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Arsenic Hazard ID

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233 References Were Found:

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

High Resolution Mapping of Complex Traits with a Four-Parent Advanced Intercross Yeast Population

Authors: Cubillos, FA; Parts, L; Salinas, F; Bergström, A; Scovacricchi, E; Zia, A; Illingworth, CJ; Mustonen, V; Ibstedt, S; Warringer, J; Louis, EJ; Durbin, R; Liti, G (In Press) Genetics (Online). HERO ID: 2064246

[Less] A large fraction of human complex trait heritability is due to a high number of variants with small . . . [More] A large fraction of human complex trait heritability is due to a high number of variants with small marginal effects, and their interactions with genotype and environment. Such alleles are more easily studied in model organisms, where environment, genetic makeup and allele frequencies can be controlled. Here, we examine the effect of natural genetic variation on heritable traits in a very large pool of baker's yeast from a multi-parent 12(th) generation intercross. We selected four representative founder strains to produce the SGRP-4X mapping population, and sequenced 192 segregants to generate an accurate genetic map. Using these individuals, we mapped 25 loci linked to growth traits under heat stress, arsenite and paraquat, the majority of which were best explained by a diverging phenotype caused by a single allele in one condition. By sequencing pooled DNA from millions of segregants grown under heat stress, we further identified 34 and 39 regions selected in haploid and diploid pools respectively, with most of the selection against a single allele. While the most parsimonious model for the majority of loci mapped using either approach was the effect of an allele private to one founder, we could validate examples of pleiotropic effects, and complex allelic series at a locus. SGRP-4X is a deeply characterised resource that provides a framework for powerful and high-resolution genetic analysis of yeast phenotypes, and serves as a test bed for testing avenues to attack human complex traits.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Randomised, double-blind, placebo-controlled trial to determine whether steroids reduce the incidence and severity of nephropathy in Henoch-Schönlein Purpura (HSP)

Authors: Dudley, J; Smith, G; Llewelyn-Edwards, A; Bayliss, K; Pike, K; Tizard, J (In Press) Archives of Disease in Childhood. HERO ID: 1797837

[Less] BACKGROUND: The long-term prognosis of Henoch-Schönlein Purpura (HSP) is predominantly determined by . . . [More] BACKGROUND: The long-term prognosis of Henoch-Schönlein Purpura (HSP) is predominantly determined by the extent of renal involvement. There is no consensus as to whether treatment with prednisolone at presentation can prevent or ameliorate the progression of nephropathy in HSP.

METHODS: Children under 18 years of age with new-onset HSP were randomly assigned to receive prednisolone or placebo for 14 days. The primary outcomes were (a) the presence of proteinuria at 12 months (defined as urine protein : creatinine ratio (UP : UC) >20 mg/mmol) and (b) the need for additional treatment (defined as the presence of hypertension requiring treatment or renal biopsy anomalies or the need for treatment of renal disease) during the 12 month study period.

RESULTS: 352 children were randomised. Of those patients with laboratory UP : UC results available at 12 months, 18/123 (15%) patients on prednisolone and 13/124 (10%) patients on placebo had UP : UC >20 mg/mmol. There was no significant difference in the proportion of patients with UP : UC >20 mg/mmol at 12 months between the treatment groups (OR (prednisolone/placebo)=1.46, 95% CI 0.68 to 3.14, n=247), even after adjusting for baseline proteinuria and medications known to affect proteinuria (adjusted OR=1.29, 95% CI 0.58 to 2.82, n=247). Similarly, there was no significant difference in the time needed for additional treatment between the two groups (hazard ratio (HR) (prednisolone/placebo)=0.53, 95% CI 0.18 to 1.59, n=323).

CONCLUSIONS: This is the largest trial of the role of steroids in children with HSP. We found no evidence to suggest that early treatment with prednisolone reduces the prevalence of proteinuria 12 months after disease onset in children with HSP.

TRIAL REGISTRATION NUMBER: ISRCTN71445600.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Natural decrease of dissolved arsenic in a small stream receiving drainages of abandoned silver mines in Guanajuato, Mexico

Authors: Ramos Arroyo, YR; Serafín Muñoz, AH; Yanez Barrientos, E; Rodriguez Huerta, I; Wrobel, K; Wrobel, K (In Press) Bulletin of Environmental Contamination and Toxicology. HERO ID: 1936024

[Less] Arsenic release from the abandoned mines and its fate in a local stream were studied. Physicochemical . . . [More] Arsenic release from the abandoned mines and its fate in a local stream were studied. Physicochemical parameters, metals/metalloids and arsenic species were determined. One of the mine drainages was found as a point source of contamination with 309 μg L(-1) of dissolved arsenic; this concentration declined rapidly to 10.5 μg L(-1) about 2 km downstream. Data analysis confirmed that oxidation of As(III) released from the primary sulfide minerals was favored by the increase of pH and oxidation reduction potential; the results obtained in multivariate approach indicated that self-purification of water was due to association of As(V) with secondary solid phase containing Fe, Mn, Ca.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Novel identification of lipid-soluble arsenic compounds using chemical derivatisations in conjunction with RP-HPLC-ICPMS/ESMS

Authors: Amayo, KO; Raab, A; Krupp, EM; Gunnlaugsdottir, H; Feldmann, J (In Press) Analytical Chemistry. HERO ID: 1936033

[Less] The identification of molecular structures of arsenolipid is pivotal for its toxicological assessment . . . [More] The identification of molecular structures of arsenolipid is pivotal for its toxicological assessment and in understanding the arsenic cycling in the environment. However, analysis of these compounds in lipid matrix is an ongoing challenge. So far only few arsenolipids have been reported, such as arsenic fatty acids (AsFAs) and arsenic hydrocarbons (AsHCs). By means of RP-HPLC-ICPMS/ESMS, we investigated Capelin oil (Mallotus villosus) for possible new species of arsenolipid. Twelve arsenolipids were identified in the fish oil including three AsFAs and seven AsHCs. Among the AsHCs, four of them identified with protonotated molecular masses 305, 331, 347 and 359 have not been reported before. In addition, the compounds with molecular formulae C20H44AsO+ and C24H44AsO+ found in low concentrations showed chromatographic properties and MS data consistent with cationic trimethylarsenio fatty alcohols. Derivatisation by acetylation and thiolation coupled with accurate mass spectrometry was successfully used to establish the occurrence of this new class of arsenolipids as cationic trimethylarsenio fatty alcohols (TMAsFOH).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Identification of novel α-N-methylation of CENP-B that regulates its binding to the centromeric DNA

Authors: Dai, X; Otake, K; You, C; Cai, Q; Wang, Z; Masumoto, H; Wang, Y (In Press) Journal of Proteome Research. HERO ID: 1936038

[Less] The eukaryotic centromere is an essential chromatin region required for accurate segregation of sister . . . [More] The eukaryotic centromere is an essential chromatin region required for accurate segregation of sister chromatids during cell division. Centromere protein B (CENP-B) is a highly conserved protein which can bind to the 17-bp CENP-B box on the centromeric DNA. In this study, we found that CENP-B could be α-N-methylated in human cells. We also showed that the level of the α-N-methylation was stimulated in cells in response to a variety of extracellular stimuli, including increased cell density, heat shock, and arsenite treatment, although the methylation level was not altered upon metaphase arrest. We identified N-terminal RCC1 methyltransferase (NRMT) as a major enzyme required for the CENP-B methylation. Additionally, we found that chromatin-bound CENP-B was primarily trimethylated and α-N-trimethylation could enhance CENP-B's binding to CENP-B box in cells. Our study also expands the function of protein α-N-methylation that has been known for decades and whose function remains largely unexplored.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Arsenic removal from contaminated water using three-dimensional graphene-carbon nanotube-iron oxide nanostructures

Authors: Vadahanambi, S; Lee, S-H; Kim, W-J; Oh, I-K (In Press) Environmental Science and Technology. HERO ID: 1936066

[Less] We report a highly versatile and one-pot microwave route to the mass production of three-dimensional . . . [More] We report a highly versatile and one-pot microwave route to the mass production of three-dimensional graphene-carbon nanotube-iron oxide nanostructures for the efficient removal of arsenic from contaminated water. The unique three-dimensional nanostructure shows that carbon nanotubes are vertically standing on graphene sheets and iron oxide nanoparticles are decorated on both the graphene and the carbon nanotubes. The material with iron oxide nanoparticles shows excellent absorption for arsenic removal from contaminated water, due to its high surface-to-volume ratio and open pore network of the graphene-carbon nanotube-iron oxide three-dimensional nanostructures.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein

Authors: Li, C; Srivastava, RK; Elmets, CA; Afaq, F; Athar, M (In Press) Biochemical and Biophysical Research Communications. HERO ID: 1936067

[Less] Arsenic exposure in humans causes a number of toxic manifestations in the skin including cutaneous neoplasm. . . . [More] Arsenic exposure in humans causes a number of toxic manifestations in the skin including cutaneous neoplasm. However, the mechanism of these alterations remains elusive. Here, we provide novel observations that arsenic induced Hippo signaling pathway in the murine skin. This pathway plays crucial roles in determining organ size during the embryonic development and if aberrantly activated in adults, contributes to the pathogenesis of epithelial neoplasm. Arsenic treatment enhanced phosphorylation-dependent activation of LATS1 kinase and other Hippo signaling regulatory proteins Sav1 and MOB1. Phospho-LATS kinase is known to catalyze the inactivation of a transcriptional co-activator, Yap. However, in arsenic-treated epidermis, we did not observed its inactivation. Thus, as expected, unphosphorylated-Yap was translocated to the nucleus in arsenic-treated epidermis. Yap by binding to the transcription factors TEADs induces transcription of its target genes. Consistently, an up-regulation of Yap-dependent target genes Cyr61, Gli2, Ankrd1 and Ctgf was observed in the skin of arsenic-treated mice. Phosphorylated Yap is important in regulating tight and adherens junctions through its binding to αCatenin. We found disruption of these junctions in the arsenic-treated mouse skin despite an increase in αCatenin. These data provide evidence that arsenic-induced canonical Hippo signaling pathway and Yap-mediated disruption of tight and adherens junctions are independently regulated. These effects together may contribute to the carcinogenic effects of arsenic in the skin.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Stable transformation of ferns using spores as targets: Pteris vittata and Ceratopteris thalictroides

Authors: Muthukumar, B; Joyce, BL; Elless, MP; Stewart, CN, Jr (In Press) Plant Physiology. HERO ID: 1936070

[Less] Ferns (Pteridophyta) are very important members of the plant kingdom that lag behind other taxa with . . . [More] Ferns (Pteridophyta) are very important members of the plant kingdom that lag behind other taxa with regards to our understanding of their genetics, genomics, and molecular biology. We report here the first instance of stable transformation of fern with recovery of transgenic sporophytes. Spores of the arsenic hyperaccumulating fern Pteris vittata (Chinese brake fern) and tetraploid Ceratopteris thalictroides (C-fern 'Express') were stably transformed by Agrobacterium tumefaciens with constructs containing the P. vittata actin promoter driving a GUSPlus reporter gene. Reporter gene expression assays were performed on multiple tissues and growth stages of gametophytes and sporophytes. Southern blot analysis confirmed stable transgene integration in recovered sporophytes and also confirmed that no plasmid from Agrobacterium was present in the sporophyte tissues. We recovered seven independent transformants of P. vittata and four independent C. thalictroides transgenics. Inheritance analyses using GUS histochemical staining revealed that the GUS transgene was stably expressed in second (T2) generation C. thalictroides sporophytic tissues. In an independent experiment, the gusA gene that was driven by the 2x CaMV 35S promoter was bombarded into P. vittata spores using biolistics in which putatively stable transgenic gametophytes were recovered. Transformation procedures required no tissue culture or selectable marker genes. However, we did attempt to use hygromycin selection, which was ineffective to recover transgenic ferns. This simple stable transformation method should help facilitate functional genomics studies in ferns.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Model-based integration and analysis of biogeochemical and isotopic dynamics in a nitrate-polluted pyritic aquifer

Authors: Zhang, Y-C; Prommer, HM; Broers, HP; Slomp, CP; Greskowiak, J; van der Grift, B; Van Cappellen, P (In Press) Environmental Science and Technology. HERO ID: 1936075

[Less] Leaching of nitrate from agricultural land to groundwater and the resulting nitrate pollution are a . . . [More] Leaching of nitrate from agricultural land to groundwater and the resulting nitrate pollution are a major environmental problem worldwide. Its impact is often mitigated in aquifers hosting sufficiently reactive reductants that can promote autotrophic denitrification. In the case of pyrite acting as reductant, however, denitrification is associated with the release of sulfate and often also with the mobilization of trace metals (e.g., arsenic). In this study, reactive transport modeling was used to reconstruct, quantify and analyze the dynamics of the dominant biogeochemical processes in a nitrate-polluted pyrite-containing aquifer and its evolution over the last 50 years in response to changing agricultural practices. Model simulations were constrained by measured concentration depth profiles. Measured 3H/3He profiles were used to support the calibration of flow and conservative transport processes, while the comparison of simulated and measured sulfur isotope signatures acted as additional calibration constraint for the reactive processes affecting sulfur cycling. The model illustrates that denitrification largely prevented an elevated discharge of nitrate to surface waters, while sulfate discharges were significantly increased, peaking around 15 years after the maximum nitrogen inputs.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Auxin and its transport play a role in plant tolerance to arsenite-induced oxidative stress in Arabidopsis thaliana

Authors: Krishnamurthy, A; Rathinasabapathi, B (In Press) Plant, Cell and Environment. HERO ID: 1519070

[Less] The role of auxin in plant development is well known; however, its possible function in root response . . . [More] The role of auxin in plant development is well known; however, its possible function in root response to abiotic stress is poorly understood. In this study, we demonstrate a novel role of auxin transport in plant tolerance to oxidative stress caused by arsenite. Plant response to arsenite [As(III)] was evaluated by measuring root growth and markers for stress on seedlings treated with control or As(III)-containing medium. Auxin transporter mutants aux1, pin1 and pin2 were significantly more sensitive to As(III) than the wild type (WT). Auxin transport inhibitors significantly reduced plant tolerance to As(III) in the WT, while exogenous supply of indole-3-acetic acid improved As(III) tolerance of aux1 and not that of WT. Uptake assays using H(3) -IAA showed As(III) affected auxin transport in WT roots. As(III) increased the levels of H2 O2 in WT but not in aux1, suggesting a positive role for auxin transport through AUX1 on plant tolerance to As(III) stress via reactive oxygen species (ROS)-mediated signalling. Compared to the WT, the mutant aux1 was significantly more sensitive to high-temperature stress and salinity, also suggesting auxin transport influences a common element shared by plant tolerance to arsenite, salinity and high-temperature stress.