control in rectal cancer, but the optimal interval between CRT and surgery is still unclear. The purpose of this study was to analyse the influence of variations in clinical practice regarding timing of surgery on pathological response at a population level. METHODS: All evaluable patients who underwent preoperative CRT for rectal cancer between 2009 and 2011 were selected from the Dutch Surgical Colorectal Audit. The interval between radiotherapy and surgery was calculated from the start of radiotherapy. The primary endpoint was pathological complete response (pCR; pathological status after chemoradiotherapy (yp) T0 N0). RESULTS: A total of 1593 patients were included. The median interval between radiotherapy and surgery was 14 (range 6-85, interquartile range 12-16) weeks. Outcome measures were calculated for intervals of less than 13 weeks (312 patients), 13-14 weeks (511 patients), 15-16 weeks (406 patients) and more than 16 weeks (364 patients). Age, tumour location and R0 resection rate were distributed equally between the four groups; significant differences were found for clinical tumour category (cT4: 17·3, 18·4, 24·5 and 26·6 per cent respectively; P = 0·010) and clinical metastasis category (cM1: 4·4, 4·8, 8·9 and 14·9 per cent respectively; P < 0·001). Resection 15-16 weeks after the start of CRT resulted in the highest pCR rate (18·0 per cent; P = 0·013), with an independent association (hazard ratio 1·63, 95 per cent confidence interval 1·20 to 2·23). Results for secondary endpoints in the group with an interval of 15-16 weeks were: tumour downstaging, 55·2 per cent (P = 0·165); nodal downstaging, 58·6 per cent (P = 0·036); and (near)-complete response, 23·2 per cent (P = 0·124). CONCLUSION: Delaying surgery until the 15th or 16th week after the start of CRT (10-11 weeks from the end of CRT) seemed to result in the highest chance of a pCR.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Genotype-phenotype matching analysis of 38 Lactococcus lactis strains using random forest methods

Authors: Bayjanov, JR; Starrenburg, MJ; van der Sijde, MR; Siezen, RJ; van Hijum, SA (In Press) BMC Microbiology. HERO ID: 1519029

[Less] BACKGROUND: Lactococcus lactis is used in dairy food fermentation and for the efficient production of . . . [More] BACKGROUND: Lactococcus lactis is used in dairy food fermentation and for the efficient production of industrially relevant enzymes. The genome content and different phenotypes have been determined for multiple L. lactis strains in order to understand intra-species genotype and phenotype diversity and annotate gene functions. In this study, we identified relations between gene presence and a collection of 207 phenotypes across 38 L. lactis strains of dairy and plant origin. Gene occurrence and phenotype data were used in an iterative gene selection procedure, based on the Random Forest algorithm, to identify genotype-phenotype relations. RESULTS: A total of 1388 gene-phenotype relations were found, of which some confirmed known gene-phenotype relations, such as the importance of arabinose utilization genes only for strains of plant origin. We also identified a gene cluster related to growth on melibiose, a plant disaccharide; this cluster is present only in melibiose-positive strains and can be used as a genetic marker in trait improvement. Additionally, several novel gene-phenotype relations were uncovered, for instance, genes related to arsenite resistance or arginine metabolism. CONCLUSIONS: Our results indicate that genotype-phenotype matching by integrating large data sets provides the possibility to identify gene-phenotype relations, possibly improve gene function annotation and identified relations can be used for screening bacterial culture collections for desired phenotypes. In addition to all gene-phenotype relations, we also provide coherent phenotype data for 38 Lactococcus strains assessed in 207 different phenotyping experiments, which to our knowledge is the largest to date for the Lactococcus lactis species.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Soil chemistry and pollution study of a closed landfill site at Ampar Tenang, Selangor, Malaysia

Authors: Mohd Adnan, SNSB; Yusoff, S; Chua, YP (In Press) . HERO ID: 1519032

[Less] A total of 20 landfills are located in State of Selangor, Malaysia. This includes the Ampar Tenang landfill . . . [More] A total of 20 landfills are located in State of Selangor, Malaysia. This includes the Ampar Tenang landfill site, which was closed on 26 January 2010. It was reported that the landfill has been upgraded to a level I type of sanitary classification. However, the dumpsite area is not being covered according to the classification. In addition, municipal solid waste was dumped directly on top of the unlined natural alluvium formation. This does not only contaminate surface and subsurface soils, but also initiates the potential risk of groundwater pollution. Based on previous studies, the Ampar Tenang soil has been proven to no longer be capable of preventing pollution migration. In this study, metal concentrations of soil samples up to 30 m depth were analyzed based on statistical analysis. It is very significant because research of this type has not been carried out before. The subsurface soils were significantly polluted by arsenic (As), lead (Pb), iron (Fe), copper (Cu) and aluminium (Al). As and Pb exceeded the safe limit values of 5.90 mg/kg and 31.00 mg/kg, respectively, based on Provincial Sediment Quality Guidelines for Metals and the Interim Sediment Quality Values. Furthermore, only Cu concentrations showed a significantly decreasing trend with increasing depth. Most metals were found on clay-type soils based on the cluster analysis method. Moreover, the analysis also differentiates two clusters: cluster I-Pb, As, zinc, Cu, manganese, calcium, sodium, magnesium, potassium and Fe; cluster II-Al. Different clustering may suggest a different contamination source of metals.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Optimization of bioleaching conditions for metal removal from CCA-treated wood by using an unknown Polyporales sp. KUC8959

Authors: Choi, Y-S; Kim, J-J; Kim, M-J; Son, J; Kim, G-H (In Press) Journal of Environmental Management. HERO ID: 1519065

[Less] The purpose of this study was to investigate the effect of extraction conditions (i.e., culture filtrate . . . [More] The purpose of this study was to investigate the effect of extraction conditions (i.e., culture filtrate concentration, extraction temperature, and extraction time) on the removal of metals from chromated copper arsenate (CCA)-treated wood particles by using an unknown Polyporales sp. KUC8959. As the first research, a 20-run central composite design using response surface methodology was applied to optimize the system and construct the models, which predicted metal removal by bioleaching. The coefficients of determination of fitted models were 0.874-0.989, which indicated that the models can predict the metal removal yield accurately under various conditions. The Cu removal model suggested that the following conditions, culture filtrate concentration of 45.8%, extraction temperature of 34.2 °C, and extraction time of 20.6 h, were required for maximal removal of Cu (82.1%). The model predicted that extraction conditions of increased severity would result in complete removal of Cr and As from CCA-treated wood particles. In order to confirm actual metals removal efficiency, metals extraction was subsequently conducted under optimal bioleaching condition evaluated in this study. By applying the model, we demonstrated 83.9% Cu, 96.0% Cr, and 99.3% As removal from treated wood particles.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Remediation of inorganic arsenic in groundwater for safe water supply: A critical assessment of technological solutions

Authors: Mondal, P; Bhowmick, S; Chatterjee, D; Figoli, A; Van der Bruggen, B (In Press) Chemosphere. [Review] HERO ID: 1519091

[Less] Arsenic contaminations of groundwater in several parts of the world are the results of natural and/or . . . [More] Arsenic contaminations of groundwater in several parts of the world are the results of natural and/or anthropogenic sources, and have a large impact on human health. Millions of people from different countries rely on groundwater containing As for drinking purposes. This paper reviews removal technologies (oxidation, coagulation flocculation, adsorption, ion exchange and membrane processes) with attention for the drawbacks and limitations of these applied technologies. The technologies suggested and applied for treatment of As rich water have various problems, including the need for further treatment of As containing secondary waste generated from these water treatment processes. More efficient technologies, with a lower tendency to generate waste include the removal of As by membrane distillation or forward osmosis, instead of using pressure driven membrane processes and subsequently reducing soluble As to commercially valuable metallic As are surveyed. An integrated approach of two or more techniques is suggested to be more beneficial than a single process. Advanced technologies such as membrane distillation, forward osmosis as well as some hybrid integrated techniques and their potentials are also discussed in this review. Membrane processes combined with other process (especially iron based technologies) are thought to be most sustainable for the removal of arsenic and further research allowing scale up of these technologies is suggested.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Protective role of AQP3 in UVA-induced NHSFs apoptosis via Bcl2 up-regulation

Authors: Xie, H; Liu, F; Liu, L; Dan, J; Luo, Y; Yi, Y; Chen, X; Li, J (In Press) Archives of Dermatological Research. HERO ID: 1519093

[Less] Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol . . . [More] Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2. However, whether it has a protective role in ultraviolet A (UVA)-induced apoptosis in normal human skin fibroblasts is not known. In this study, we demonstrate that mild UVA treatment fails to induce oxidative cell stress and apoptosis in normal human skin fibroblasts (NHSFs) overexpressing AQP3. After severe UVA irradiation, there was an increase in oxidative cell stress and apoptosis when AQP3 levels decreased. We also found that silencing AQP3 sensitized NHSFs to low-dose UVA. Overexpressing AQP3 was protective against high-dose UVA-induced oxidative stress and apoptosis. Besides, we observed that Bcl-2 may be involved in UVA-induced apoptosis. Our findings suggested that the water/glycerol-transporting protein AQP3 plays a role in resistance to UVA-induced apoptosis.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Batch effects and pathway analysis: Two potential perils in cancer studies involving DNA methylation array analysis

Authors: Harper, KN; Peters, BA; Gamble, MV (In Press) Cancer Epidemiology Biomarkers and Prevention. HERO ID: 1579252

[Less] Background: DNA methylation microarrays have become an increasingly popular means of studying the role . . . [More] Background: DNA methylation microarrays have become an increasingly popular means of studying the role of epigenetics in cancer, though the methods used to analyze these arrays are still being developed and existing methods are not always widely disseminated among microarray users. Methods: We investigated two problems likely to confront DNA methylation microarray users: 1) batch effects; and 2) the use of widely available pathway analysis software to analyze results. First, DNA taken from individuals exposed to low and high levels of drinking water arsenic were plated twice on Illumina's Infinium 450K humanmethylation array, once in order of exposure and again following randomization. Second, we performed simulations in which random CpG sites were drawn from the 450K array and subjected to pathway analysis using Ingenuity's IPA software. Results: The majority of differentially methylated CpG sites identified in Run One were due to batch effects; few sites were also identified in Run Two. In addition, the pathway analysis software reported many significant associations between our data, randomly drawn from the 450K array, and various diseases and biological functions. Conclusions: Data from our own laboratory illustrate the pitfalls of not properly controlling for chip-specific batch effects as well as using pathway analysis software created for gene expression arrays to analyze DNA methylation array data. Impact: We present evidence that 1) chip-specific effects can simulate plausible differential methylation results; and 2) popular pathway analysis software developed for expression arrays can yield spurious results when used in tandem with methylation microarrays.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Arsenic Toxicity on Ludwigia octovalvis in Spiked Sand

Authors: Titah, HS; Abdullah, SR; Mushrifah, I; Anuar, N; Basri, H; Mukhlisin, M (In Press) Bulletin of Environmental Contamination and Toxicology. HERO ID: 1579304

[Less] Wilting, especially of the leaves, was observed as an initial symptom of arsenate [As(V)] to Ludwigia . . . [More] Wilting, especially of the leaves, was observed as an initial symptom of arsenate [As(V)] to Ludwigia octovalvis (Jacq.) P. H. Raven. The plants tolerated As(V) levels of 39 mg kg(-1) for as long as 35 days of exposure. After 91 days, the maximum concentration of As uptake in the plant occurred at As(V) concentration of 65 mg kg(-1) while As concentration in the stems, roots and leaves were 6139.9 ± 829.5, 1284.5 ± 242.9 and 1126.1 ± 117.2 mg kg(-1), respectively. In conclusion, As(V) could cause toxic effects in L. octovalvis and the plants could uptake and accumulate As in plant tissues.