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Diisononyl Phthalate (DINP)

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1,072 References Were Found:

Technical Report
Technical Report

Human health tier II assessment for diisononyl phthalates and related compounds

Author: NICNAS (2017) HERO ID: 3687925


Technical Report
Technical Report

Diisononyl phthalate chemical sampling information

Author: OSHA (2017) HERO ID: 3688043


Technical Report
Technical Report

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to di-isononylphthalate (DINP) for use in food contact materials. Question N° EFSA-Q-2003-194. The EFSA Journal 244, 1-18

Author: OSHA (2017) HERO ID: 3688079


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Production of Antimicrobial Metabolites by Streptomyces lavendulocolor VHB-9 Isolated from Granite Mines

Authors: Bindu, HBSSN; Muvva, V; Munaganti, RK; Naragani, K; Konda, S; Dorigondla, KR (2017) HERO ID: 3860238

[Less] The actinobacterial strain Streptomyces lavendulocolor VHB-9 was isolated from granite mine soil samples . . . [More] The actinobacterial strain Streptomyces lavendulocolor VHB-9 was isolated from granite mine soil samples of Khammam district, Telangana state, India. The strain was identified based on detailed microorphological, cultural and phylogenetic analysis. Bioactive guided isolation of the secondary metabolites of the strain was carried out by growing the strain in optimized medium (0.5% lactose, 0.5% peptone, 0.05% K2HPO4, 0.2% CaCO3 with pH adjusted to 7.0). Separation and purification of the active fractions from the crude ethyl acetate extract was carried out by silica gel column chromatography and resulted in the isolation of two active fractions. Structural elucidation of the two (B2 and B3) active compounds was carried out by FT-IR, Mass and NMR spectroscopy and were identified as Bis (7-methyloctyl) phthalate and (Z)-3-aminoacrylic acid. The antimicrobial activity of the bioactive compounds produced by S. lavendulocolor VHB-9 was expressed in terms of minimum inhibitory concentration against opportunistic pathogenic bacteria and fungi. Both fractions exhibited good antimicrobial potential against the bacteria and fungi tested.

Technical Report
Technical Report

Human health tier II assessment for Propane, 1-bromo-

Author: NICNAS (2017) HERO ID: 3827327


The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Epigenetic impacts of endocrine disruptors in the brain

Authors: Walker, DM; Gore, AC (2017) Frontiers in Neuroendocrinology 44:1-26. [Review] HERO ID: 3688561

[Less] The acquisition of reproductive competence is organized and activated by steroid hormones acting upon . . . [More] The acquisition of reproductive competence is organized and activated by steroid hormones acting upon the hypothalamus during critical windows of development. This review describes the potential role of epigenetic processes, particularly DNA methylation, in the regulation of sexual differentiation of the hypothalamus by hormones. We examine disruption of these processes by endocrine-disrupting chemicals (EDCs) in an age-, sex-, and region-specific manner, focusing on how perinatal EDCs act through epigenetic mechanisms to reprogram DNA methylation and sex steroid hormone receptor expression throughout life. These receptors are necessary for brain sexual differentiation and their altered expression may underlie disrupted reproductive physiology and behavior. Finally, we review the literature on histone modifications and non-coding RNA involvement in brain sexual differentiation and their perturbation by EDCs. By putting these data into a sex and developmental context we conclude that perinatal EDC exposure alters the developmental trajectory of reproductive neuroendocrine systems in a sex-specific manner.

Journal Article
Journal Article

Reproducibility discrepancies following reanalysis of raw data for a previously published study on diisononyl phthalate (DINP) in rats

Authors: Chen, M; Alyea, R; Morfeld, P; Otter, R; Kemmerling, J; Palermo, C (2017) Data in Brief 13:208-213. HERO ID: 3859100

[Less] A 2011 publication by Boberg et al. entitled "Reproductive and behavioral effects of diisononyl . . . [More] A 2011 publication by Boberg et al. entitled "Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats" [1] reported statistically significant changes in sperm parameters, testicular histopathology, anogenital distance and retained nipples in developing males. Using the statistical methods as reported by Boberg et al. (2011) [1], we reanalyzed the publically available raw data ([dataset] US EPA (United States Environmental Protection Agency), 2016) [2]. The output of our reanalysis and the discordances with the data as published in Boberg et al. (2011) [1] are highlighted herein. Further discussion of the basis for the replication discordances and the insufficiency of the Boberg et al. (2011) [1] response to address them can be found in a companion letter of correspondence (doi: 10.1016/j.reprotox.2017.03.013.; (Morfeld et al., 2011) [3]).

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Phthalate metabolites in 24-h urine samples of the German Environmental Specimen Bank (ESB) from 1988 to 2015 and a comparison with US NHANES data from 1999 to 2012

Authors: Koch, HM; Rüther, M; Schütze, A; Conrad, A; Pälmke, C; Apel, P; Brüning, T; Kolossa-Gehring, M (2017) International Journal of Hygiene and Environmental Health 220:130-141. HERO ID: 3469204

[Less] The German Environmental Specimen Bank (ESB) continuously collects 24-h urine samples since the early . . . [More] The German Environmental Specimen Bank (ESB) continuously collects 24-h urine samples since the early 1980s in Germany. In this study we analyzed 300 urine samples from the years 2007 to 2015 for 21 phthalate metabolites (representing exposure to 11 parent phthalates) and combined the data with two previous retrospective measurement campaigns (1988 to 2003 and 2002 to 2008). The combined dataset comprised 1162 24-h urine samples spanning the years 1988 to 2015. With this detailed set of human biomonitoring data we describe the time course of phthalate exposure in Germany over a time frame of 27 years. For the metabolites of the endocrine disrupting phthalates di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DnBP) and butylbenzyl phthalate (BBzP) we observed a roughly ten-fold decline in median metabolite levels from their peak levels in the late 1980s/early 1990s compared to most recent levels from 2015. Probably, bans (first enacted in 1999) and classifications/labelings (enacted in 2001 and 2004) in the European Union lead to this drop. A decline in di-isobutyl phthalate (DiBP) metabolite levels set in only quite recently, possibly due to its later classification as a reproductive toxicant in the EU in 2009. In a considerable number of samples collected before 2002 health based guidance values (BE, HBM I) have been exceeded for DnBP (27.2%) and DEHP (2.3%) but also in recent samples some individual exceedances can still be observed (DEHP 1.0%). A decrease in concentration for all low molecular weight phthalates, labelled or not, was seen in the most recent years of sampling. For the high molecular weight phthalates, DEHP seems to have been substituted in part by di-isononyl phthalate (DiNP), but DiNP metabolite levels have also been declining in the last years. Probably, non-phthalate alternatives increasingly take over for the phthalates in Germany. A comparison with NHANES (National Health and Nutrition Examination Survey) data from the United States covering the years 1999 to 2012 revealed both similarities and differences in phthalate exposure between Germany and the US. Exposure to critical phthalates has decreased in both countries with metabolite levels more and more aligning with each other, but high molecular weight phthalates substituting DEHP (such as DiNP) seem to become more important in the US than in Germany.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Occurrence, spatial distribution, historical trend and ecological risk of phthalate esters in the Jiulong River, Southeast China

Authors: Li, R; Liang, J; Gong, Z; Zhang, N; Duan, H (2017) Science of the Total Environment 580:388-397. HERO ID: 3483279

[Less] The occurrence and spatial distribution of phthalate esters (PAEs) in the Jiulong River of southeast . . . [More] The occurrence and spatial distribution of phthalate esters (PAEs) in the Jiulong River of southeast China were investigated in water and sediment samples collected from 35 stations along the river in Mar. 2014. The historical trend of the past 26years was reconstructed with a sediment core collected in Dec. 2012 via a 210Pb dating technique. The potential ecological risk of PAEs was assessed using the risk quotient (RQ) method. Of the 16 PAE congeners analyzed, only 6 PAEs, including dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DIBP), di-n-butyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP) and diisononyl phthalate (DINP), were identified and quantified; the remaining 10 PAEs were below their respective limits of quantification (LOQs) for the analytical methods used here. The cumulative concentration of 6 PAEs (∑6PAEs) found in the samples spanned a range of 3.48-17.7μg/L in water and 0.046-1.65mg/kg in sediment. The most abundant PAEs in the water-phase were DEHP and DIBP, together accounting for 84.9% of ∑6PAEs in the North River, 82.8% of ∑6PAEs in the West River and 91.6% of ∑6PAEs in the estuary. DEHP and DINP were the richest congeners in the sediment-phase, with proportions of 84.9% in the North River, 81.0% in the West River and 65.4% in the estuary. The spatial distribution of ∑6PAEs in water and sediment phases showed that the riverside environment had influence on the distribution pattern. The reconstruction profile of the PAE congeners and the ∑6PAEs vs the depth of the sediment core indicated that PAEs became increasingly present pollutants around 2006 in the Jiulong River. The results of the potential ecological risk assessment of the RQ method revealed that DIBP and DEHP posed a high risk because of their relatively higher concentrations, while DBP and DINP posed a medium risk to the aquatic system. The baseline data of PAEs in this river will be benefits to the regulatory attention and future strategies of the pollutants control along the river network.

The "refereed" or "peer review" status of a journal comes from the Ulrichsweb Global Serials Directory (http://ulrichsweb.serialssolutions.com/), as supplied by the publisher. The term refers to the system of critical evaluation of manuscripts/articles by professional colleagues or peers. The content of refereed publications is sanctioned, vetted, or otherwise approved by a peer-review or editorial board. The peer-review and evaluation system is utilized to protect, maintain, and raise the quality of scholarly material published in serials. Publications subject to the referee process are assumed, then, to contain higher quality content than those that are not.
Peer Reviewed Journal Article

Determination of phthalate esters in distillates by ultrasound-vortex-assisted dispersive liquid-liquid micro-extraction (USVADLLME) coupled with gas chromatography/mass spectrometry

Authors: Montevecchi, G; Masino, F; Zanasi, L; Antonelli, A (2017) Food Chemistry 221:1354-1360. HERO ID: 3515158

[Less] A method for the extraction of phthalate esters (PAEs) by Ultrasound-Vortex-Assisted Dispersive Liquid-Liquid . . . [More] A method for the extraction of phthalate esters (PAEs) by Ultrasound-Vortex-Assisted Dispersive Liquid-Liquid Micro-Extraction (USVADLLME) approach was optimised and applied for the first time to a historical series of brandies. These contaminants are widely spread in the environment as a consequence of about half century of use in different fields of applications. The concern about these substances and the recent legal restrictions of China in distillates import need a quick and sensitive method for their quantification. The proposed method, moreover, is environmentally oriented due to the disposal of micro-quantities of solvent required. In fact, sub-ppm-limits of detection were achieved with a solvent volume as low as 160μL. The analysed samples were within the legal limits, except for some very ancient brandies whose contamination was probably due to a PAEs concentration effect as a consequence of long ageing and for the use of plastic pipelines no more operative.